(Q33928982)

English

Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis

scientific article

Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis.

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Europe PubMed Central

PubMed publication ID

30 July 2017

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis (English)

2 references

Europe PubMed Central

PubMed publication ID

30 July 2017

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

Escherichia coli

0 references

0 references

multivariate statistics

1 reference

based on heuristic

inferred from title

Escherichia coli

object named as

Escherichia coli

1 reference

based on heuristic

inferred from title

author name string

Sjöström M

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Wold S

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Wieslander A

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Rilfors L

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

M. Sjöström

1

1 reference

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

S. Wold

2

1 reference

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

A. Wieslander

3

1 reference

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

L. Rilfors

4

1 reference

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

language of work or name

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publication date

1 March 1987

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

March 1987

1 reference

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

The EMBO Journal

2 references

Europe PubMed Central

PubMed publication ID

30 July 2017

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

6

2 references

Europe PubMed Central

PubMed publication ID

30 July 2017

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

3

2 references

Europe PubMed Central

PubMed publication ID

30 July 2017

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

823-831

2 references

Europe PubMed Central

PubMed publication ID

30 July 2017

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

The cleavable pre-sequence of an imported chloroplast protein directs attached polypeptides into yeast mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The ultimate localization of an outer membrane protein of Escherichia coli K-12 is not determined by the signal sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

A simple method for displaying the hydropathic character of a protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Secretion and membrane localization of proteins in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and the mature form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Amino acid sequence of the signal peptide of ompA protein, a major outer membrane protein of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The nucleotide sequences defining the signal peptides of the galactose-binding protein and the arabinose-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Patterns of amino acids near signal-sequence cleavage sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Sequence analysis of the heat-labile enterotoxin subunit B gene originating in human enterotoxigenic Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

DNA sequence encoding the NH2-terminal peptide involved in transport of lambda receptor, an Escherichia coli secretory protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Mechanism of toxin secretion by Vibrio cholerae investigated in strains harboring plasmids that encode heat-labile enterotoxins of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of the phoS gene, the structural gene for the phosphate-binding protein of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Characterization of the gene encoding heat-stable toxin II and preliminary molecular epidemiological studies of enterotoxigenic Escherichia coli heat-stable toxin II producers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The amino acid sequence of D-ribose-binding protein from Escherichia coli K12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Primary structure of toetolCgene that codes for an outer membrane protein ofEscherichia coliK12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Escherichia coli heat-labile enterotoxin. Nucleotide sequence of the A subunit gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The nudeotide sequence of the promoter and the ammo-terminal region of alkaline phosphatase structural gene (phoA) of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of the filamentous bacteriophage M13 DNA genome: comparison with phage fd

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of the bacterial transposon Tn1681 encoding a heat-stable (ST) toxin and its identification in enterotoxigenic Escherichia coli strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of the amylase gene fromBacillus subtilis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Correspondence of homologies in amino acid sequence and tertiary structure of protein molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The fimA gene encoding the type-1 fimbrial subunit of Escherichia coli. Nucleotide sequence and primary structure of the protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of the papA gene encoding the Pap pilus subunit of human uropathogenic Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Secretion cloning vectors in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

K88ab gene of Escherichia coli encodes a fimbria-like protein distinct from the K88ab fimbrial adhesin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Relations between chemical structure and biological activity in peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Signal sequences. The limits of variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

An inner membrane protein N-terminal signal sequence is able to promote efficient localisation of an outer membrane protein in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The complete nucleotide sequences of the Escherichia coli LIV-BP and LS-BP genes. Implications for the mechanism of high-affinity branched-chain amino acid transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

An artificial anchor domain: hydrophobicity suffices to stop transfer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of the gene for the vitamin B12 receptor protein in the outer membrane of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Fusions of secreted proteins to alkaline phosphatase: an approach for studying protein secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The C terminus of penicillin-binding protein 5 is essential for localisation to the E. coli inner membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Translocation of nascent non-signal sequence protein in heated Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Crystallization and x-ray diffraction studies of a phosphate-binding protein involved in active transport in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Identification, immunochemical characterization, and purification of a major lipoprotein antigen associated with the inner (cytoplasmic) membrane of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Secretion activities of Bacillus subtilis alpha-amylase signal peptides of different lengths in Escherichia coli cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Secretion of haemolysin by Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Translational control of exported proteins in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2',3'-cyclic phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Lipoprotein-28, a cytoplasmic membrane lipoprotein from Escherichia coli. Cloning, DNA sequence, and expression of its gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The ompA signal peptide directed secretion of Staphylococcal nuclease A by Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Secretion into the culture medium of a foreign gene product from Escherichia coli: use of the ompF gene for secretion of human beta-endorphin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Gene products specifying adhesion of uropathogenic Escherichia coli are minor components of pili

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Molecular biology of fimbriae of enterotoxigenic Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Nucleotide sequence of pilA, the gene encoding the structural component of type 1 pili in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

An outer membrane protein (OmpA) of Escherichia coli K-12 undergoes a conformational change during export.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Partial amino acid sequence of penicillinase coded by Escherichia coli plasmid R6K

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

Asymmetric orientation of a phage coat protein in cytoplasmic membrane of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

5 July 2018

The E. coli beta-lactamase attenuator mediates growth rate-dependent regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

29 October 2018

Complete nucleotide sequence of phoE, the structural gene for the phosphate limitation inducible outer membrane pore protein of Escherichia coli K12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

29 October 2018

Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

29 October 2018

DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro-OmpC protein of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

29 October 2018

Nucleotide sequence of the gene encoding the F72 fimbrial subunit of a uropathogenic Escherichia coli strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553468

29 October 2018

Studies on bacteriophage fd DNA. IV. The sequence of messenger RNA for the major coat protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of synthesis, processing, and membrane transport of heat-labile enterotoxin, a periplasmic protein in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a comparative anatomy of N-terminal topogenic protein sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multivariate study of the relationship between the genetic code and the physical-chemical properties of amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Information in the signal peptide?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene sequence of the lambda receptor, an outer membrane protein of E. coli K12

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How signal sequences maintain cleavage specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NH2-terminal sequence of a precursor form of the arabinose binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fine structure of a membrane anchor domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prediction of bradykinin potentiating potency of pentapeptides. An example of a peptide quantitative structure-activity relationship

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nine amino acid residues at the NH2-terminal of lipoprotein are sufficient for its modification, processing, and localization in the outer membrane of Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/3556168

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/J.1460-2075.1987.TB04825.X

1 reference

10.1002/j.1460-2075.1987.tb04825.x

https://api.crossref.org/v1/works/https://doi.org/10.1002/j.1460-2075.1987.tb04825.x

20 December 2022

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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