(Q33777704)

29 July 2017

1 reference

title

Apoptosis: definition, mechanisms, and relevance to disease (English)

1 reference

29 July 2017

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Saikumar P

1

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29 July 2017

Dong Z

2

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29 July 2017

Mikhailov V

3

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29 July 2017

Denton M

4

1 reference

29 July 2017

Weinberg JM

5

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29 July 2017

Venkatachalam MA

6

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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American Journal of Medicine

29 July 2017

published in

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29 July 2017

volume

107

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29 July 2017

issue

5

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29 July 2017

page(s)

489-506

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

29 July 2017

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15 Methods for Detecting and Quantifying Apoptosis

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A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

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7 January 2021

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Programmed cell death during mammary gland involution

7 January 2021

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Caspase activation in the terminal differentiation of human epidermal keratinocytes

7 January 2021

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Neuronal cell death: when, why and how

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Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat.

7 January 2021

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Induction of necrosis but not apoptosis after anoxia and reoxygenation in isolated adult cardiomyocytes of rat

7 January 2021

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Heat-induced apoptosis and p53 in cultured mammalian cells

7 January 2021

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Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation

7 January 2021

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7 January 2021

How does HIV cause AIDS?

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The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses

7 January 2021

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Apoptosis and thyroiditis

7 January 2021

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Immune cell signaling defects in lupus: activation, anergy and death

7 January 2021

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Oxidative stress and the pathogenesis of Parkinson's disease

7 January 2021

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Fate of Schwann cells in CMT1A and HNPP: evidence for apoptosis

7 January 2021

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Enhanced cell survival and tumorigenesis.

7 January 2021

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The molecular biology of apoptosis

7 January 2021

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Evolutionary conservation of a genetic pathway of programmed cell death

7 January 2021

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The genetics of programmed cell death in the nematode Caenorhabditis elegans.

7 January 2021

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Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

7 January 2021

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Interaction and regulation of subcellular localization of CED-4 by CED-9

7 January 2021

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Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

7 January 2021

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The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease

7 January 2021

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Anchorage dependence, integrins, and apoptosis

7 January 2021

1 reference

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Stable transfection of PC12 cells with estrogen receptor (ERalpha): protective effects of estrogen on cell survival after serum deprivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Estrogen causes cell death of estrogen receptor stably transfected cells via apoptosis

7 January 2021

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Signalling by CD95 and TNF receptors: not only life and death.

7 January 2021

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Apoptosis by death factor

7 January 2021

1 reference

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Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model

7 January 2021

1 reference

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A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

7 January 2021

1 reference

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The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

7 January 2021

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

7 January 2021

1 reference

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

7 January 2021

1 reference

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A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other

7 January 2021

1 reference

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

7 January 2021

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Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection

7 January 2021

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

7 January 2021

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Radiation-induced apoptosis--the ceramide-SAPK signaling pathway and clinical aspects

7 January 2021

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Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

7 January 2021

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Human ICE/CED-3 protease nomenclature

7 January 2021

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

7 January 2021

1 reference

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7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

The CARD domain: a new apoptotic signalling motif

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

7 January 2021

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Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Activation of the c-Jun N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Differential requirement for caspase 9 in apoptotic pathways in vivo.

7 January 2021

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

7 January 2021

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Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

7 January 2021

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Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities

7 January 2021

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

7 January 2021

1 reference

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development

7 January 2021

1 reference

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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

7 January 2021

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

7 January 2021

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RAIDD is a new 'death' adaptor molecule

7 January 2021

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

7 January 2021

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The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis

7 January 2021

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Inhibition of death receptor signals by cellular FLIP

7 January 2021

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

7 January 2021

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Lethal effect of the anti-Fas antibody in mice

7 January 2021

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Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

7 January 2021

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7 January 2021

Bcl-2 family proteins

1 reference

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bcl-2 inhibits death of central neural cells induced by multiple agents

7 January 2021

1 reference

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

7 January 2021

1 reference

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Recessive mutations in a common pathway block thymocyte apoptosis induced by multiple signals

7 January 2021

1 reference

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Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

7 January 2021

1 reference

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Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

7 January 2021

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Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

7 January 2021

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The Bcl-2 protein family: arbiters of cell survival

7 January 2021

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis

7 January 2021

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

7 January 2021

1 reference

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Investigation of bax-induced release of cytochrome c from yeast mitochondria permeability of mitochondrial membranes, role of VDAC and ATP requirement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bcl-2 regulates amplification of caspase activation by cytochrome c.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Bcl-2 family proteins as ion-channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Inhibition of Bax channel-forming activity by Bcl-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Modulation of endoplasmic reticulum calcium pump by Bcl-2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

IAP family proteins--suppressors of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Selective proteolysis of the nuclear replication factor MCM3 in apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9343%2899%2900259-4

Beta cell apoptosis in T cell-mediated autoimmune diabetes

7 January 2021

1 reference

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The role of Fas in autoimmune diabetes

7 January 2021

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Interactions between T lymphocytes and endothelial cells in allograft rejection.

7 January 2021

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Apoptosis: mechanisms of life and death in the immune system

7 January 2021

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ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis

7 January 2021

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Expression of bcl-2 in fetal thymus, thymomas and thymic carcinomas. Association with p53 expression and review of the literature.

7 January 2021

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Bcl-2: a repressor of lymphocyte death

7 January 2021

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p53-dependent cell cycle control: response to genotoxic stress

7 January 2021

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Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

7 January 2021

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p53, the cellular gatekeeper for growth and division

7 January 2021

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

7 January 2021

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Bax suppresses tumorigenesis and stimulates apoptosis in vivo

7 January 2021

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The Li-Fraumeni syndrome: An inherited susceptibility to cancer

7 January 2021

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Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?

7 January 2021

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Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

7 January 2021

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The Fas counterattack: cancer as a site of immune privilege

7 January 2021

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Regulation of the proinflammatory effects of Fas ligand (CD95L).

7 January 2021

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I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

7 January 2021

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Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

7 January 2021

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Neuronal death in glaucoma

7 January 2021

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Cell death in the inner ear associated with aging is apoptosis?

7 January 2021

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Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

7 January 2021

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

7 January 2021

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ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis

7 January 2021

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Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis

7 January 2021

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T cell apoptosis in HIV infection: mechanisms and relevance for AIDS pathogenesis

7 January 2021

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Apoptosis: programmed cell death in fetal development

7 January 2021

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Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways

7 January 2021

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The adenovirus E3-14.7K protein and the E3-10.4K/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid

7 January 2021

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7 January 2021

The adenovirus E3-10.4K/14.5K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis

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7 January 2021

Regulation of apoptosis by viral gene products

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7 January 2021

Aging and regulation of apoptosis

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7 January 2021

10.1016/S0002-9343(99)00259-4

Identifiers

DOI

1 reference

29 July 2017

1 reference