(Q33278100)

25 July 2017

title

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon (English)

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25 July 2017

author

Adrian Robert Krainer

5

object named as

Adrian R Krainer

1 reference

25 July 2017

Yimin Hua

1

1 reference

25 July 2017

Timothy A Vickers

2

1 reference

25 July 2017

Brenda F Baker

3

1 reference

25 July 2017

C Frank Bennett

4

1 reference

25 July 2017

language of work or name

English

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publication date

1 April 2007

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25 July 2017

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25 July 2017

volume

5

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25 July 2017

issue

4

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25 July 2017

page(s)

e73

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Creative Commons Attribution 4.0 International

25 July 2017

copyright license

start time

13 March 2007

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide

21 June 2018

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Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron

21 June 2018

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Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

21 June 2018

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Chimeric peptide nucleic acid compounds modulate splicing of the bcl-x gene in vitro and in vivo

21 June 2018

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21 June 2018

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Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs

21 June 2018

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Promoter usage and alternative splicing

21 June 2018

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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

21 June 2018

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The regulation and regulatory activities of alternative splicing of the SMN gene

21 June 2018

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Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles

21 June 2018

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Survival motor neuron protein facilitates assembly of stress granules

21 June 2018

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In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes

21 June 2018

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21 June 2018

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Advances in Duchenne muscular dystrophy gene therapy

21 June 2018

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Antisense-mediated redirection of mRNA splicing

21 June 2018

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Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts

21 June 2018

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Essential role for the SMN complex in the specificity of snRNP assembly

21 June 2018

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Identification of a cis-acting element for the regulation of SMN exon 7 splicing

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

An extensive network of coupling among gene expression machines

21 June 2018

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Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Modulation of survival motor neuron pre-mRNA splicing by inhibition of alternative 3' splice site pairing

21 June 2018

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Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

21 June 2018

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The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

The survival motor neuron protein in spinal muscular atrophy

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

An 11 base pair duplication in exon 6 of the SMN gene produces a type I spinal muscular atrophy (SMA) phenotype: further evidence for SMN as the primary SMA-determining gene.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

A novel nuclear structure containing the survival of motor neurons protein

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Identification and characterization of a spinal muscular atrophy-determining gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Can a 'patch' in a skipped exon make the pre-mRNA splicing machine run better?

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Correction of disease-associated exon skipping by synthetic exon-specific activators

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820610

An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy

31 October 2018

1 reference

12 December 2020

International SMA consortium meeting. (26-28 June 1992, Bonn, Germany)

1 reference

12 December 2020

Mammalian in vitro splicing assays

1 reference

12 December 2020

SMN oligomerization defect correlates with spinal muscular atrophy severity

1 reference

12 December 2020

SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

1 reference

12 December 2020

Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing

1 reference

12 December 2020

A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy

1 reference

12 December 2020

An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.0050073

Identifiers

DOI

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25 July 2017

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25 July 2017

1 reference