(Q33217148)

24 July 2017

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title

Gene discovery by ribozyme and siRNA libraries (English)

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24 July 2017

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3

Kazunari Taira

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24 July 2017

Hideo Akashi

1

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24 July 2017

Sahohime Matsumoto

series ordinal

2

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24 July 2017

publication date

1 May 2005

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Nature Reviews Molecular Cell Biology

24 July 2017

published in

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24 July 2017

volume

6

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24 July 2017

issue

5

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24 July 2017

page(s)

413-422

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The knockout mouse project

24 July 2017

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An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

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Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes

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Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes

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LIM kinase-2 targeting as a possible anti-metastasis therapy

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Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation.

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Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach

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Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes

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Simple RNA enzymes with new and highly specific endoribonuclease activities

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Nature of the chemical bond formed with the structural metal ion at the A9/G10.1 motif derived from hammerhead ribozymes

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Analysis of the conserved P9-G10.1 metal-binding motif in hammerhead ribozymes with an extra nucleotide inserted between A9 and G10.1 residues

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Expression of small, therapeutic RNAs in human cell nuclei.

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Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells

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RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA

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Functional siRNAs and miRNAs Exhibit Strand Bias

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Asymmetry in the assembly of the RNAi enzyme complex

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

21 January 2018

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Synthetic shRNAs as potent RNAi triggers

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Activation of the interferon system by short-interfering RNAs

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Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

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Small interfering RNA-induced transcriptional gene silencing in human cells

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Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity

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21 January 2018

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Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries

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A small catalytic oligoribonucleotide

21 January 2018

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The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA

21 January 2018

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NMR-based reappraisal of the coordination of a metal ion at the pro-Rp oxygen of the A9/G10.1 site in a hammerhead ribozyme

31 March 2020

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Analysis on a cooperative pathway involving multiple cations in hammerhead reactions

31 March 2020

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Generality of the NUX rule: kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of hammerhead ribozymes

31 March 2020

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Ribozymes as potential anti-HIV-1 therapeutic agents.

31 March 2020

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Ribozyme mediated destruction of RNA in vivo

31 March 2020

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Recognition of engineered tRNAs with an extended 3' end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells.

31 March 2020

1 reference

The protein family of RNA helicases

31 March 2020

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Simple and rapid synthesis of siRNA derived from in vitro transcribed shRNA

31 March 2020

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Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1646

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Dimensions Publication ID

24 July 2017

1018609955

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