(Q30428127)

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Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition

scientific article published on August 1, 1997

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21 June 2017

Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition (English)

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21 June 2017

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition (English)

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10.1021/JM9607459

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11 November 2024

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hydroxymethyl and formyl transferases

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11 November 2024

author name string

Romines WH 3rd

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21 June 2017

M. D. Varney

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C. L. Palmer

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W. H. Romines

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T. Boritzki

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S. A. Margosiak

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R. Almassy

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C. A. Janson

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C. Bartlett

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E. J. Howland

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11 November 2024

R. Ferre

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1 August 1997

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full work available at URL

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11 November 2024

Journal of Medicinal Chemistry

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21 June 2017

40

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21 June 2017

16

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21 June 2017

2502-2524

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21 June 2017

The renewed potential for folate antagonists in contemporary cancer chemotherapy

1

1 reference

10.1021/JM9607459

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11 November 2024

Journal of Biological Chemistry

4

253

4244

author name string

Dev I. K.

publication date

1978

1 reference

10.1021/JM9607459

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Small-angle neutron scattering study of Bence-Jones protein Mcg: comparison of structures in solution and in crystal

5

1 reference

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Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

6

1 reference

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Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer

9

1 reference

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11 November 2024

Journal of Organic Chemistry

13

59

7098

author name string

Taylor E. C.

publication date

1994

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11 November 2024

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

14

1 reference

10.1021/JM9607459

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11 November 2024

17

28

1178

author name string

Taylor E. C.

publication date

1989

1 reference

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Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids

18

1 reference

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Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid

19

1 reference

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Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents

20

1 reference

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Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid

22

1 reference

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Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase

25

1 reference

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Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy

26

1 reference

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Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution

27

1 reference

10.1021/JM9607459

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11 November 2024

Journal of Applied Crystallography

31

21

278

author name string

Fitzgerald P. M. D. MERLOT

publication date

1988

1 reference

10.1021/JM9607459

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11 November 2024

Journal of the Chemical Society

34

603

606

author name string

Baker J. A.

publication date

1969

1 reference

10.1021/JM9607459

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A new, highly efficient method for the conversion of alcohols to thiolesters and thiols

36

1 reference

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Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives

38

1 reference

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11 November 2024

Journal of the American Chemical Society

40

115

7635

author name string

Nicolaou K. C.

publication date

1993

1 reference

10.1021/JM9607459

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11 November 2024

Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase

41

1 reference

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11 November 2024

Journal of the American Chemical Society

42

111

7665

author name string

Taylor E. C.

publication date

1989

1 reference

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11 November 2024

Organic Syntheses

43

72

13

author name string

Schmid C. R.

publication date

1993

1 reference

10.1021/JM9607459

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11 November 2024

Tetrahedron Letters

45

31

5644

author name string

Chini M.

publication date

1990

1 reference

10.1021/JM9607459

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11 November 2024

Journal of the Chemical Society

46

579

585

author name string

Chapman J. H.

publication date

1950

1 reference

10.1021/JM9607459

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11 November 2024

An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver

47

1 reference

10.1021/JM9607459

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11 November 2024

Cancer Research

49

44

3370

author name string

Fry D. W.

publication date

1984

1 reference

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

50

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Measurement of folylpolyglutamate synthetase in mammalian tissues

51

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

52

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Mammalian folyl polyglutamate synthetase: partial purification and properties of the mouse liver enzyme

53

1 reference

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Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds

56

1 reference

10.1021/JM9607459

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Cancer Research

59

54

1026

author name string

Leitner T. A.

publication date

1994

1 reference

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Macromodel?an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

62

1 reference

10.1021/JM9607459

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An all atom force field for simulations of proteins and nucleic acids

65

1 reference

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Semianalytical treatment of solvation for molecular mechanics and dynamics

66

1 reference

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Journal of the Chemical Society

67

1866

1869

author name string

Spinelli D.

publication date

1972

1 reference

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11 November 2024

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10.1021/JM9607459

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

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