(Q30426766)

21 June 2017

title

Double-mutant cycles: a powerful tool for analyzing protein structure and function (English)

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21 June 2017

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Horovitz A

1

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21 June 2017

publication date

1 January 1996

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21 June 2017

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21 June 2017

volume

1

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21 June 2017

issue

6

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21 June 2017

page(s)

R121-6

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The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

21 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Additivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Quantitative interpretations of double mutations of enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Long-range, small magnitude nonadditivity of mutational effects in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Non-additivity in protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The Effect of Structure upon the Reactions of Organic Compounds. Benzene Derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

On the choice of reference mutant states in the application of the double-mutant cycle method

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Surface electrostatic interactions contribute little of stability of barnase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Aromatic-aromatic interactions and protein stability. Investigation by double-mutant cycles

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Strength and co-operativity of contributions of surface salt bridges to protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Are buried salt bridges important for protein stability and conformational specificity?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Contributions of a hydrogen bond/salt bridge network to the stability of secondary and tertiary structure in lambda repressor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Importance of two buried salt bridges in the stability and folding pathway of barnase.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Histidine-aromatic interactions in barnase. Elevation of histidine pKa and contribution to protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Decomposition of the Free Energy of a System in Terms of Specific Interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The meaning of component analysis: decomposition of the free energy in terms of specific interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Decomposition of interaction free energies in proteins and other complex systems.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Co-operative interactions during protein folding.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Subsite interactions of ribonuclease T1: Asn36 and Asn98 accelerate GpN transesterification through interactions with the leaving nucleoside N.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Investigation of the functional interplay between the primary site and the subsite of RNase T1: Kinetic analysis of single and multiple mutants for modified substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The net energetic contribution of interhelical electrostatic attractions to coiled-coil stability

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Protein destabilization by electrostatic repulsions in the two-stranded alpha-helical coiled-coil/leucine zipper

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Thermodynamic characterization of the coupled folding and association of heterodimeric coiled coils (leucine zippers).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Measurement of interhelical electrostatic interactions in the GCN4 leucine zipper

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Response: how much solar radiation do clouds absorb?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Rapid, electrostatically assisted association of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Prediction of an inter-residue interaction in the chaperonin GroEL from multiple sequence alignment is confirmed by double-mutant cycle analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

COSMIC analysis of the major alpha-helix of barnase during folding.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The development of tertiary interactions during the folding of a large protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

The folding of an enzyme. III. Structure of the transition state for unfolding of barnase analysed by a protein engineering procedure

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Analysis of the role of the KMSKS loop in the catalytic mechanism of the tyrosyl-tRNA synthetase using multimutant cycles

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Protein-protein interactions: additivity of the free energies of association of amino acid residues.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Additivity of mutant effects assessed by binomial mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Potential use of additivity of mutational effects in simplifying protein engineering

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

Long-range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-0278%2896%2900056-9

7 January 2021

10.1016/S1359-0278(96)00056-9

Identifiers

DOI

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21 June 2017

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