(Q29820548)

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Laminin G domain, protein family

1 reference

Leucine-rich repeat N-terminal domain, protein family

1 reference

Cystine knot, C-terminal domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

1 reference

9 May 2019

heparin binding

1 reference

8 April 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

Roundabout binding

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

IPI

9 May 2019

Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

IPI

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

IBA

cell component

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

1 reference

9 May 2019

Slit-Robo signaling complex

TAS

1 reference

9 May 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

biological process

neuron migration

1 reference

9 May 2019

Roundabout 2 regulates migration of sensory neurons by signaling in trans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

outflow tract morphogenesis

1 reference

9 May 2019

Cellular components and signals required for the cardiac outflow tract assembly in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

1 reference

9 May 2019

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

1 reference

9 May 2019

axon guidance

Repellent signaling by Slit requires the leucine-rich repeats.

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

IPI

9 May 2019

The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Integrins regulate responsiveness to slit repellent signals.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Slit is the midline repellent for the robo receptor in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Repellent signaling by Slit requires the leucine-rich repeats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Repellent signaling by Slit requires the leucine-rich repeats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

epithelial cell migration, open tracheal system

1 reference

9 May 2019

Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

salivary gland boundary specification

1 reference

9 May 2019

NETRIN and SLIT guide salivary gland migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

digestive tract mesoderm development

1 reference

9 May 2019

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

mesoderm migration involved in gastrulation

mesodermal cell migration

1 reference

9 May 2019

Slit is the midline repellent for the robo receptor in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

glial cell migration

1 reference

9 May 2019

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

gonad development

1 reference

9 May 2019

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

regulation of epithelial cell migration

1 reference

9 May 2019

Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

axon midline choice point recognition

beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS.

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Abelson tyrosine kinase is required to transduce midline repulsive cues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

positive regulation of cell-cell adhesion

1 reference

9 May 2019

Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

1 reference

9 May 2019

neuron differentiation

1 reference

9 May 2019

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

embryonic heart tube development

3 references

9 May 2019

Slit and Robo control cardiac cell polarity and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Slit coordinates cardiac morphogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

9 May 2019

Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

Roundabout signaling pathway

1 reference

9 May 2019

Slit is the midline repellent for the robo receptor in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

dendrite morphogenesis

1 reference

9 May 2019

Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

induction of negative chemotaxis

1 reference

9 May 2019

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

regulation of epithelial cell migration, open tracheal system

1 reference

9 May 2019

Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

synaptic target inhibition

1 reference

9 May 2019

Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

positive regulation of cell migration

1 reference

9 May 2019

Guidance signalling regulates leading edge behaviour during collective cell migration of cardiac cells in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

EGF-like calcium-binding, conserved site

has part(s)

1 reference

Laminin G domain

1 reference

cysteine-rich flanking region, C-terminal

1 reference

leucine-rich repeat N-terminal domain

1 reference

EGF-like domain

1 reference

leucine-rich repeat, typical subtype

1 reference

EGF-like, conserved site

1 reference

Cystine knot, C-terminal

1 reference

Leucine-rich repeat

1 reference

EGF-like calcium-binding domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference