(Q29810293)

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Laminin G domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Cadherin-like, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Cadherin conserved site, protein family

1 reference

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 May 2019

Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

The atypical cadherin fat directly regulates mitochondrial function and metabolic state

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

cadherin binding

1 reference

9 May 2019

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

calcium ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

3 references

9 May 2019

9 May 2019

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

IBA

cell component

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

1 reference

9 May 2019

plasma membrane

integral component of plasma membrane

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

The evolution of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

ISS

27 February 2018

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

apical plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

1 reference

9 May 2019

apicolateral plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

integral component of plasma membrane

cell morphogenesis involved in differentiation

biological process

1 reference

9 May 2019

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

establishment of planar polarity

Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

establishment of imaginal disc-derived wing hair orientation

Planar polarity: photoreceptors on a high fat diet

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Atypical Cadherins Dachsous and Fat Control Dynamics of Noncentrosomal Microtubules in Planar Cell Polarity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Two Frizzled Planar Cell Polarity Signals in the Drosophila Wing Are Differentially Organized by the Fat/Dachsous Pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

1 reference

9 May 2019

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

establishment of tissue polarity

imaginal disc growth

3 references

9 May 2019

Cell behaviour of Drosophila fat cadherin mutations in wing development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

imaginal disc pattern formation

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

imaginal disc-derived wing morphogenesis

1 reference

9 May 2019

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

cell population proliferation

1 reference

9 May 2019

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

negative regulation of cell population proliferation

3 references

9 May 2019

Cell behaviour of Drosophila fat cadherin mutations in wing development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

tissue development

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

negative regulation of gene expression

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

ommatidial rotation

1 reference

27 February 2018

Planar polarity: photoreceptors on a high fat diet

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

establishment or maintenance of polarity of larval imaginal disc epithelium

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

The evolution of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

ISS

27 February 2018

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

peptide cross-linking

1 reference

9 May 2019

Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

regulation of protein localization

1 reference

9 May 2019

The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

regulation of tube length, open tracheal system

1 reference

9 May 2019

Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

pupal development

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

wing disc development

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

hippo signaling

1 reference

27 February 2018

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

negative regulation of hippo signaling

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

establishment of ommatidial planar polarity

A three-tiered mechanism for regulation of planar cell polarity.

6 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

27 February 2018

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

cell-cell adhesion mediated by cadherin

1 reference

9 May 2019

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

establishment of epithelial cell apical/basal polarity

1 reference

9 May 2019

Fidelity in planar cell polarity signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

regulation of imaginal disc growth

1 reference

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

negative regulation of growth

1 reference

9 May 2019

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

regulation of organ growth

1 reference

27 February 2018

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33450&geneProductId=UniProtKB:P33450

establishment of body hair planar orientation

1 reference

9 May 2019

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

Wnt signaling pathway, planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

1 reference

9 May 2019

microtubule cytoskeleton organization involved in establishment of planar polarity

1 reference

9 May 2019

Atypical Cadherins Dachsous and Fat Control Dynamics of Noncentrosomal Microtubules in Planar Cell Polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

protein localization involved in establishment of planar polarity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

cell-cell adhesion

1 reference

8 April 2019

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

establishment of imaginal disc-derived wing hair orientation

4 references

9 May 2019

Atypical Cadherins Dachsous and Fat Control Dynamics of Noncentrosomal Microtubules in Planar Cell Polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Two Frizzled Planar Cell Polarity Signals in the Drosophila Wing Are Differentially Organized by the Fat/Dachsous Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

homophilic cell adhesion via plasma membrane adhesion molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

1 reference

9 May 2019

establishment of tissue polarity

1 reference

9 May 2019

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

positive regulation of hippo signaling

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

In vivo regulation of Yorkie phosphorylation and localization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

establishment of ommatidial planar polarity

Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

9 May 2019

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

negative regulation of imaginal disc growth

1 reference

9 May 2019

Zyxin Links Fat Signaling to the Hippo Pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33450

1 reference

cadherin

1 reference

EGF-like domain

1 reference

Cadherin conserved site

1 reference

EGF-like, conserved site

1 reference

EGF-like calcium-binding domain

1 reference