(Q28189493)

7 January 2021

Dysregulation of apoptosis in cancer

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7 January 2021

The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

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7 January 2021

The Hallmarks of Cancer

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7 January 2021

The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms

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7 January 2021

The protein tyrosine kinase family of the human genome

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7 January 2021

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7 January 2021

Cell signaling by receptor tyrosine kinases

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7 January 2021

Dimerization of cell surface receptors in signal transduction

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7 January 2021

Protein tyrosine kinase structure and function

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7 January 2021

Autoregulatory mechanisms in protein-tyrosine kinases

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7 January 2021

Receptor signaling: when dimerization is not enough

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7 January 2021

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

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7 January 2021

Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors

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7 January 2021

A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation

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7 January 2021

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

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7 January 2021

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

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7 January 2021

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

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7 January 2021

The RET proto-oncogene in human cancers

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7 January 2021

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

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7 January 2021

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

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7 January 2021

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

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7 January 2021

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

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7 January 2021

C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

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7 January 2021

Signal transduction by the receptor tyrosine kinase Ret.

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7 January 2021

The biology of stem cell factor and its receptor C-kit

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7 January 2021

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor

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7 January 2021

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

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7 January 2021

Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction

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7 January 2021

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

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7 January 2021

The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

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7 January 2021

Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1

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7 January 2021

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

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7 January 2021

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

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7 January 2021

RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia

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7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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7 January 2021

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7 January 2021

Selected glimpses into the activation and function of Src kinase

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7 January 2021

Structures of Src-family tyrosine kinases

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7 January 2021

Activating SRC mutation in a subset of advanced human colon cancers

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7 January 2021

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

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7 January 2021

Regulation of cell death by the Abl tyrosine kinase

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7 January 2021

Role of the p53-homologue p73 in E2F1-induced apoptosis

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7 January 2021

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

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7 January 2021

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

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7 January 2021

Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells

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7 January 2021

BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway

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7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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7 January 2021

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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7 January 2021

Jaks and stats in cytokine signaling

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7 January 2021

STATs and Gene Regulation

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7 January 2021

Activation of STAT proteins and growth control

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7 January 2021

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7 January 2021

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.

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7 January 2021

Negative regulation of cytokine signaling pathways

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7 January 2021

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

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7 January 2021

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

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7 January 2021

Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line

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7 January 2021

Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation

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7 January 2021

STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

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7 January 2021

TOR, a central controller of cell growth

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7 January 2021

Cell-cycle-dependent translational control

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7 January 2021

Ribosomal S6 kinase signaling and the control of translation

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7 January 2021

Cellular signaling: pivoting around PDK-1.

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7 January 2021

Regulation of protein kinase B.

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7 January 2021

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

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7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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7 January 2021

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

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7 January 2021

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

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7 January 2021

p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

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7 January 2021

Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia

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7 January 2021

NF1 tumor suppressor gene function: narrowing the GAP

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

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7 January 2021

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

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7 January 2021