(Q27765712)

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Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

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Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a (English)

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author name string

R Baumgartner

1

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C Fernandez-Catalan

2

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A Winoto

3

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R Huber

4

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R A Engh

5

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T A Holak

6

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language of work or name

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publication date

15 October 1998

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6

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10

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1279-90

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Cancer cell cycles

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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A cell cycle regulator potentially involved in genesis of many tumor types

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The p19INK4D Cyclin dependent kinase inhibitor gene is altered in osteosarcoma

1 reference

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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

1 reference

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Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines

1 reference

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Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?

1 reference

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

1 reference

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Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4

1 reference

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Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

1 reference

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Structure of the cyclin-dependent kinase inhibitor p19Ink4d

1 reference

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Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

1 reference

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NMR structural characterization of the CDK inhibitor p19INK4d.

1 reference

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A consensus residue analysis of loop and helix-capping residues in four- alpha-helical-bundle proteins

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Role of a nonnative interaction in the folding of the protein G B1 domain as inferred from the conformational analysis of the alpha-helix fragment

1 reference

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Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

1 reference

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The structural basis of ankyrin-like repeat function as revealed by the solution structure of myotrophin

1 reference

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Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

1 reference

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The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA

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Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A

1 reference

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Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

1 reference

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Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma

1 reference

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Ankyrin for clues about the function 0fp16INK4a

1 reference

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Mutations associated with familial melanoma impair p16INK4 function.

1 reference

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Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma

1 reference

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Analysis of p16INK4aand Its Interaction with CDK4

1 reference

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The CCP4 suite: programs for protein crystallography

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Refinement of macromolecular structures by the maximum-likelihood method

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AMoRe: an automated package for molecular replacement

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The ANK repeat: a ubiquitous motif involved in macromolecular recognition

1 reference

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10.1016/S0969-2126(98)00128-2

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