(Q27703612)

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High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme

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3 October 2019

High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme (English)

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3 October 2019

X-ray diffraction

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Blundell TL

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3 October 2019

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Sali A

1

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3 October 2019

Veerapandian B

2

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3 October 2019

Cooper JB

3

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3 October 2019

Foundling SI

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3 October 2019

Hoover DJ

5

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3 October 2019

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1 August 1989

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3 October 2019

The EMBO Journal

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3 October 2019

8

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3 October 2019

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3 October 2019

2179-2188

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2676515%20AND%20SRC:MED&resulttype=core&format=json

3 October 2019

The active site of aspartic proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Structure and refinement of penicillopepsin at 1.8 Å resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

The structure of a synthetic pepsin inhibitor complexed with endothiapepsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Potent new inhibitors of human renin

1 reference

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20 March 2017

Pepstatin, a new pepsin inhibitor produced by Actinomycetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Three-dimensional structure of human renin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

20 March 2017

Structural dynamics of liganded myoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Electronic distributions within protein phenylalanine aromatic rings are reflected by the three-dimensional oxygen atom environments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Enzymes of the Renin-Angiotensin System and their Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

The first Sir George Pickering memorial lecture. Which inhibitors will give us true insight into what renin really does?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Identification of structural motifs from protein coordinate data: secondary structure and first-level supersecondary structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

The mechanism of the catalytic action of pepsin and related acid proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Conformation of amino acid side-chains in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Structural evidence for gene duplication in the evolution of the acid proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

29 September 2017

Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

2 June 2018

Structure of ethanol-inhibited porcine pepsin at 2-A resolution and binding of the methyl ester of phenylalanyl-diiodotyrosine to the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

2 June 2018

Hydrophobic bonding and accessible surface area in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

2 June 2018

Amino Acid Sequence around the Epoxide-reactive Residues in Pepsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

2 June 2018

Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

2 June 2018

Packing of α-helices: Geometrical constraints and contact areas

1 reference

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2 June 2018

Three-dimensional structure, specificity and catalytic mechanism of renin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=401145

27 November 2018

Computer graphics modelling of human renin. Specificity, catalytic activity and intron-exon junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/2676515

12 December 2020

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Construction of a model for the three-dimensional structure of human renal renin

1 reference

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12 December 2020

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Inhibitors of aspartic proteinases and their relevance to the design of antihypertensive agents

1 reference

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12 December 2020

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Effect of secondary substrate binding in penicillopepsin: contributions of subsites S3 and S2' to kcat

1 reference

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12 December 2020

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An x-ray crystallographic study of the rennin-like enzyme of Endothia parasitica

1 reference

https://pubmed.ncbi.nlm.nih.gov/2676515

12 December 2020

based on heuristic

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The Carboxylate Ion in the Active Center of Pepsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2676515

12 December 2020

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inferred from PubMed ID database lookup

Ab initio calculations on large molecules using molecular fragments. Model peptide studies

1 reference

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12 December 2020

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Inhibitors of renin and their utility in physiologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/2676515

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Identifiers

10.1002/J.1460-2075.1989.TB08340.X

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2676515%20AND%20SRC:MED&resulttype=core&format=json

3 October 2019

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2676515%20AND%20SRC:MED&resulttype=core&format=json

3 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2676515%20AND%20SRC:MED&resulttype=core&format=json

3 October 2019

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