(Q27548506)

English

E3 ubiquitin-protein ligase BRE1 YDL074C

fungal protein found in Saccharomyces cerevisiae S288c

E3 ubiquitin-protein ligase BRE1
BRE1
YDL074C

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Statements

1 reference

25 May 2022

1 reference

10 December 2016

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

DNA replication origin binding

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

A role for H2B ubiquitylation in DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IDA

transferase activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

identical protein binding

determination method or standard

IPI

4 references

retrieved

9 May 2019

stated in

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IPI

retrieved

9 May 2019

stated in

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IPI

retrieved

9 May 2019

stated in

A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IPI

retrieved

9 May 2019

stated in

Defining the budding yeast chromatin‐associated interactome

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IPI

nucleic acid binding

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

ubiquitin-protein transferase activity

determination method or standard

3 references

9 May 2019

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

retrieved

9 May 2019

stated in

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IDA

biological process

telomere maintenance via recombination

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Telomerase-null survivor screening identifies novel telomere recombination regulators.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IGI

histone ubiquitination

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

A role for H2B ubiquitylation in DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IMP

protein K63-linked ubiquitination

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

K63 polyubiquitination is a new modulator of the oxidative stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IMP

mitotic intra-S DNA damage checkpoint signaling

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IMP

meiotic DNA double-strand break formation

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IMP

double-strand break repair via homologous recombination

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IGI

regulation of DNA-dependent DNA replication initiation

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

A role for H2B ubiquitylation in DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IMP

mitotic G1 DNA damage checkpoint signaling

determination method or standard

IMP

protein ubiquitination

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

histone monoubiquitination

determination method or standard

3 references

9 May 2019

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IMP

retrieved

9 May 2019

stated in

A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

chromatin organization

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07457

determination method or standard

IEA

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Saccharomyces Genome Database ID

1 reference

20 March 2022

(Q27548506)

E3 ubiquitin-protein ligase BRE1 YDL074C

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