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Inventing new medicines: The FGF21 story
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title
Inventing new medicines: The FGF21 story
(English)
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stated in
PubMed
author name string
Alexei Kharitonenkov
series ordinal
1
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stated in
Crossref
Andrew C. Adams
series ordinal
2
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stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
June 2014
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stated in
PubMed
published in
Molecular Metabolism
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stated in
Crossref
volume
3
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stated in
PubMed
issue
3
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stated in
PubMed
page(s)
221-9
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PubMed
cites work
Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Different roles of N- and C- termini in the functional activity of FGF21
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
FGF21 N- and C-termini play different roles in receptor interaction and activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
BetaKlotho is required for metabolic activity of fibroblast growth factor 21
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
FGF-21 as a novel metabolic regulator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Fibroblast growth factor receptors, developmental corruption and malignant disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
FGF21 requires βklotho to act in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Fundamentals of FGF19 & FGF21 action in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
7 April 2017
Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
FGF21 contributes to neuroendocrine control of female reproduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
Role of fibroblast growth factor 21 in biology of glucagon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
Fibroblast growth factor 21 mediates specific glucagon actions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Circulating fibroblast growth factors as metabolic regulators--a critical appraisal
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
retrieved
28 September 2017
Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Adiponectin: mechanistic insights and clinical implications
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PubMed Central
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28 September 2017
Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Metabolic Disease Drug Discovery— “Hitting the Target” Is Easier Said Than Done
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PubMed Central
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28 September 2017
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1
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PubMed Central
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28 September 2017
Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
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PubMed Central
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28 September 2017
High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects
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PubMed Central
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28 September 2017
FGF21 reloaded: challenges of a rapidly growing field
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PubMed Central
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28 September 2017
Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease
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28 September 2017
Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
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PubMed Central
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28 September 2017
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
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PubMed Central
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28 September 2017
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli
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PubMed Central
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28 September 2017
Relevant use of Klotho in FGF19 subfamily signaling system in vivo
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
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PubMed Central
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28 September 2017
Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia
1 reference
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PubMed Central
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28 September 2017
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects
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PubMed Central
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28 September 2017
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 September 2017
FGF21 is an Akt-regulated myokine
1 reference
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PubMed Central
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28 September 2017
Fibroblast growth factor 21 corrects obesity in mice
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PubMed Central
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28 September 2017
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.
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PubMed Central
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28 September 2017
Does insulin detemir have a role in reducing risk of insulin-associated weight gain?
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28 September 2017
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.
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PubMed Central
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28 September 2017
The effects of statins on high-density lipoproteins
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28 September 2017
Dysregulation of the fibroblast growth factor system in major depression
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28 September 2017
Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease
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28 September 2017
The growing prevalence of type 2 diabetes: increased incidence or improved survival?
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31 May 2018
Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
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PubMed Central
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31 May 2018
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
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31 May 2018
Increased FGF21 plasma levels in humans with sepsis and SIRS.
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31 May 2018
Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.
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PubMed Central
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31 May 2018
FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity
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PubMed Central
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31 May 2018
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho
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PubMed Central
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31 May 2018
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
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31 May 2018
Fibroblast growth factor 1: a key regulator of human adipogenesis.
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31 May 2018
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
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PubMed Central
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28 November 2018
Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
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28 November 2018
Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
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28 November 2018
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
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28 November 2018
Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
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28 November 2018
A novel approach to improve the function of FGF21.
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PubMed Central
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28 November 2018
Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities
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PubMed Central
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28 November 2018
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.
1 reference
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PubMed Central
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28 November 2018
Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys
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PubMed Central
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28 November 2018
Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 November 2018
Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3986619
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28 November 2018
Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.
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PubMed Central
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28 November 2018
Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice
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28 November 2018
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.
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28 November 2018
Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.
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28 November 2018
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.
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PubMed Central
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28 November 2018
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.
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28 November 2018
Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease.
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28 November 2018
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12 December 2020
based on heuristic
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based on heuristic
inferred from PubMed ID database lookup
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/24749049
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
How to revive breakthrough innovation in the pharmaceutical industry
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based on heuristic
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Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes
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Identifiers
DOI
10.1016/J.MOLMET.2013.12.003
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
756261
OpenCitations bibliographic resource ID
756261
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
756261
PMC publication ID
3986619
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
756261
PubMed publication ID
24749049
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
756261
ResearchGate publication ID
261773915
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