Wikidata

(Q2472777)

English

Parkin RBR E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

  • Parkinson disease protein 2
  • parkinson juvenile disease protein 2
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • parkinson protein 2 E3 ubiquitin protein ligase
  • E3 ubiquitin-protein ligase parkin
  • PRKN
  • PARK2
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
39 references
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin accumulation in aggresomes due to proteasome impairment
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin interacts with Ambra1 to induce mitophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Ataxin-3 is a multivalent ligand for the parkin Ubl domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
14-3-3eta is a novel regulator of parkin ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Parkin ubiquitinates and promotes the degradation of RanBP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
An empirical framework for binary interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
retrieved
9 May 2019
stated in
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IPI
ubiquitin-protein transferase activity
determination method or standard
IDA
TAS
IEA
10 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Ubiquitin is phosphorylated by PINK1 to activate parkin
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
ubiquitin protein ligase activity
determination method or standard
IDA
IEA
NAS
TAS
16 references
retrieved
27 March 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
27 March 2018
stated in
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
27 March 2018
stated in
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Dopamine covalently modifies and functionally inactivates parkin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
ubiquitin protein ligase activity
determination method or standard
IBA
IDA
IEA
NAS
TAS
17 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
9 May 2019
stated in
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
9 May 2019
stated in
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Dopamine covalently modifies and functionally inactivates parkin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IBA
cell component
cytoplasm
determination method or standard
IDA
IEA
8 references
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
cytosol
determination method or standard
IDA
TAS
IMP
IEA
11 references
retrieved
27 March 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
27 March 2018
stated in
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin interacts with Ambra1 to induce mitophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
mitochondrion
determination method or standard
IDA
IEA
IMP
9 references
retrieved
27 March 2018
stated in
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
27 March 2018
stated in
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
27 March 2018
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
cytoplasm
determination method or standard
IBA
IDA
IEA
9 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IBA
mitochondrion
determination method or standard
IBA
IDA
IEA
IMP
10 references
retrieved
9 May 2019
stated in
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IBA
cytosol
determination method or standard
IBA
IDA
IEA
IMP
TAS
12 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
9 May 2019
stated in
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin interacts with Ambra1 to induce mitophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IBA
biological process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
determination method or standard
IDA
IEA
IMP
6 references
retrieved
9 May 2019
stated in
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
protein K63-linked ubiquitination
determination method or standard
NAS
IDA
TAS
6 references
retrieved
9 May 2019
stated in
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
9 May 2019
stated in
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
9 May 2019
stated in
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
protein ubiquitination
determination method or standard
IEA
IDA
IMP
8 references
retrieved
9 May 2019
stated in
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IEA
retrieved
9 May 2019
stated in
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
ubiquitin-dependent protein catabolic process
determination method or standard
IC
IDA
NAS
TAS
5 references
retrieved
27 March 2018
stated in
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
27 March 2018
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
27 March 2018
stated in
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
27 March 2018
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260
determination method or standard
IC
protein polyubiquitination
determination method or standard
IBA
IDA
5 references
retrieved
9 May 2019
stated in
Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Dopamine covalently modifies and functionally inactivates parkin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IBA
ubiquitin-dependent protein catabolic process
determination method or standard
IBA
IC
IDA
NAS
TAS
6 references
retrieved
9 May 2019
stated in
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
TAS
retrieved
9 May 2019
stated in
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
NAS
retrieved
9 May 2019
stated in
Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death
GOA
curator
UniProt
UniProt protein ID
O60260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IDA
retrieved
9 May 2019
stated in
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IC
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260
determination method or standard
IBA
Gene Atlas image
PBB GE PARK2 207058 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Freebase ID
/m/03r3tb
0 references
 
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