(Q24671923)

English

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors

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Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors (English)

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ORCID Public Data File 2021

author name string

J Zhao

1

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L H Ben

2

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Y L Wu

3

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W Hu

4

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K Ling

5

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S M Xin

6

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H L Nie

7

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L Ma

8

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G Pei

9

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language of work or name

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publication date

5 July 1999

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Journal of Experimental Medicine

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190

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1

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101-11

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Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha

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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

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7 April 2017

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1 reference

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7 April 2017

Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops

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7 April 2017

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

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7 April 2017

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

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7 April 2017

Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during aging

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7 April 2017

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

1 reference

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7 April 2017

Chemokines and leukocyte traffic

1 reference

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7 April 2017

Chemokines--chemotactic cytokines that mediate inflammation

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7 April 2017

gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5

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28 September 2017

Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

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28 September 2017

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

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28 September 2017

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

1 reference

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28 September 2017

Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Can the immune response control HIV infection?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Role of C-X-C chemokines as regulators of angiogenesis in lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Cloning of trichosanthin cDNA and its expression in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Chemokines in viral disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

Characterisation of the RANTES/MIP-1 alpha receptor (CC CKR-1) stably transfected in HEK 293 cells and the recombinant ligands.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

28 September 2017

The role of chemokines in inflammation

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28 September 2017

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1 reference

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28 September 2017

Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization

1 reference

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30 May 2018

CD8+ T lymphocyte-derived chemokines and other HIV-suppressive factors: mini-review

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30 May 2018

Lymphocyte responses to chemokines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

30 May 2018

Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization

1 reference

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30 May 2018

delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization

1 reference

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30 May 2018

A phase II study of effect of addition of trichosanthin to zidovudine in patients with HIV disease and failing antiretroviral agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

30 May 2018

Purification and characterization of trichosanthin. Homology to the ricin A chain and implications as to mechanism of abortifacient activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

30 May 2018

Isolation and characterization of an immunosuppressive protein from Trichosanthes kirilowii root tubers

1 reference

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30 May 2018

Effects of GLQ223 on HIV replication in human monocyte/macrophages chronically infected in vitro with HIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2195565

30 May 2018

Chemokine receptors: keys to AIDS pathogenesis?

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

Chemokines beyond inflammation

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

Carboxyl Terminus of Delta Opioid Receptor Is Required for Agonist-Dependent Receptor Phosphorylation

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

HIV-1--co-receptors binding

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21 January 2018

Chemokines and chemokine receptors: the key to understanding AIDS.

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28 November 2018

The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study.

1 reference

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28 November 2018

Spoilt for choice of co-receptors

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

HIV blocked by chemokine antagonist

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

Trichosanthin, α-momorcharin and β-momorcharin: identity of abortifacient and ribosome-inactivating proteins

1 reference

https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

Trichosanthin treatment of HIV-induced immune dysregulation

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https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

A phase I/II study of trichosanthin treatment of HIV disease

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21 January 2018

Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization

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21 January 2018

High level synthesis of biologically active recombinant trichosanthin in Escherichia coli

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21 January 2018

Trichokirin, a ribosome-inactivating protein from the seeds of Trichosanthes kirilowii Maximowicz. Purification, partial characterization and use for preparation of immunotoxins

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21 January 2018

Carboxyl terminus of mitosin is sufficient to confer spindle pole localization

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21 January 2018

Position 120-123, a potential active site of trichosanthin

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https://api.crossref.org/works/10.1084%2FJEM.190.1.101

21 January 2018

Crystallographic refinement of trichosanthin at 2.6A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/10429674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal and molecular structure of trichosanthin at 2.6 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/10429674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refined structure of trichosanthin at 1.73 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/10429674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunomodulatory and antitumor activities of trichosanthin-an abortifacient protein isolated from tian-hua-fen (Trichosanthes kirilowii)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10429674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Treatment of malignant trophoblastic neoplasia with trichosanthin]

1 reference

https://pubmed.ncbi.nlm.nih.gov/10429674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early trials of GLQ223/trichosanthin: what do they show?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10429674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.190.1.101

1 reference

https://api.fatcat.wiki/v0/release/hnmohaxlg5dthetrqt6nisyw4m

30 July 2022

based on heuristic

mapped directly with Wikidata item

release_hnmohaxlg5dthetrqt6nisyw4m

1 reference

https://api.fatcat.wiki/v0/release/hnmohaxlg5dthetrqt6nisyw4m

30 July 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

https://api.fatcat.wiki/v0/release/hnmohaxlg5dthetrqt6nisyw4m

30 July 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

https://api.fatcat.wiki/v0/release/hnmohaxlg5dthetrqt6nisyw4m

30 July 2022

based on heuristic

mapped directly with Wikidata item

ResearchGate publication ID

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