(Q24652628)

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The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model

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The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model (English)

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Rhinovirus infection

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David J Erle

11

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author name string

Yasuhiro Nakagami

1

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Silvio Favoreto

2

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Guohua Zhen

3

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Sung-Woo Park

4

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Louis T Nguyenvu

5

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Douglas A Kuperman

6

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Gregory M Dolganov

7

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Xiaozhu Huang

8

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Homer A Boushey

9

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Pedro C Avila

10

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language of work or name

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publication date

1 August 2008

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Journal of Immunology

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181

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3

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2203-10

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IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production

1 reference

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7 April 2017

Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

The Pendred syndrome gene encodes a chloride-iodide transport protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Dissecting asthma using focused transgenic modeling and functional genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

1 reference

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7 April 2017

A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

7 April 2017

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1 reference

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28 September 2017

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1 reference

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28 September 2017

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1 reference

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28 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Ion and liquid transport across the bronchiolar epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Airway surface dehydration in cystic fibrosis: pathogenesis and therapy

1 reference

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28 September 2017

How viral infections cause exacerbation of airway diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Relationship of airway epithelial ion transport to chronic bronchitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Structure and function of CLCA proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Mechanisms of rhinovirus-induced asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT

1 reference

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28 September 2017

Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Molecular physiology of the renal chloride-formate exchanger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

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1 reference

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The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 September 2017

Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

30 May 2018

Effects of allergic inflammation of the nasal mucosa on the severity of rhinovirus 16 cold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

30 May 2018

Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 November 2018

The asthma channel? Stay tuned . . .

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 November 2018

Niflumic acid suppresses interleukin-13-induced asthma phenotypes

1 reference

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28 November 2018

Mucus clearance and lung function in cystic fibrosis with hypertonic saline

1 reference

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28 November 2018

IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production

1 reference

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28 November 2018

Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

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Characterization of airway plugging in fatal asthma.

1 reference

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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 November 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

28 November 2018

A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

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Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2491716

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Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome

1 reference

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Localization of epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18641360

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18641360

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18641360

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10.4049/JIMMUNOL.181.3.2203

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