(Q24319081)

DOI

10.1124/MOL.110.069708

https://api.crossref.org/works/10.1124/MOL.110.069708

smoothened, frizzled class receptor

20 November 2024

main subject

1 reference

GOA release 2020-03-11

drug binding

1 reference

Smoothened, frizzled class receptor

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

2

Elisabeth Traiffort

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21177415

20 November 2024

8

Fabrizio Manetti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21177415

20 November 2024

author name string

Hermine Roudaut

1

0 references

Tatiana Gorojankina

3

0 references

Ludwig Vincent

4

0 references

Helene Faure

5

0 references

Angele Schoenfelder

6

0 references

Andre Mann

7

0 references

Antonio Solinas

9

0 references

Maurizio Taddei

10

0 references

Martial Ruat

11

0 references

language of work or name

English

0 references

publication date

March 2011

0 references

21 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21177415

full work available at URL

20 November 2024

http://molpharm.aspetjournals.org/cgi/content/abstract/79/3/453

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21177415

https://syndication.highwire.org/content/doi/10.1124/mol.110.069708

20 November 2024

1 reference

DOI

10.1124/MOL.110.069708

https://api.crossref.org/works/10.1124/MOL.110.069708

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics

20 November 2024

published in

Molecular Pharmacology

0 references

volume

79

0 references

issue

3

0 references

page(s)

453-60

0 references

cites work

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

GDC-0449-a potent inhibitor of the hedgehog pathway

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Smoothened antagonists for hair inhibition.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Sonic Hedgehog signalling in the developing and adult brain

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Tissue repair and stem cell renewal in carcinogenesis

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Vertebrate Smoothened functions at the primary cilium

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

A paracrine requirement for hedgehog signalling in cancer

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

The structure and function of G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Dual and opposing roles of primary cilia in medulloblastoma development

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Small molecule modulation of Smoothened activity

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Distribution of Smoothened at hippocampal mossy fiber synapses

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Sonic Hedgehog signaling in the mammalian brain.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Patched1 regulates hedgehog signaling at the primary cilium

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Towards an integrated view of Wnt signaling in development

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021

Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb.

1 reference

https://api.crossref.org/works/10.1124%2FMOL.110.069708

7 January 2021