(Q24311758)

GOA release 2020-03-11

FKBP prolyl isomerase 1A

1 reference

GOA release 2020-03-11

amyloid fibril formation

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GOA release 2020-03-11

1 reference

6

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Zeger Debyser

2

object named as

Zeger Debyser

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Yves Engelborghs

7

object named as

Yves Engelborghs

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author name string

Melanie Gerard

1

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Linda Desender

3

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Johan Baert

4

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Inger Brandt

Journal of Neurochemistry

5

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language of work or name

English

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publication date

July 2008

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published in

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volume

106

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issue

1

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page(s)

121-33

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cites work

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

alpha-Synuclein locus triplication causes Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

20 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2008.05342.X

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

A Drosophila model of Parkinson's disease

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Immunophilins and their ligands: insights into survival and growth of human neurons

20 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

The immunosuppressant drug FK506 is a potent trophic agent for human fetal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

A Nonimmunosuppressant FKBP-12 Ligand Increases Nerve Regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Postischemic changes in the immunophilin FKBP12 in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

The binding of thioflavin-T to amyloid fibrils: localisation and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Parkinson's disease: Distribution of Lewy bodies and monoamine neuron system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

FK‐506–A Novel Immunosuppressant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Assessing protein disorder and induced folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Catalysis of protein folding by parvulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

High brain densities of the immunophilin FKBP colocalized with calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Characterization of an exchange reaction between soluble FKBP-12 and the FKBP.ryanodine receptor complex. Modulation by FKBP mutants deficient in peptidyl-prolyl isomerase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Comparative mutational analysis of peptidyl prolyl cis/trans isomerases: active sites of Escherichia coli trigger factor and human FKBP12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis–trans isomerases, is only partially inhibited by FK506

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

Affinity purification of the ryanodine receptor/calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Double-stranded DNA stimulates the fibrillation of alpha-synuclein in vitro and is associated with the mature fibrils: an electron microscopy study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

The subcellular distribution of FK506 binding proteins in rat brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Immunophilins in protein folding and immunosuppression.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05342.X

7 January 2021