(Q24298721)

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The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity

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The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity (English)

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molecular chaperones

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Synuclein alpha

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GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

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8

object named as

Elisa Greggio

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Elisa

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Greggio

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PubMed publication ID

9 December 2023

7

object named as

Elisa Belluzzi

author given names

Elisa

author last names

Belluzzi

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PubMed publication ID

9 December 2023

object named as

Dhruv Kumar

2

author given names

Dhruv

author last names

Kumar

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PubMed publication ID

9 December 2023

Nicoletta Plotegher

object named as

Nicoletta Plotegher

1

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Nicoletta

author last names

Plotegher

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PubMed publication ID

9 December 2023

Francesca Munari

object named as

Francesca Munari

5

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Francesca

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Munari

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9 December 2023

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Laura Tosatto

6

author given names

Laura

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Tosatto

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9 December 2023

Stefano Capaldi

object named as

Stefano Capaldi

10

author given names

Stefano

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Capaldi

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PubMed publication ID

9 December 2023

Isabella Tessari

object named as

Isabella Tessari

3

author given names

Isabella

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Tessari

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9 December 2023

object named as

Marco Brucale

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author given names

Marco

author last names

Brucale

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9 December 2023

object named as

Hugo L Monaco

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author given names

Hugo L

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Monaco

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9 December 2023

object named as

Luigi Bubacco

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author given names

Luigi

author last names

Bubacco

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PubMed publication ID

9 December 2023

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object named as

Stefano Mammi

author given names

Stefano

author last names

Mammi

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PubMed publication ID

9 December 2023

9

object named as

Marco Bisaglia

author given names

Marco

author last names

Bisaglia

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PubMed publication ID

9 December 2023

11

object named as

Daniel Aioanei

author given names

Daniel

author last names

Aioanei

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PubMed publication ID

9 December 2023

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Bruno Samo

14

author given names

Bruno

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Samo

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9 December 2023

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publication date

1 November 2014

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Human Molecular Genetics

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23

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21

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5615-29

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Epidemiology of Parkinson's disease

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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

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Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations

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α-Synuclein mutations cluster around a putative protein loop

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α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

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The many faces of alpha-synuclein mutations

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

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α-Synuclein in Lewy bodies

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

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Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity

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21 January 2018

Intrinsically disordered proteins from A to Z

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21 January 2018

Understanding protein non-folding.

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

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Expanding the proteome: disordered and alternatively folded proteins

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

A soluble α-synuclein construct forms a dynamic tetramer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

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21 January 2018

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Observation of spatial propagation of amyloid assembly from single nuclei

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

In vivo demonstration that alpha-synuclein oligomers are toxic

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Countering amyloid polymorphism and drug resistance with minimal drug cocktails

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

14-3-3 proteins in the nervous system

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Structural basis for protein-protein interactions in the 14-3-3 protein family

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

C-terminal binding: an expanded repertoire and function of 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

14-3-3eta is a novel regulator of parkin ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains

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21 January 2018

Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience

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21 January 2018

alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice

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21 January 2018

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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21 January 2018

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.

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21 January 2018

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases

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21 January 2018

Specification of 14-3-3 proteins in Lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Role of different regions of alpha-synuclein in the assembly of fibrils.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Direct observation of the interconversion of normal and toxic forms of α-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Confocal Fluorescence Anisotropy and FRAP Imaging of α-Synuclein Amyloid Aggregates in Living Cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Formation of toxic oligomeric alpha-synuclein species in living cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

A new method for purification of recombinant human alpha-synuclein in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Structural properties of pore-forming oligomers of alpha-synuclein

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

21 January 2018

Molecular composition of sub-stoichiometrically labeled α-synuclein oligomers determined by single-molecule photobleaching

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7 January 2021

based on heuristic

inferred from DOI database lookup

Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

7 January 2021

based on heuristic

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Atomic force microscopy under controlled conditions reveals structure of C-terminal region of α-synuclein in amyloid fibrils

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

7 January 2021

based on heuristic

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Structural insights on physiological functions and pathological effects of alpha-synuclein.

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

7 January 2021

based on heuristic

inferred from DOI database lookup

Probable participation of 14-3-3 in tau protein oligomerization and aggregation.

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https://api.crossref.org/works/10.1093%2FHMG%2FDDU275

7 January 2021

based on heuristic

inferred from DOI database lookup

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