(Q2356259)

Gap junction alpha-1 protein (Cx43), alpha helix domain superfamily

1 reference

Connexin, C-terminal

1 reference

Connexin, N-terminal domain superfamily

1 reference

Gap junction alpha-1 protein (Cx43), C-terminal domain, protein family

1 reference

Connexin, N-terminal domain, protein family

1 reference

Gap junction protein family

1 reference

Connexin, conserved site, protein family

1 reference

gap junction channel activity involved in cardiac conduction electrical coupling

1 reference

18 July 2018

1 reference

18 July 2018

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

gap junction channel activity involved in cell communication by electrical coupling

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

protein domain specific binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

SH3 domain binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

ion transmembrane transporter activity

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

PDZ domain binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

transmembrane transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

protein binding

5 references

26 September 2017

Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

connexin binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

gap junction channel activity

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

signal transducer activity

disordered domain specific binding

IMP

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cell component

cytoplasm

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

endosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

focal adhesion

1 reference

26 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

mitochondrion

1 reference

26 September 2017

Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

multivesicular body

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

mitochondrial outer membrane

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

lysosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

fascia adherens

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

extracellular exosome

1 reference

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

late endosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

early endosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

gap junction

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

Golgi-associated vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

integral component of plasma membrane

1 reference

26 September 2017

Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

1 reference

26 September 2017

connexin complex

Functional analysis of human cardiac gap junction channel mutants

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

intercalated disc

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

ISS

26 September 2017

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

biological process

muscle contraction

1 reference

26 September 2017

Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of protein catabolic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

regulation of bicellular tight junction assembly

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cellular response to mechanical stimulus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

vascular transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of cell communication by chemical coupling

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

negative regulation of wound healing

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

negative regulation of cell population proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

heart development

Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of vasoconstriction

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of glomerular filtration

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

negative regulation of cardiac muscle cell proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

chronic inflammatory response

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

neuron projection morphogenesis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to glucose

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to fluid shear stress

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

atrial cardiac muscle cell action potential

1 reference

26 September 2017

Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

transmembrane transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of behavioral fear response

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

negative regulation of DNA biosynthetic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of insulin secretion

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

regulation of calcium ion transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

ATP transport

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of cytosolic calcium ion concentration

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cell-cell signaling

Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cell communication by electrical coupling involved in cardiac conduction

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to peptide hormone

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

negative regulation of endothelial cell proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

ion transmembrane transport

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

protein complex oligomerization

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

endothelium development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to pH

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

positive regulation of I-kappaB kinase/NF-kappaB signaling

IMP

1 reference

26 September 2017

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

IMP

signal transduction

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to ischemia

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to lipopolysaccharide

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

response to retinoic acid

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

decidualization

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cell communication by electrical coupling

3 references

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

26 September 2017

Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

epididymis development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

regulation of transmembrane transporter activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

cellular response to parathyroid hormone stimulus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

transport

1 reference

26 September 2017

Molecular characterization and functional expression of the human cardiac gap junction channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17302&geneProductId=UniProtKB:P17302

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4151

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2447

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

4278

English

17 August 2016

Gene Atlas image

PBB GE GJA1 201667 at fs.png
732 × 530; 11 KB

0 references

Commons category

Connexin 43

0 references

Identifiers

1 reference

18 May 2018

1 reference

18 July 2018

1 reference

1 reference

28 October 2013

1 reference

5 August 2016