Wikidata

(Q21981319)

English

Dishevelled segment polarity protein 2

mammalian protein found in Mus musculus

  • DSH homolog 2
  • dishevelled-2
  • dishevelled 2, dsh homolog
  • Dvl2
  • segment polarity protein dishevelled homolog DVL-2
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
16 references
retrieved
14 February 2019
stated in
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Dishevelled-2 docks and activates Src in a Wnt-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Structural Analysis of the Interaction between Dishevelled2 and Clathrin AP-2 Adaptor, A Critical Step in Noncanonical Wnt Signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Molecular basis of Wnt activation via the DIX domain protein Ccd1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Diversin regulates heart formation and gastrulation movements in development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Mechanism of activation of the Formin protein Daam1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
retrieved
14 February 2019
stated in
Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IPI
cell component
cytoplasm
determination method or standard
IDA
IEA
ISO
8 references
retrieved
14 February 2019
stated in
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
ISO
retrieved
14 February 2019
stated in
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
14 February 2019
stated in
Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Dynamic recruitment of axin by Dishevelled protein assemblies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
plasma membrane
determination method or standard
IDA
IGI
IEA
6 references
retrieved
14 February 2019
stated in
Dynamic recruitment of axin by Dishevelled protein assemblies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IGI
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
14 February 2019
stated in
Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
biological process
Wnt signaling pathway
determination method or standard
NAS
IDA
IEA
ISO
6 references
retrieved
24 April 2018
stated in
Wnt-mediated relocalization of dishevelled proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
NAS
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
ISO
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
24 April 2018
stated in
Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IDA
canonical Wnt signaling pathway
determination method or standard
IDA
IGI
IEA
IMP
ISO
8 references
retrieved
16 July 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
ISO
retrieved
16 July 2018
stated in
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IMP
retrieved
16 July 2018
stated in
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IMP
retrieved
16 July 2018
stated in
Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IGI
retrieved
16 July 2018
stated in
Dynamic recruitment of axin by Dishevelled protein assemblies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IGI
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
16 July 2018
stated in
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
16 July 2018
stated in
Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838
determination method or standard
IDA
canonical Wnt signaling pathway
determination method or standard
IBA
IDA
IEA
IGI
IMP
ISO
10 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
ISO
retrieved
14 February 2019
stated in
Molecular basis of Wnt activation via the DIX domain protein Ccd1
GOA
curator
UniProt
UniProt protein ID
Q60838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IMP
retrieved
14 February 2019
stated in
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IMP
retrieved
14 February 2019
stated in
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IMP
retrieved
14 February 2019
stated in
Dynamic recruitment of axin by Dishevelled protein assemblies
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IGI
retrieved
14 February 2019
stated in
Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IEA
retrieved
14 February 2019
stated in
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838
determination method or standard
IBA

Identifiers

 
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