(Q21496072)

Protein kinase-like domain superfamily

1 reference

Fibronectin type III superfamily

1 reference

ephrin receptor type-A /type-B

1 reference

Galactose-binding-like domain superfamily

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Sterile alpha motif/pointed domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

ephrin receptor

1 reference

Sterile alpha motif domain, protein family

1 reference

Tyrosine-protein kinase ephrin type A/B receptor-like, protein family

1 reference

Ephrin type-B receptor 2, ligand binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Tyrosine-protein kinase, receptor class V, conserved site, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Ephrin receptor ligand binding domain, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

nucleotide binding

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

protein kinase activity

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

transmembrane-ephrin receptor activity

1 reference

9 August 2016

kinase activity

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

protein binding

12 references

9 August 2016

14 February 2019

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

EphB2 guides axons at the midline and is necessary for normal vestibular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Crystal structure of an Eph receptor-ephrin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

transmembrane receptor protein tyrosine kinase activity

1 reference

9 August 2016

protein tyrosine kinase activity

1 reference

9 August 2016

ATP binding

3 references

amyloid-beta binding

1 reference

14 February 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

protein tyrosine kinase activity

5 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

ISO

14 January 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

14 January 2019

14 January 2019

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

transmembrane-ephrin receptor activity

Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

TAS

14 February 2019

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

signaling receptor activity

1 reference

14 February 2019

Crystal structure of an Eph receptor-ephrin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

identical protein binding

1 reference

14 February 2019

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

protein-containing complex binding

protein tyrosine kinase activity

ISO

3 references

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

14 February 2019

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

cell component

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

1 reference

14 February 2019

synapse

NAS

1 reference

14 February 2019

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

integral component of plasma membrane

NAS

Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues

3 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

16 September 2017

16 September 2017

Nuk controls pathfinding of commissural axons in the mammalian central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54763&geneProductId=UniProtKB:P54763

soma

1 reference

14 February 2019

Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

integral component of plasma membrane

Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

14 February 2019

Nuk controls pathfinding of commissural axons in the mammalian central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

neuron projection

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

receptor complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

glutamatergic synapse

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

ISO

14 February 2019

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

integral component of postsynaptic membrane

EXP

1 reference

14 February 2019

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

integral component of presynaptic membrane

1 reference

14 February 2019

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

positive regulation of synapse assembly

biological process

3 references

9 August 2016

14 February 2019

Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

9 August 2016

nervous system development

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

axon guidance

1 reference

9 August 2016

multicellular organism development

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

protein phosphorylation

dendritic spine morphogenesis

3 references

9 August 2016

14 February 2019

Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

peptidyl-tyrosine phosphorylation

1 reference

9 August 2016

central nervous system projection neuron axonogenesis

1 reference

9 August 2016

ephrin receptor signaling pathway

1 reference

9 August 2016

negative regulation of protein phosphorylation

1 reference

14 February 2019

Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

3 references

14 February 2019

14 February 2019

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

axon guidance

EphB2 guides axons at the midline and is necessary for normal vestibular function

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

learning or memory

1 reference

14 February 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

peptidyl-tyrosine phosphorylation

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

positive regulation of synaptic plasticity

1 reference

14 February 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

negative regulation of Ras protein signal transduction

1 reference

14 February 2019

Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

ephrin receptor signaling pathway

3 references

14 February 2019

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

regulation of synapse assembly

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

14 February 2019

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

negative regulation of ERK1 and ERK2 cascade

EXP

1 reference

14 February 2019

Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission

1 reference

14 February 2019

Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

neuron projection retraction

1 reference

14 February 2019

Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

positive regulation of long-term synaptic potentiation

1 reference

14 February 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

negative regulation of NMDA glutamate receptor activity

1 reference

14 February 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

positive regulation of NMDA glutamate receptor activity

1 reference

14 February 2019

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54763

Ephrin receptor, transmembrane domain

has part(s)

1 reference

fibronectin type III

1 reference

tyrosine-protein kinase ephrin type A/B receptor-like

1 reference

tyrosine-protein kinase, receptor class V, conserved site

1 reference

sterile alpha motif domain

1 reference

ephrin receptor ligand binding domain

1 reference

tyrosine-protein kinase, active site

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

Ephrin type-B receptor 2, ligand binding domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016