(Q21495090)

http://www.ebi.ac.uk/interpro/protein/O88551

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Manner of interaction of heterogeneous claudin species within and between tight junction strands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

structural molecule activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

1 reference

14 February 2019

identical protein binding

1 reference

14 February 2019

Manner of interaction of heterogeneous claudin species within and between tight junction strands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

integral component of membrane

cell component

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

14 February 2019

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

14 February 2019

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

integral component of plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

1 reference

14 February 2019

bicellular tight junction

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

basolateral plasma membrane

ISO

apical plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

lateral plasma membrane

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

biological process

1 reference

14 February 2019

Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

establishment of skin barrier

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

ISO

14 February 2019

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

ageing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

response to toxic substance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

hyperosmotic salinity response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

response to ethanol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

cellular response to lead ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

cellular response to interferon-gamma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

cellular response to tumor necrosis factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

response to dexamethasone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

cellular response to transforming growth factor beta stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

liver regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

cellular response to butyrate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

viral entry into host cell

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88551

has part(s)

Claudin, conserved site

1 reference

InterPro Release 71.0