(Q21494601)

Hint domain superfamily

1 reference

hedgehog protein

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Hint domain C-terminal domain, protein family

1 reference

Hint domain N-terminal domain, protein family

1 reference

Hedgehog protein, Hint domain, protein family

1 reference

Hedgehog, N-terminal signalling domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

1 reference

8 April 2019

protein binding

IPI

1 reference

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

IPI

patched binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

14 February 2019

Characterization of two patched receptors for the vertebrate hedgehog protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

patched binding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Characterization of two patched receptors for the vertebrate hedgehog protein family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

calcium ion binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

1 reference

8 April 2019

plasma membrane

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

1 reference

14 February 2019

extracellular matrix

1 reference

8 April 2019

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

pattern specification process

biological process

1 reference

8 April 2019

Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of collagen biosynthetic process

1 reference

8 April 2019

Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

negative regulation of T cell differentiation in thymus

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cell differentiation

1 reference

8 April 2019

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of T cell differentiation in thymus

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

head morphogenesis

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

negative regulation of immature T cell proliferation in thymus

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

embryonic pattern specification

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

ossification

1 reference

8 April 2019

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

epithelial cell morphogenesis

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

multicellular organism growth

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of smoothened signaling pathway

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

camera-type eye photoreceptor cell fate commitment

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

vitelline membrane formation

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

negative regulation of eye pigmentation

1 reference

8 April 2019

Siva is an apoptosis-selective p53 target gene important for neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cell fate specification

1 reference

14 February 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

negative regulation of cell differentiation

1 reference

8 April 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cell-cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

1 reference

8 April 2019

negative regulation of alpha-beta T cell differentiation

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

epithelial cell-cell adhesion

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

neuron development

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

in utero embryonic development

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cell maturation

1 reference

8 April 2019

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

bone resorption

1 reference

8 April 2019

Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

retinal pigment epithelium development

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

morphogenesis of a branching structure

1 reference

8 April 2019

Regulation of pancreas development by hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

somite development

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

heart looping

1 reference

8 April 2019

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

intein-mediated protein splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

1 reference

8 April 2019

vasculature development

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

proteoglycan metabolic process

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of mesenchymal cell proliferation

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

embryonic camera-type eye morphogenesis

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

chondrocyte proliferation

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of cell population proliferation

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

smooth muscle tissue development

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

branching involved in blood vessel morphogenesis

1 reference

8 April 2019

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

embryonic digestive tract morphogenesis

1 reference

8 April 2019

Hedgehog signals regulate multiple aspects of gastrointestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

regulation of growth

1 reference

8 April 2019

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

camera-type eye development

1 reference

8 April 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of alpha-beta T cell differentiation

1 reference

8 April 2019

Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

embryonic skeletal joint development

1 reference

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

embryonic digit morphogenesis

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cartilage development

1 reference

8 April 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

osteoblast differentiation

Disruption of Scube2 Impairs Endochondral Bone Formation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

chondrocyte differentiation involved in endochondral bone morphogenesis

1 reference

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

skeletal system development

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

smoothened signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

14 February 2019

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

14 February 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

maternal process involved in female pregnancy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

liver regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

cell fate specification

smoothened signaling pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Disruption of Scube2 Impairs Endochondral Bone Formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

regulation of gene expression

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97812

Intein N-terminal splicing region

has part(s)

1 reference

Hedgehog, N-terminal signalling domain

1 reference

Hint domain N-terminal

1 reference

Hint domain C-terminal

1 reference

Hedgehog protein, Hint domain

1 reference