(Q21245720)

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Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

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Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis (English)

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1 reference

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Xiyong Liu

7

author given names

Xiyong

author last names

Liu

1 reference

Dimensions Publication ID

18 August 2022

author name string

Keqiang Zhang

1

author given names

Keqiang

author last names

Zhang

1 reference

Dimensions Publication ID

18 August 2022

Shuya Hu

2

author given names

Shuya

author last names

Hu

1 reference

Dimensions Publication ID

18 August 2022

Jun Wu

3

author given names

Jun

author last names

Wu

1 reference

Dimensions Publication ID

18 August 2022

Linling Chen

4

author given names

Linling

author last names

Chen

1 reference

Dimensions Publication ID

18 August 2022

Jianming Lu

5

author given names

Jianming

author last names

Lu

1 reference

Dimensions Publication ID

18 August 2022

Xiaochen Wang

6

author given names

Xiaochen

author last names

Wang

1 reference

Dimensions Publication ID

18 August 2022

Bingsen Zhou

8

author given names

Bingsen

author last names

Zhou

1 reference

Dimensions Publication ID

18 August 2022

Yun Yen

9

author given names

Yun

author last names

Yen

1 reference

Dimensions Publication ID

18 August 2022

language of work or name

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publication date

2009

0 references

Molecular Cancer

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8

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1

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11

0 references

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

19 March 2017

Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

19 March 2017

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

19 March 2017

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

19 March 2017

Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

19 March 2017

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

7 April 2017

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

7 April 2017

Angiogenesis in cancer, vascular, rheumatoid and other disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

7 April 2017

Ribonucleotide reductases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

7 April 2017

Angiogenesis in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

7 April 2017

Tumorigenesis and the angiogenic switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

7 April 2017

RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Regulation of tumor angiogenesis by thrombospondin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

RRM1-induced metastasis suppression through PTEN-regulated pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Angiogenesis in ischemic and neoplastic disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Identification of genes expressed in premalignant breast disease by microscopy-directed cloning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

12 September 2017

Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Counteraction of pRb-dependent protection after extreme hypoxia by elevated ribonucleotide reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

27 September 2017

Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

29 November 2018

Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

29 November 2018

Determination of deoxyribonucleoside triphosphate pool sizes in ribonucleotide reductase cDNA transfected human KB cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662784

29 November 2018

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250552

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250552

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250552

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribonucleotide diphosphate reductase from human metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250552

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-8-11

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-8-11

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