(Q21175110)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BQB6

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Vitamin K epoxide reductase

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

1 reference

9 May 2019

vitamin-K-epoxide reductase (warfarin-sensitive) activity

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB6&geneProductId=UniProtKB:Q9BQB6

1 January 2018

The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB6&geneProductId=UniProtKB:Q9BQB6

EXP

quinone binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

1 reference

9 May 2019

vitamin-K-epoxide reductase (warfarin-sensitive) activity

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB6&geneProductId=UniProtKB:Q9BQB6

10 September 2018

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB6&geneProductId=UniProtKB:Q9BQB6

10 September 2018

The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BQB6&geneProductId=UniProtKB:Q9BQB6

vitamin-K-epoxide reductase (warfarin-insensitive) activity

EXP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

vitamin-K-epoxide reductase (warfarin-sensitive) activity

1 reference

1 January 2018

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

vitamin-K-epoxide reductase (warfarin-sensitive) activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

9 May 2019

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

1 reference

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

1 reference

9 May 2019

intracellular membrane-bounded organelle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

peptidyl-glutamic acid carboxylation

biological process

1 reference

8 April 2019

Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

blood coagulation

1 reference

8 April 2019

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

1 reference

9 May 2019

vitamin K metabolic process

ISS

response to organonitrogen compound

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

regulation of blood coagulation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

response to antibiotic

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

blood coagulation

peptidyl-glutamic acid carboxylation

vitamin K metabolic process

2 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

3 references

9 May 2019

TAS

9 May 2019

Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BQB6

physically interacts with

1 reference

2645

17 August 2016

1 reference

6808

17 August 2016

1 reference

6838

17 August 2016

1 reference

6839

17 August 2016

1 reference

6853

English

object of statement has role

17 August 2016

phenindione

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL711

has part(s)

Vitamin K epoxide reductase domain

1 reference

InterPro Release 71.0