Wikidata

(Q21117462)

English

CYLD lysine 63 deubiquitinase

mammalian protein found in Homo sapiens

  • deubiquitinating enzyme CYLD
  • ubiquitin-specific-processing protease CYLD
  • cylindromatosis (turban tumor syndrome)
  • ubiquitin thiolesterase CYLD
  • CYLD
  • ubiquitin carboxyl-terminal hydrolase CYLD
  • probable ubiquitin carboxyl-terminal hydrolase CYLD
  • ubiquitin specific peptidase like 2
  • ubiquitin thioesterase CYLD
  • Deubiquitinating Enzyme CYLD
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
11 references
retrieved
8 April 2019
stated in
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IPI
thiol-dependent deubiquitinase
determination method or standard
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IEA
retrieved
8 April 2019
stated in
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IBA
Lys63-specific deubiquitinase activity
determination method or standard
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IEA
retrieved
8 April 2019
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IBA
cell component
biological process
protein K63-linked deubiquitination
determination method or standard
IDA
IEA
5 references
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC7&geneProductId=UniProtKB:Q9NQC7
determination method or standard
IEA
retrieved
16 July 2018
stated in
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC7&geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
16 July 2018
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC7&geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
16 July 2018
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC7&geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
16 July 2018
stated in
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQC7&geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
protein K63-linked deubiquitination
determination method or standard
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IEA
retrieved
8 April 2019
stated in
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module
GOA
curator
UniProt
UniProt protein ID
Q9NQC7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQC7
determination method or standard
IBA

Identifiers

MeSH descriptor ID
D000074749
subject named as
Deubiquitinating Enzyme CYLD
0 references
RefSeq protein ID
 
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