(Q21104701)

Voltage-dependent channel domain superfamily

1 reference

voltage-gated ion channel

1 reference

Transporter Classification Database ID

1.A.1.11.27

2 October 2019

hierarchical database ID heuristic

Ion transport domain, protein family

1 reference

inferred from protein domain or family

Voltage-dependent calcium channel, alpha-1 subunit, IQ domain, protein family

1 reference

inferred from protein domain or family

Voltage-dependent L-type calcium channel, IQ-associated domain, protein family

1 reference

inferred from protein domain or family

image

CACNA1A.png
1,920 × 975; 743 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

voltage-gated ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

syntaxin binding

1 reference

8 April 2019

Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

protein binding

3 references

8 April 2019

Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

voltage-gated calcium channel activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

5 references

28 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

28 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

28 February 2017

28 February 2017

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

28 February 2017

Systematic identification of splice variants in human P/Q-type channel alpha1(2.1) subunits: implications for current density and Ca2+-dependent inactivation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

high voltage-gated calcium channel activity

2 references

28 February 2017

Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

28 February 2017

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

amyloid-beta binding

IC

1 reference

8 April 2019

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

voltage-gated calcium channel activity

IC

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

1 January 2018

ISS

1 January 2018

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

1 January 2018

1 January 2018

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

1 January 2018

Systematic identification of splice variants in human P/Q-type channel alpha1(2.1) subunits: implications for current density and Ca2+-dependent inactivation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00555&geneProductId=UniProtKB:O00555

high voltage-gated calcium channel activity

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

IMP

8 April 2019

Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

voltage-gated calcium channel activity

A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

8 April 2019

Systematic identification of splice variants in human P/Q-type channel alpha1(2.1) subunits: implications for current density and Ca2+-dependent inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

calcium channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

cell component

cytoplasm

1 reference

8 April 2019

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

voltage-gated calcium channel complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

cell projection

1 reference

8 April 2019

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

nucleus

1 reference

8 April 2019

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

integral component of membrane

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

TAS

8 April 2019

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

8 April 2019

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

soma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

ISS

biological process

calcium ion transport

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

1 reference

28 February 2017

cell death

1 reference

8 April 2019

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

membrane depolarization during action potential

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

1 reference

28 February 2017

regulation of ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

transport

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O00555

1 reference

28 February 2017

regulation of insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

calcium ion transmembrane transport

TAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

8 April 2019

Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

8 April 2019

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

membrane depolarization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

1 reference

8 April 2019

chemical synaptic transmission

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

modulation of chemical synaptic transmission

1 reference

8 April 2019

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

calcium ion import

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

response to amyloid-beta

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00555

http://purl.uniprot.org/uniprot/O00555

exact match

1 reference

Voltage-dependent L-type calcium channel, IQ-associated domain

Identifiers.org

has part(s)

1 reference

Ion transport domain

1 reference

Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

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1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

language of work or name

English

1.A.1.11.27

2 references

Transporter Classification database

13 March 2020

Transporter Classification database