(Q2062543)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

type II transforming growth factor beta receptor binding

TGF beta signals through a heteromeric protein kinase receptor complex

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Cloning and developmental expression of the chick type II and type III TGF beta receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

protein N-terminus binding

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cytokine activity

1 reference

17 October 2017

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

enzyme binding

1 reference

17 October 2017

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

antigen binding

1 reference

17 October 2017

Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

type I transforming growth factor beta receptor binding

protein homodimerization activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

protein serine/threonine kinase activator activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

protein binding

23 references

17 October 2017

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Agrin binds BMP2, BMP4 and TGFbeta1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Mechanisms for asporin function and regulation in articular cartilage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1).

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Latent TGF-β structure and activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

protein heterodimerization activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

type III transforming growth factor beta receptor binding

transforming growth factor beta receptor binding

identical protein binding

1 reference

17 October 2017

Latent TGF-β structure and activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cell component

nucleus

1 reference

17 October 2017

TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

microvillus

1 reference

17 October 2017

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

blood microparticle

1 reference

17 October 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

secretory granule

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

axon

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

soma

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

Golgi lumen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

platelet alpha granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

3 references

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of histone deacetylation

biological process

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of transcription regulatory region DNA binding

1 reference

17 October 2017

Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

ureteric bud development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

tolerance induction to self antigen

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein phosphorylation

1 reference

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

endoderm development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to cholesterol

1 reference

17 October 2017

Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of MAP kinase activity

1 reference

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of sodium ion transport

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to progesterone

1 reference

17 October 2017

Opposite regulation of transforming growth factors-beta2 and -beta3 expression in the human endometrium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of cell cycle

1 reference

17 October 2017

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to organic substance

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

mammary gland development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

T cell homeostasis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of ossification

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of hyaluronan biosynthetic process

1 reference

17 October 2017

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

T cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of vascular permeability

1 reference

17 October 2017

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

animal organ regeneration

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of blood vessel endothelial cell migration

1 reference

17 October 2017

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of epithelial cell proliferation

Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Bone morphogenetic proteins and growth and differentiation factors in the human cornea

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

inner ear development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

myelination

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of macrophage cytokine production

1 reference

17 October 2017

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cell population proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

transforming growth factor beta receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

4 references

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

face morphogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of cell population proliferation

1 reference

17 October 2017

Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of receptor clustering

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

positive regulation of collagen biosynthetic process

Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta

6 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to transforming growth factor beta stimulus

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

pathway-restricted SMAD protein phosphorylation

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of actin cytoskeleton reorganization

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of fat cell differentiation

1 reference

17 October 2017

Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein metabolic process

1 reference

17 October 2017

Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cell-cell junction organization

1 reference

17 October 2017

Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of myoblast differentiation

1 reference

17 October 2017

Inhibition of myogenesis by transforming growth factor beta is density-dependent and related to the translocation of transcription factor MEF2 to the cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein kinase B signaling

1 reference

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

common-partner SMAD protein phosphorylation

1 reference

17 October 2017

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

SMAD protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

epidermal growth factor receptor signaling pathway

1 reference

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

macrophage derived foam cell differentiation

1 reference

17 October 2017

Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of blood vessel endothelial cell migration

1 reference

17 October 2017

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein dephosphorylation

1 reference

17 October 2017

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

extrinsic apoptotic signaling pathway

1 reference

17 October 2017

Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of extracellular matrix disassembly

1 reference

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

mitotic cell cycle checkpoint signaling

1 reference

17 October 2017

Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of fibroblast proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of cell differentiation

1 reference

17 October 2017

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of branching involved in mammary gland duct morphogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of exit from mitosis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of transforming growth factor beta receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

negative regulation of gene expression

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Suppression of type I collagen production by microRNA-29b in cultured human stellate cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibitory effect of hsa-miR-590-5p on cardiosphere-derived stem cells differentiation through downregulation of TGFB signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

morphogenesis of a branching structure

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of SMAD protein signal transduction

1 reference

17 October 2017

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of peptidyl-serine phosphorylation

2 references

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cell activation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of neuroblast proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

6 references

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

negative regulation of T cell proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to wounding

1 reference

17 October 2017

TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of chemotaxis

1 reference

17 October 2017

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

protein export from nucleus

3 references

17 October 2017

TGF-beta activates ERK5 in human renal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibition of myogenesis by transforming growth factor beta is density-dependent and related to the translocation of transcription factor MEF2 to the cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

17 October 2017

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein import into nucleus

1 reference

17 October 2017

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of cardiac muscle cell differentiation

1 reference

17 October 2017

Inhibitory effect of hsa-miR-590-5p on cardiosphere-derived stem cells differentiation through downregulation of TGFB signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

oligodendrocyte development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of interleukin-17 production

2 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of interleukin-17 production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

T cell activation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

Notch signaling pathway

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of protein phosphorylation

1 reference

17 October 2017

Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of blood vessel remodeling

SMAD protein complex assembly

NAS

1 reference

17 October 2017

Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to vitamin D

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

chondrocyte differentiation

1 reference

17 October 2017

Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulatory T cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of cartilage development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

branch elongation involved in mammary gland duct branching

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of bone mineralization

1 reference

17 October 2017

Bone formation zones in heterotopic ossifications: histologic findings and increased expression of bone morphogenetic protein 2 and transforming growth factors beta2 and beta3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of epithelial cell proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

female pregnancy

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to organic cyclic compound

1 reference

17 October 2017

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of extracellular matrix assembly

1 reference

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular calcium ion homeostasis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

wound healing

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of transcription by RNA polymerase II

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to glucose

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of epithelial to mesenchymal transition

The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to dexamethasone stimulus

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of production of miRNAs involved in gene silencing by miRNA

1 reference

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

mitigation of host defenses by virus

1 reference

17 October 2017

Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

lens fiber cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of NF-kappaB transcription factor activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

ATP biosynthetic process

1 reference

17 October 2017

Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

hematopoietic progenitor cell differentiation

1 reference

17 October 2017

FLRG, member of the follistatin family, a new player in hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of interleukin-23 production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein secretion

1 reference

17 October 2017

Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

frontal suture morphogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

epithelial to mesenchymal transition

phosphate-containing compound metabolic process

1 reference

17 October 2017

Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of gene expression

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of release of sequestered calcium ion into cytosol

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to radiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

mononuclear cell proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of transcription, DNA-templated

negative regulation of T cell activation

2 references

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of odontogenesis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

lipopolysaccharide-mediated signaling pathway

1 reference

17 October 2017

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein localization to nucleus

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of cell migration

1 reference

17 October 2017

Holding their own: the noncanonical roles of Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to hypoxia

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

hyaluronan catabolic process

1 reference

17 October 2017

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of phagocytosis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to organic cyclic compound

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of protein-containing complex assembly

1 reference

17 October 2017

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

protein kinase B signaling

1 reference

17 October 2017

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of cell-cell adhesion

1 reference

17 October 2017

Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of gene silencing by miRNA

1 reference

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of regulatory T cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to growth factor stimulus

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of pathway-restricted SMAD protein phosphorylation

mammary gland branching involved in thelarche

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

response to laminar fluid shear stress

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

ageing

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of regulatory T cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

platelet degranulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

negative regulation of DNA replication

1 reference

17 October 2017

Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

myeloid dendritic cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

salivary gland morphogenesis

1 reference

17 October 2017

Developing human minor salivary glands: morphological parallel relation between the expression of TGF-beta isoforms and cytoskeletal markers of glandular maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

receptor catabolic process

1 reference

17 October 2017

Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

MAPK cascade

1 reference

17 October 2017

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of histone acetylation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of transforming growth factor beta receptor signaling pathway

1 reference

17 October 2017

Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of phosphatidylinositol 3-kinase activity

1 reference

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of protein localization to plasma membrane

1 reference

17 October 2017

Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of NAD+ ADP-ribosyltransferase activity

1 reference

17 October 2017

Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of immune response

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of cell population proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of skeletal muscle tissue development

1 reference

17 October 2017

Inhibition of myogenesis by transforming growth factor beta is density-dependent and related to the translocation of transcription factor MEF2 to the cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of peptidyl-threonine phosphorylation

2 references

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of smooth muscle cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of isotype switching to IgA isotypes

1 reference

17 October 2017

Impaired IgA class switching in APRIL-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

connective tissue replacement involved in inflammatory response wound healing

1 reference

17 October 2017

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

ossification involved in bone remodeling

1 reference

17 October 2017

Bone formation zones in heterotopic ossifications: histologic findings and increased expression of bone morphogenetic protein 2 and transforming growth factors beta2 and beta3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of apoptotic process

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of vascular endothelial growth factor production

1 reference

17 October 2017

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of superoxide anion generation

1 reference

17 October 2017

Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

digestive tract development

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cell migration

1 reference

17 October 2017

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

germ cell migration

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

negative regulation of mitotic cell cycle

1 reference

17 October 2017

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of SMAD protein signal transduction

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of gene expression

miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

9 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Suppression of type I collagen production by microRNA-29b in cultured human stellate cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Regulation and function of miR-214 in pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

The microRNA-29 family in cartilage homeostasis and osteoarthritis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of cell population proliferation

miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

17 October 2017

Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

liver regeneration

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of mononuclear cell migration

ISS

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to insulin-like growth factor stimulus

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of cell migration

response to immobilization stress

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to mechanical stimulus

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

cellular response to ionizing radiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

membrane protein intracellular domain proteolysis

1 reference

17 October 2017

Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

leukocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

positive regulation of ERK1 and ERK2 cascade

1 reference

17 October 2017

Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

BMP signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

cell development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

1 reference

17 October 2017

apoptotic process

1 reference

17 October 2017

Intron-exon structure of the human transforming growth factor-beta precursor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of pri-miRNA transcription by RNA polymerase II

1 reference

17 October 2017

SMAD proteins control DROSHA-mediated microRNA maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

positive regulation of production of miRNAs involved in gene silencing by miRNA

1 reference

17 October 2017

SMAD proteins control DROSHA-mediated microRNA maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

regulation of signaling receptor activity

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137

imported from Wikimedia project

Gene Atlas image

PBB GE TGFB1 203085 s at.png
255 × 135; 723 bytes

1 reference

English Wikipedia

has part(s)

Transforming growth factor beta, conserved site

1 reference

Transforming growth factor-beta, C-terminal

1 reference

TGF-beta, propeptide

1 reference

Identifiers

MeSH descriptor ID

D053773

subject named as

Transforming Growth Factor beta1

0 references

MeSH tree code

D12.644.276.374.687.100

0 references

D12.644.276.954.775.100

0 references

D12.776.467.374.687.100

0 references

D12.776.467.942.775.100

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023