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Lucas Miranda

Universidade de Lisboa, Línguas e Literaturas, Graduate Student

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Papers by Lucas Miranda

Functional MRI applications for psychiatric disease subtyping: a review

Background Psychiatric disorders have historically been classified using symptom information alon... more Background Psychiatric disorders have historically been classified using symptom information alone. With the advent of new technologies that allowed researchers to investigate brain mechanisms in a more direct manner, interest in not only the mechanistic rationale behind defined pathologies but also aetiology redefinition has greatly increased. This is particularly appealing for the field of personalised medicine, which searches for data-driven approaches to improve diagnosis, prognosis and treatment selection on an individual basis. Objective In the present article, we intend to systematically analyse the usage of functional MRI on both the elucidation of psychiatric disease biotypes and the interpretation/validation of subtypes obtained via unsupervised learning techniques applied to symptom or biomarker data. Methods Using PubMed, we searched the existing literature for functional MRI applications to the obtention or interpretation/validation of psychiatric disease subtypes in humans. The PRISMA guidelines were applied to filter the retrieved studies, and the active learning framework ASReviews was applied for article prioritization. Results From the 20 studies that met the inclusion criteria, 5 used functional MRI data to interpret symptom-derived disease clusters, 4 used it for the interpretation of clusters derived from biomarker data other than fMRI itself, and 11 applied clustering techniques to fMRI directly. Major depression disorder and schizophrenia were the two most studied pathologies (35% and 30% of the retrieved studies, respectively), followed by ADHD (15%), psychosis (10%), autism disorder (5%), and the consequences of early violence (5%). No trans-diagnostic studies were retrieved. Functional MRI applications for psychiatric disease subtyping: a review Conclusions While interest in personalised medicine and data-driven disease subtyping is on the rise and psychiatry is not the exception, unsupervised analyses of functional MRI data are inconsistent to date, and much remains to be done in terms of gathering and centralising data, standardising pipelines and model validation, and method refinement. The usage of fMRI in the field of trans-diagnostic psychiatry, of great importance for the aforementioned goals, remains vastly unexplored.

A short review of phase transition in a chaotic system

The European Physical Journal Special Topics, 2021

On the Flow of Software Security Advisories

IEEE Transactions on Network and Service Management, 2021

In this paper, we report results on a large scale measurement campaign to collect temporal inform... more In this paper, we report results on a large scale measurement campaign to collect temporal information about events associated with software vulnerabilities. The data is curated so as to extract dates from each of the analyzed security advisories. The resulting time series are our object of study. From our measurements we were able to identify which role was assumed by different platforms (such as websites and forums) in the security landscape, including sources and aggregators of information about vulnerabilities. Then, we propose an analytical model to express the flow of information through security advisories across multiple platforms. The model is based on a queueing network, where each platform corresponds to a queue which adds a delay in the information propagation. Such delays, in turn, have an impact on the visibility of the information at different platforms. Leveraging the proposed model and the collected data, we assess how different system parameters, such as the delays incurred by each platform to propagate its messages, impact the overall flow of information across platforms.

The Transcription Factor NF-κB Mediates Thyrotropin-Stimulated Expression of Thyroid Differentiation Markers

Thyroid, 2021

BACKGROUND The Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcripti... more BACKGROUND The Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor is a key regulator of cell survival, proliferation and gene expression. Although activation of NF-κB signaling in thyroid follicular cells following thyrotropin (TSH) receptor (TSHR) engagement has been reported, the downstream signaling leading to NF-κB activation remains unexplored. Here, we sought to elucidate the mechanisms that regulate NF-κB signaling activation in response to TSH stimulation. METHODS Fisher rat-derived thyroid cell lines and primary cultures of NF-κB essential modulator (NEMO)-deficient mice thyrocytes were used as models. Signaling pathways leading to the activation of NF-κB were investigated using chemical inhibitors and phospho-specific antibodies. Luciferase reporter gene assays and site-directed mutagenesis were used to monitor NF-κB-dependent gene transcriptional activity and the expression of thyroid differentiation markers was assessed by RT/qPCR and Western blot, respectively. Chromatin immunoprecipitation was carried out to investigate NF-κB subunit p65 DNA binding, and siRNA-mediated gene-knock-down approaches were used for studying gene function. RESULTS Using thyroid cell lines, we observed that TSH treatment leads to PKC-mediated canonical NF-κB p65 subunit nuclear expression. Moreover, TSH stimulation phosphorylated the kinase TAK-1, and its knock-down abolished TSH-induced NF-κB transcriptional activity. TSH induced the transcriptional activity of the NF-κB subunit p65 in a PKA-dependent phosphorylation at Ser-276. In addition, p65 phosphorylation at Ser-276 induced acetyl transferase p300 recruitment, leading to its acetylation on Lys-310 and thereby enhancing its transcriptional activity. Evaluation of the role played by NF-κB in thyroid physiology demonstrated that the canonical NF-κB inhibitor BAY11-7082 reduced TSH-induced expression of thyroid differentiation markers. Of note, the involvement of NF-κB signaling in thyroid physiology was confirmed by assessing the TSH-induced gene expression in primary cultures of NEMO-deficient mice thyrocytes. Moreover, chromatin immunoprecipitation and the knock-down experiments revealed that p65 is a nuclear effector of TSH actions, inducing the transcripcional expression of thyroid differentiation markers. CONCLUSIONS Taken together, our results point to NF-κB being a pivotal mediator in the TSH-induced thyroid follicular cell differentiation, a relevant finding with potential physiological and pathophysiological implications. .

Measuring and Modeling Software Vulnerability Security Advisory Platforms

Lecture Notes in Computer Science, 2021

In this paper, we report results on a large scale measurement campaign to collect temporal inform... more In this paper, we report results on a large scale measurement campaign to collect temporal information about events associated with software vulnerabilities. The data is curated so as to extract dates from each of the analyzed security advisories. The resulting time series are our object of study. From our measurements we were able to identify which role was assumed by different platforms (such as websites and forums) in the security landscape, including sources and aggregators of information about vulnerabilities. Then, we propose an analytical model to express the flow of information through security advisories across multiple platforms. The model is based on a queueing network, where each platform corresponds to a queue which adds a delay in the information propagation. Such delays, in turn, have an impact on the visibility of the information at different platforms. Leveraging the proposed model and the collected data, we assess how different system parameters, such as the delays incurred by each platform to propagate its messages, impact the overall flow of information across platforms.

A promoção do Letramento Científico através de matérias jornalísticas de Ciência e Tecnologia da emissora Al Jazeera

A Al Jazeera e a maior emissora de jornalismo do Qatar e se consolidou como a mais importante do ... more A Al Jazeera e a maior emissora de jornalismo do Qatar e se consolidou como a mais importante do mundo arabe (hoje contando com jornalistas de cerca de 70 nacionalidades e em mais de 100 paises, o que a torna um veiculo global de comunicacao). O objetivo deste trabalho foi verificar, atraves de tres materias da secao de Ciencia e Tecnologia no site da emissora, se ela promove o chamado letramento cientifico, tomando como referencia autores nacionais e internacionais que se destacam nesse campo de estudos. Para avaliar as materias foram elencados oito criterios que auxiliam na promocao do letramento cientifico e verificou-se, em cada uma das materias, quais desses elementos sao atendidos. Foi possivel verificar que as tres materias atendem a uma parcela expressiva dos criterios estabelecidos. Desse modo, pelos casos analisados, a Al Jazeera demonstrou promover uma divulgacao cientifica de boa qualidade, formando leitores criticos e cientes das limitacoes e possibilidades da Ciencia e...

Comparação Interanual Do Saldo De Radiação Na Floresta Nacional Do Tapajós

Bitcoin e lavagem de dinheiro: como as criptomoedas podem revolucionar o crime de lavagem de dinheiro

Educação Física Escolar: O Ensino Fundamental a Partir Do Olhar Dos Estudantes

FIEP Bulletin On-line, 2017

Este texto apresenta parte dos resultados de investigacao, cujo objeto de estudo foi o processo d... more Este texto apresenta parte dos resultados de investigacao, cujo objeto de estudo foi o processo de aprendizagemensinoda educacao fisica no ensino fundamental. Estabelece analise considerando a teoria do reconhecimento de Honneth(2003). Identificamos que o conhecimento e apropriado no ensino fundamental e assaz limitado. Como forma de romper com acondicao vislumbrada, reconhecemos nas esferas do reconhecimento (amor, direito, solidariedade), alternativa, para processosde aprendizagem-ensino mais contextualizados e coerentes com a responsabilidade da Educacao Fisica contribuir com aformacao humana dos estudantes.

Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping

Frontiers in Psychiatry, 2021

Background: Psychiatric disorders have been historically classified using symptom information alo... more Background: Psychiatric disorders have been historically classified using symptom information alone. Recently, there has been a dramatic increase in research interest not only in identifying the mechanisms underlying defined pathologies but also in redefining their etiology. This is particularly relevant for the field of personalized medicine, which searches for data-driven approaches to improve diagnosis, prognosis, and treatment selection for individual patients.Methods: This review aims to provide a high-level overview of the rapidly growing field of functional magnetic resonance imaging (fMRI) from the perspective of unsupervised machine learning applications for disease subtyping. Following the PRISMA guidelines for protocol reproducibility, we searched the PubMed database for articles describing functional MRI applications used to obtain, interpret, or validate psychiatric disease subtypes. We also employed the active learning framework ASReview to prioritize publications in a...

Comprehensive identification of pathogenic gene variants in patients with neuroendocrine disorders

Yearbook of Paediatric Endocrinology, 2021

PURPOSE Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mut... more PURPOSE Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the prevalence of mutations in known and candidate genes for this disorder. It could also increase the proportion of patients that receive a genetic diagnosis. METHODS We conducted target panel genetic screening using single-molecule molecular inversion probes sequencing to assess the frequency of mutations in known hypopituitarism genes and new candidates in Argentina. We captured genomic DNA from 170 pediatric patients with CH, either alone or with other abnormalities. We performed promoter activation assays to test the functional effects of patient variants in LHX3 and LHX4. RESULTS We found variants classified as pathogenic, likely pathogenic or with uncertain significance in 15.3% of cases. These variants were identified in known CH causative genes (LHX3, LHX4, GLI2, OTX2 and HESX1), in less frequently reported genes (FOXA2, BMP4, FGFR1, PROKR2, PNPLA6) and in new candidate genes (BMP2, HMGA2, HNF1A, NKX2-1). CONCLUSION In this work, we report the prevalence of mutations in known CH genes in Argentina and provide evidence for new candidate genes. We show that CH is a genetically heterogeneous disease with high phenotypic variation and incomplete penetrance, and our results support the need for further gene discovery for CH. Identifying population-specific pathogenic variants will improve the capacity of genetic data to predict eventual clinical outcomes.

Proposta de um plano de recuperação de uma área degradada pela extração de argila no município de Crato-CE

Brazilian Journal of Development, 2020

The Self is Dead – Alienation and Nihilism in Rick and Morty

Class Race Corporate Power, 2017

Drawing upon Erich Fromm's psychoanalytical-diagnosis of man in capitalism, this essay reflects u... more Drawing upon Erich Fromm's psychoanalytical-diagnosis of man in capitalism, this essay reflects upon some of the most political and philosophical themes of Cartoon Network's adult animated sitcom Rick and Morty. It focuses mainly in juxtaposing the nihilism and the alienation of the characters Rick and Jerry, respectively. Discussing the loss of agency due to the illusions and repressions of contemporary society, the essay concludes that capitalism benefits from both Jerry and Rick's self-destructive worldviews.

Ultraconservatives in a Contentious Cusp between Past and Future: A Review of Dan Brown’s novel "Origin

Class, Race and Corporate Power, 2019

Taking Dan Brown's latest novel Originas a thought-provoking heuristic device, this essay discuss... more Taking Dan Brown's latest novel Originas a thought-provoking heuristic device, this essay discusses the many facets of ultraconservatives' anti-intellectualism (from their stances on evolution and climate change, and also their conspiracy theories). Brown's novel particularly details the cultural tension between progressives and conservatives, depicting a very real far-right and how they respond to a hopeful and diverse youth (while exploring how political perception, fake news, and public information in the virtual era affect politics). The essay concludes that by raging war at science and deliberately making policies against progress, conservatives are at war against rationality itself, by defaming reason and allowing fascistic-authoritarianism to shape politics when, at the age of information, we should be moving to a more open, democratic, and post-capitalist world.

A Análise da Implementação da Estratégia B2C em um Canal B2B: um estudo de caso da Coloplast

Revista de Administração, Sociedade e Inovação, 2018

Uma vez estabelecidos, os conceitos, as categorias e as estratégias se tornam difíceis de serem f... more Uma vez estabelecidos, os conceitos, as categorias e as estratégias se tornam difíceis de serem flexibilizados ou combinados. Essa inflexibilidade na mescla de estratégias pode trazer uma limitação na eficiência. Este estudo propõe estudar uma estratégia híbrida, de uma empresa dinamarquesa de dispositivos médicos, que tem em sua unidade de negócios estudada o Business to Business como modelo de negócio. A estratégia insere um foco no consumidor final, Business to Consumer, dentro da estratégia B2B. O planejamento e implementação desta estratégia em um projeto piloto é estudado, usando os 4P's do marketing mix como moldura. Analisa-se, também, o resultado desta nova estratégia, usando como mensurável metas e premissas de crescimento definidas no início do projeto. A metodologia usada foi a descrição do caso, proposições teóricas e análises matemáticas. Os objetivos foram atingidos e resultados satisfatórios, porém, limitações como tempo transcorrido e amostragem reduzida não nos deixam afirmar que modelo proposto é uma estratégia eficiente.

New Processing and Seismic Interpretation for the Northern São Francisco Basin, Brazil - Part 2

Proceedings of the 16th International Congress of the Brazilian Geophysical Society&Expogef, 2019

Contents of this paper were reviewed by the Technical Committee of the 16 th International Congre... more Contents of this paper were reviewed by the Technical Committee of the 16 th International Congress of the Brazilian Geophysical Society and do not necessarily represent any position of the SBGf, its officers or members. Electronic reproduction or storage of any part of this paper for commercial purposes without the written consent of the Brazilian Geophysical Society is prohibited.

Um estudo da função de Fraser-Suzuki e sua aplicabilidade à cinética não-isotérmica de reações competitivas

C.Q.D.– Revista Eletrônica Paulista de Matemática, 2019

Um estudo da função de Fraser-Suzuki e sua aplicabilidadeà cinética não-isotérmica de reações com... more Um estudo da função de Fraser-Suzuki e sua aplicabilidadeà cinética não-isotérmica de reações competitivas A study of the Fraser-Suzuki function and its applicability to non-isothermal kinetics of competitive reactions Resumo O propósito deste trabalhoé apresentar um estudo das funções Gaussiana e Fraser-Suzuki aplicadasà cinética não-isotérmica. Devido a sua assimetria a função de Fraser-Suzuki mostrou ser adequada ao ajuste de curvas cinéticas de reações em fase condensada, quaisquer que sejam os modelos cinéticos. Observou-se que no caso de processos constituídos por reações competitivas, um procedimento de deconvolução baseado no ajuste da soma das funções de Fraser-Suzuki foi uma boa alternativa para a análise cinética das reações individuais.

Beyond the Last Jedi – Uncompromising Hope in the Politics of Star Wars

Class Race Corporate Power, 2018

Star Wars: The Last Jedi was probably the most political movie of the franchise so far. In this p... more Star Wars: The Last Jedi was probably the most political movie of the franchise so far. In this piece, I analyze how this film has subverted much of the SW lore by, interestingly, making its political dimensions significantly more real (and hence more complex). Throughout the piece, I use this reflection as a heuristic device to comment on how the movie might teach us how to interpret, critique, and deal with politics in a more sound, effective, and hopeful manner. E. H. Carr is invoked to assist in this endeavor, as I reflect upon the themes of (neoliberal) war profiteering, the efficacy of heroism, and the traps of political idolatry and ideological fanaticism.

Aflatoxins and ochratoxin A in different cocoa clones (Theobroma cacao L.) developed in the southern region of Bahia, Brazil

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2018

Brazil is the sixth largest producer of cocoa beans in the world, after Côte d'Ivoire, Ghana,... more Brazil is the sixth largest producer of cocoa beans in the world, after Côte d'Ivoire, Ghana, Indonesia, Nigeria and Cameroon. The southern region of Bahia stands out as the country's largest producer, accounting for approximately 60% of production. Due to damage caused by infestation of the cocoa crop with the fungus Moniliophthora perniciosa, which causes 'witch's broom disease', research in cocoa beans has led to the cloning of species that are resistant to the disease; however, there is little information about the development of other fungal genera in these clones, such as Aspergillus, which do not represent a phytopathogenicity problem but can grow during the pre-processing of cocoa beans and produce mycotoxins. Thus, the aim of this work was to determine the presence of aflatoxin (AF) and ochratoxin A (OTA) in cocoa clones developed in Brazil. Aflatoxin and ochratoxin A contamination were determined in 130 samples from 13 cocoa clones grown in the south of...

Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19

Current drug delivery, Jan 8, 2018

PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatme... more PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84.6:15.4 lipid:Tween, w/w). Lipid concentration varied from 20 to 40 mM. We evaluated the entrapment percentage, mean diameter, zeta potential and stability at 4 oC of the formulations. The skin permeation assays were performed with abdominal human skin using Franz diffusion cell with 3 cm2 diffusion area at 32 oC and a fluorescent derivative of the peptide, containing 5-TAMRA, bound to PnPP-19 C-terminal region, where an extra lysine was inserted. Our results showed variable entrapment efficiencies, from 6% to 30%, depe...

Functional MRI applications for psychiatric disease subtyping: a review

Background Psychiatric disorders have historically been classified using symptom information alon... more Background Psychiatric disorders have historically been classified using symptom information alone. With the advent of new technologies that allowed researchers to investigate brain mechanisms in a more direct manner, interest in not only the mechanistic rationale behind defined pathologies but also aetiology redefinition has greatly increased. This is particularly appealing for the field of personalised medicine, which searches for data-driven approaches to improve diagnosis, prognosis and treatment selection on an individual basis. Objective In the present article, we intend to systematically analyse the usage of functional MRI on both the elucidation of psychiatric disease biotypes and the interpretation/validation of subtypes obtained via unsupervised learning techniques applied to symptom or biomarker data. Methods Using PubMed, we searched the existing literature for functional MRI applications to the obtention or interpretation/validation of psychiatric disease subtypes in humans. The PRISMA guidelines were applied to filter the retrieved studies, and the active learning framework ASReviews was applied for article prioritization. Results From the 20 studies that met the inclusion criteria, 5 used functional MRI data to interpret symptom-derived disease clusters, 4 used it for the interpretation of clusters derived from biomarker data other than fMRI itself, and 11 applied clustering techniques to fMRI directly. Major depression disorder and schizophrenia were the two most studied pathologies (35% and 30% of the retrieved studies, respectively), followed by ADHD (15%), psychosis (10%), autism disorder (5%), and the consequences of early violence (5%). No trans-diagnostic studies were retrieved. Functional MRI applications for psychiatric disease subtyping: a review Conclusions While interest in personalised medicine and data-driven disease subtyping is on the rise and psychiatry is not the exception, unsupervised analyses of functional MRI data are inconsistent to date, and much remains to be done in terms of gathering and centralising data, standardising pipelines and model validation, and method refinement. The usage of fMRI in the field of trans-diagnostic psychiatry, of great importance for the aforementioned goals, remains vastly unexplored.

A short review of phase transition in a chaotic system

The European Physical Journal Special Topics, 2021

On the Flow of Software Security Advisories

IEEE Transactions on Network and Service Management, 2021

In this paper, we report results on a large scale measurement campaign to collect temporal inform... more In this paper, we report results on a large scale measurement campaign to collect temporal information about events associated with software vulnerabilities. The data is curated so as to extract dates from each of the analyzed security advisories. The resulting time series are our object of study. From our measurements we were able to identify which role was assumed by different platforms (such as websites and forums) in the security landscape, including sources and aggregators of information about vulnerabilities. Then, we propose an analytical model to express the flow of information through security advisories across multiple platforms. The model is based on a queueing network, where each platform corresponds to a queue which adds a delay in the information propagation. Such delays, in turn, have an impact on the visibility of the information at different platforms. Leveraging the proposed model and the collected data, we assess how different system parameters, such as the delays incurred by each platform to propagate its messages, impact the overall flow of information across platforms.

The Transcription Factor NF-κB Mediates Thyrotropin-Stimulated Expression of Thyroid Differentiation Markers

Thyroid, 2021

BACKGROUND The Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcripti... more BACKGROUND The Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor is a key regulator of cell survival, proliferation and gene expression. Although activation of NF-κB signaling in thyroid follicular cells following thyrotropin (TSH) receptor (TSHR) engagement has been reported, the downstream signaling leading to NF-κB activation remains unexplored. Here, we sought to elucidate the mechanisms that regulate NF-κB signaling activation in response to TSH stimulation. METHODS Fisher rat-derived thyroid cell lines and primary cultures of NF-κB essential modulator (NEMO)-deficient mice thyrocytes were used as models. Signaling pathways leading to the activation of NF-κB were investigated using chemical inhibitors and phospho-specific antibodies. Luciferase reporter gene assays and site-directed mutagenesis were used to monitor NF-κB-dependent gene transcriptional activity and the expression of thyroid differentiation markers was assessed by RT/qPCR and Western blot, respectively. Chromatin immunoprecipitation was carried out to investigate NF-κB subunit p65 DNA binding, and siRNA-mediated gene-knock-down approaches were used for studying gene function. RESULTS Using thyroid cell lines, we observed that TSH treatment leads to PKC-mediated canonical NF-κB p65 subunit nuclear expression. Moreover, TSH stimulation phosphorylated the kinase TAK-1, and its knock-down abolished TSH-induced NF-κB transcriptional activity. TSH induced the transcriptional activity of the NF-κB subunit p65 in a PKA-dependent phosphorylation at Ser-276. In addition, p65 phosphorylation at Ser-276 induced acetyl transferase p300 recruitment, leading to its acetylation on Lys-310 and thereby enhancing its transcriptional activity. Evaluation of the role played by NF-κB in thyroid physiology demonstrated that the canonical NF-κB inhibitor BAY11-7082 reduced TSH-induced expression of thyroid differentiation markers. Of note, the involvement of NF-κB signaling in thyroid physiology was confirmed by assessing the TSH-induced gene expression in primary cultures of NEMO-deficient mice thyrocytes. Moreover, chromatin immunoprecipitation and the knock-down experiments revealed that p65 is a nuclear effector of TSH actions, inducing the transcripcional expression of thyroid differentiation markers. CONCLUSIONS Taken together, our results point to NF-κB being a pivotal mediator in the TSH-induced thyroid follicular cell differentiation, a relevant finding with potential physiological and pathophysiological implications. .

Measuring and Modeling Software Vulnerability Security Advisory Platforms

Lecture Notes in Computer Science, 2021

In this paper, we report results on a large scale measurement campaign to collect temporal inform... more In this paper, we report results on a large scale measurement campaign to collect temporal information about events associated with software vulnerabilities. The data is curated so as to extract dates from each of the analyzed security advisories. The resulting time series are our object of study. From our measurements we were able to identify which role was assumed by different platforms (such as websites and forums) in the security landscape, including sources and aggregators of information about vulnerabilities. Then, we propose an analytical model to express the flow of information through security advisories across multiple platforms. The model is based on a queueing network, where each platform corresponds to a queue which adds a delay in the information propagation. Such delays, in turn, have an impact on the visibility of the information at different platforms. Leveraging the proposed model and the collected data, we assess how different system parameters, such as the delays incurred by each platform to propagate its messages, impact the overall flow of information across platforms.

A promoção do Letramento Científico através de matérias jornalísticas de Ciência e Tecnologia da emissora Al Jazeera

A Al Jazeera e a maior emissora de jornalismo do Qatar e se consolidou como a mais importante do ... more A Al Jazeera e a maior emissora de jornalismo do Qatar e se consolidou como a mais importante do mundo arabe (hoje contando com jornalistas de cerca de 70 nacionalidades e em mais de 100 paises, o que a torna um veiculo global de comunicacao). O objetivo deste trabalho foi verificar, atraves de tres materias da secao de Ciencia e Tecnologia no site da emissora, se ela promove o chamado letramento cientifico, tomando como referencia autores nacionais e internacionais que se destacam nesse campo de estudos. Para avaliar as materias foram elencados oito criterios que auxiliam na promocao do letramento cientifico e verificou-se, em cada uma das materias, quais desses elementos sao atendidos. Foi possivel verificar que as tres materias atendem a uma parcela expressiva dos criterios estabelecidos. Desse modo, pelos casos analisados, a Al Jazeera demonstrou promover uma divulgacao cientifica de boa qualidade, formando leitores criticos e cientes das limitacoes e possibilidades da Ciencia e...

Comparação Interanual Do Saldo De Radiação Na Floresta Nacional Do Tapajós

Bitcoin e lavagem de dinheiro: como as criptomoedas podem revolucionar o crime de lavagem de dinheiro

Educação Física Escolar: O Ensino Fundamental a Partir Do Olhar Dos Estudantes

FIEP Bulletin On-line, 2017

Este texto apresenta parte dos resultados de investigacao, cujo objeto de estudo foi o processo d... more Este texto apresenta parte dos resultados de investigacao, cujo objeto de estudo foi o processo de aprendizagemensinoda educacao fisica no ensino fundamental. Estabelece analise considerando a teoria do reconhecimento de Honneth(2003). Identificamos que o conhecimento e apropriado no ensino fundamental e assaz limitado. Como forma de romper com acondicao vislumbrada, reconhecemos nas esferas do reconhecimento (amor, direito, solidariedade), alternativa, para processosde aprendizagem-ensino mais contextualizados e coerentes com a responsabilidade da Educacao Fisica contribuir com aformacao humana dos estudantes.

Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping

Frontiers in Psychiatry, 2021

Background: Psychiatric disorders have been historically classified using symptom information alo... more Background: Psychiatric disorders have been historically classified using symptom information alone. Recently, there has been a dramatic increase in research interest not only in identifying the mechanisms underlying defined pathologies but also in redefining their etiology. This is particularly relevant for the field of personalized medicine, which searches for data-driven approaches to improve diagnosis, prognosis, and treatment selection for individual patients.Methods: This review aims to provide a high-level overview of the rapidly growing field of functional magnetic resonance imaging (fMRI) from the perspective of unsupervised machine learning applications for disease subtyping. Following the PRISMA guidelines for protocol reproducibility, we searched the PubMed database for articles describing functional MRI applications used to obtain, interpret, or validate psychiatric disease subtypes. We also employed the active learning framework ASReview to prioritize publications in a...

Comprehensive identification of pathogenic gene variants in patients with neuroendocrine disorders

Yearbook of Paediatric Endocrinology, 2021

PURPOSE Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mut... more PURPOSE Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the prevalence of mutations in known and candidate genes for this disorder. It could also increase the proportion of patients that receive a genetic diagnosis. METHODS We conducted target panel genetic screening using single-molecule molecular inversion probes sequencing to assess the frequency of mutations in known hypopituitarism genes and new candidates in Argentina. We captured genomic DNA from 170 pediatric patients with CH, either alone or with other abnormalities. We performed promoter activation assays to test the functional effects of patient variants in LHX3 and LHX4. RESULTS We found variants classified as pathogenic, likely pathogenic or with uncertain significance in 15.3% of cases. These variants were identified in known CH causative genes (LHX3, LHX4, GLI2, OTX2 and HESX1), in less frequently reported genes (FOXA2, BMP4, FGFR1, PROKR2, PNPLA6) and in new candidate genes (BMP2, HMGA2, HNF1A, NKX2-1). CONCLUSION In this work, we report the prevalence of mutations in known CH genes in Argentina and provide evidence for new candidate genes. We show that CH is a genetically heterogeneous disease with high phenotypic variation and incomplete penetrance, and our results support the need for further gene discovery for CH. Identifying population-specific pathogenic variants will improve the capacity of genetic data to predict eventual clinical outcomes.

Proposta de um plano de recuperação de uma área degradada pela extração de argila no município de Crato-CE

Brazilian Journal of Development, 2020

The Self is Dead – Alienation and Nihilism in Rick and Morty

Class Race Corporate Power, 2017

Drawing upon Erich Fromm's psychoanalytical-diagnosis of man in capitalism, this essay reflects u... more Drawing upon Erich Fromm's psychoanalytical-diagnosis of man in capitalism, this essay reflects upon some of the most political and philosophical themes of Cartoon Network's adult animated sitcom Rick and Morty. It focuses mainly in juxtaposing the nihilism and the alienation of the characters Rick and Jerry, respectively. Discussing the loss of agency due to the illusions and repressions of contemporary society, the essay concludes that capitalism benefits from both Jerry and Rick's self-destructive worldviews.

Ultraconservatives in a Contentious Cusp between Past and Future: A Review of Dan Brown’s novel "Origin

Class, Race and Corporate Power, 2019

Taking Dan Brown's latest novel Originas a thought-provoking heuristic device, this essay discuss... more Taking Dan Brown's latest novel Originas a thought-provoking heuristic device, this essay discusses the many facets of ultraconservatives' anti-intellectualism (from their stances on evolution and climate change, and also their conspiracy theories). Brown's novel particularly details the cultural tension between progressives and conservatives, depicting a very real far-right and how they respond to a hopeful and diverse youth (while exploring how political perception, fake news, and public information in the virtual era affect politics). The essay concludes that by raging war at science and deliberately making policies against progress, conservatives are at war against rationality itself, by defaming reason and allowing fascistic-authoritarianism to shape politics when, at the age of information, we should be moving to a more open, democratic, and post-capitalist world.

A Análise da Implementação da Estratégia B2C em um Canal B2B: um estudo de caso da Coloplast

Revista de Administração, Sociedade e Inovação, 2018

Uma vez estabelecidos, os conceitos, as categorias e as estratégias se tornam difíceis de serem f... more Uma vez estabelecidos, os conceitos, as categorias e as estratégias se tornam difíceis de serem flexibilizados ou combinados. Essa inflexibilidade na mescla de estratégias pode trazer uma limitação na eficiência. Este estudo propõe estudar uma estratégia híbrida, de uma empresa dinamarquesa de dispositivos médicos, que tem em sua unidade de negócios estudada o Business to Business como modelo de negócio. A estratégia insere um foco no consumidor final, Business to Consumer, dentro da estratégia B2B. O planejamento e implementação desta estratégia em um projeto piloto é estudado, usando os 4P's do marketing mix como moldura. Analisa-se, também, o resultado desta nova estratégia, usando como mensurável metas e premissas de crescimento definidas no início do projeto. A metodologia usada foi a descrição do caso, proposições teóricas e análises matemáticas. Os objetivos foram atingidos e resultados satisfatórios, porém, limitações como tempo transcorrido e amostragem reduzida não nos deixam afirmar que modelo proposto é uma estratégia eficiente.

New Processing and Seismic Interpretation for the Northern São Francisco Basin, Brazil - Part 2

Proceedings of the 16th International Congress of the Brazilian Geophysical Society&Expogef, 2019

Contents of this paper were reviewed by the Technical Committee of the 16 th International Congre... more Contents of this paper were reviewed by the Technical Committee of the 16 th International Congress of the Brazilian Geophysical Society and do not necessarily represent any position of the SBGf, its officers or members. Electronic reproduction or storage of any part of this paper for commercial purposes without the written consent of the Brazilian Geophysical Society is prohibited.

Um estudo da função de Fraser-Suzuki e sua aplicabilidade à cinética não-isotérmica de reações competitivas

C.Q.D.– Revista Eletrônica Paulista de Matemática, 2019

Um estudo da função de Fraser-Suzuki e sua aplicabilidadeà cinética não-isotérmica de reações com... more Um estudo da função de Fraser-Suzuki e sua aplicabilidadeà cinética não-isotérmica de reações competitivas A study of the Fraser-Suzuki function and its applicability to non-isothermal kinetics of competitive reactions Resumo O propósito deste trabalhoé apresentar um estudo das funções Gaussiana e Fraser-Suzuki aplicadasà cinética não-isotérmica. Devido a sua assimetria a função de Fraser-Suzuki mostrou ser adequada ao ajuste de curvas cinéticas de reações em fase condensada, quaisquer que sejam os modelos cinéticos. Observou-se que no caso de processos constituídos por reações competitivas, um procedimento de deconvolução baseado no ajuste da soma das funções de Fraser-Suzuki foi uma boa alternativa para a análise cinética das reações individuais.

Beyond the Last Jedi – Uncompromising Hope in the Politics of Star Wars

Class Race Corporate Power, 2018

Star Wars: The Last Jedi was probably the most political movie of the franchise so far. In this p... more Star Wars: The Last Jedi was probably the most political movie of the franchise so far. In this piece, I analyze how this film has subverted much of the SW lore by, interestingly, making its political dimensions significantly more real (and hence more complex). Throughout the piece, I use this reflection as a heuristic device to comment on how the movie might teach us how to interpret, critique, and deal with politics in a more sound, effective, and hopeful manner. E. H. Carr is invoked to assist in this endeavor, as I reflect upon the themes of (neoliberal) war profiteering, the efficacy of heroism, and the traps of political idolatry and ideological fanaticism.

Aflatoxins and ochratoxin A in different cocoa clones (Theobroma cacao L.) developed in the southern region of Bahia, Brazil

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2018

Brazil is the sixth largest producer of cocoa beans in the world, after Côte d'Ivoire, Ghana,... more Brazil is the sixth largest producer of cocoa beans in the world, after Côte d'Ivoire, Ghana, Indonesia, Nigeria and Cameroon. The southern region of Bahia stands out as the country's largest producer, accounting for approximately 60% of production. Due to damage caused by infestation of the cocoa crop with the fungus Moniliophthora perniciosa, which causes 'witch's broom disease', research in cocoa beans has led to the cloning of species that are resistant to the disease; however, there is little information about the development of other fungal genera in these clones, such as Aspergillus, which do not represent a phytopathogenicity problem but can grow during the pre-processing of cocoa beans and produce mycotoxins. Thus, the aim of this work was to determine the presence of aflatoxin (AF) and ochratoxin A (OTA) in cocoa clones developed in Brazil. Aflatoxin and ochratoxin A contamination were determined in 130 samples from 13 cocoa clones grown in the south of...

Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19

Current drug delivery, Jan 8, 2018

PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatme... more PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84.6:15.4 lipid:Tween, w/w). Lipid concentration varied from 20 to 40 mM. We evaluated the entrapment percentage, mean diameter, zeta potential and stability at 4 oC of the formulations. The skin permeation assays were performed with abdominal human skin using Franz diffusion cell with 3 cm2 diffusion area at 32 oC and a fluorescent derivative of the peptide, containing 5-TAMRA, bound to PnPP-19 C-terminal region, where an extra lysine was inserted. Our results showed variable entrapment efficiencies, from 6% to 30%, depe...