Papers by Sophie Couffignal
Table S2. Weighting associated to each stratum (gender, age and district). The table shows weight... more Table S2. Weighting associated to each stratum (gender, age and district). The table shows weights used to account for differences between participants and non-participants. (DOCX 25 kb)
Table S1. Projection of sample size calculation of each age-sex domain based on the 2011 census. ... more Table S1. Projection of sample size calculation of each age-sex domain based on the 2011 census. The table shows the resident population of Grand-Duchy of Luxembourg based on the 2011 census, the invited individuals and the projection of participating individuals - broken down by gender, age and district. (DOCX 27 kb)
to the ORISCAV-LUX population-based study on cardiovascular risk factors in Luxembourg
Background: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular heal... more Background: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1) to describe the study design and conduct, and 2) to present the salient outcomes of the study, in particular the prevalence of the potentially modifiable and treatable cardiovascular disease risk factors in the adult population residing in Luxembourg. Method: ORISCAV-LUX is a cross-sectional study based on a random sample of 4496 subjects, stratified by gender, age categories and district, drawn from the national insurance registry of 18-69 years aged Luxembourg residents, assuming a response rate of 30 % and a proportion of 5 % of institutionalized subjects in each stratum. The cardiovascular health status was assessed by means of a self-administered questionnaire, clinical and anthropometric measures, as well as by blood, urine and hair examinations. The potentially modifiable an...
Associations between quality of life and socioeconomic factors, functional impairments and dissat... more Associations between quality of life and socioeconomic factors, functional impairments and dissatisfaction with received information and home-care services among survivors living at home two years after stroke onset
This paper describes a survey based on a stroke register in Luxembourg with the aim of examining ... more This paper describes a survey based on a stroke register in Luxembourg with the aim of examining the impact of dissatisfaction with quality of service, functional impairments and information provision upon stroke survivors’ quality of life at two years after stroke. This is a worthy aim, but I have serious concerns about the paper in its present form. These concerns fall into three principal domains: the logic of the design, the statistical analyses and the language.
Les registres du cancer jouent un role important dans la lutte contre le cancer. Afin d'obten... more Les registres du cancer jouent un role important dans la lutte contre le cancer. Afin d'obtenir des donnees de qualite et comparables, des standards de codification internationaux et maintes bonnes pratiques de codification medicale doivent etre respectes. Cet article propose une approche d'aide aux encodeurs dans le cadre des registres du cancer et decrit l'application de raisonnement a partir de cas. Cet article detaille egalement une implementation prototype de l'approche decrite et des resultats preliminaires.
Lecture Notes in Computer Science, 2017
Cancer registries are important tools in the fight against cancer. At the heart of these registri... more Cancer registries are important tools in the fight against cancer. At the heart of these registries is the data collection and coding process. Ruled by complex international standards and numerous best practices, operators are easily overwhelmed. In this paper, a system is presented to assist operators in the interpretation of best medical coding practices. By leveraging the arguments used by the coding experts to determine the best coding option, the proposed system is designed to answer the coding questions from operators and provide an answer associated with a partial explanation for the proposed solution.
Artificial Intelligence in Health, 2019
In the fight against cancer, cancer registries are an important tool. At the heart of these regis... more In the fight against cancer, cancer registries are an important tool. At the heart of these registries is the data collection and coding process. This process is ruled by complex international standards and numerous best practices, which can easily overwhelm (coding) operators. In this paper, a system assisting operators in the interpretation of best medical coding practices and a short evaluation are presented. By leveraging the arguments used by the coding experts to determine the best coding option, the proposed system answers coding questions from operators and provides a partial explanation for the proposed solution.
Revue d'Épidémiologie et de Santé Publique, 2017
BMC Public Health, 2010
Background: The ORISCAV-LUX study is the first baseline survey of an ongoing cardiovascular healt... more Background: The ORISCAV-LUX study is the first baseline survey of an ongoing cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1) to describe the study design and conduct, and 2) to present the salient outcomes of the study, in particular the prevalence of the potentially modifiable and treatable cardiovascular disease risk factors in the adult population residing in Luxembourg. Method: ORISCAV-LUX is a cross-sectional study based on a random sample of 4496 subjects, stratified by gender, age categories and district, drawn from the national insurance registry of 18-69 years aged Luxembourg residents, assuming a response rate of 30% and a proportion of 5% of institutionalized subjects in each stratum. The cardiovascular health status was assessed by means of a self-administered questionnaire, clinical and anthropometric measures, as well as by blood, urine and hair examinations. The potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Both univariate and multivariate statistical analyses used weighted methods to account for the stratified sampling scheme. Results: A total of 1432 subjects took part in the survey, yielding a participation rate of 32.2%. This figure is higher than the minimal sample size of 1285 subjects as estimated by power calculation. The most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%. All prevalence rates increased with age (except smoking) with marked gender differences (except diabetes). There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth. The proportion of subjects cumulating two or more cardiovascular risk factors increased remarkably with age and was more predominant in men than in women (P<0.0001). Only 14.7% of men and 23.1% of women were free of any cardiovascular risk factor. High prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population. Conclusion: The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors. From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg.
Questionnaires ORISCAV-LUX 2. (Nurse Questionnaire) English version. (PDF 872 kb)
BMC Medical Research Methodology
Background: It is challenging to manage data collection as planned and creation of opportunities ... more Background: It is challenging to manage data collection as planned and creation of opportunities to adapt during the course of enrolment may be needed. This paper aims to summarize the different sampling strategies adopted in the second wave of Observation of Cardiovascular Risk Factors (ORISCAV-LUX, 2016-17), with a focus on population coverage and sample representativeness. Methods: Data from the first nationwide cross-sectional, population-based ORISCAV-LUX survey, 2007-08 and from the newly complementary sample recruited via different pathways, nine years later were analysed. First, we compare the socio-demographic characteristics and health profiles between baseline participants and non-participants to the second wave. Then, we describe the distribution of subjects across different strategy-specific samples and performed a comparison of the overall ORISCAV-LUX2 sample to the national population according to stratification criteria. Results: For the baseline sample (1209 subjects), the participants (660) were younger than the non-participants (549), with a significant difference in average ages (44 vs 45.8 years; P = 0.019). There was a significant difference in terms of education level (P < 0.0001), 218 (33%) participants having university qualification vs. 95 (18%) non-participants. The participants seemed having better health perception (p < 0.0001); 455 (70.3%) self-reported good or very good health perception compared to 312 (58.2%) non-participants. The prevalence of obesity (P < 0.0001), hypertension (P < 0.0001), diabetes (P = 0.007), and mean values of related biomarkers were significantly higher among the non-participants. The overall sample (1558 participants) was mainly composed of randomly selected subjects, including 660 from the baseline sample and 455 from other health examination survey sample and 269 from civil registry sample (constituting in total 88.8%), against only 174 volunteers (11.2%), with significantly different characteristics and health status. The ORISCAV-LUX2 sample was representative of national population for geographical district, but not for sex and age; the younger (25-34 years) and older (65-79 years) being underrepresented, whereas middle-aged adults being overrepresented, with significant sex-specific difference (p < 0.0001). Conclusion: This study represents a careful first-stage analysis of the ORISCAV-LUX2 sample, based on available information on participants and non-participants. The ORISCAV-LUX datasets represents a relevant tool for epidemiological research and a basis for health monitoring and evidence-based prevention of cardiometabolic risk in Luxembourg.
BMC Public Health
Background: The European Health Examination Survey in Luxembourg (EHES-LUX) is a population based... more Background: The European Health Examination Survey in Luxembourg (EHES-LUX) is a population based survey performed from 2013 to 2015 with the aim to establish baseline information on the general health status of the Luxembourg population aged 25 to 64 years. The paper introduces the study design, recruitment method and representativeness of the sample, and summarizes the sociodemographic characteristics of participants and the prevalence of major health outcomes. Methods: EHES-LUX is based on a random sample representative of the population of Luxembourg based on gender, age and district of residence. The sample size of the study was determined to provide accurate prevalence estimates for major chronic conditions. During two visits, data were collected from participants through a questionnaire (personal data, health status and health care), medical examinations (anthropometric measures, electrocardiogram and spirometry) and biological analysis (blood, urine and hair). Means and frequencies were used to describe the general characteristics of the population and a one-way ANOVA to test the representativeness of the sample and the comparability of participants and non-participants. Results: A total of 1529 individuals participated in this study (participation rate of 24.1%). Differences between participants and non-participants based on gender, age and district of residence were corrected by sampling weights. The mean age (±SD) of participants was 44.9 (±10.1) years, of which 52.8% were women. Based on clinical measurements, nearly 20% of participants were obese and more than one in three participants were overweight. From measurements (respectively from self-report), 22.0% (respectively 12.2%) were hypertensive, 49.3% (respectively 22.5%) had hypercholesterolemia, 3.5% (respectively 3.7%) had diabetes and 7.6% (respectively 6.0%) had depressive symptoms. Conclusions: This nationwide epidemiological study on the general health status of Luxembourg residents provides updated prevalence estimates on a range of major health conditions. This information can be used by health authorities to evaluate policies and public health initiatives. At European level, prevalence data obtained by this study following the EHES-Reference Committee (EHES-RC) recommendations, will be comparable between European countries participating in this program.
Background: Life satisfaction (LS) of cerebrovascular disease survivors and their family caregive... more Background: Life satisfaction (LS) of cerebrovascular disease survivors and their family caregivers may relate to socioeconomic factors, impaired functions, health-related quality of life (QoL), but their respective influences remain unclear. This study assessed, two years post-stroke onset, the effects of these factors on patients' LS and family caregivers' LS in Luxembourg. Methods: All stroke patients admitted to all hospitals in Luxembourg were identified by the 'Inspection Général de la Sécurité Sociale' using the only national system database for care expenditure reimbursement. Their diagnosis was confirmed by medical investigator. The sample included ninety four patients living at home having given consent (mean age 65.5 years) and sixty two main caregivers (mean age 59.3 years). Questionnaires were completed during face-to-face interviews. LS was assessed via European single question (range 1-10), survivors' QoL via Newsqol (11 dimensions), and caregivers' QoL via Whoqol-bref (4 domains) (range 0-100). Data were analysed using multiple regression models. Results: Two years after stroke onset, 44.7% of patients suffered from impaired sensory function, 35.1% from impaired motor function, and 31.9% from impaired memory function. Mean patient' LS was 7.1/10 (SD 1.9). It was higher in women (+12.4) and lower among unemployed socioeconomically active patients (−13.1, vs. retired people). Adjusted for sex, occupation, impaired motor and memory functions, LS positively correlated with scores of Newsqol feelings, sleep, emotion, cognition and pain dimensions (slopes 0.20 to 0.31), but did not correlate with those of caregivers' Whoqol-bref domains. Family caregiver' LS was 7.2 (SD 1.7). It was lower in those with patients suffering from impaired memory function (−12.8) as well as from feelings and emotion issues (slopes 0.22). It was associated with all caregivers' Whoqol-bref domains (physical health, psychological health, environment, and social relationships) (slopes 0.53 to 0.68).
Bmc Neurology, 2012
Background: Life satisfaction (LS) of cerebrovascular disease survivors and their family caregive... more Background: Life satisfaction (LS) of cerebrovascular disease survivors and their family caregivers may relate to socioeconomic factors, impaired functions, health-related quality of life (QoL), but their respective influences remain unclear. This study assessed, two years post-stroke onset, the effects of these factors on patients' LS and family caregivers' LS in Luxembourg. Methods: All stroke patients admitted to all hospitals in Luxembourg were identified by the 'Inspection Général de la Sécurité Sociale' using the only national system database for care expenditure reimbursement. Their diagnosis was confirmed by medical investigator. The sample included ninety four patients living at home having given consent (mean age 65.5 years) and sixty two main caregivers (mean age 59.3 years). Questionnaires were completed during face-to-face interviews. LS was assessed via European single question (range 1-10), survivors' QoL via Newsqol (11 dimensions), and caregivers' QoL via Whoqol-bref (4 domains) (range 0-100). Data were analysed using multiple regression models. Results: Two years after stroke onset, 44.7% of patients suffered from impaired sensory function, 35.1% from impaired motor function, and 31.9% from impaired memory function. Mean patient' LS was 7.1/10 (SD 1.9). It was higher in women (+12.4) and lower among unemployed socioeconomically active patients (−13.1, vs. retired people). Adjusted for sex, occupation, impaired motor and memory functions, LS positively correlated with scores of Newsqol feelings, sleep, emotion, cognition and pain dimensions (slopes 0.20 to 0.31), but did not correlate with those of caregivers' Whoqol-bref domains. Family caregiver' LS was 7.2 (SD 1.7). It was lower in those with patients suffering from impaired memory function (−12.8) as well as from feelings and emotion issues (slopes 0.22). It was associated with all caregivers' Whoqol-bref domains (physical health, psychological health, environment, and social relationships) (slopes 0.53 to 0.68).
Resultats de l'étude oriscav-Lux « observation des risques et de la santé cardio-vasculaire a... more Resultats de l'étude oriscav-Lux « observation des risques et de la santé cardio-vasculaire au Luxembourg» etude financée par le ministère de la santé et le ministère de l'enseignement supérieur et de la recherche, Departement santé publique 2 | Enjeux Santé | nº4
Resultats de l'étude oriscav-Lux « observation des risques et de la santé cardio-vasculaire a... more Resultats de l'étude oriscav-Lux « observation des risques et de la santé cardio-vasculaire au Luxembourg» etude financée par le ministère de la santé et le ministère de l'enseignement supérieur et de la recherche, Departement santé publique 2 | Enjeux Santé | nº4
Resultats de l'étude oriscav-Lux « observation des risques et de la santé cardio-vasculaire a... more Resultats de l'étude oriscav-Lux « observation des risques et de la santé cardio-vasculaire au Luxembourg» etude financée par le ministère de la santé et le ministère de l'enseignement supérieur et de la recherche, Departement santé publique 2 | Enjeux Santé | nº4
Uploads
Papers by Sophie Couffignal