Papers by NUH Z A F E R CANTURK
Journal of Dental Research, Dental Clinics, Dental Prospects, 2015
Background and aims. Oral lichen planus (OLP) is an immunologic disorder. A large number of studi... more Background and aims. Oral lichen planus (OLP) is an immunologic disorder. A large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. Here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases. Materials and methods. The present cross-sectional study evaluated 88 patients referring to the Department of Oral Medicine in 3 groups (Group 1: erosive OLP; Group 2: non-erosive OLP; Group 3: healthy). A total of 3 mL of blood sample was taken from each subject and the serum levels of cholesterol, triglycerides, HDL and LDL were determined. The mean outcomes of each group were compared with each other and analyzed two by two. Results. The results of statistical analyses showed no significant differences in mean HDL and LDL serum levels between the three groups. The results of post hoc LSD test showed that mean serum levels of subjects with erosive and non-erosive lichen planus were higher than those in healthy subjects. In relation to triglyceride serum levels, the mean serum levels of triglycerides were higher in erosive and non-erosive OLP patients compared to healthy subjects. Conclusion. Triglyceride and cholesterol can be considered to have a critical role in the incidence of lichen planus and in its manifestations as predisposing factors.
American Journal of Hematology, 1998
Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) (250 μg/m2) was administered subcutaneo... more Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) (250 μg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3½ times baseline by day 14. At day 5 marrow mitotic cells were increased and post‐mitotic cells decreased, and the transit time through the post‐mitotic marrow pool accelerated (normal = 6.4 days, GM‐CSF = 3.9 days; P < 0.01). Treatment had little effect on the blood neutrophil half‐life (normal = 9.6 ± 1.3 hours; GM‐CSF = 13.1 ± 2.4 hours, P > 0.05); or the neutrophil turnover rate (normal = 78.5 ± 11.9 × 107/cells/kg/day, GM‐CSF = 91.4 ± 19.8 × 107/cells/kg/day, P > 0.05). GM‐CSF reduced the number of neutrophils migrating to skin chambers (normal = 104 ± 25.0 × 106/cells, GM‐CSF = 48.6 ± 16.0 × 106/cells; P < 0.05). Treatment increased expression of CD11b/CD18 but not Fcγ receptors (CD16, CD32, CD64). Treatment also stimulated the in vitro neutrophil respiratory burst in response to a variety of agonists, and this enhancement persisted for the duration of treatment. All subjects experienced local and systemic adverse effects and developed eosinophilia. This study indicates that GM‐CSF at a dose of 250 μg/m2 causes neutrophilia chiefly by accelerating delivery of neutrophils from the marrow to the blood and by decreasing migration from the blood to the tissues, with only a modest effect on neutrophil production and blood half‐life. Am. J. Hematol. 57:7–15, 1998. © 1998 Wiley‐Liss, Inc.
Sustainability, Mar 30, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Meme sağlığı dergisi, 2011
... kullanı- lan hastalarda en çok kullanılan boya 14 (%50) merkezde izosül-fan mavisi iken, 11 (... more ... kullanı- lan hastalarda en çok kullanılan boya 14 (%50) merkezde izosül-fan mavisi iken, 11 (%39.3) merkezde boya olarak metilen mavi-si tercih ... 1985; 312: 674-81.( PMID:3883168) 8. Veronesi U, Cascinelli M, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E ...
Türk biyokimya dergisi, Aug 1, 2018
East African medical journal, 2013
OBJECTIVE To determine the prevalence andintensity of single and mixed schistosomiasis infection ... more OBJECTIVE To determine the prevalence andintensity of single and mixed schistosomiasis infection among primary school children in Rachuonyo North District, Homabay County in western Kenya. DESIGN A descriptive cross sectional study. SETTING A parasitological survey involving six primary schools in Rachuonyo North District, Homabay County. SUBJECTS Four hundred and seventy four(474) school children, seven to 15 years old. Each child provided a urine and stool sample for diagnosis of schistosome and soil-transmitted helminth infections. Urine samples were processed using the filtration technique and the sample examined by microscopy for Schistosoma haematobium ova. Stool samples were processed by the Kato-Katz technique and the sample examined by microscopy for ova of S. mansoni and soil-transmitted helminths. RESULTS Prevelance of S.haematobium was 37.6%, S.mansoni (12.2%), hookworm (14.6%), Ascaris lumbricoides (6.3%), Trichuris trichiura (5.3%) among the children in the participati...
European Journal of Gynaecological Oncology, 2020
The aim of the study was to evaluate the severity of systemic responses to trauma; and thus, to d... more The aim of the study was to evaluate the severity of systemic responses to trauma; and thus, to determine the most advanta geous timing for surgery among different phases of the menstrual cycle. Materials and Methods: 99 women were included in this study. They were patients who were in the postmenopausal period and patients in the different menstrual cycle phases of the premenopausal period. Creactive protein, interleukin1β, interleukin6 and tumor necrosis factorα levels were measured before and after surgery. Re sults: Among the menstrual cycle phases, the highest increases in the concentrations of IL6 and TNFα during the postoperative period were found in follicular phase patients. Luteal phase patients showed the lowest increases in interleukin1β and interleukin6 levels. TNFα and CRP levels were increased significantly in all phases but not in the luteal phase. Conclusion: Timing of surgery in pre menopausal patients seems effective on systemic inflammatory responses to trauma. Performing the operation based on the timing of the menstrual cycle will minimize the risk of operative trauma among premenopausal patients. This may be beneficial for their wellbeing.
Annals of Surgical Treatment and Research, 2016
The aim of this study was to define the clinical and laboratory characteristics of patients opera... more The aim of this study was to define the clinical and laboratory characteristics of patients operated on for primary hyperpatathyroidism (PHPT) at university hospitals in Türkiye, and to investigate the differences in the clinical presenta tions of the disease between different geographical regions. Methods: Patients operated on for PHPT in the university hospitals of Türkiye were included in the study. The demographic, clinical, and laboratory findings and the operational data of the patients were investigated according to the whole country and to different geographical regions. Comparisons were performed according to whole country and regions. Results: A total of 1,162 cases were included in the study from different regions and 20 university hospitals. The mean age of patients was 52.4 ± 0.38 (mean ± standard error) in the general population of Türkiye. The rates of hypertension, urolithiasis, bone disease and 25hydroxyvitamin D insufficiency were 35%, 18.6%, 67.6%, and 63%, respectively. The median parathormone (PTH), serum total calcium (Ca +2) and phosphorus value were 220 pg/mL (range, 70-2,500 pg/mL), 11.2 mg/dL (range, 9.5-11.2 mg/dL), and 2.4 mg/dL (range, 1-4.7 mg/dL), respectively. The median size of the adenomas resected was 16 mm (range, 4-70 mm). Significant differences were observed in the clinical and laboratory findings of the patients operated on due to PHPT between different geographical regions of Türkiye (P < 0.05). Conclusion: The clinical and laboratory characteristics of the patients with PHPT in different geographical regions of Türkiye differ. Furthermore, the general findings of the cases in Türkiye give us a hint that the severity of the disease here is somewhere between Eastern and Western countries.
Turkiye Klinikleri Genel Cerrahi Ozel Dergisi, 2013
Clinical Nutrition, 2002
FBackground and aims: Changes of lipoprotein pattern in plasma occur in many acute infections.The... more FBackground and aims: Changes of lipoprotein pattern in plasma occur in many acute infections.The aim of this study was to analyse the role of total cholesterol and HDL cholesterol in postsurgical patients with nosocomial infection. Methods: Four hundred and eighteen patients admitted to our department and operated on for various diseases are included in this prospective study.Various conventional risk factors for nosocomial infections were recorded. Biochemical parameters with plasma total cholesterol and HDL-cholesterol (HDL-C) levels were measured. Results: In our study, the most frequent infection was surgical site infection.There was an increased association between low HDL-C level and nosocomial infections such as surgical site and pulmonary infections. HDL levels may be used as predictive parameter for surgical nosocomial infections. Conclusions: HDL-C levels seem to be one of the risk factors for postoperative nosocomial infection. Although total cholesterol level was not signi¢cantly increased, it may be also associated with the infection risk. Screening of lipoprotein pattern in patients undergoing operation may be useful for ascertaining of risk for nosocomial infection.
Canadian Journal of Physiology and Pharmacology, 2004
Possible mechanisms for nicotine-induced relaxation were investigated in the isolated sheep's... more Possible mechanisms for nicotine-induced relaxation were investigated in the isolated sheep's sphincter of Oddi. Sheep's sphincter of Oddi rings were mounted in tissue bath with modified Krebs-Henseleit solution and aerated with 95% oxygen and 5% carbon dioxide. Tension was measured with isometric force transducers, and muscle relaxation was expressed as percent decrease of precontraction induced by carbachol. Nicotine (1 × 105 to 3 × 103 mol/L) produced concentration-dependent relaxation on sphincter of Oddi precontracted by carbachol (106 mol/L). Nicotine-induced relaxation was 72.8 ± 4.2% of precontraction with carbachol (106 mol/L) (mean pD2 value, 3.76 ± 0.05 mol/L). Nicotine-induced relaxation was not affected by N(w)-nitro L-arginine methyl ester (L-NAME) (3 × 105 mol/L), methylene blue (105 mol/L), indomethacin (105 mol/L), hexamethonium (105 mol/L), glibenclamide (105 mol/L), 4-aminopyridine (103 mol/L), tetraethylammonium (3 × 104 mol/L), clotrimazole (1...
DergiPark (Istanbul University), Nov 30, 1996
DergiPark (Istanbul University), Nov 30, 1996
Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the ... more Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. It accounts for approximately 1–2% of thyroid cancers. The production of calcitonin is a characteristic feature of this tumor. Most of the MTCs are sporadic whereas 25% of cases are familial as part of the multiple endocrine neoplasia type 2 (MEN2) syndrome. For sporadic MTCs, there are no germline RET mutations. The most common presentation of sporadic MTC is a solitary thyroid nodule. Systemic symptoms may occur due to hormonal secretion by the tumor. Most sporadic MTCs also secrete carcinoembryonic antigen (CEA). The diagnosis of sporadic MTC is usually made after fine needle aspiration (FNAB) biopsy in a patient who has a solitary thyroid nodule. Patients with sporadic MTC can be cured only by complete resection of the thyroid tumor with bilateral central neck lymph node dissection. For patients with the residual or recurrent disease after primary surgery or for those with distant metastases, the most appropriate treatment is less clear and still debatable.
PubMed, May 3, 2000
Backgrounds/aims: Depression of non-specific immunity is one of the systemic complications of bil... more Backgrounds/aims: Depression of non-specific immunity is one of the systemic complications of biliary obstruction. Vitamin E, which decreases during prolonged obstructive jaundice, may be beneficial to diseased function of neutrophils. In this study we want to investigate changes in neutrophil phagocytosis and the effect that vitamin E supplementation has on this function Methodology: Rats were divided into 5 groups as follows: the control group and 4 other groups that underwent double ligation and division of the common bile duct. Two of these 4 groups (Group 3 and 5) received vitamin E during the experiment. Alkaline phosphatase, aspartate aminotransferase, bilirubin serum levels, white blood cell count and neutrophil phagocytosis index were determined for group 2 and 3 at the end of the 15 days and for group 1, 4 and 5 at the end of the 21 days. Results: There was a significant increase in white blood cell counts and biochemical parameters in group 2, 3, 4, and 5 (P < 0.05). Neutrophil phagocytosis index significantly increased 15 days after bile duct ligation (P < 0.001) (Group 2) and significantly decreased 21 days after bile duct ligation (P < 0.001) (Group 4). Neutrophil phagocytosis index in vitamin E pretreated groups were significantly decreased at the end of the 15 days (P < 0.001) (Group 3) and increased at the end of the 21 days (P < 0.001) (Group 5). Conclusions: Finally, If vitamin E is administered for further days and weeks of prolonged jaundiced, neutrophil phagocytosis index improves.
DergiPark (Istanbul University), Apr 30, 1997
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2021
PubMed, Sep 1, 1998
We investigated the effect of 16,16-dimethyl prostaglandin E2 indomethacin and Ginkgo biloba extr... more We investigated the effect of 16,16-dimethyl prostaglandin E2 indomethacin and Ginkgo biloba extract on the survival in two experimental sepsis models in rats due to administration of 1 x 10(7) cfu and 1 x 10(9) cfu Escherichia coli. Animals in each model were then randomly divided (10/group) into four groups, administered saline, indomethacin, G. biloba extract and prostaglandin E2 respectively. When compared, there was no significant difference in the survival period between the two sepsis models (P > 0.05). The best survival rate was observed in the PGE2-administered animals in the first major model (P < 0.05). Indomethacin appeared not to decrease the mortality rates. There was no significant difference in PGE2 levels between two sepsis models (P > 0.05). Our results suggest that elevated prostaglandin E2 levels following major trauma are not responsible for the postinjury increased susceptibility to infectious complications. Our observations should also discourage aggressive use of cyclo-oxygenase inhibitors for protection against infectious complications after major trauma.
Turkish journal of trauma & emergency surgery, 1998
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Papers by NUH Z A F E R CANTURK