Abstract: Aquasomes are the nanobiopharmaceutical carrier system contains the particle core compo... more Abstract: Aquasomes are the nanobiopharmaceutical carrier system contains the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film. Aquasomes are spherical 60300 nm particles used for ...
The buccal mucoadhesive tablets of nifedipine were fabricated with objective of avoiding first pa... more The buccal mucoadhesive tablets of nifedipine were fabricated with objective of avoiding first pass metabolism and prolonging duration of action. The mucoadhesive polymers used in formulations were carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), carboxy methyl cellulose (CMC), and tamarind seed polysaccharide (TSP) .These formulations were characterized for physiochemical parameters, in vitro retention time, in vitro bioadhesive strength, percent hydration and drug release. The modified in vitro assembly was used to measure the bioadhesive strength of tablets with fresh goat buccal mucosa as a model tissue. The best mucoadhesive performance and in vitro drug release profile were exhibited by the tablet containg carbopol and TSP in the ratio of 1:1. This formulation was more comfortable to the user due to less erosion, faster hydration rate, and optimum pH of surrounding medium.
Abstract: Aquasomes are the nanobiopharmaceutical carrier system contains the particle core compo... more Abstract: Aquasomes are the nanobiopharmaceutical carrier system contains the particle core composed of nanocrystalline calcium phosphate or ceramic diamond, and is covered by a polyhydroxyl oligomeric film. Aquasomes are spherical 60300 nm particles used for ...
The buccal mucoadhesive tablets of nifedipine were fabricated with objective of avoiding first pa... more The buccal mucoadhesive tablets of nifedipine were fabricated with objective of avoiding first pass metabolism and prolonging duration of action. The mucoadhesive polymers used in formulations were carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), carboxy methyl cellulose (CMC), and tamarind seed polysaccharide (TSP) .These formulations were characterized for physiochemical parameters, in vitro retention time, in vitro bioadhesive strength, percent hydration and drug release. The modified in vitro assembly was used to measure the bioadhesive strength of tablets with fresh goat buccal mucosa as a model tissue. The best mucoadhesive performance and in vitro drug release profile were exhibited by the tablet containg carbopol and TSP in the ratio of 1:1. This formulation was more comfortable to the user due to less erosion, faster hydration rate, and optimum pH of surrounding medium.
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