A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors ... more A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to a-CA, b-CA, and c-CA classes (VchCAa, VchCAb, and VchCAc). The determined K i values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship analysis highlighted that all tested compounds proved to be active inhibitors of VchCAa at nanomolar concentration. The VchCAb activity was lower to respect inhibitory efficacy toward VchCAa, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAc. Interestingly, compound 7e combined the best activity toward VchCAa and VchCAb. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAb.
Australian Journal of Maritime & Ocean Affairs, 2018
In the recent period, India has emerged as one of the key political and economic players at the g... more In the recent period, India has emerged as one of the key political and economic players at the global level. In order to make its mark as a major maritime power, it has adopted an ambitious plan of naval modernization. India is an aspirant for maritime power, which is backed by its strategic location in the Indian Ocean. This brings to the fore the question how successive governments in India have sought to promote the country’s interests. A section of the Indian elites see strong correlation between their country’s maritime ambitions and its search for great power status. As such, maritime concerns are viewed seriously by the ruling elite. In the recent years, India under the UPA rule played an assertive role in the Indian Ocean region in order to protect its interests and strategic preponderance. India’s Indian Ocean strategy has, among other things, focused on countering the growing Chinese influence among the Indian Ocean littoral countries. Nevertheless, it was seen that the U...
Being a maritime nation with considerable economic and military power, India has shown keen inter... more Being a maritime nation with considerable economic and military power, India has shown keen interest in demonstrating its role as a major security provider in the IOR. In the Southwest Indian Ocean too, India has sought to develop a security presence and strengthen its position by capitalising on its historic ties with the littoral nations of the region through provision of military training, defence equipment and security advisors. India’s efforts are mostly directed at making the Indian influence more visible in the strategic affairs of the region that seem to be clouded by the increasing Chinese forays into the region. The paper evaluates the strategic relationships through the maritime dimensions of India’s engagement with these littoral nations. The intensity of India’s efforts to be seen as an important maritime security providing power of the region and the response of these littoral states to India’s call for greater cooperation forms an important thrust of the paper. The article argues that India’s national security concerns and great power ambitions manifest itself in India’s engagement in the region. However, greater exploitation of its strategic ties with Mauritius and Seychelles hold the key for greater maritime strategic influence in the region.
Australian Journal of Maritime & Ocean Affairs, 2018
In the recent period, India has emerged as one of the key political
and economic players at the g... more In the recent period, India has emerged as one of the key political and economic players at the global level. In order to make its mark as a major maritime power, it has adopted an ambitious plan of naval modernisation. This brings to the fore the question how successive governments in India have sought to promote the country’s interests. In the recent years, India under the UPA rule played an assertive role in the Indian Ocean region in order to protect its interests and strategic preponderance. India’s Indian Ocean strategy has, among other things, focused on countering the growing Chinese influence among the Indian Ocean littoral countries. Nevertheless, it was seen that the UPA government did not show enough dynamism to formulate a strong Indian Ocean policy. The new government under Prime Minister Modi is seen to pursue an active Indian Ocean policy in pursuit of maritime power and influence. Thus, the paper seeks to study the evolution and variations in the strategies adopted by the UPA and NDA rule towards the Indian Ocean. Among other things, the paper also tries to explore how China figures in India’s strategic ambitions in the sea.
A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors ... more A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to a-CA, b-CA, and c-CA classes (VchCAa, VchCAb, and VchCAc). The determined K i values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship analysis highlighted that all tested compounds proved to be active inhibitors of VchCAa at nanomolar concentration. The VchCAb activity was lower to respect inhibitory efficacy toward VchCAa, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAc. Interestingly, compound 7e combined the best activity toward VchCAa and VchCAb. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAb.
Australian Journal of Maritime & Ocean Affairs, 2018
In the recent period, India has emerged as one of the key political and economic players at the g... more In the recent period, India has emerged as one of the key political and economic players at the global level. In order to make its mark as a major maritime power, it has adopted an ambitious plan of naval modernization. India is an aspirant for maritime power, which is backed by its strategic location in the Indian Ocean. This brings to the fore the question how successive governments in India have sought to promote the country’s interests. A section of the Indian elites see strong correlation between their country’s maritime ambitions and its search for great power status. As such, maritime concerns are viewed seriously by the ruling elite. In the recent years, India under the UPA rule played an assertive role in the Indian Ocean region in order to protect its interests and strategic preponderance. India’s Indian Ocean strategy has, among other things, focused on countering the growing Chinese influence among the Indian Ocean littoral countries. Nevertheless, it was seen that the U...
Being a maritime nation with considerable economic and military power, India has shown keen inter... more Being a maritime nation with considerable economic and military power, India has shown keen interest in demonstrating its role as a major security provider in the IOR. In the Southwest Indian Ocean too, India has sought to develop a security presence and strengthen its position by capitalising on its historic ties with the littoral nations of the region through provision of military training, defence equipment and security advisors. India’s efforts are mostly directed at making the Indian influence more visible in the strategic affairs of the region that seem to be clouded by the increasing Chinese forays into the region. The paper evaluates the strategic relationships through the maritime dimensions of India’s engagement with these littoral nations. The intensity of India’s efforts to be seen as an important maritime security providing power of the region and the response of these littoral states to India’s call for greater cooperation forms an important thrust of the paper. The article argues that India’s national security concerns and great power ambitions manifest itself in India’s engagement in the region. However, greater exploitation of its strategic ties with Mauritius and Seychelles hold the key for greater maritime strategic influence in the region.
Australian Journal of Maritime & Ocean Affairs, 2018
In the recent period, India has emerged as one of the key political
and economic players at the g... more In the recent period, India has emerged as one of the key political and economic players at the global level. In order to make its mark as a major maritime power, it has adopted an ambitious plan of naval modernisation. This brings to the fore the question how successive governments in India have sought to promote the country’s interests. In the recent years, India under the UPA rule played an assertive role in the Indian Ocean region in order to protect its interests and strategic preponderance. India’s Indian Ocean strategy has, among other things, focused on countering the growing Chinese influence among the Indian Ocean littoral countries. Nevertheless, it was seen that the UPA government did not show enough dynamism to formulate a strong Indian Ocean policy. The new government under Prime Minister Modi is seen to pursue an active Indian Ocean policy in pursuit of maritime power and influence. Thus, the paper seeks to study the evolution and variations in the strategies adopted by the UPA and NDA rule towards the Indian Ocean. Among other things, the paper also tries to explore how China figures in India’s strategic ambitions in the sea.
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Papers by CHINMOYEE DAS
article argues that India’s national security concerns and great power ambitions manifest itself in India’s engagement in the region. However, greater exploitation of its strategic ties with Mauritius and Seychelles hold the key for greater maritime strategic influence in the region.
and economic players at the global level. In order to make its
mark as a major maritime power, it has adopted an ambitious
plan of naval modernisation. This brings to the fore the question
how successive governments in India have sought to promote the
country’s interests. In the recent years, India under the UPA rule
played an assertive role in the Indian Ocean region in order to
protect its interests and strategic preponderance. India’s Indian
Ocean strategy has, among other things, focused on countering
the growing Chinese influence among the Indian Ocean littoral
countries. Nevertheless, it was seen that the UPA government did
not show enough dynamism to formulate a strong Indian Ocean
policy. The new government under Prime Minister Modi is seen to
pursue an active Indian Ocean policy in pursuit of maritime power
and influence. Thus, the paper seeks to study the evolution and
variations in the strategies adopted by the UPA and NDA rule
towards the Indian Ocean. Among other things, the paper also
tries to explore how China figures in India’s strategic ambitions in
the sea.
article argues that India’s national security concerns and great power ambitions manifest itself in India’s engagement in the region. However, greater exploitation of its strategic ties with Mauritius and Seychelles hold the key for greater maritime strategic influence in the region.
and economic players at the global level. In order to make its
mark as a major maritime power, it has adopted an ambitious
plan of naval modernisation. This brings to the fore the question
how successive governments in India have sought to promote the
country’s interests. In the recent years, India under the UPA rule
played an assertive role in the Indian Ocean region in order to
protect its interests and strategic preponderance. India’s Indian
Ocean strategy has, among other things, focused on countering
the growing Chinese influence among the Indian Ocean littoral
countries. Nevertheless, it was seen that the UPA government did
not show enough dynamism to formulate a strong Indian Ocean
policy. The new government under Prime Minister Modi is seen to
pursue an active Indian Ocean policy in pursuit of maritime power
and influence. Thus, the paper seeks to study the evolution and
variations in the strategies adopted by the UPA and NDA rule
towards the Indian Ocean. Among other things, the paper also
tries to explore how China figures in India’s strategic ambitions in
the sea.