International Journal of Clinical and Experimental Physiology, Dec 27, 2019
Background and Aim: Cardiovascular disease and diabetes mellitus are major health concerns In Ind... more Background and Aim: Cardiovascular disease and diabetes mellitus are major health concerns In India. Prediabetes shares common pathology with these two diseases. However, the factors contributing to myocardial dysfunction in prediabetes have not been assessed. In this study, we have assessed various cardiometabolic factors contributing to myocardial work stress in in prediabetic subjects. Methods: In the present study, the anthropometric parameters, parameters of insulin resistance, inflammation, oxidative stress, glycated hemoglobin (HbA1c), lipid profile, atherogenic lipid risk factors and Rate-pressure Product (RPP), the marker of myocardial work stress were assessed in early middle-aged prediabetes population (n=33) and compared with healthy non-diabetic controls (n=36). Results: Prediabetes subjects had increased body mass index (P<0.01), waist-hip ratio (P<0.05), lipid risk factors of atherosclerosis [TC/ HDL-C; P<0.05, LDL C/ HDL-C; P<0.05 and atherogenic index (AI) P<0.05], HbA1c (P<0.001), oxidative stress (increased malondialdehyde; P<0.001 and decreased total antioxidant status, P<0.001) and increased high-sensitive C-reactive protein (P<0.01). They had higher Basal Heart Rate (BHR) (P<0.05) and RPP (P<0.05) denoting increased CV risk in comparison to controls. Conclusion: There is myocardial work stress in the form of increased RPP in Indian prediabetic population. The RPP in prediabetes could be linked to increases HbA1c. RPP being a non-invasive risk marker may be studied further to assess its implication as a screening tool for determining CV risks in prediabetes.
International journal of clinical and experimental physiology, 2015
The link of sympathovagal imbalance (SVI) to rate-pressure product (RPP), the marker of myocardia... more The link of sympathovagal imbalance (SVI) to rate-pressure product (RPP), the marker of myocardial stress in prehypertension has not been elucidated. Body mass index (BMI), cardiovascular parameters, spectral analysis of heart rate variability, and RPP were assessed in young normotensives (n = 58) and prehypertensives (n = 58). BMI, heart rate, blood pressure, RPP and low-frequency to high-frequency (LF-HF) ratio were more in prehypertensives compared to normotensives. Pearson correlation revealed a significant association of LF-HF with RPP in prehypertensives, but not in normotensives. Bivariate regression analysis revealed the independent contribution of LF-HF ratio to RPP in prehypertensives. It was concluded that SVI contributed to myocardial work stress in young prehypertensives.
International journal of clinical and experimental physiology, 2015
Preobesity and obesity are among the leading causes of preventable deaths worldwide. Decreased va... more Preobesity and obesity are among the leading causes of preventable deaths worldwide. Decreased vagal activities and high basal heart rate (BHR) observed in obesity have been reported to be associated with the future cardiovascular events. Therefore, in the present study, the difference in BHR and time domain indices (TDI) among preobese and obese subjects has been assessed. Body mass index, BHR, and TDI of heart rate variability were assessed in overweight (n = 50) and obese (n = 50) group subjects. BHR and TDI, which primarily reflect the parasympathetic cardiac modulation, were not found to be significantly different between the preobese and obese subjects. To conclude, high BHR and decreased TDI observed in the studied population suggest that there was no difference in vagal activities between the preobese and obese subjects.
International journal of clinical and experimental physiology, 2015
Background and Aim: Obesity is one among the prominent public health threats globally. Altered bo... more Background and Aim: Obesity is one among the prominent public health threats globally. Altered body composition and increased basal metabolism (BM) have been reported in obesity. However, the association of body composition and metabolic indices with cardiovascular (CV) risk in obese Indian population has not been studied. Therefore, the purpose of the present study was to determine the independent contribution of body composition and BM indices to CV risk in apparently healthy obese subjects. Methods: Basal CV and body composition parameters were recorded in 100 subjects divided into controls (n = 48) and obese (n = 52) groups. Association and independent contribution of body mass index (BMI), BM to body fat (BM/BF) ratio and BF mass index (BFMI) with rate pressure product (RPP), an established CV risk was performed by Pearson's correlation and multiple regression analysis, respectively. Results: Basal CV parameters were significantly increased in obese group compared to controls. Body composition parameters were also found to be significantly altered in obese group compared to controls. BMI, BM/BF, and BFMI had an independent contribution to RPP in the obese group, whereas no such association was observed in controls. Among these parameters, RPP had maximum association with BFMI (β =0.411, P ≤ 0.001) and BM/BF (β =0.373, P = 0.005) in obese group. Conclusion: Findings of the present study demonstrates increased RPP in obese subjects, predisposing them to future cardiac related morbidities. BFMI and BM/BF ratio appears to be better markers of CV risk in obese Indian population.
Background & objectives: Although insulin resistance (IR) is a known complication in obesity,... more Background & objectives: Although insulin resistance (IR) is a known complication in obesity, the physiological mechanisms linking IR with cardiometabolic risks in obesity have not been well studied. This study was conducted to assess the difference in cardiovascular (CV) risk profile in IR and non-IR (NIR) conditions, and contribution of IR to cardiometabolic risks in pre-obese and obese individuals. Methods: Basal CV, blood pressure variability, autonomic function test and cardiometabolic parameters were recorded in pre-obese (n=86) and obese (n=77) individuals during 2012 and 2015. The association of altered cardiometabolic parameters with homeostatic model for IR (HOMA-IR) in pre-obese and obese groups and with baroreceptor sensitivity (BRS) in IR and NIR groups was calculated by appropriate statistical analysis. Results: Decreased BRS, a known CV risk and cardiometabolic parameters were significant in IR (pre-obese and obese) group compared to the NIR group. Sympathovagal imbalance in the form of increased sympathetic and decreased parasympathetic activities was observed in individuals with IR. There was no significant difference in the level of independent contribution of HOMA-IR to cardiometabolic parameters in pre-obese and obese groups. Adiponectin and inflammatory markers had an independent contribution to BRS in IR group. Interpretation & conclusions: Findings of the present study demonstrated that the intensity of cardiometabolic derangements and CV risk were comparable between IR, pre-obese and obese individuals. Pro-inflammatory state, dyslipidaemia and hypoadiponectinaemia might contribute to CV risk in these individuals with IR. IR could possibly be the link between altered metabolic profile and increased CV risks in these individuals independent of the adiposity status.
Gestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. ... more Gestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. Though yoga is known to be beneficial in pregnancy, the effects of yoga rendered for twenty weeks starting from 16th week of gestation in pregnant women having risk of GH on the incidence of hypertension, cardiometabolic risks and fetomaternal outcomes have not been studied. A randomized control trial was conducted on 234 pregnant women having risk of GH receiving standard antenatal care (Control group, n = 113), and receiving standard care + yoga (Study group, n = 121). Interventions were given for twenty weeks starting at 16th week of gestation. Baroreflex sensitivity (BRS), heart rate variability (HRV), insulin resistance, lipid-risk factors, and markers of inflammation, oxidative stress and vascular endothelial dysfunction (VED) were assessed before and after intervention. Incidence of new-onset hypertension, level of cardiometabolic risks at 36th week, and fetomaternal-neonatal outc...
International Journal of Clinical and Experimental Physiology, 2021
Background and Aim: Though the effects of yoga on fetomaternal outcomes in GDM have been assessed... more Background and Aim: Though the effects of yoga on fetomaternal outcomes in GDM have been assessed earlier, a complete cardiometabolic profile and fetomaternal outcomes have not been studied yet. Also, there is no report of practice of a short course yoga therapy administered prior to parturition in GDM patients. Therefore, in the present study, effects of a structured short-course yoga module on cardiometabolic risks, fetomaternal outcomes and psychophysical health in GDM were assessed. Methods: A total of 21 pregnant women diagnosed to have GDM, admitted to Obstetrics Ward of tertiary care hospital prior to their delivery were recruited for the study. Anthropometric indices such as height, weight and BMI were calculated. Cardiometabolic risk (CMR) parameters such as heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded, and rate pressure product (RPP) was calculated. The psychophysical health was assessed by using two questionnaires such as Perceived Stress Scale (PSS) scoring and Quality of Life (QoL) scoring. The participants were provided yoga therapy consisting of basic asanas and slow pranayamas daily and the schedule continued till their delivery. Yoga therapy was administered for a minimum of seven days and maximum of ten days. All the parameters before and after yoga were compared. Correlation of RPP, the marker of myocardial work stress was done with various parameters to assess the association of stress and metabolic status with the cardiovascular (CV) risk. Results: There was a significant decrease (P=0.000) in BHR, SBP, DBP, RPP after yoga intervention when compared to the pre-yoga assessment. There was also a significant decrease (P=0.001) in blood glucose after yoga intervention. The comparison of PSS and QoL before and after yoga intervention revealed a significant reduction in stress level (P=0.000) and improvement in QoL (P=0.000) after yoga intervention. RPP was significantly correlated with PSS. Conclusion: Practice of yoga for about one week consisting of basic asanas and slow pranayama significantly decreases blood glucose and stress levels and improves fetomaternal outcomes in GDM patients. The myocardial work stress in GDM patients could be linked to the psychological stress in them.
International Journal of Clinical and Experimental Physiology, 2020
Background and Aim: The present study was conducted to assess the role of dopamine in amygdala in... more Background and Aim: The present study was conducted to assess the role of dopamine in amygdala in the body weight, blood glucose, lipid profile and lipid risk factors in albino Wistar rats. Methods: A total of 16 albino Wistar rats were taken for the study and were divided into medial amygdalar group and control group with 8 rats in each group. Stereotaxic cannulation was performed and dopamine was injected into the medial amygdalar nuclei. Blood sample was obtained for estimation of metabolic parameters (blood glucose and lipid parameters) before and after dopamine injection, by computerized metabometer and autoanalyzer. Results: Following dopamine injection, there was decrease in body weight, blood glucose, lipid profile and lipid risk factors in medial amygdala group compared to control group. There was positive correlation of body weight with blood glucose, triglyceride, very low-density lipoprotein and atherogenic index. Conclusion: Decrease in body weight, blood glucose, lipid...
International Journal of Clinical and Experimental Physiology, 2021
Background and Aim: Hypertension is often prevalent among diabetes patients. However, the risk fa... more Background and Aim: Hypertension is often prevalent among diabetes patients. However, the risk factors of hypertension are mostly affected by age, gender, and ethnicity, which are non-modifiable. Therefore, in the present study, we have analyzed the prevalence of hypertension and various risk factors associated with it among women with diabetes mellitus from Tamilian community. Methods: We conducted a cross-sectional survey of type 2 diabetes mellitus patients in our Institute hospital. We recruited female patients with Tamil origin of three generations. The case history and personal history and basal demographic parameters were noted down. Five ml of fasting blood was collected for routine analysis. Plasma was stored for estimation of osteoprotegerin (OPG) and insulin. Results: Hypertension was associated with family history of cardiovascular disease (CVD), abdominal obesity, dyslipidemia and higher rate pressure product. Conclusion: Diabetes women of Tamil community and with family history of CVD may benefit from weight loss, lifestyle modification and monitoring of blood pressure in early part of life.
International Journal of Clinical and Experimental Physiology, 2021
Background and Aim: Increase prevalence of cardiovascular morbidity and mortality has been report... more Background and Aim: Increase prevalence of cardiovascular morbidity and mortality has been reported in people living with epilepsy (PWE) compared to the general population. This study was done to assess the cardiovascular risk of PWE using Heart rate variability (HRV) and Blood Pressure variability (BPV) techniques. Methods: Twenty-seven patients with epilepsy and thirty age and gender-matched healthy individuals were included in the study and control group, respectively. Basal cardiovascular parameters (heart rate-HR, systolic blood pressure-SBP, diastolic blood pressure-DBP), HRV indices, and BPV parameters were recorded and compared between the study and control group individuals. In addition, the association of the Total Power (TP) of HRV with other study parameters was assessed by Pearson correlation coefficient test. Results: Cardiovascular parameters such as HR, SBP, DBP, rate pressure product, cardiac output and total peripheral resistance were significantly high in PWE compared to healthy individuals. Baroreflex sensitivity (BRS) and HRV parameters indicative of cardiac parasympathetic drive (TP, SDNN, RMSSD, and pNN50) were significantly low in these individuals. While a significant negative correlation was observed between TP, BHR and DBP, a significant positive correlation was observed between TP and BRS. Conclusion: Cardiac sympathovagal imbalance characterized by increased sympathetic and decreased parasympathetic activity was evident in PWE. These changes in the autonomic nervous system could predispose them to increased risk of cardiovascular morbidity.
Alternative therapies in health and medicine, 2021
Context Diabetic neuropathy, a common debilitating complication of type 2 diabetes, can occur des... more Context Diabetic neuropathy, a common debilitating complication of type 2 diabetes, can occur despite adequate treatment. To date, no studies have occurred on the use alternative medicine as an adjunct therapy for treating diabetic neuropathy. Objective The study assessed the effects of three months of honey supplementation on insulin resistance, lipid profiles, oxidant status, nerve conduction, and QOL in patients with diabetic neuropathy. Methods/Design The research team designed a single-arm, open-label pilot study. Setting The study took place at the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) in Puducherry, India. Participants The study included 48 patients with diabetic neuropathy at the institute, with a mean age of 58.91 ± 7.976 years. Intervention Participants took honey for three months at a dose of 0.5 gm/Kg of body weight per day. Outcome Measures Participants completed the Neuropathy Total Symptom Score-6 (NTSS-6) questionnaire and the N...
International Journal of Clinical and Experimental Physiology, Dec 27, 2019
Background and Aim: Cardiovascular disease and diabetes mellitus are major health concerns In Ind... more Background and Aim: Cardiovascular disease and diabetes mellitus are major health concerns In India. Prediabetes shares common pathology with these two diseases. However, the factors contributing to myocardial dysfunction in prediabetes have not been assessed. In this study, we have assessed various cardiometabolic factors contributing to myocardial work stress in in prediabetic subjects. Methods: In the present study, the anthropometric parameters, parameters of insulin resistance, inflammation, oxidative stress, glycated hemoglobin (HbA1c), lipid profile, atherogenic lipid risk factors and Rate-pressure Product (RPP), the marker of myocardial work stress were assessed in early middle-aged prediabetes population (n=33) and compared with healthy non-diabetic controls (n=36). Results: Prediabetes subjects had increased body mass index (P<0.01), waist-hip ratio (P<0.05), lipid risk factors of atherosclerosis [TC/ HDL-C; P<0.05, LDL C/ HDL-C; P<0.05 and atherogenic index (AI) P<0.05], HbA1c (P<0.001), oxidative stress (increased malondialdehyde; P<0.001 and decreased total antioxidant status, P<0.001) and increased high-sensitive C-reactive protein (P<0.01). They had higher Basal Heart Rate (BHR) (P<0.05) and RPP (P<0.05) denoting increased CV risk in comparison to controls. Conclusion: There is myocardial work stress in the form of increased RPP in Indian prediabetic population. The RPP in prediabetes could be linked to increases HbA1c. RPP being a non-invasive risk marker may be studied further to assess its implication as a screening tool for determining CV risks in prediabetes.
International journal of clinical and experimental physiology, 2015
The link of sympathovagal imbalance (SVI) to rate-pressure product (RPP), the marker of myocardia... more The link of sympathovagal imbalance (SVI) to rate-pressure product (RPP), the marker of myocardial stress in prehypertension has not been elucidated. Body mass index (BMI), cardiovascular parameters, spectral analysis of heart rate variability, and RPP were assessed in young normotensives (n = 58) and prehypertensives (n = 58). BMI, heart rate, blood pressure, RPP and low-frequency to high-frequency (LF-HF) ratio were more in prehypertensives compared to normotensives. Pearson correlation revealed a significant association of LF-HF with RPP in prehypertensives, but not in normotensives. Bivariate regression analysis revealed the independent contribution of LF-HF ratio to RPP in prehypertensives. It was concluded that SVI contributed to myocardial work stress in young prehypertensives.
International journal of clinical and experimental physiology, 2015
Preobesity and obesity are among the leading causes of preventable deaths worldwide. Decreased va... more Preobesity and obesity are among the leading causes of preventable deaths worldwide. Decreased vagal activities and high basal heart rate (BHR) observed in obesity have been reported to be associated with the future cardiovascular events. Therefore, in the present study, the difference in BHR and time domain indices (TDI) among preobese and obese subjects has been assessed. Body mass index, BHR, and TDI of heart rate variability were assessed in overweight (n = 50) and obese (n = 50) group subjects. BHR and TDI, which primarily reflect the parasympathetic cardiac modulation, were not found to be significantly different between the preobese and obese subjects. To conclude, high BHR and decreased TDI observed in the studied population suggest that there was no difference in vagal activities between the preobese and obese subjects.
International journal of clinical and experimental physiology, 2015
Background and Aim: Obesity is one among the prominent public health threats globally. Altered bo... more Background and Aim: Obesity is one among the prominent public health threats globally. Altered body composition and increased basal metabolism (BM) have been reported in obesity. However, the association of body composition and metabolic indices with cardiovascular (CV) risk in obese Indian population has not been studied. Therefore, the purpose of the present study was to determine the independent contribution of body composition and BM indices to CV risk in apparently healthy obese subjects. Methods: Basal CV and body composition parameters were recorded in 100 subjects divided into controls (n = 48) and obese (n = 52) groups. Association and independent contribution of body mass index (BMI), BM to body fat (BM/BF) ratio and BF mass index (BFMI) with rate pressure product (RPP), an established CV risk was performed by Pearson's correlation and multiple regression analysis, respectively. Results: Basal CV parameters were significantly increased in obese group compared to controls. Body composition parameters were also found to be significantly altered in obese group compared to controls. BMI, BM/BF, and BFMI had an independent contribution to RPP in the obese group, whereas no such association was observed in controls. Among these parameters, RPP had maximum association with BFMI (β =0.411, P ≤ 0.001) and BM/BF (β =0.373, P = 0.005) in obese group. Conclusion: Findings of the present study demonstrates increased RPP in obese subjects, predisposing them to future cardiac related morbidities. BFMI and BM/BF ratio appears to be better markers of CV risk in obese Indian population.
Background & objectives: Although insulin resistance (IR) is a known complication in obesity,... more Background & objectives: Although insulin resistance (IR) is a known complication in obesity, the physiological mechanisms linking IR with cardiometabolic risks in obesity have not been well studied. This study was conducted to assess the difference in cardiovascular (CV) risk profile in IR and non-IR (NIR) conditions, and contribution of IR to cardiometabolic risks in pre-obese and obese individuals. Methods: Basal CV, blood pressure variability, autonomic function test and cardiometabolic parameters were recorded in pre-obese (n=86) and obese (n=77) individuals during 2012 and 2015. The association of altered cardiometabolic parameters with homeostatic model for IR (HOMA-IR) in pre-obese and obese groups and with baroreceptor sensitivity (BRS) in IR and NIR groups was calculated by appropriate statistical analysis. Results: Decreased BRS, a known CV risk and cardiometabolic parameters were significant in IR (pre-obese and obese) group compared to the NIR group. Sympathovagal imbalance in the form of increased sympathetic and decreased parasympathetic activities was observed in individuals with IR. There was no significant difference in the level of independent contribution of HOMA-IR to cardiometabolic parameters in pre-obese and obese groups. Adiponectin and inflammatory markers had an independent contribution to BRS in IR group. Interpretation & conclusions: Findings of the present study demonstrated that the intensity of cardiometabolic derangements and CV risk were comparable between IR, pre-obese and obese individuals. Pro-inflammatory state, dyslipidaemia and hypoadiponectinaemia might contribute to CV risk in these individuals with IR. IR could possibly be the link between altered metabolic profile and increased CV risks in these individuals independent of the adiposity status.
Gestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. ... more Gestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. Though yoga is known to be beneficial in pregnancy, the effects of yoga rendered for twenty weeks starting from 16th week of gestation in pregnant women having risk of GH on the incidence of hypertension, cardiometabolic risks and fetomaternal outcomes have not been studied. A randomized control trial was conducted on 234 pregnant women having risk of GH receiving standard antenatal care (Control group, n = 113), and receiving standard care + yoga (Study group, n = 121). Interventions were given for twenty weeks starting at 16th week of gestation. Baroreflex sensitivity (BRS), heart rate variability (HRV), insulin resistance, lipid-risk factors, and markers of inflammation, oxidative stress and vascular endothelial dysfunction (VED) were assessed before and after intervention. Incidence of new-onset hypertension, level of cardiometabolic risks at 36th week, and fetomaternal-neonatal outc...
International Journal of Clinical and Experimental Physiology, 2021
Background and Aim: Though the effects of yoga on fetomaternal outcomes in GDM have been assessed... more Background and Aim: Though the effects of yoga on fetomaternal outcomes in GDM have been assessed earlier, a complete cardiometabolic profile and fetomaternal outcomes have not been studied yet. Also, there is no report of practice of a short course yoga therapy administered prior to parturition in GDM patients. Therefore, in the present study, effects of a structured short-course yoga module on cardiometabolic risks, fetomaternal outcomes and psychophysical health in GDM were assessed. Methods: A total of 21 pregnant women diagnosed to have GDM, admitted to Obstetrics Ward of tertiary care hospital prior to their delivery were recruited for the study. Anthropometric indices such as height, weight and BMI were calculated. Cardiometabolic risk (CMR) parameters such as heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded, and rate pressure product (RPP) was calculated. The psychophysical health was assessed by using two questionnaires such as Perceived Stress Scale (PSS) scoring and Quality of Life (QoL) scoring. The participants were provided yoga therapy consisting of basic asanas and slow pranayamas daily and the schedule continued till their delivery. Yoga therapy was administered for a minimum of seven days and maximum of ten days. All the parameters before and after yoga were compared. Correlation of RPP, the marker of myocardial work stress was done with various parameters to assess the association of stress and metabolic status with the cardiovascular (CV) risk. Results: There was a significant decrease (P=0.000) in BHR, SBP, DBP, RPP after yoga intervention when compared to the pre-yoga assessment. There was also a significant decrease (P=0.001) in blood glucose after yoga intervention. The comparison of PSS and QoL before and after yoga intervention revealed a significant reduction in stress level (P=0.000) and improvement in QoL (P=0.000) after yoga intervention. RPP was significantly correlated with PSS. Conclusion: Practice of yoga for about one week consisting of basic asanas and slow pranayama significantly decreases blood glucose and stress levels and improves fetomaternal outcomes in GDM patients. The myocardial work stress in GDM patients could be linked to the psychological stress in them.
International Journal of Clinical and Experimental Physiology, 2020
Background and Aim: The present study was conducted to assess the role of dopamine in amygdala in... more Background and Aim: The present study was conducted to assess the role of dopamine in amygdala in the body weight, blood glucose, lipid profile and lipid risk factors in albino Wistar rats. Methods: A total of 16 albino Wistar rats were taken for the study and were divided into medial amygdalar group and control group with 8 rats in each group. Stereotaxic cannulation was performed and dopamine was injected into the medial amygdalar nuclei. Blood sample was obtained for estimation of metabolic parameters (blood glucose and lipid parameters) before and after dopamine injection, by computerized metabometer and autoanalyzer. Results: Following dopamine injection, there was decrease in body weight, blood glucose, lipid profile and lipid risk factors in medial amygdala group compared to control group. There was positive correlation of body weight with blood glucose, triglyceride, very low-density lipoprotein and atherogenic index. Conclusion: Decrease in body weight, blood glucose, lipid...
International Journal of Clinical and Experimental Physiology, 2021
Background and Aim: Hypertension is often prevalent among diabetes patients. However, the risk fa... more Background and Aim: Hypertension is often prevalent among diabetes patients. However, the risk factors of hypertension are mostly affected by age, gender, and ethnicity, which are non-modifiable. Therefore, in the present study, we have analyzed the prevalence of hypertension and various risk factors associated with it among women with diabetes mellitus from Tamilian community. Methods: We conducted a cross-sectional survey of type 2 diabetes mellitus patients in our Institute hospital. We recruited female patients with Tamil origin of three generations. The case history and personal history and basal demographic parameters were noted down. Five ml of fasting blood was collected for routine analysis. Plasma was stored for estimation of osteoprotegerin (OPG) and insulin. Results: Hypertension was associated with family history of cardiovascular disease (CVD), abdominal obesity, dyslipidemia and higher rate pressure product. Conclusion: Diabetes women of Tamil community and with family history of CVD may benefit from weight loss, lifestyle modification and monitoring of blood pressure in early part of life.
International Journal of Clinical and Experimental Physiology, 2021
Background and Aim: Increase prevalence of cardiovascular morbidity and mortality has been report... more Background and Aim: Increase prevalence of cardiovascular morbidity and mortality has been reported in people living with epilepsy (PWE) compared to the general population. This study was done to assess the cardiovascular risk of PWE using Heart rate variability (HRV) and Blood Pressure variability (BPV) techniques. Methods: Twenty-seven patients with epilepsy and thirty age and gender-matched healthy individuals were included in the study and control group, respectively. Basal cardiovascular parameters (heart rate-HR, systolic blood pressure-SBP, diastolic blood pressure-DBP), HRV indices, and BPV parameters were recorded and compared between the study and control group individuals. In addition, the association of the Total Power (TP) of HRV with other study parameters was assessed by Pearson correlation coefficient test. Results: Cardiovascular parameters such as HR, SBP, DBP, rate pressure product, cardiac output and total peripheral resistance were significantly high in PWE compared to healthy individuals. Baroreflex sensitivity (BRS) and HRV parameters indicative of cardiac parasympathetic drive (TP, SDNN, RMSSD, and pNN50) were significantly low in these individuals. While a significant negative correlation was observed between TP, BHR and DBP, a significant positive correlation was observed between TP and BRS. Conclusion: Cardiac sympathovagal imbalance characterized by increased sympathetic and decreased parasympathetic activity was evident in PWE. These changes in the autonomic nervous system could predispose them to increased risk of cardiovascular morbidity.
Alternative therapies in health and medicine, 2021
Context Diabetic neuropathy, a common debilitating complication of type 2 diabetes, can occur des... more Context Diabetic neuropathy, a common debilitating complication of type 2 diabetes, can occur despite adequate treatment. To date, no studies have occurred on the use alternative medicine as an adjunct therapy for treating diabetic neuropathy. Objective The study assessed the effects of three months of honey supplementation on insulin resistance, lipid profiles, oxidant status, nerve conduction, and QOL in patients with diabetic neuropathy. Methods/Design The research team designed a single-arm, open-label pilot study. Setting The study took place at the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) in Puducherry, India. Participants The study included 48 patients with diabetic neuropathy at the institute, with a mean age of 58.91 ± 7.976 years. Intervention Participants took honey for three months at a dose of 0.5 gm/Kg of body weight per day. Outcome Measures Participants completed the Neuropathy Total Symptom Score-6 (NTSS-6) questionnaire and the N...
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