Index Medicus for South-East Asia Region (IMSEAR) is a compiled and maintained by Information Man... more Index Medicus for South-East Asia Region (IMSEAR) is a compiled and maintained by Information Management and Dissemination Unit, Department of Sustainable Development and Healthy Environments, World Health Organization, Regional Office for South-East Asia.
In this paper, we examine the internal dynamics of a market through the various stages of its evo... more In this paper, we examine the internal dynamics of a market through the various stages of its evolution. Using comprehensive auction data from about 300 art auctions across about 50 auction houses over a 13 year period, we examine the behavior of market participants and its impact on multiple outcomes of interest including the price formation process and the valuation
Most studies of the potential for discovery of superpartners at the Fermilab Tevatron or CERN LHC... more Most studies of the potential for discovery of superpartners at the Fermilab Tevatron or CERN LHC have focused on the so-called mSUGRA (minimal supergravity mediated supersymmetry breaking) model, not because it is well motivated but because it has a minimal number of parameters. If signals are seen that could be superpartners, most analyses will attempt to interpret them in the mSUGRA framework since the needed software and computational tools exist. With only a few signal channels, and initially large statistical and systematic errors, it is very likely that an mSUGRA interpretation will look all right even if it is not. We present an approach to studying any potential signals of new physics in "inclusive signature space" that sensitively tests any proposed interpretation, and apply it to the mSUGRA case. The approach also has significant experimental advantages, reducing the sensitivity to jet energy corrections, dependence on beam luminosity, and other systematics. Basically, if one (or more) instances of reported data lies outside certain bounded regions of inclusive signature space characteristic of the physics being tested, that physics is excluded for any parameters. The approach can be used to study supersymmetry breaking and to point to the form of the underlying theory even without detailed measurements of a number of important parameters which will be difficult or impossible to measure at hadron colliders. ‡
We demonstrate that in effective theories arising from N = 1 fluxless compactifications of Mtheor... more We demonstrate that in effective theories arising from N = 1 fluxless compactifications of Mtheory on a G2 manifold with low energy supersymmetry, CP-violating phases do not appear in the soft-breaking Lagrangian except via the Yukawas. Such a mechanism may be present in other string compactifications as well; we describe properties sufficient for this to occur. CP violation is generated via the Yukawas since the soft trilinear matrices are generically not proportional to the Yukawa matrices. Within the framework considered, the estimated theoretical upper bounds for electric dipole moments (EDM) of the electron, neutron and mercury are all within the current experimental limits and could be probed in the near future.
A series of 5-(pyridyl)-2H-tetrazol-2-acetic acids (16-21), esters (10-15), and amides (22-27) wa... more A series of 5-(pyridyl)-2H-tetrazol-2-acetic acids (16-21), esters (10-15), and amides (22-27) was synthesized in order to investigate the effect of 5-substituents (R1 = 2-, 3- or 4-pyridyl) and alpha-substituents (R2 = H, Me) on anti-inflammatory activity. The point of attachment of the R1-pyridyl substituent influenced potency. The relative potencies in the acetic acid ester, acetic acid and acetamide classes of compounds were 2- and 4- greater than 3-pyr, 2- and 3- greater than 4-pyr, and 4- greater than 2- and 3-pyr, respectively. In the acetic acid ester and acetamide classes, compounds having a R2 hydrogen substituent were generally more potent than corresponding methyl substituted compounds, whereas, in the acetic acid class the reverse applied. The relative order of anti-inflammatory potency was generally amide greater than ester greater than acid. 2-[5-(4-Pyridyl)-2H-tetrazol-2-yl]acetamide (26) was the most effective antiinflammatory agent in the series, reducing inflammation by 53% at 3 and 5 hr after a 25 mg/kg po dose.
Abstract 2-Amino-5-mercapto-1, 3, 4-thiadiazole was condensed with various 6-substituted 2-phenyl... more Abstract 2-Amino-5-mercapto-1, 3, 4-thiadiazole was condensed with various 6-substituted 2-phenylbenzoxazin-4 (3H)-ones to yield the compounds 1. When these compounds were subjected to mercaptoetherification the title compounds 2–4 were obtained. They were ...
A group of N-substituted-1,4-dihydropyridylacetic acids (13-16), esters (4-12), and amides (17-23... more A group of N-substituted-1,4-dihydropyridylacetic acids (13-16), esters (4-12), and amides (17-23) were synthesized in order to investigate the effect of 4-substituents (R2 = Ph, n-Bu or Me) and alpha-substituents (R3 = H, Me) on antiinflammatory activity. In the acetic ester class of compounds, the relative activities (R2-substituents) were Ph greater than n-Bu greater than Me. The presence of an R3 methyl substituent enhanced activity. Increasing the length of the alkyl ester substituent enhanced activity, since the tri-ester (7) was more active than the bis-ester (6), and the bis-ester (11) was more active than the mono-ester (10). The relative order of antiinflammatory potency was generally ester greater than amide greater than acid. Methyl 2-methyl-2-(-1-[4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihy dropyridyl]) acetate (9) was the most active antiinflammatory agent in the series, reducing inflammation 73.9% at 3 hr after a 100 mg/kg po dose.
Azomycin glucuronate was coupled to a PnAO ligand to create azomycin-based ligands that would for... more Azomycin glucuronate was coupled to a PnAO ligand to create azomycin-based ligands that would form water-soluble 99mTc-azomycin complexes for imaging hypoxic tissue. 1-beta-D-(2-Nitroimidazolyl)glucuronic acid, (see structure in text), was synthesized by coupling 2-nitroimidazole with 1-alpha-bromo-2,3,4-tri-O-acetyl-6-methyl glucuronate, followed by deprotection. Reaction of (see structure in text) with 6-methyl-6-methylamino-HMPnAO (Pn-44) in the presence of BOP reagent in anhydrous dimethyl sulfoxide afforded the PnAO-glucuronides (see structure in text) and (see structure in text). Compound (see structure in text) was isolated in three rotomeric forms. Biological evaluation of (see structure in text) (99mTc-5) indicated selective binding to hypoxic EMT-6 cells, and cytotoxicity to fibroblasts and HeLa, sk24, sk23, and g361 cancer cell lines, at an IC20 <2.5 microgram/ml. In vivo biodistribution of two formulations of (see structure in text) in Balb/c mice with EMT-6 tumor produced diverse results, with one formulation showing no tumor preference, and the other providing a tumor/blood ratio of 2.3 at 4 h post-injection. The latter formulation delineated tumor, large intestine and liver in scintigraphic images.
We develop a general set of methods for computing the oblique electroweak parameters S and T for ... more We develop a general set of methods for computing the oblique electroweak parameters S and T for bottom-up and top-down motivated scenarios in which the Higgs weakly mixes with a superconformal extra sector. In addition to their utility in phenomenological studies, the observables S and T are also of purely theoretical interest as they are defined by correlation functions of broken symmetries. We show that in the limit where the extra sector enjoys an approximate custodial symmetry, the leading contributions to S and T can be recast as calculable data of the theory in the conformal phase. Using this result, we also obtain model-independent bounds on the sign and size of oblique electroweak corrections from unitary superconformal theories.
String/M theory compactifications with low energy supersymmetry tend to predict that dark matter ... more String/M theory compactifications with low energy supersymmetry tend to predict that dark matter has two components: axions and WIMPs \cite{1004.5138,1204.2795}. In accord with this, we show that the tentative 130 GeV gamma-line signal reported in \cite{1204.2797} can be interpreted as arising from the annihilation of 145 GeV mass, Wino-like WIMPs into a Z-boson and a photon. In this context, the signal implies a second component of dark matter which we interpret as being composed of axions - the relative Wino/Axion abundances being approximately equal. Further predictions are implied: signals in both diffuse and monochromatic photons from dwarf spheroidal galaxies; monochromatic photons with energy 145 GeV; for the LHC, the Higgs boson mass has been predicted in this framework \cite{1112.1059}, and the current Higgs limits provide interesting constraints on the mass of the Gluino.
The synthesis of various 2′,3′-dideoxypyrimidine nucleosides, starting from 5-(2,2,2-trifluoroeth... more The synthesis of various 2′,3′-dideoxypyrimidine nucleosides, starting from 5-(2,2,2-trifluoroethoxymethyl) (10) and 5-(bis-2,2,2-trifluoroethoxy)methyl-2′-deoxyuridine (11), is described. These compounds were synthesized for screening against herpes simplex virus type-1 and type-2, and HIV virus.
Index Medicus for South-East Asia Region (IMSEAR) is a compiled and maintained by Information Man... more Index Medicus for South-East Asia Region (IMSEAR) is a compiled and maintained by Information Management and Dissemination Unit, Department of Sustainable Development and Healthy Environments, World Health Organization, Regional Office for South-East Asia.
In this paper, we examine the internal dynamics of a market through the various stages of its evo... more In this paper, we examine the internal dynamics of a market through the various stages of its evolution. Using comprehensive auction data from about 300 art auctions across about 50 auction houses over a 13 year period, we examine the behavior of market participants and its impact on multiple outcomes of interest including the price formation process and the valuation
Most studies of the potential for discovery of superpartners at the Fermilab Tevatron or CERN LHC... more Most studies of the potential for discovery of superpartners at the Fermilab Tevatron or CERN LHC have focused on the so-called mSUGRA (minimal supergravity mediated supersymmetry breaking) model, not because it is well motivated but because it has a minimal number of parameters. If signals are seen that could be superpartners, most analyses will attempt to interpret them in the mSUGRA framework since the needed software and computational tools exist. With only a few signal channels, and initially large statistical and systematic errors, it is very likely that an mSUGRA interpretation will look all right even if it is not. We present an approach to studying any potential signals of new physics in "inclusive signature space" that sensitively tests any proposed interpretation, and apply it to the mSUGRA case. The approach also has significant experimental advantages, reducing the sensitivity to jet energy corrections, dependence on beam luminosity, and other systematics. Basically, if one (or more) instances of reported data lies outside certain bounded regions of inclusive signature space characteristic of the physics being tested, that physics is excluded for any parameters. The approach can be used to study supersymmetry breaking and to point to the form of the underlying theory even without detailed measurements of a number of important parameters which will be difficult or impossible to measure at hadron colliders. ‡
We demonstrate that in effective theories arising from N = 1 fluxless compactifications of Mtheor... more We demonstrate that in effective theories arising from N = 1 fluxless compactifications of Mtheory on a G2 manifold with low energy supersymmetry, CP-violating phases do not appear in the soft-breaking Lagrangian except via the Yukawas. Such a mechanism may be present in other string compactifications as well; we describe properties sufficient for this to occur. CP violation is generated via the Yukawas since the soft trilinear matrices are generically not proportional to the Yukawa matrices. Within the framework considered, the estimated theoretical upper bounds for electric dipole moments (EDM) of the electron, neutron and mercury are all within the current experimental limits and could be probed in the near future.
A series of 5-(pyridyl)-2H-tetrazol-2-acetic acids (16-21), esters (10-15), and amides (22-27) wa... more A series of 5-(pyridyl)-2H-tetrazol-2-acetic acids (16-21), esters (10-15), and amides (22-27) was synthesized in order to investigate the effect of 5-substituents (R1 = 2-, 3- or 4-pyridyl) and alpha-substituents (R2 = H, Me) on anti-inflammatory activity. The point of attachment of the R1-pyridyl substituent influenced potency. The relative potencies in the acetic acid ester, acetic acid and acetamide classes of compounds were 2- and 4- greater than 3-pyr, 2- and 3- greater than 4-pyr, and 4- greater than 2- and 3-pyr, respectively. In the acetic acid ester and acetamide classes, compounds having a R2 hydrogen substituent were generally more potent than corresponding methyl substituted compounds, whereas, in the acetic acid class the reverse applied. The relative order of anti-inflammatory potency was generally amide greater than ester greater than acid. 2-[5-(4-Pyridyl)-2H-tetrazol-2-yl]acetamide (26) was the most effective antiinflammatory agent in the series, reducing inflammation by 53% at 3 and 5 hr after a 25 mg/kg po dose.
Abstract 2-Amino-5-mercapto-1, 3, 4-thiadiazole was condensed with various 6-substituted 2-phenyl... more Abstract 2-Amino-5-mercapto-1, 3, 4-thiadiazole was condensed with various 6-substituted 2-phenylbenzoxazin-4 (3H)-ones to yield the compounds 1. When these compounds were subjected to mercaptoetherification the title compounds 2–4 were obtained. They were ...
A group of N-substituted-1,4-dihydropyridylacetic acids (13-16), esters (4-12), and amides (17-23... more A group of N-substituted-1,4-dihydropyridylacetic acids (13-16), esters (4-12), and amides (17-23) were synthesized in order to investigate the effect of 4-substituents (R2 = Ph, n-Bu or Me) and alpha-substituents (R3 = H, Me) on antiinflammatory activity. In the acetic ester class of compounds, the relative activities (R2-substituents) were Ph greater than n-Bu greater than Me. The presence of an R3 methyl substituent enhanced activity. Increasing the length of the alkyl ester substituent enhanced activity, since the tri-ester (7) was more active than the bis-ester (6), and the bis-ester (11) was more active than the mono-ester (10). The relative order of antiinflammatory potency was generally ester greater than amide greater than acid. Methyl 2-methyl-2-(-1-[4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihy dropyridyl]) acetate (9) was the most active antiinflammatory agent in the series, reducing inflammation 73.9% at 3 hr after a 100 mg/kg po dose.
Azomycin glucuronate was coupled to a PnAO ligand to create azomycin-based ligands that would for... more Azomycin glucuronate was coupled to a PnAO ligand to create azomycin-based ligands that would form water-soluble 99mTc-azomycin complexes for imaging hypoxic tissue. 1-beta-D-(2-Nitroimidazolyl)glucuronic acid, (see structure in text), was synthesized by coupling 2-nitroimidazole with 1-alpha-bromo-2,3,4-tri-O-acetyl-6-methyl glucuronate, followed by deprotection. Reaction of (see structure in text) with 6-methyl-6-methylamino-HMPnAO (Pn-44) in the presence of BOP reagent in anhydrous dimethyl sulfoxide afforded the PnAO-glucuronides (see structure in text) and (see structure in text). Compound (see structure in text) was isolated in three rotomeric forms. Biological evaluation of (see structure in text) (99mTc-5) indicated selective binding to hypoxic EMT-6 cells, and cytotoxicity to fibroblasts and HeLa, sk24, sk23, and g361 cancer cell lines, at an IC20 <2.5 microgram/ml. In vivo biodistribution of two formulations of (see structure in text) in Balb/c mice with EMT-6 tumor produced diverse results, with one formulation showing no tumor preference, and the other providing a tumor/blood ratio of 2.3 at 4 h post-injection. The latter formulation delineated tumor, large intestine and liver in scintigraphic images.
We develop a general set of methods for computing the oblique electroweak parameters S and T for ... more We develop a general set of methods for computing the oblique electroweak parameters S and T for bottom-up and top-down motivated scenarios in which the Higgs weakly mixes with a superconformal extra sector. In addition to their utility in phenomenological studies, the observables S and T are also of purely theoretical interest as they are defined by correlation functions of broken symmetries. We show that in the limit where the extra sector enjoys an approximate custodial symmetry, the leading contributions to S and T can be recast as calculable data of the theory in the conformal phase. Using this result, we also obtain model-independent bounds on the sign and size of oblique electroweak corrections from unitary superconformal theories.
String/M theory compactifications with low energy supersymmetry tend to predict that dark matter ... more String/M theory compactifications with low energy supersymmetry tend to predict that dark matter has two components: axions and WIMPs \cite{1004.5138,1204.2795}. In accord with this, we show that the tentative 130 GeV gamma-line signal reported in \cite{1204.2797} can be interpreted as arising from the annihilation of 145 GeV mass, Wino-like WIMPs into a Z-boson and a photon. In this context, the signal implies a second component of dark matter which we interpret as being composed of axions - the relative Wino/Axion abundances being approximately equal. Further predictions are implied: signals in both diffuse and monochromatic photons from dwarf spheroidal galaxies; monochromatic photons with energy 145 GeV; for the LHC, the Higgs boson mass has been predicted in this framework \cite{1112.1059}, and the current Higgs limits provide interesting constraints on the mass of the Gluino.
The synthesis of various 2′,3′-dideoxypyrimidine nucleosides, starting from 5-(2,2,2-trifluoroeth... more The synthesis of various 2′,3′-dideoxypyrimidine nucleosides, starting from 5-(2,2,2-trifluoroethoxymethyl) (10) and 5-(bis-2,2,2-trifluoroethoxy)methyl-2′-deoxyuridine (11), is described. These compounds were synthesized for screening against herpes simplex virus type-1 and type-2, and HIV virus.
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Papers by Piyush kumar