In this work we have synthesized a series of novel porphyrin derivatives, 1-5, in high yields. Th... more In this work we have synthesized a series of novel porphyrin derivatives, 1-5, in high yields. The metal complexes of two of the newly synthesized porphyrin derivatives, 1a-d and 2a-d, have also been synthesized in high yields and characterized. In the synthesis of the new porphyrins and metallo-porphrins, we employed our reported strategy in which we utilized dimethyl formamide (DMF) as capping agent in the reaction of pyrrole with different hetero-aryl aldehydes. The new porphyrin derivatives are equipped with different 2 aromatic substituents and hetero-cycles at peripheral position. The structures of the new compounds were confirmed by elemental and spectral analyses. The geometry and magnetic properties of the new metalloporphyrins 1a-d and 2a-d have also been studied. Antioxidant and cytotoxic activities of the new compounds were evaluated and structure activity relationships were performed. Porphyrin derivatives 2a and 4 showed exceptional antioxidant activity compared to ascorbic acid as a reference. While the derivatives 2, 3 and 5 exhibited very strong cytotoxic activity against two human cell lines, HePG-2 and MCF-7. Docking for the most promising antioxidant porphyrins, 2a and 4, into the binding active site of antioxidant protein Human Peroxiredoxin (code: 1HD2) has been carried out to detect the degree of recognition antioxidant activity. Molecular docking of the most cytotoxic active porphyrins, 3 and 5, into the biding site of telomerase inhibitor enzyme has been carried out to assess the degree of recognition cytotoxic activity.
Background sustained virological response (SVR) can be achieved in high percentage of HCV patient... more Background sustained virological response (SVR) can be achieved in high percentage of HCV patients with the availability of direct acting antiviral agents DAAs. However, the effect of DAAs on insulin resistance and glycemic control has to be clearly documented in patients with HCV infection and type 2diabtes mellitus. We hypothesize that treatment of HCV with novel direct-acting antiviral medications may have effect on glycemic control and decreased requirement for DM-modulating medications at the time of SVR. Patients and methods: the present study involved 50 patients with Chronic HCV attended to outpatient hepatology clinic of One Day Surgery Hospital for treatment with DAAs. Measurement of HbA1c, FPG, fasting insulin hormone, c-peptide and calculation of HOMA-IR before and 3 months after DDAs therapy is done. Statistical analysis was done for these data. Results : After achievement of SVR; HbA1c decreased from 9.57±1.39 to 7.22 ± 0.7 in diabetic patients, HOMA-IR decreased signi...
Minia Journal of Tourism and Hospitality Research MJTHR, 2019 , 2019
About King Khafre, the history of the king through a wonderful artifact that represents him, belo... more About King Khafre, the history of the king through a wonderful artifact that represents him, belongs to his era, and reminds us of an ancient historical period from the most glorious eras of ancient Egypt. He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynasty. His father was King Khufu, and his son Menkaure, these are kings of the era of the Old Kingdom, This was the era of the pyramid builders, which was considered the most prosperous era of ancient Egypt, during which Egypt enjoyed prosperity and stability, and This became clear in the sculpture creations of the Fourth Dynasty, including the statue of King Khafre, the subject of research, and of course this is considered a fundamental reason for choosing this beautiful artifact, as a subject of research, from the masterpieces of the Egyptian Museum in Cairo. He is the forth king of the Fourth Dynasty, His royal family , The Grand-Father is Snefru, his Father is Cheops (khufu), perhaps his Mother is Henutsen and his wives: Khamernebti I, Meres ankh III (probably, she is the mother of Menkaure, his son and builder the third Pyramid), and perhaps there were two other queens, Predecessor: Djedefre (succeeded the short-lived Djedefre, his elder half-brother from the King father khufu) Successor: Bakare (?)
Journal of Archaeological Research and Studies , 0
He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynast... more He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynasty. His father was King Khufu, and his son Menkaure, these are kings of the era of the Old Kingdom, This was the era of the pyramid builders, which was considered the most prosperous era of ancient Egypt, during which Egypt enjoyed prosperity and stability, and This became clear in the sculpture creations of the Fourth Dynasty, including the statue of King Khafre, the subject of research, and of course this is considered a fundamental reason for choosing this beautiful artifact, as a subject of research, from the masterpieces of the Egyptian Museum in Cairo. Ancient Egyptian art was based on religious beliefs, and even Egyptian civilization in general relied heavily on ancient religious thought that was formulated by the priests in ancient Egyptian myths, and the glorification of the idea of the divine king on earth. Therefore, the idea of the divinity of the king appeared on earth, and that the king is a god who rules Egypt with divine legitimacy. The philosophical perspective of sculpting the statue in general supports the symbolism of the ideal sculpture of the king as an absolute ruler of the country
This investigation was conducted to study the effects of copper on growth and metabolism of Ankis... more This investigation was conducted to study the effects of copper on growth and metabolism of Ankistrodesmus falcatus isolated from sewage water at El-Dare Treatment Plant. The alga was grown in BG-11 medium containing different cu concentrations (0.0, 0.5, 5, 10, 50, 100, 150, 200 and 250µm Cu +2). The test organism was left to grow for 12 days under the various cu levels. The effect of copper on the growth, photosynthetic pigments, protein metabolism (soluble, insoluble), antioxidant compounds (phenolic, Proline) were determined. The cell number and dry weight were increased highly significantly up to 10 µm cu +2), then the cell number and dry weight reduced gradually by increasing the doses of the copper .The concentration of photosynthetically active pigment peaked up to 10 µm cu +2), Then they remained more or less unchanged up to 50 µm cu +2) , after this it was reduced. The content of soluble carbohydrates decreased dramatically up to 10 µm cu +2 , and then it was increased smoothly as the cu concentration increased in culture media. Cu Stress induced a significant changes in the soluble protein up to the level of 10 µm Cu +2 , then a high significant accumulation was obtained which peaked at the highest concentration of Cu +2 (250 µm). The insoluble and total proteins remained more or less unchanged at the all Cu concentration used. Aminoacids content accumulated progressively and irregularly by cu treatment. While proline content decreased by about 65.6% at the level of 10 µm cu +2 concentration. It is on other hand increased by 261.7% at the level of 250 µm cu +2 in relation to control value. Phenolic compounds seemed to be not affected by copper treatment.
Minia Journal of Tourism and Hospitality Research MJTHR , 2019
Naqada III is the last phase of the Naqada culture of ancient Egyptian prehistory, dating approxi... more Naqada III is the last phase of the Naqada culture of ancient Egyptian prehistory, dating approximately from 3200 to 3000 BC. It is the period during which the process of state formation, which had begun to take place in Naqada II, became highly visible, with named kings heading powerful polities. Naqada III is often referred to as Dynasty 0 or the Protodynastic Period to reflect the presence of kings at the head of influential states, although, in fact, the kings involved would not have been a part of a dynasty. They would more probably have been completely unrelated and very possibly in competition with each other. In this period, those kings' names were inscribed in the form of serekhs on a variety of surfaces including pottery and tombs.
Developments in Soil Salinity Assessment and Reclamation, 2012
Geographical distribution of soil salinity, alkalinity, calcicity, soil texture, and organic matt... more Geographical distribution of soil salinity, alkalinity, calcicity, soil texture, and organic matter (grid system-log distance of 2 km) has been evaluated and mapped in the study area (about 770 km 2) using GIS-ILWIS format. It is found that in the soils of Tamia District, ECe ranged between 1.22 and 22.4 dS m −1 and 1.03 and 97.1 dS m −1 in Fayoum District soils within the top layer. Results show 91.5% of Tamia soils and 56.5% of Fayoum District soils present ECe > 4 dS m −1 , indicating that salt-affected soils are distributed throughout the study area. About 94.5% of Tamia soils and 30% of Fayoum soils are calcareous (>10% CaCO 3 eq), due to the nature of parent material from which these soils are evolved. Soil pH of more than 8.00 was found in about 3.25% of Tamia soils and 73% of Fayoum District soils, whereas the soils with pH >8.5 are 3.96% in Tamia and 9.53% in Fayoum District. The organic matter contents seldom exceeded 1% in Tamia soils and did not exceed 1.5% for Fayoum soils. Soil texture in both districts is found as clay, sandy clay, sandy clay loam, sandy loam, and sandy. The maps generated through GIS are useful for decision makers for land use planning, conservation, and uses, as well as interest to researchers and soil science students to use the information for further investigations.
Macro elements availability in soils is an important aspect in context of soil fertility and agri... more Macro elements availability in soils is an important aspect in context of soil fertility and agricultural productivity. This study was performed to determine the levels of some macro elements availability in El-kharga oasis soils, New Valley, Egypt. To achieve this goal, hundred surface soil samples (0-30 cm) were collected from El-Kharga and Barisoasis, New Valley, Egypt. The collected soil samples were subjected for chemical analyses. The obtained results showed that the dominant problems are salinity and low organic matter content, The summarized data showed that 35% of the samples have low available nitrogen and 65% have medium nitrogen which was associated with low organic matter (100% of the samples have less than 1% OM). However 91% of the samples have high available P(˃15mg/kg), where as 5% and 4% of the samples were categorized as low and medium available P. Also, 98% of the samples were high in available potassium and only 2% were medium. The high content of available P a...
Four cases of a locally invasive sarcoma of the chest wall are described in children aged between... more Four cases of a locally invasive sarcoma of the chest wall are described in children aged between 8 and 14 years. Although its morphology resembles a Ewing's sarcoma of bone there are light and electron microscopical features that are distinctive. The sarcoma is thought to represent an entity which has not previously been defined. Its clinical importance lies in the
In this work we have synthesized a series of novel porphyrin derivatives, 1-5, in high yields. Th... more In this work we have synthesized a series of novel porphyrin derivatives, 1-5, in high yields. The metal complexes of two of the newly synthesized porphyrin derivatives, 1a-d and 2a-d, have also been synthesized in high yields and characterized. In the synthesis of the new porphyrins and metallo-porphrins, we employed our reported strategy in which we utilized dimethyl formamide (DMF) as capping agent in the reaction of pyrrole with different hetero-aryl aldehydes. The new porphyrin derivatives are equipped with different 2 aromatic substituents and hetero-cycles at peripheral position. The structures of the new compounds were confirmed by elemental and spectral analyses. The geometry and magnetic properties of the new metalloporphyrins 1a-d and 2a-d have also been studied. Antioxidant and cytotoxic activities of the new compounds were evaluated and structure activity relationships were performed. Porphyrin derivatives 2a and 4 showed exceptional antioxidant activity compared to ascorbic acid as a reference. While the derivatives 2, 3 and 5 exhibited very strong cytotoxic activity against two human cell lines, HePG-2 and MCF-7. Docking for the most promising antioxidant porphyrins, 2a and 4, into the binding active site of antioxidant protein Human Peroxiredoxin (code: 1HD2) has been carried out to detect the degree of recognition antioxidant activity. Molecular docking of the most cytotoxic active porphyrins, 3 and 5, into the biding site of telomerase inhibitor enzyme has been carried out to assess the degree of recognition cytotoxic activity.
Background sustained virological response (SVR) can be achieved in high percentage of HCV patient... more Background sustained virological response (SVR) can be achieved in high percentage of HCV patients with the availability of direct acting antiviral agents DAAs. However, the effect of DAAs on insulin resistance and glycemic control has to be clearly documented in patients with HCV infection and type 2diabtes mellitus. We hypothesize that treatment of HCV with novel direct-acting antiviral medications may have effect on glycemic control and decreased requirement for DM-modulating medications at the time of SVR. Patients and methods: the present study involved 50 patients with Chronic HCV attended to outpatient hepatology clinic of One Day Surgery Hospital for treatment with DAAs. Measurement of HbA1c, FPG, fasting insulin hormone, c-peptide and calculation of HOMA-IR before and 3 months after DDAs therapy is done. Statistical analysis was done for these data. Results : After achievement of SVR; HbA1c decreased from 9.57±1.39 to 7.22 ± 0.7 in diabetic patients, HOMA-IR decreased signi...
Minia Journal of Tourism and Hospitality Research MJTHR, 2019 , 2019
About King Khafre, the history of the king through a wonderful artifact that represents him, belo... more About King Khafre, the history of the king through a wonderful artifact that represents him, belongs to his era, and reminds us of an ancient historical period from the most glorious eras of ancient Egypt. He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynasty. His father was King Khufu, and his son Menkaure, these are kings of the era of the Old Kingdom, This was the era of the pyramid builders, which was considered the most prosperous era of ancient Egypt, during which Egypt enjoyed prosperity and stability, and This became clear in the sculpture creations of the Fourth Dynasty, including the statue of King Khafre, the subject of research, and of course this is considered a fundamental reason for choosing this beautiful artifact, as a subject of research, from the masterpieces of the Egyptian Museum in Cairo. He is the forth king of the Fourth Dynasty, His royal family , The Grand-Father is Snefru, his Father is Cheops (khufu), perhaps his Mother is Henutsen and his wives: Khamernebti I, Meres ankh III (probably, she is the mother of Menkaure, his son and builder the third Pyramid), and perhaps there were two other queens, Predecessor: Djedefre (succeeded the short-lived Djedefre, his elder half-brother from the King father khufu) Successor: Bakare (?)
Journal of Archaeological Research and Studies , 0
He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynast... more He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynasty. His father was King Khufu, and his son Menkaure, these are kings of the era of the Old Kingdom, This was the era of the pyramid builders, which was considered the most prosperous era of ancient Egypt, during which Egypt enjoyed prosperity and stability, and This became clear in the sculpture creations of the Fourth Dynasty, including the statue of King Khafre, the subject of research, and of course this is considered a fundamental reason for choosing this beautiful artifact, as a subject of research, from the masterpieces of the Egyptian Museum in Cairo. Ancient Egyptian art was based on religious beliefs, and even Egyptian civilization in general relied heavily on ancient religious thought that was formulated by the priests in ancient Egyptian myths, and the glorification of the idea of the divine king on earth. Therefore, the idea of the divinity of the king appeared on earth, and that the king is a god who rules Egypt with divine legitimacy. The philosophical perspective of sculpting the statue in general supports the symbolism of the ideal sculpture of the king as an absolute ruler of the country
This investigation was conducted to study the effects of copper on growth and metabolism of Ankis... more This investigation was conducted to study the effects of copper on growth and metabolism of Ankistrodesmus falcatus isolated from sewage water at El-Dare Treatment Plant. The alga was grown in BG-11 medium containing different cu concentrations (0.0, 0.5, 5, 10, 50, 100, 150, 200 and 250µm Cu +2). The test organism was left to grow for 12 days under the various cu levels. The effect of copper on the growth, photosynthetic pigments, protein metabolism (soluble, insoluble), antioxidant compounds (phenolic, Proline) were determined. The cell number and dry weight were increased highly significantly up to 10 µm cu +2), then the cell number and dry weight reduced gradually by increasing the doses of the copper .The concentration of photosynthetically active pigment peaked up to 10 µm cu +2), Then they remained more or less unchanged up to 50 µm cu +2) , after this it was reduced. The content of soluble carbohydrates decreased dramatically up to 10 µm cu +2 , and then it was increased smoothly as the cu concentration increased in culture media. Cu Stress induced a significant changes in the soluble protein up to the level of 10 µm Cu +2 , then a high significant accumulation was obtained which peaked at the highest concentration of Cu +2 (250 µm). The insoluble and total proteins remained more or less unchanged at the all Cu concentration used. Aminoacids content accumulated progressively and irregularly by cu treatment. While proline content decreased by about 65.6% at the level of 10 µm cu +2 concentration. It is on other hand increased by 261.7% at the level of 250 µm cu +2 in relation to control value. Phenolic compounds seemed to be not affected by copper treatment.
Minia Journal of Tourism and Hospitality Research MJTHR , 2019
Naqada III is the last phase of the Naqada culture of ancient Egyptian prehistory, dating approxi... more Naqada III is the last phase of the Naqada culture of ancient Egyptian prehistory, dating approximately from 3200 to 3000 BC. It is the period during which the process of state formation, which had begun to take place in Naqada II, became highly visible, with named kings heading powerful polities. Naqada III is often referred to as Dynasty 0 or the Protodynastic Period to reflect the presence of kings at the head of influential states, although, in fact, the kings involved would not have been a part of a dynasty. They would more probably have been completely unrelated and very possibly in competition with each other. In this period, those kings' names were inscribed in the form of serekhs on a variety of surfaces including pottery and tombs.
Developments in Soil Salinity Assessment and Reclamation, 2012
Geographical distribution of soil salinity, alkalinity, calcicity, soil texture, and organic matt... more Geographical distribution of soil salinity, alkalinity, calcicity, soil texture, and organic matter (grid system-log distance of 2 km) has been evaluated and mapped in the study area (about 770 km 2) using GIS-ILWIS format. It is found that in the soils of Tamia District, ECe ranged between 1.22 and 22.4 dS m −1 and 1.03 and 97.1 dS m −1 in Fayoum District soils within the top layer. Results show 91.5% of Tamia soils and 56.5% of Fayoum District soils present ECe > 4 dS m −1 , indicating that salt-affected soils are distributed throughout the study area. About 94.5% of Tamia soils and 30% of Fayoum soils are calcareous (>10% CaCO 3 eq), due to the nature of parent material from which these soils are evolved. Soil pH of more than 8.00 was found in about 3.25% of Tamia soils and 73% of Fayoum District soils, whereas the soils with pH >8.5 are 3.96% in Tamia and 9.53% in Fayoum District. The organic matter contents seldom exceeded 1% in Tamia soils and did not exceed 1.5% for Fayoum soils. Soil texture in both districts is found as clay, sandy clay, sandy clay loam, sandy loam, and sandy. The maps generated through GIS are useful for decision makers for land use planning, conservation, and uses, as well as interest to researchers and soil science students to use the information for further investigations.
Macro elements availability in soils is an important aspect in context of soil fertility and agri... more Macro elements availability in soils is an important aspect in context of soil fertility and agricultural productivity. This study was performed to determine the levels of some macro elements availability in El-kharga oasis soils, New Valley, Egypt. To achieve this goal, hundred surface soil samples (0-30 cm) were collected from El-Kharga and Barisoasis, New Valley, Egypt. The collected soil samples were subjected for chemical analyses. The obtained results showed that the dominant problems are salinity and low organic matter content, The summarized data showed that 35% of the samples have low available nitrogen and 65% have medium nitrogen which was associated with low organic matter (100% of the samples have less than 1% OM). However 91% of the samples have high available P(˃15mg/kg), where as 5% and 4% of the samples were categorized as low and medium available P. Also, 98% of the samples were high in available potassium and only 2% were medium. The high content of available P a...
Four cases of a locally invasive sarcoma of the chest wall are described in children aged between... more Four cases of a locally invasive sarcoma of the chest wall are described in children aged between 8 and 14 years. Although its morphology resembles a Ewing's sarcoma of bone there are light and electron microscopical features that are distinctive. The sarcoma is thought to represent an entity which has not previously been defined. Its clinical importance lies in the
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Papers by Asmaa Ahmed
He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynasty. His father was King Khufu, and his son Menkaure, these are kings of the era of the Old Kingdom, This was the era of the pyramid builders, which was considered the most prosperous era of ancient Egypt, during which Egypt enjoyed prosperity and stability, and This became clear in the sculpture creations of the Fourth Dynasty, including the statue of King Khafre, the subject of research, and of course this is considered a fundamental reason for choosing this beautiful artifact, as a subject of research, from the masterpieces of the Egyptian Museum in Cairo.
He is the forth king of the Fourth Dynasty, His royal family , The Grand-Father is Snefru, his Father is Cheops (khufu), perhaps his Mother is Henutsen and his wives: Khamernebti I, Meres ankh III (probably, she is the mother of Menkaure, his son and builder the third Pyramid), and perhaps there were two other queens, Predecessor: Djedefre (succeeded the short-lived Djedefre, his elder half-brother from the King father khufu) Successor: Bakare (?)
He is King Khafre (Chephren) (2558 - 2532 BCE), One of the kings of the Fourth Dynasty. His father was King Khufu, and his son Menkaure, these are kings of the era of the Old Kingdom, This was the era of the pyramid builders, which was considered the most prosperous era of ancient Egypt, during which Egypt enjoyed prosperity and stability, and This became clear in the sculpture creations of the Fourth Dynasty, including the statue of King Khafre, the subject of research, and of course this is considered a fundamental reason for choosing this beautiful artifact, as a subject of research, from the masterpieces of the Egyptian Museum in Cairo.
He is the forth king of the Fourth Dynasty, His royal family , The Grand-Father is Snefru, his Father is Cheops (khufu), perhaps his Mother is Henutsen and his wives: Khamernebti I, Meres ankh III (probably, she is the mother of Menkaure, his son and builder the third Pyramid), and perhaps there were two other queens, Predecessor: Djedefre (succeeded the short-lived Djedefre, his elder half-brother from the King father khufu) Successor: Bakare (?)