Papers by zohre ghotbeddin
DOAJ (DOAJ: Directory of Open Access Journals), Sep 1, 2022
Background and Objective: Hypoxia is one of the most common clinical stresses that occur during p... more Background and Objective: Hypoxia is one of the most common clinical stresses that occur during pregnancy, which has adverse effects on fetal development. Fish oil, with its antioxidant properties, prevents fetal disorders during pregnancy. This study was conducted to determine the effects of fish oil on apparent congenital abnormalities and fetal dimensions caused by hypoxia during gestation in rats. Methods: In this experimental study, 36 female pregnant Wistar rats were divided into 6 groups of control, hypoxia, fish oil 0.5 ml, fish oil 1 ml, hypoxia+fish oil 0.5 ml, and hypoxia + fish oil 1 ml. Fish oil was administered by gavage, and the hypoxia model was established between 6 and 15 days of gestation by 3 hours of daily exposure to 10% oxygen and 90% nitrogen. On the 20th day of pregnancy, the embryos were removed from the uterus. First, the number of obtained embryos from each group was counted. Then, in terms of apparent abnormalities, the number of live fetuses and fetal resorption was evaluated. Finally, the length and weight of the fetuses were measured. Results: The frequency of embryos with apparent abnormalities in the hypoxia and control groups was 18.18% and nil, respectively. The frequency of fetal resorptions in the hypoxia and control groups was 27.27% and 1.92%, respectively. Moreover, fetal weight and length were significantly reduced in the hypoxia group compared with the control group (P<0.05). However, the average weight and length of fetuses in the hypoxia groups receiving fish oil showed a significant increase compared to the hypoxia group (P<0.05). Conclusion: Hypoxia during pregnancy in rats reduces fetal body dimensions and increases fetal abnormalities. However, fish oil can reduce the harmful effects of hypoxia on apparent congenital abnormalities and fetal body dimensions during pregnancy.
Background and Objectives Nowadays, the application of Low Frequency Stimulations (LFS) has been ... more Background and Objectives Nowadays, the application of Low Frequency Stimulations (LFS) has been considered as an alternative treatment in drug-resistant epileptic patients. So, the aim of this study was to determine the co-administration effects of LFS and carbamazepine (CBZ) during epileptogenesis in dorsal hippocampus using electrical Kindling method on seizure scales in adult male rats. Materials and Methods: In this experimental study, 56 adult male wistar rats were randomly divided into 8 equal groups including: Kindled (KND), KLFS, MCK, CBZ20K, CBZ40K, CBZ20KLFS, CBZ40KLFS, and MCKLFS. Animals in the Kindled group received daily stimulation of kindling. In the KLFS group, LFS were applied daily after the termination of kindling stimulation. In the MCK group, before induction of kindling stimulation, the amount of 0.2 ml of %0.5 methyl cellulose was injected, and CBZ20K and CBZ40K groups received CBZ20 and 40mg / kg. In the CBZ20KLFS, CBZ40KLFS, and MCKLFS groups in addition t...
Epilepsy is a chronic cerebral disorder associated with recurrently occurring seizures resulting ... more Epilepsy is a chronic cerebral disorder associated with recurrently occurring seizures resulting from over activity of brain neurons. Since more than one percent of the world’s population is suffering from epilepsy, this disease is recognized as one of the mos t important neurological disorders in modern medicine. Studies indicate that impairment in balance and motor activity are known as one of the side effects of epilepsy. Therefore, the use of an antiepileptic drug such as carbamazepine can help to improve these disorders. So, in this research, the effect of carbamazepine during epileptogenesis in dorsal hippocampal kindling on balance and motor activity in adult male rats was inves tigated. In this s tudy, 60 adult male rats were randomly divided into 6 groups: surgical control, methylcellulose (MC), Kindled, carbamazepine (CBZ), kindled-carbamazepine (KCBZ) and the methylcellulose-Kindled (MCK). Animals in the Kindled group s timulate were rapidly kindled by daily s timulation ...
Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by in... more Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of
Electromagnetic fields (EMFs) for water and wastewater treatments show promising potentials. Safe... more Electromagnetic fields (EMFs) for water and wastewater treatments show promising potentials. Safety, compatibility and simplicity, environmentally friendliness, low operating cost and not proven harmful effects are the main advantages of EMFs over conventional methods for wastewater treatment. In addition to the antimicrobial and antibacterial effects of EMFs on wastewater, these fields have special properties useful for wastewater treatment process: modifying the physical and chemical properties of water molecules and other elements, sludge precipitation, phosphorus and organic compounds removal from wastewater are some of these characteristics. The present study reviews the current advances in EMFs applications in sewage and wastewater treatment and the mechanisms of action. In addition, future perspectives of technologies in this field are reviewed.
Pakistan Journal of Biological Sciences, May 1, 2008
Journal of Pure and Applied Microbiology, Oct 1, 2014
ABSTRACT Electromagnetic fields (EMFs) for water and wastewater treatments show promising potenti... more ABSTRACT Electromagnetic fields (EMFs) for water and wastewater treatments show promising potentials. Safety, compatibility and simplicity, environmentally friendliness, low operating cost and not proven harmful effects are the main advantages of EMFs over conventional methods for wastewater treatment. In addition to the antimicrobial and antibacterial effects of EMFs on wastewater, these fields have special properties useful for wastewater treatment process: modifying the physical and chemical properties of water molecules and other elements, sludge precipitation, phosphorus and organic compounds removal from wastewater are some of these characteristics. The present study reviews the current advances in EMFs applications in sewage and wastewater treatment and the mechanisms of action. In addition, future perspectives of technologies in this field are reviewed. Dramatic increase in the world population, transition to the modern life and increasing the polluting agents have introduced the water pollution as the main problem of human colonies, especially in municipal areas. Various methods have been developed for the wastewater treatment (WWT). Sewage treatment is the process of eliminating contaminants from wastewater, including household sewage and runoff 1 . In this process, for physical, chemical and biological contaminants appropriate physical, chemical, and biological processes are used, respectively. Conventional WWTs consist of three stages: primary, secondary and tertiary treatment. In a brief, the whole process is as follows: In primary treatment the sewage is temporarily hold in a quiescent basin to settle heavy solids while oil, grease and lighter solids remain in the surface 1, 2 . After removing the settled and floating materials, the remaining liquid is discharged or subjected to secondary treatment where dissolved and suspended biological matters are removed
Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by in... more Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal CA1 region. However, cellular mechanisms of these processes are not clear. In the present study, changes in the electrophysiological properties of hippocampal CA1 pyramidal neurons following amygdala kindling were examined in rat. Methods: Animals were rapidly kindled by stimulation of right amygdala (12 stimulation per day, 1 ms pulse duration at 50Hz). Twenty-four hours after amygdala kindling, electrophysiological properties and inward currents of CA1 pyramidal neurons were assessed by using whole-cell patch clamp technique. Results: Amygdala kindling findings show that percentage broadening of the last spike compared to the first spike during a trains of action potentials was significantly increased in kindled rats (p<0.05). The number of rebound action potential was significantly increased from 1±1 in control rats to 6±1 in kindled rats (p<0.01). The amplitude of post stimulus afterhyperpolarization potential (Post AHP) following a trains of action potential was also significantly (p<0.05) increased in kindled group (-5±2mV) compared to normal rats (-3±1mV). Under voltage clamp condition, amygdala kindling produced a significantly larger inward current (-5344.25±33.19 pA, p<0.001) in CA1 pyramidal neurons compared to normal cells (-9203.6±44.99pA). Conclusion: The present findings show that amygdala kindling resulted in neuronal hyperexcitability through alteration of the electrophysiological characteristics possibly by increasing the inward currents in hippocampal CA1 pyramidal neurons.
Objective: To see the dose dependent effects of zinc chloride on the short-term and long-term mem... more Objective: To see the dose dependent effects of zinc chloride on the short-term and long-term memory in a shuttle box (rats). Methodology: Six pair adult wistar rats were taken for this experiment. One group of pregnant rats received a daily oral dose of 20mg/kg Zn as zinc chloride and the remaining groups received a daily oral dose of (30, 50, 70,100mg/kg) zinc chloride for two weeks by gavage. One month after birth, a shuttle box was used to test short-term and long-term memory. Two criteria were considered to behavioral test, including latency in entering dark chamber and time spent in the dark chamber. Result: This experiment showed that oral administration of ZnCl2 with (20, 30, 50 mg/kg/day) doses after 2 weeks at the stage of pregnancy, can improve the working memory of their offspring (p
Pakistan journal of biological sciences : PJBS, Jan 15, 2007
The aim of the present study was to evaluate the effects of dose-dependent of zinc chloride on sh... more The aim of the present study was to evaluate the effects of dose-dependent of zinc chloride on short-term and long-term memory in a shuttle box. Young Wistar rats (94+/-10 g) (age 27-30 days) consumed zinc chloride drinking water in five different doses (20, 30, 50, 70 and 100 mg kg(-1) day(-1)) for two weeks by gavage. After 14 days on experimental diets, a shuttle box used to test short- and long-term memory. Two criteria considering for behavioral test, including latency in entering dark chamber and time spent in the dark chamber. This experiment shows that after 2 weeks oral administration of ZnCl2 with (20, 30 and 50 mg kg(-1) day(-1)) doses, the rat's working (short-term) has been improved (p<0.05). Whereas ZnCl2 with 30 mg kg(-1) day(-1) dose has been more effected than other doses (p<0.001). But rat which received ZnCl2 with 100 mg kg(-1) day(-1), has been shown significant impairment in working memory (p<0.05) and there was no significant difference in referenc...
Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by in... more Introduction: Many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal CA1 region. However, cellular mechanisms of these processes are not clear. In the present study, changes in the electrophysiological properties of hippocampal CA1 pyramidal neurons following amygdala kindling were examined in rat. Methods: Animals were rapidly kindled by stimulation of right amygdala (12 stimulation per day, 1 ms pulse duration at 50Hz). Twenty-four hours after amygdala kindling, electrophysiological properties and inward currents of CA1 pyramidal neurons were assessed by using whole-cell patch clamp technique. Results: Amygdala kindling findings show that percentage broadening of the last spike compared to the first spike during a trains of action potentials was significantly increased in kindled rats (p<0.05). The number of rebound action potential was significantly increased from 1±1 in control rats to 6±1 in kindled rats (p<0.01). The amplitude of post stimulus afterhyperpolarization potential (Post AHP) following a trains of action potential was also significantly (p<0.05) increased in kindled group (-5±2mV) compared to normal rats (-3±1mV). Under voltage clamp condition, amygdala kindling produced a significantly larger inward current (-5344.25±33.19 pA, p<0.001) in CA1 pyramidal neurons compared to normal cells (-9203.6±44.99pA). Conclusion: The present findings show that amygdala kindling resulted in neuronal hyperexcitability through alteration of the electrophysiological characteristics possibly by increasing the inward currents in hippocampal CA1 pyramidal neurons.
Uploads
Papers by zohre ghotbeddin