A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primar... more A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primary aromatic amines with Vilsmeier reagent (DMF/POCl 3) has been carried out. The reaction occurred in a few minutes under microwave irradiation providing good yields. All the synthesized compounds have been screened for their in vitro antibacterial activity against S. aureus, S. epidermis, B. cereus, B. subtilis, Ps. aureus, Kl. pneumonia and E. coli and antifungal activity against A. niger and C. albicans. Their minimal inhibitory concentration (MIC) values range between 25-100 µg/mL. The screening data indicates that the compounds 3c, 3e, 3g and 3i have promising anti-bacterial activity and compounds 3b, 3c and 3h have promising antifungal activity.
A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primar... more A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primary aromatic amines with Vilsmeier reagent (DMF/POCl 3) has been carried out. The reaction occurred in a few minutes under microwave irradiation providing good yields. All the synthesized compounds have been screened for their in vitro antibacterial activity against S. aureus, S. epidermis, B. cereus, B. subtilis, Ps. aureus, Kl. pneumonia and E. coli and antifungal activity against A. niger and C. albicans. Their minimal inhibitory concentration (MIC) values range between 25-100 µg/mL. The screening data indicates that the compounds 3c, 3e, 3g and 3i have promising anti-bacterial activity and compounds 3b, 3c and 3h have promising antifungal activity.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo-and regioselective ... more A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo-and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such as oxypurinol and emivirine are reported.
Peroxide in, phenol out: The catalyst [γ-PW(10)O(38)V(2)(μ-OH)(2)](3-) showed high activity in th... more Peroxide in, phenol out: The catalyst [γ-PW(10)O(38)V(2)(μ-OH)(2)](3-) showed high activity in the hydroxylation of various aromatic compounds with aqueous H(2)O(2). The system was regioselective, producing para-phenols from monosubstituted benzene derivatives. Furthermore, alkylarenes with reactive side-chain C sp 3-H bonds could be chemoselectively hydroxylated without significant formation of side-chain oxygenated products.
Fused pyridine derivatives Fused pyridine derivatives R 0450 Triphenyl Phosphonium Perchlorate Ca... more Fused pyridine derivatives Fused pyridine derivatives R 0450 Triphenyl Phosphonium Perchlorate Catalyzed Imino Diels-Alder Reactions: Diastereoselective Synthesis of Indolylquinolines.-Indolylquinolines find application as antileishmanial and antibacterial agents and are used as pesticides, antioxidants, and corrosion inhibitors.-(ZULYKAMA, Y.; NAGARAJAN, R.;
Road traffic noise barriers being used to reduce the noise, but the city surroundings inhibition,... more Road traffic noise barriers being used to reduce the noise, but the city surroundings inhibition, ecosystem disturbance, and it is difficult to maintain. Can enhance or complement the existing noise barrier performance, so that it is necessary to develop an electronic noise-reduction system In this paper, we proposed an electronic road noise reduction devices to reduce road noise for a DSP-based signal processing and analog signal input-output controller. In order to verify the control performance, we performed noise reduction experimentation of ANC by filtered-X LMS algorithm and traffic noise signal injection. The controller is equipped with noise reduction algorithms were tested on the characteristics of directional and omnidirectional speaker.
Nucleophilic substitution products of Baylis–Hillman adducts are valuable synthons. In an attempt... more Nucleophilic substitution products of Baylis–Hillman adducts are valuable synthons. In an attempt to improve the functionality of Baylis–Hillman adducts we report the regio- and chemo-selective fuctionalization of Baylis–Hillman bromides with symmetric and asymmetric bifunctional aromatics.
A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primar... more A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primary aromatic amines with Vilsmeier reagent (DMF/POCl 3) has been carried out. The reaction occurred in a few minutes under microwave irradiation providing good yields. All the synthesized compounds have been screened for their in vitro antibacterial activity against S. aureus, S. epidermis, B. cereus, B. subtilis, Ps. aureus, Kl. pneumonia and E. coli and antifungal activity against A. niger and C. albicans. Their minimal inhibitory concentration (MIC) values range between 25-100 µg/mL. The screening data indicates that the compounds 3c, 3e, 3g and 3i have promising anti-bacterial activity and compounds 3b, 3c and 3h have promising antifungal activity.
A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primar... more A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primary aromatic amines with Vilsmeier reagent (DMF/POCl 3) has been carried out. The reaction occurred in a few minutes under microwave irradiation providing good yields. All the synthesized compounds have been screened for their in vitro antibacterial activity against S. aureus, S. epidermis, B. cereus, B. subtilis, Ps. aureus, Kl. pneumonia and E. coli and antifungal activity against A. niger and C. albicans. Their minimal inhibitory concentration (MIC) values range between 25-100 µg/mL. The screening data indicates that the compounds 3c, 3e, 3g and 3i have promising anti-bacterial activity and compounds 3b, 3c and 3h have promising antifungal activity.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo-and regioselective ... more A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo-and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such as oxypurinol and emivirine are reported.
Peroxide in, phenol out: The catalyst [γ-PW(10)O(38)V(2)(μ-OH)(2)](3-) showed high activity in th... more Peroxide in, phenol out: The catalyst [γ-PW(10)O(38)V(2)(μ-OH)(2)](3-) showed high activity in the hydroxylation of various aromatic compounds with aqueous H(2)O(2). The system was regioselective, producing para-phenols from monosubstituted benzene derivatives. Furthermore, alkylarenes with reactive side-chain C sp 3-H bonds could be chemoselectively hydroxylated without significant formation of side-chain oxygenated products.
Fused pyridine derivatives Fused pyridine derivatives R 0450 Triphenyl Phosphonium Perchlorate Ca... more Fused pyridine derivatives Fused pyridine derivatives R 0450 Triphenyl Phosphonium Perchlorate Catalyzed Imino Diels-Alder Reactions: Diastereoselective Synthesis of Indolylquinolines.-Indolylquinolines find application as antileishmanial and antibacterial agents and are used as pesticides, antioxidants, and corrosion inhibitors.-(ZULYKAMA, Y.; NAGARAJAN, R.;
Road traffic noise barriers being used to reduce the noise, but the city surroundings inhibition,... more Road traffic noise barriers being used to reduce the noise, but the city surroundings inhibition, ecosystem disturbance, and it is difficult to maintain. Can enhance or complement the existing noise barrier performance, so that it is necessary to develop an electronic noise-reduction system In this paper, we proposed an electronic road noise reduction devices to reduce road noise for a DSP-based signal processing and analog signal input-output controller. In order to verify the control performance, we performed noise reduction experimentation of ANC by filtered-X LMS algorithm and traffic noise signal injection. The controller is equipped with noise reduction algorithms were tested on the characteristics of directional and omnidirectional speaker.
Nucleophilic substitution products of Baylis–Hillman adducts are valuable synthons. In an attempt... more Nucleophilic substitution products of Baylis–Hillman adducts are valuable synthons. In an attempt to improve the functionality of Baylis–Hillman adducts we report the regio- and chemo-selective fuctionalization of Baylis–Hillman bromides with symmetric and asymmetric bifunctional aromatics.
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