Journal of Drug Delivery and Therapeutics, Sep 15, 2021
_________________________________________________________________________________________________... more ______________________________________________________________________________________________________ Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil. Questions were whether date powder could be used as alternatives of carbon sources for Bacillus megaterium submerged state cultivation? Approach: To evaluate the effects of the using date powder; The fermentation was carried out in shake flasks using a complex medium consisting of (g/L) ammonium tartrate, 2.0; magnesium sulphateheptahydrate, 4.0; dipotassium phosphate, 14.0; calcium chloride, 0.2, NaHPO4, 4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0(4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0) were replaced by dates powder at three rates; 5,10 and15 g/L Results show that the rate of production of biomass during submerged fermentation by Bacillus megaterium at 30±1°C for 24 hours of incubation using date powder was maximizes between 18 and 24 hr of fermentation. The experimental runs and results for the Box-Behnken design. The 15 runs in a single block were used to study the effects using date powder in different rates on one response. Biomass concentration ranged from 6.5cfu /l to 12.9cfu /.comparing with 14.8 cfu/ g for the commercial growth media. The ANOVA tables give the statistical significance of the effects for biomass. These effects were dates powder rates, the optimized growth medium with pH 7, inoculums' size 10 6 , temp 24 o C and moisture dates powder 15 g/L. The biomass concentrations obtained under the optimal conditions 12.9cfu/l.
The purpose of this review is to give an up-to-date, thorough, and timely overview of monkeypox (... more The purpose of this review is to give an up-to-date, thorough, and timely overview of monkeypox (Mpox), a severe infectious viral disease. Furthermore, this review provides an up-to-date treatment option for Mpox. The monkeypox virus (MPXV) has remained the most virulent poxvirus for humans since the elimination of smallpox approximately 41 years ago, with distribution mainly in central and west Africa. Mpox in humans is a zoonotically transferred disease that results in symptoms like those of smallpox. It had spread throughout west and central Africa when it was first diagnosed in the Republic of Congo in 1970. Mpox has become a major threat to global health security, necessitating a quick response by virologists, veterinarians, public health professionals, doctors, and researchers to create high-efficiency diagnostic tests, vaccinations, antivirals, and other infection control techniques. The emergence of epidemics outside of Africa emphasizes the disease’s global significance. A ...
Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-infected phle... more Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-infected phlebotomine sandflies. Each year approximately 58,500 cases of leishmaniasis are diagnosed across the globe, with a mortality rate of nearly seven percent. There are over 20 parasitic strains of Leishmania which are known to cause distinct types of leishmaniasis and pose an endemic threat to humans worldwide. Therefore, it is crucial to develop potential medications and vaccines to combat leishmaniasis. However, the task of developing therapeutic solutions is challenging due to Leishmania’s digenetic lifecycle. The challenge is further intensified by cases of resistance against the available drugs. Owing to these challenges, the conventional drug development regimen is further limited by target discovery and ligand suitability for the targets. On the other hand, as an added advantage, the emergence of omics-based tools, such as high-end proteomics, transcriptomics and genomics, has hastened...
Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly imp... more Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly improved cancer therapy. Nevertheless, the existing traditional anticancer treatments have been reported to cause serious side effects and resistance to cancer and even to severely affect the quality of life of cancer survivors, which indicates the utmost urgency to develop effective and safe anticancer treatments. As the primary focus of cancer nanotheranostics, nanomaterials with unique surface chemistry and shape have been investigated for integrating cancer diagnostics with treatment techniques, including guiding a prompt diagnosis, precise imaging, treatment with an effective dose, and real-time supervision of therapeutic efficacy. Several theranostic nanosystems have been explored for cancer diagnosis and treatment in the past decade. However, metal-based nanotheranostics continue to be the most common types of nonentities. Consequently, the present review covers the physical characte...
As medical science and technology progress towards the era of “big data”, a multi-dimensional dat... more As medical science and technology progress towards the era of “big data”, a multi-dimensional dataset pertaining to medical diagnosis and treatment is becoming accessible for mathematical modelling. However, these datasets are frequently inconsistent, noisy, and often characterized by a significant degree of redundancy. Thus, extensive data processing is widely advised to clean the dataset before feeding it into the mathematical model. In this context, Artificial intelligence (AI) techniques, including machine learning (ML) and deep learning (DL) algorithms based on artificial neural networks (ANNs) and their types, are being used to produce a precise and cross-sectional illustration of clinical data. For prostate cancer patients, datasets derived from the prostate-specific antigen (PSA), MRI-guided biopsies, genetic biomarkers, and the Gleason grading are primarily used for diagnosis, risk stratification, and patient monitoring. However, recording diagnoses and further stratifying ...
Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil.... more Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil. Questions were whether date powder could be used as alternatives of carbon sources for Bacillus megaterium submerged state cultivation? Approach: To evaluate the effects of the using date powder; The fermentation was carried out in shake flasks using a complex medium consisting of (g/L) ammonium tartrate, 2.0; magnesium sulphateheptahydrate, 4.0; dipotassium phosphate, 14.0; calcium chloride, 0.2, NaHPO4, 4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0(4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0) were replaced by dates powder at three rates; 5,10 and15 g/L Results show that the rate of production of biomass during submerged fermentation by Bacillus megaterium at 30±1°C for 24 hours of incubation using date powder was maximizes between 18 and 24 hr of fermentation. The experimental runs and results for the Box– Behnken design. The 15 runs in a single bl...
Journal of Drug Delivery and Therapeutics, Sep 15, 2021
_________________________________________________________________________________________________... more ______________________________________________________________________________________________________ Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil. Questions were whether date powder could be used as alternatives of carbon sources for Bacillus megaterium submerged state cultivation? Approach: To evaluate the effects of the using date powder; The fermentation was carried out in shake flasks using a complex medium consisting of (g/L) ammonium tartrate, 2.0; magnesium sulphateheptahydrate, 4.0; dipotassium phosphate, 14.0; calcium chloride, 0.2, NaHPO4, 4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0(4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0) were replaced by dates powder at three rates; 5,10 and15 g/L Results show that the rate of production of biomass during submerged fermentation by Bacillus megaterium at 30±1°C for 24 hours of incubation using date powder was maximizes between 18 and 24 hr of fermentation. The experimental runs and results for the Box-Behnken design. The 15 runs in a single block were used to study the effects using date powder in different rates on one response. Biomass concentration ranged from 6.5cfu /l to 12.9cfu /.comparing with 14.8 cfu/ g for the commercial growth media. The ANOVA tables give the statistical significance of the effects for biomass. These effects were dates powder rates, the optimized growth medium with pH 7, inoculums' size 10 6 , temp 24 o C and moisture dates powder 15 g/L. The biomass concentrations obtained under the optimal conditions 12.9cfu/l.
The purpose of this review is to give an up-to-date, thorough, and timely overview of monkeypox (... more The purpose of this review is to give an up-to-date, thorough, and timely overview of monkeypox (Mpox), a severe infectious viral disease. Furthermore, this review provides an up-to-date treatment option for Mpox. The monkeypox virus (MPXV) has remained the most virulent poxvirus for humans since the elimination of smallpox approximately 41 years ago, with distribution mainly in central and west Africa. Mpox in humans is a zoonotically transferred disease that results in symptoms like those of smallpox. It had spread throughout west and central Africa when it was first diagnosed in the Republic of Congo in 1970. Mpox has become a major threat to global health security, necessitating a quick response by virologists, veterinarians, public health professionals, doctors, and researchers to create high-efficiency diagnostic tests, vaccinations, antivirals, and other infection control techniques. The emergence of epidemics outside of Africa emphasizes the disease’s global significance. A ...
Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-infected phle... more Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-infected phlebotomine sandflies. Each year approximately 58,500 cases of leishmaniasis are diagnosed across the globe, with a mortality rate of nearly seven percent. There are over 20 parasitic strains of Leishmania which are known to cause distinct types of leishmaniasis and pose an endemic threat to humans worldwide. Therefore, it is crucial to develop potential medications and vaccines to combat leishmaniasis. However, the task of developing therapeutic solutions is challenging due to Leishmania’s digenetic lifecycle. The challenge is further intensified by cases of resistance against the available drugs. Owing to these challenges, the conventional drug development regimen is further limited by target discovery and ligand suitability for the targets. On the other hand, as an added advantage, the emergence of omics-based tools, such as high-end proteomics, transcriptomics and genomics, has hastened...
Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly imp... more Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly improved cancer therapy. Nevertheless, the existing traditional anticancer treatments have been reported to cause serious side effects and resistance to cancer and even to severely affect the quality of life of cancer survivors, which indicates the utmost urgency to develop effective and safe anticancer treatments. As the primary focus of cancer nanotheranostics, nanomaterials with unique surface chemistry and shape have been investigated for integrating cancer diagnostics with treatment techniques, including guiding a prompt diagnosis, precise imaging, treatment with an effective dose, and real-time supervision of therapeutic efficacy. Several theranostic nanosystems have been explored for cancer diagnosis and treatment in the past decade. However, metal-based nanotheranostics continue to be the most common types of nonentities. Consequently, the present review covers the physical characte...
As medical science and technology progress towards the era of “big data”, a multi-dimensional dat... more As medical science and technology progress towards the era of “big data”, a multi-dimensional dataset pertaining to medical diagnosis and treatment is becoming accessible for mathematical modelling. However, these datasets are frequently inconsistent, noisy, and often characterized by a significant degree of redundancy. Thus, extensive data processing is widely advised to clean the dataset before feeding it into the mathematical model. In this context, Artificial intelligence (AI) techniques, including machine learning (ML) and deep learning (DL) algorithms based on artificial neural networks (ANNs) and their types, are being used to produce a precise and cross-sectional illustration of clinical data. For prostate cancer patients, datasets derived from the prostate-specific antigen (PSA), MRI-guided biopsies, genetic biomarkers, and the Gleason grading are primarily used for diagnosis, risk stratification, and patient monitoring. However, recording diagnoses and further stratifying ...
Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil.... more Problems statement: A study had shown a strain of Bacillus megaterium was isolated from the soil. Questions were whether date powder could be used as alternatives of carbon sources for Bacillus megaterium submerged state cultivation? Approach: To evaluate the effects of the using date powder; The fermentation was carried out in shake flasks using a complex medium consisting of (g/L) ammonium tartrate, 2.0; magnesium sulphateheptahydrate, 4.0; dipotassium phosphate, 14.0; calcium chloride, 0.2, NaHPO4, 4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0(4.0, yeast extract, 3.0, trace elements, 2.0ml and glucose 6.0) were replaced by dates powder at three rates; 5,10 and15 g/L Results show that the rate of production of biomass during submerged fermentation by Bacillus megaterium at 30±1°C for 24 hours of incubation using date powder was maximizes between 18 and 24 hr of fermentation. The experimental runs and results for the Box– Behnken design. The 15 runs in a single bl...
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