Papers by wiphawee hochaame
Proceedings of the 7th Biennial Meeting of Asian Society of Gynecologic Oncology, 2021
Histologically diagnosed patients with vulvar Paget disease from January 2000 to April 2020 were ... more Histologically diagnosed patients with vulvar Paget disease from January 2000 to April 2020 were identified. Clinical data were collected from medical records and histologic data were verified by pathological review. Pathologic specimens were collected. HER2 and PD-L1 immunohistochemistry were performed. The results of staining were reported by two pathologists. Data were analyzed using descriptive statistics and reported as percentage and 95% confidence interval (CI). Clinical outcomes were correlated with immunohistochemistry expression. Results: Thirty-three vulvar Paget disease cases were included in the study. Twenty patients (60.6%, 95% CI=42.1-77.1) had HER2 overexpression. All patients were negative for PD-L1 immunohistochemistry. HER2 positive patients had hazard of death 2.94 (95% CI=0.61-14.23) times compared with HER2 negative patients. HER2 positive status had relative risk 1.95 and 1.73 for invasive and metastatic disease respectively. Conclusion: More than half of vulvar Paget disease patients had HER2 overexpression and might benefit from anti-HER2 targeted therapy. A higher proportion of HER2 overexpression was found in invasive and metastatic vulvar Paget disease. PD-L1 was not expressed in vulvar Paget disease.
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Papers by wiphawee hochaame