is an assistant professor at the Indian Institute of Management. His teaching centers around fina... more is an assistant professor at the Indian Institute of Management. His teaching centers around financial management, valuation, financial restructuring and venture capital finance. His current research and consulting interests include venture fund performance, venture capital structuring and monitoring issues, and venture backed IPOs.
Endogenous retroviruses (ERVs) are abundant, repetitive elements dispersed across the human genom... more Endogenous retroviruses (ERVs) are abundant, repetitive elements dispersed across the human genome and are implicated in various diseases. We investigated two potential roles for ERVs in prostate cancer (PCa). First, the PCa of Black Americans (BA) is diagnosed at an earlier median age and at a more advanced stage than the PCa of White Americans (WA). We used publicly available RNA-seq data from tumor-enriched samples of 27 BA and 65 WA PCa patients in order to identify 12 differentially expressed ERVs (padj < 0.1) and used a tissue microarray of the PCa cores from an independent set of BA and WA patients to validate the differential protein expression of one of these ERVs, ERV3-1 (p = 2.829 × 10−7). Second, we used 57 PCa tumors from patients of all ancestries from one hospital as a training set to identify the ERVs associated with time to biochemical relapse. A 29-ERV prognostic panel was then tested and validated on 35 separate PCa tumors from patients obtained in two differen...
The problem of appearance invariant subject recognition for Entry-Exit surveillance applications ... more The problem of appearance invariant subject recognition for Entry-Exit surveillance applications is addressed. A novel Semantic Entry-Exit matching model that makes use of ancillary information about subjects such as height, build, complexion and clothing color to endorse exit of every subject who had entered private area is proposed in this paper. The proposed method is robust to variations in clothing. Each describing attribute is given equal weight while computing the matching score and hence the proposed model achieves high rank-k accuracy on benchmark datasets. The soft biometric traits used as a combination though cannot achieve high rank-1 accuracy, it helps to narrow down the search to match using reliable biometric traits such as gait and face whose learning and matching time is costlier when compared to the visual soft biometrics.
Techniques to automate video surveillance around places where cameras are forbidden due to privac... more Techniques to automate video surveillance around places where cameras are forbidden due to privacy concerns are yet under-addressed. This can be achieved by building conceptual models and algorithms to investigate the credibility of monitoring of events using the video frames captured by mounting the cameras so as to have the view of the entrances of such camera-forbidden areas. Evaluation of these models and algorithms require standard datasets. The proposal here is to introduce a new benchmark dataset—“EnEx dataset” as no traces specific to the problem were found in the literature. The dataset comprises of video frames captured in 5 different locations accounting 90 entry–exit event pairs based on 9 different sequences involving 36 participants. Ground statistics of the dataset is reported. This work ventures a new sub-domain for research in the area of automated video surveillance.
MHD flow of an electrically conducting Newtonian fluid over a super linear stretching sheet in th... more MHD flow of an electrically conducting Newtonian fluid over a super linear stretching sheet in the presence of suction/injection and Navier slip is studied using modified Adomain decomposition method (MADM) and Pad´e approximants. Governing nonlinear partial differential equations are transformed into nonlinear ordinary differential equations using an appropriate similarity transformation. The transformed equations are solved analytically by the modified ADM and Pad´e approximation. The modified ADM for solving nonlinear differential equations is purely and solely the traditional Taylor's series method. Pad´e approximants are applied to increase the convergence of the given series. The developed analytical technique is verified comprehensively. It is found that Navier's slip condition can lead to a non-essential growth of the boundary layer thickness and a decrease in the axial and transverse velocities.
International Journal of Computer Applications, 2019
Entry-Exit surveillance is a novel research problem that addresses security concerns when people ... more Entry-Exit surveillance is a novel research problem that addresses security concerns when people attain absolute privacy in camera forbidden areas such as toilets and changing rooms that are basic amenities to the humans in public places such as Shopping malls, Airports, Bus and Rail stations. The objective is, if not inside these camera forbidden areas, from outside, the individuals are to be monitored to analyze the time spent by them inside and also the suspecting transformations in their appearances if any. In this paper, firstly, a pseudo-annotated dataset of a laboratory observation of people entering and exiting the camera forbidden area captured using two cameras in contrast to the state-of-the-art single-camera based EnEx dataset is presented. Conventionally the proposed dataset is named EnEx2. Next, a spatial transition based event detection to determine the entry or exit of individuals is presented with standard results by evaluating the proposed model using the proposed dataset and the publicly available standard video surveillance datasets that are hypothesized to Entry-Exit surveillance scenarios. The proposed dataset is expected to enkindle active research in Entry-Exit Surveillance domain.
Journal of King Saud University - Computer and Information Sciences, 2018
Today, VLSI technology has taken a fundamental role in developing most of the high-tech electroni... more Today, VLSI technology has taken a fundamental role in developing most of the high-tech electronic circuits. Even though VLSI design is renowned for its smaller size, lower cost, lower power, high reliability and high functionality, the design process takes long time and produces high risk. So, to obtain the knowledge regarding the different contributions on VLSI design, about 52 papers on the design of VLSI using optimization are reviewed here. Accordingly, VLSI design optimization is analyzed through different bio-inspired algorithms and the performance measures of different VLSI experimentations are compared. Further, various improvements on Self-Adaptive Particle Swarm Optimization (SA-PSO) and VLSI design optimization, without the adoption of bio-inspired algorithms, are examined. Additionally, the floor planning problem of VLSI is considered and reviewed. Eventually, this paper provides the diverse research gaps and challenges in VLSI design, which may be helpful for the authors and the philosophers to contribute for further research.
Floor planning is necessary to design the VLSI circuit. The complete computational characteristic... more Floor planning is necessary to design the VLSI circuit. The complete computational characteristics of the manufactured chip are evaluated by floor planning process. It is the multi-objective problem in which different objectives are fulfilled at a time. Here, a new Interactive Self-Improvement based Adaptive Particle Swarm Optimization (ISI-APSO) technique is proposed to enhance the exploration efficiency and accuracy than convolutional PSO. Within less computation time the proposed ISI-APSO technique attains best global search throughout the space. The simulation results show that the proposed ISI-APSO algorithm achieves better performance than other heuristic algorithms in exploring efficiency and speed of convergence. In order to place the whole modules and their internally connected wire lengths, the Multi-objective optimization method is utilized. Therefore the necessary layout area is minimized. Moreover, the implemented results demonstrate the importance of the proposed algorithm with respect to the robust performance.
The viscous fluid flow past a semi-infinite porous solid, which is proportionally sheared at one ... more The viscous fluid flow past a semi-infinite porous solid, which is proportionally sheared at one boundary with the possibility of the fluid slipping according to Navier’s slip or second order slip, is considered here. Such an assumption takes into consideration several of the boundary conditions used in the literature, and is a generalization of them. Upon introducing a similarity transformation, the governing equations for the problem under consideration reduces to a system of nonlinear partial differential equations. Interestingly, we were able to obtain an exact analytical solution for the velocity, though the equation is nonlinear. The flow through the porous solid is assumed to obey the Brinkman equation, and is considered relevant to several applications.
Indian venture capital industry is one of the predominant players among South Asian countries. Ne... more Indian venture capital industry is one of the predominant players among South Asian countries. New funds have opened their shop here and are continuing to bring in more funds. The industry has undergone a major shift in focus. India is not a country which offers lower-cost production alternatives but is a high-tech and global outsourcing centre. The present study reports four factors which are used by the venture capitalists to screen new venture proposals. Using Kendall's tau-c analysis, the study brings out strong association between several variable pairs. Broadly, the analysis finds that: Successful venture teams put in sustained efforts on identified target markets. They are highly meticulous while attending to the details. These teams are adept at dealing with risk because of their impeccable past experience. Indian venture capitalists do not seem to be much enamoured of technology venturing; at least some of the successful ventures funded by them do not seem to show signs...
Serum samples from 51 apparently healthy breeding bulls were screened for bovine herpesvirus-1 (B... more Serum samples from 51 apparently healthy breeding bulls were screened for bovine herpesvirus-1 (BHV-1) antibodies using an avidin-biotin enzyme-linked immunosorbent assay, revealing a sero-positive prevalence rate of 45.09%. Semen samples were then collected from 12 of the sero-positive and 12 of the sero-negative bulls and tested for BHV-1 antigen using both a virus isolation assay and a polymerase chain reaction (PCR) assay; PCR was applied to detect BHV-1 deoxyribonucleic acid by using primers selected from the relatively conserved sequence of the gI glycoprotein gene to amplify a 468 base pair fragment. The PCR-amplified products were confirmed as BHV-1 by restriction enzyme, Dde 1, which produced fragments of predictable sizes, namely 340 and 128 base pairs. Positive virus isolation test results, confirmed by virus neutralisation, found BHV-1 antigen in the semen of five sero-positive and six sero-negative bulls. In comparison, positive PCR results found BHV-1 genome in the semen of six sero-positive and eight sero-negative bulls. From the 24 semen samples tested, 14 were shown to be positive by PCR and 11 by virus isolation. The sensitivity and specificity of virus isolation were 57.14% and 70% respectively, and were significantly lower than PCR. In the semen samples taken from sero-negative bulls, BHV-1 was detected more often by PCR methods than by virus-isolation, suggesting that PCR is a more sensitive method for BHV-1 screening in bulls.
Following publication of this article [1], it has come to our attention that an incomplete versio... more Following publication of this article [1], it has come to our attention that an incomplete version of Fig. 7 was included in this article. The complete figure is shown below with the missing text included to the left of the chart.
Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical ... more Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical modeling helps provide a mechanistic understanding for the studied process, separating the main drivers from the circumstantial ones, bounding the outcomes of experiments and guiding engineering approaches. Among different modeling schemes, the quantification of intracellular metabolic fluxes (i.e. the rate of each reaction in cellular metabolism) is of particular interest for metabolic engineering because it describes how carbon and energy flow throughout the cell. In addition to flux analysis, new methods for the effective use of the ever more readily available and abundant -omics data (i.e. transcriptomics, proteomics and metabolomics) are urgently needed. The jQMM library presented here provides an open-source, Python-based framework for modeling internal metabolic fluxes and leveraging other -omics data for the scientific study of cellular metabolism and bioengineering purposes. Fir...
Цель исследования-изучить анатомические и морфологические особенности носа и околоносовых пазух к... more Цель исследования-изучить анатомические и морфологические особенности носа и околоносовых пазух кролика. Материал и методы. Авторами дается подробное описание анатомии полости носа и верхнечелюстной пазухи кролика, гистологическое строение различных участков слизистой оболочки. результаты. обоснована целесообразность использования полости носа кролика для проведения экспериментальных исследований. Ключевые слова: кролик, полость носа, верхнечелюстная пазуха, головной мозг, обонятельный анализатор. Objective: to study the anatomical and morphological characteristics of the rabbit nose and paranasal sinuses. Material and methods. The anatomy of the rabbit nose and maxillary sinus and the histological structure of their different mucosal parts were described in detail. Results. There is evidence that it is expedient to use the rabbit nasal cavity to conduct experimental studies.
Current limitations in quantitatively predicting biological behavior hinder our efforts to engine... more Current limitations in quantitatively predicting biological behavior hinder our efforts to engineer biological systems to produce biofuels and other desired chemicals. Here, we present a new method for calculating metabolic fluxes, key targets in metabolic engineering, that incorporates data from 13C labeling experiments and genome-scale models. The data from 13C labeling experiments provide strong flux constraints that eliminate the need to assume an evolutionary optimization principle such as the growth rate optimization assumption used in Flux Balance Analysis (FBA). This effective constraining is achieved by making the simple but biologically relevant assumption that flux flows from core to peripheral metabolism and does not flow back. The new method is significantly more robust than FBA with respect to errors in genome-scale model reconstruction. Furthermore, it can provide a comprehensive picture of metabolite balancing and predictions for unmeasured extracellular fluxes as co...
Baba et al., 2006T. Baba, T. Ara, M. Hasegawa, Y. Takai, Y. Okumura, M. Baba, KA Datsenko, M. Tom... more Baba et al., 2006T. Baba, T. Ara, M. Hasegawa, Y. Takai, Y. Okumura, M. Baba, KA Datsenko, M. Tomita, BL Warmer and H. Mori, Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection, Mol Syst Biol. 2 (2006) 2006 ...
2008 IEEE International Conference on Bioinformatics and Biomeidcine Workshops, 2008
Abstract The size of publication databases in biomedicine (eg, PubMed, MEDLINE) are growing rapid... more Abstract The size of publication databases in biomedicine (eg, PubMed, MEDLINE) are growing rapidly every year, as are public databases of experimental biological data and annotations derived from the data. Publications often contain evidence that confirms or ...
The title compound arises from an unexpected rearrangement and oxidation. The molecules contain a... more The title compound arises from an unexpected rearrangement and oxidation. The molecules contain a center of symmetry and are held together by hydrogen bonds. The relatively strainfree molecules are closely packed with a density of 1.441 g cm Ϫ3. The compound crystallizes in space group P-1 with cell dimensions a ϭ 8.999(3), b ϭ 9.142(2), c ϭ 8.625(3) Å , Ͱ ϭ 95.47(3), ͱ ϭ 105.06(3), and Ͳ ϭ 83.08(2)Њ There are two independent molecules per cell with each sitting on a center of symmetry.
Imino sugar compound 3 was prepared by two alternative routes starting from ribose and D-serine. ... more Imino sugar compound 3 was prepared by two alternative routes starting from ribose and D-serine. From D-serine (3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methylpyrrolidin-2-one was prepared in five steps in 50% overall yield, which was further converted into (2R,3R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-3,4-diol in three steps in 23% overall yield.
is an assistant professor at the Indian Institute of Management. His teaching centers around fina... more is an assistant professor at the Indian Institute of Management. His teaching centers around financial management, valuation, financial restructuring and venture capital finance. His current research and consulting interests include venture fund performance, venture capital structuring and monitoring issues, and venture backed IPOs.
Endogenous retroviruses (ERVs) are abundant, repetitive elements dispersed across the human genom... more Endogenous retroviruses (ERVs) are abundant, repetitive elements dispersed across the human genome and are implicated in various diseases. We investigated two potential roles for ERVs in prostate cancer (PCa). First, the PCa of Black Americans (BA) is diagnosed at an earlier median age and at a more advanced stage than the PCa of White Americans (WA). We used publicly available RNA-seq data from tumor-enriched samples of 27 BA and 65 WA PCa patients in order to identify 12 differentially expressed ERVs (padj < 0.1) and used a tissue microarray of the PCa cores from an independent set of BA and WA patients to validate the differential protein expression of one of these ERVs, ERV3-1 (p = 2.829 × 10−7). Second, we used 57 PCa tumors from patients of all ancestries from one hospital as a training set to identify the ERVs associated with time to biochemical relapse. A 29-ERV prognostic panel was then tested and validated on 35 separate PCa tumors from patients obtained in two differen...
The problem of appearance invariant subject recognition for Entry-Exit surveillance applications ... more The problem of appearance invariant subject recognition for Entry-Exit surveillance applications is addressed. A novel Semantic Entry-Exit matching model that makes use of ancillary information about subjects such as height, build, complexion and clothing color to endorse exit of every subject who had entered private area is proposed in this paper. The proposed method is robust to variations in clothing. Each describing attribute is given equal weight while computing the matching score and hence the proposed model achieves high rank-k accuracy on benchmark datasets. The soft biometric traits used as a combination though cannot achieve high rank-1 accuracy, it helps to narrow down the search to match using reliable biometric traits such as gait and face whose learning and matching time is costlier when compared to the visual soft biometrics.
Techniques to automate video surveillance around places where cameras are forbidden due to privac... more Techniques to automate video surveillance around places where cameras are forbidden due to privacy concerns are yet under-addressed. This can be achieved by building conceptual models and algorithms to investigate the credibility of monitoring of events using the video frames captured by mounting the cameras so as to have the view of the entrances of such camera-forbidden areas. Evaluation of these models and algorithms require standard datasets. The proposal here is to introduce a new benchmark dataset—“EnEx dataset” as no traces specific to the problem were found in the literature. The dataset comprises of video frames captured in 5 different locations accounting 90 entry–exit event pairs based on 9 different sequences involving 36 participants. Ground statistics of the dataset is reported. This work ventures a new sub-domain for research in the area of automated video surveillance.
MHD flow of an electrically conducting Newtonian fluid over a super linear stretching sheet in th... more MHD flow of an electrically conducting Newtonian fluid over a super linear stretching sheet in the presence of suction/injection and Navier slip is studied using modified Adomain decomposition method (MADM) and Pad´e approximants. Governing nonlinear partial differential equations are transformed into nonlinear ordinary differential equations using an appropriate similarity transformation. The transformed equations are solved analytically by the modified ADM and Pad´e approximation. The modified ADM for solving nonlinear differential equations is purely and solely the traditional Taylor's series method. Pad´e approximants are applied to increase the convergence of the given series. The developed analytical technique is verified comprehensively. It is found that Navier's slip condition can lead to a non-essential growth of the boundary layer thickness and a decrease in the axial and transverse velocities.
International Journal of Computer Applications, 2019
Entry-Exit surveillance is a novel research problem that addresses security concerns when people ... more Entry-Exit surveillance is a novel research problem that addresses security concerns when people attain absolute privacy in camera forbidden areas such as toilets and changing rooms that are basic amenities to the humans in public places such as Shopping malls, Airports, Bus and Rail stations. The objective is, if not inside these camera forbidden areas, from outside, the individuals are to be monitored to analyze the time spent by them inside and also the suspecting transformations in their appearances if any. In this paper, firstly, a pseudo-annotated dataset of a laboratory observation of people entering and exiting the camera forbidden area captured using two cameras in contrast to the state-of-the-art single-camera based EnEx dataset is presented. Conventionally the proposed dataset is named EnEx2. Next, a spatial transition based event detection to determine the entry or exit of individuals is presented with standard results by evaluating the proposed model using the proposed dataset and the publicly available standard video surveillance datasets that are hypothesized to Entry-Exit surveillance scenarios. The proposed dataset is expected to enkindle active research in Entry-Exit Surveillance domain.
Journal of King Saud University - Computer and Information Sciences, 2018
Today, VLSI technology has taken a fundamental role in developing most of the high-tech electroni... more Today, VLSI technology has taken a fundamental role in developing most of the high-tech electronic circuits. Even though VLSI design is renowned for its smaller size, lower cost, lower power, high reliability and high functionality, the design process takes long time and produces high risk. So, to obtain the knowledge regarding the different contributions on VLSI design, about 52 papers on the design of VLSI using optimization are reviewed here. Accordingly, VLSI design optimization is analyzed through different bio-inspired algorithms and the performance measures of different VLSI experimentations are compared. Further, various improvements on Self-Adaptive Particle Swarm Optimization (SA-PSO) and VLSI design optimization, without the adoption of bio-inspired algorithms, are examined. Additionally, the floor planning problem of VLSI is considered and reviewed. Eventually, this paper provides the diverse research gaps and challenges in VLSI design, which may be helpful for the authors and the philosophers to contribute for further research.
Floor planning is necessary to design the VLSI circuit. The complete computational characteristic... more Floor planning is necessary to design the VLSI circuit. The complete computational characteristics of the manufactured chip are evaluated by floor planning process. It is the multi-objective problem in which different objectives are fulfilled at a time. Here, a new Interactive Self-Improvement based Adaptive Particle Swarm Optimization (ISI-APSO) technique is proposed to enhance the exploration efficiency and accuracy than convolutional PSO. Within less computation time the proposed ISI-APSO technique attains best global search throughout the space. The simulation results show that the proposed ISI-APSO algorithm achieves better performance than other heuristic algorithms in exploring efficiency and speed of convergence. In order to place the whole modules and their internally connected wire lengths, the Multi-objective optimization method is utilized. Therefore the necessary layout area is minimized. Moreover, the implemented results demonstrate the importance of the proposed algorithm with respect to the robust performance.
The viscous fluid flow past a semi-infinite porous solid, which is proportionally sheared at one ... more The viscous fluid flow past a semi-infinite porous solid, which is proportionally sheared at one boundary with the possibility of the fluid slipping according to Navier’s slip or second order slip, is considered here. Such an assumption takes into consideration several of the boundary conditions used in the literature, and is a generalization of them. Upon introducing a similarity transformation, the governing equations for the problem under consideration reduces to a system of nonlinear partial differential equations. Interestingly, we were able to obtain an exact analytical solution for the velocity, though the equation is nonlinear. The flow through the porous solid is assumed to obey the Brinkman equation, and is considered relevant to several applications.
Indian venture capital industry is one of the predominant players among South Asian countries. Ne... more Indian venture capital industry is one of the predominant players among South Asian countries. New funds have opened their shop here and are continuing to bring in more funds. The industry has undergone a major shift in focus. India is not a country which offers lower-cost production alternatives but is a high-tech and global outsourcing centre. The present study reports four factors which are used by the venture capitalists to screen new venture proposals. Using Kendall's tau-c analysis, the study brings out strong association between several variable pairs. Broadly, the analysis finds that: Successful venture teams put in sustained efforts on identified target markets. They are highly meticulous while attending to the details. These teams are adept at dealing with risk because of their impeccable past experience. Indian venture capitalists do not seem to be much enamoured of technology venturing; at least some of the successful ventures funded by them do not seem to show signs...
Serum samples from 51 apparently healthy breeding bulls were screened for bovine herpesvirus-1 (B... more Serum samples from 51 apparently healthy breeding bulls were screened for bovine herpesvirus-1 (BHV-1) antibodies using an avidin-biotin enzyme-linked immunosorbent assay, revealing a sero-positive prevalence rate of 45.09%. Semen samples were then collected from 12 of the sero-positive and 12 of the sero-negative bulls and tested for BHV-1 antigen using both a virus isolation assay and a polymerase chain reaction (PCR) assay; PCR was applied to detect BHV-1 deoxyribonucleic acid by using primers selected from the relatively conserved sequence of the gI glycoprotein gene to amplify a 468 base pair fragment. The PCR-amplified products were confirmed as BHV-1 by restriction enzyme, Dde 1, which produced fragments of predictable sizes, namely 340 and 128 base pairs. Positive virus isolation test results, confirmed by virus neutralisation, found BHV-1 antigen in the semen of five sero-positive and six sero-negative bulls. In comparison, positive PCR results found BHV-1 genome in the semen of six sero-positive and eight sero-negative bulls. From the 24 semen samples tested, 14 were shown to be positive by PCR and 11 by virus isolation. The sensitivity and specificity of virus isolation were 57.14% and 70% respectively, and were significantly lower than PCR. In the semen samples taken from sero-negative bulls, BHV-1 was detected more often by PCR methods than by virus-isolation, suggesting that PCR is a more sensitive method for BHV-1 screening in bulls.
Following publication of this article [1], it has come to our attention that an incomplete versio... more Following publication of this article [1], it has come to our attention that an incomplete version of Fig. 7 was included in this article. The complete figure is shown below with the missing text included to the left of the chart.
Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical ... more Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical modeling helps provide a mechanistic understanding for the studied process, separating the main drivers from the circumstantial ones, bounding the outcomes of experiments and guiding engineering approaches. Among different modeling schemes, the quantification of intracellular metabolic fluxes (i.e. the rate of each reaction in cellular metabolism) is of particular interest for metabolic engineering because it describes how carbon and energy flow throughout the cell. In addition to flux analysis, new methods for the effective use of the ever more readily available and abundant -omics data (i.e. transcriptomics, proteomics and metabolomics) are urgently needed. The jQMM library presented here provides an open-source, Python-based framework for modeling internal metabolic fluxes and leveraging other -omics data for the scientific study of cellular metabolism and bioengineering purposes. Fir...
Цель исследования-изучить анатомические и морфологические особенности носа и околоносовых пазух к... more Цель исследования-изучить анатомические и морфологические особенности носа и околоносовых пазух кролика. Материал и методы. Авторами дается подробное описание анатомии полости носа и верхнечелюстной пазухи кролика, гистологическое строение различных участков слизистой оболочки. результаты. обоснована целесообразность использования полости носа кролика для проведения экспериментальных исследований. Ключевые слова: кролик, полость носа, верхнечелюстная пазуха, головной мозг, обонятельный анализатор. Objective: to study the anatomical and morphological characteristics of the rabbit nose and paranasal sinuses. Material and methods. The anatomy of the rabbit nose and maxillary sinus and the histological structure of their different mucosal parts were described in detail. Results. There is evidence that it is expedient to use the rabbit nasal cavity to conduct experimental studies.
Current limitations in quantitatively predicting biological behavior hinder our efforts to engine... more Current limitations in quantitatively predicting biological behavior hinder our efforts to engineer biological systems to produce biofuels and other desired chemicals. Here, we present a new method for calculating metabolic fluxes, key targets in metabolic engineering, that incorporates data from 13C labeling experiments and genome-scale models. The data from 13C labeling experiments provide strong flux constraints that eliminate the need to assume an evolutionary optimization principle such as the growth rate optimization assumption used in Flux Balance Analysis (FBA). This effective constraining is achieved by making the simple but biologically relevant assumption that flux flows from core to peripheral metabolism and does not flow back. The new method is significantly more robust than FBA with respect to errors in genome-scale model reconstruction. Furthermore, it can provide a comprehensive picture of metabolite balancing and predictions for unmeasured extracellular fluxes as co...
Baba et al., 2006T. Baba, T. Ara, M. Hasegawa, Y. Takai, Y. Okumura, M. Baba, KA Datsenko, M. Tom... more Baba et al., 2006T. Baba, T. Ara, M. Hasegawa, Y. Takai, Y. Okumura, M. Baba, KA Datsenko, M. Tomita, BL Warmer and H. Mori, Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection, Mol Syst Biol. 2 (2006) 2006 ...
2008 IEEE International Conference on Bioinformatics and Biomeidcine Workshops, 2008
Abstract The size of publication databases in biomedicine (eg, PubMed, MEDLINE) are growing rapid... more Abstract The size of publication databases in biomedicine (eg, PubMed, MEDLINE) are growing rapidly every year, as are public databases of experimental biological data and annotations derived from the data. Publications often contain evidence that confirms or ...
The title compound arises from an unexpected rearrangement and oxidation. The molecules contain a... more The title compound arises from an unexpected rearrangement and oxidation. The molecules contain a center of symmetry and are held together by hydrogen bonds. The relatively strainfree molecules are closely packed with a density of 1.441 g cm Ϫ3. The compound crystallizes in space group P-1 with cell dimensions a ϭ 8.999(3), b ϭ 9.142(2), c ϭ 8.625(3) Å , Ͱ ϭ 95.47(3), ͱ ϭ 105.06(3), and Ͳ ϭ 83.08(2)Њ There are two independent molecules per cell with each sitting on a center of symmetry.
Imino sugar compound 3 was prepared by two alternative routes starting from ribose and D-serine. ... more Imino sugar compound 3 was prepared by two alternative routes starting from ribose and D-serine. From D-serine (3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methylpyrrolidin-2-one was prepared in five steps in 50% overall yield, which was further converted into (2R,3R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-3,4-diol in three steps in 23% overall yield.
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Papers by vinay kumar