An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
R factor = 0.047; wR factor = 0.134; data-to-parameter ratio = 13.0. The title compound, C16H16N2... more R factor = 0.047; wR factor = 0.134; data-to-parameter ratio = 13.0. The title compound, C16H16N2O2, was synthesized using a novel tandem annulation reaction between 1-(1H-benzo[d]i-]imidazol-2-yl)ethanone and ethyl (E)-4-bromobut-2-enoate under mild conditions. The dihedral angles formed by the mean plane of the five-membered imidazole ring with the dihydropyridin and benzene rings are 1.54 (9) and 1.85 (9), respectively. Related literature For the synthesis and characterization of pyrido[1,2-a]benz-
Abstract Baicalein is an important flavonoid compound extracted from the roots of Scutellaria bai... more Abstract Baicalein is an important flavonoid compound extracted from the roots of Scutellaria baicalensis. The interaction between baicalein and DPPC liposomes has been studied by differential scanning calorimetry, synchrotron X-ray diffraction and Fourier transform infrared spectroscopy. The results showed the phase states of liposomes change under the disturbance of baicalein. When the molar percentage of baicalein (x) is not more than 5%, the baicalein molecules promote the hydration degree of the head groups. At x=5%, the liposomes undergo a change from Lβ′ to Lβ phase. When x is between 5% and 10%, the liposomes are in Pβ′ phase. When x is more than 10%, the baicalein molecules alter the hydration state of head groups. Meanwhile, the phase states shift from Pβ′ to Pβ. This study is of great significance to further study the interaction between drugs and biomimetic membranes and to further investigate the phase transition mechanisms of DPPC liposome.
A novel tetracycline (TC) imprinted polymer was prepared in visible light via synergy of dual fun... more A novel tetracycline (TC) imprinted polymer was prepared in visible light via synergy of dual functional group monomers methacrylic acid (MAA) and itaconic acid (IA) for selective detection of TC in urine and milk samples.
Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease worldwide. ... more Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease worldwide. ω3-Fatty acids (ω3FAs) were found to attenuate kidney inflammation, glomerulosclerosis, and albuminuria in experimental and clinical studies of DN. As G protein-coupled receptor 120 (GPR120) was firstly identified as the receptor of ω3FAs, we here investigated the function of GPR120 in DN. We first examined the renal biopsies of DN patients, and found that GPR120 expression was negatively correlated with the progression of DN. Immunofluorescence staining analysis revealed that GPR120 protein was mainly located in the podocytes of the glomerulus. A potent and selective GPR120 agonist TUG-891 (35 mg • kg −1 • d −1 , ig) was administered to db/db mice for 4 weeks. We showed that TUG-891 administration significantly improved urinary albumin excretion, protected against podocyte injury, and reduced collagen deposition in the glomerulus. In db/db mice, TUG-891 administration significantly inhibited the mRNA and protein expression of fibronectin, collagen IV, α-SMA, TGF-β1, and IL-6, and downregulated the phosphorylation of Smad3 and STAT3 to alleviate glomerulosclerosis. Similar results were observed in high-glucose-treated MPC5 podocytes in the presence of TUG-891 (10 μM). Furthermore, we showed that TUG-891 effectively upregulated GPR120 expression, and suppressed TAK1-binding protein-1 expression as well as the phosphorylation of TAK1, IKKβ, NF-κB p65, JNK, and p38 MAPK in db/db mice and high-glucose-treated MPC5 podocytes. Knockdown of GPR120 in MPC5 podocytes caused the opposite effects of TUG-891. In summary, our results highlight that activation of GPR120 in podocytes ameliorates renal inflammation and fibrosis to protect against DN.
Differential scanning calorimetry and synchrotron X-ray diffraction techniques have been employed... more Differential scanning calorimetry and synchrotron X-ray diffraction techniques have been employed to investigate the interaction of paeonol with DPPC liposomes and to investigate the location of paeonol molecules in liposomes. The results showed that the location of the paeonol molecules in liposomes is concentration dependent. When the concentration of the paeonol is not more than 5 mol%, both main transition temperature and transition enthalpy of liposomes decrease with increasing the concentration of paeonol, indicating that paeonol molecules incorporate into the hydrophobic region of DPPC molecules. When the concentration of the paeonol is between 5 and 15 mol%, additional paeonol molecules will incorporate into the hydrophilic region of the DPPC molecules and interact with its polar groups, resulting in an increase tendency of the main transition enthalpy. When the concentration of the paeonol is more than 15 mol%, both main transition temperature and transition enthalpy of liposomes decrease with increasing the concentration of paeonol, indicating that the additional paeonol molecules locate at the region of hydrocarbon chains of DPPC again. Calorimetric data show that the main transition temperature of all paeonol/DPPC liposomes is lower than that of pure DPPC liposomes but the enthalpy of liposomes containing more than 10 mol% paeonol is higher than that of pure DPPC liposome, which is related to the nonsynchronous change of the head and tail part of DPPC molecules during the main transition. This study will play an important role in the further investigation of interaction of drugs with biomimetic membranes and in the further study of phase transition mechanisms of DPPC liposome.
Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequ... more Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequency, it is not clear whether this is because of altered hemodynamics caused by the effects of matrix metalloproteinases (MMPs) and/or vertebral artery dominance (VAD). Therefore, we investigate the relationship between plasma levels of MMPs and VBE in patients with vertigo or dizziness who also have vascular risk factors, in order to determine whether high levels of MMPs in VBE are independent of VAD. Methods: We prospectively studied 285 patients with vertigo or dizziness and at least one vascular risk factor. Plasma levels of MMPs, tissue inhibitor of metalloproteinases (TIMPs) and cathepsin L were measured. Subjects were classified as VBE-negative or VBE-positive, who were further classified based on the presence of VAD with magnetic resonance angiography. Acute ischemic stroke was screened by diffusion-weighted imaging, generally after bedside evaluation and the drawing of blood samples. Receiver operating characteristic (ROC) curves were applied to evaluate the utility of these potential biomarkers in predicting risk for ischemic stroke. Results: The prevalence of VBE in patients with vertigo or dizziness was 16.5%. Of the 82 patients with ischemic stroke, 14 strokes involved the cortex or subcortex. MMP-9 levels were significantly higher in the VBE-positive group than in the VBE-negative group (P = 0.022). There was a significant difference in the risk of posterior circulation ischemic stroke between the VBE-positive group and the VBE-negative group (P = 0.002). Levels of MMP-2 and cathepsin L tended to be higher in the VBE-negative group (P = 0.054, P = 0.060, respectively). Compared with the non-VAD subgroup, levels of MMP-2,−3,−9, TIMP-1,−2, and cathepsin L were similar in the VAD subgroup. ROC analysis showed that MMP-9 predicted risk for ischemic stroke (AUC = 0.582, 95%CI, 0.510-0.654, P = 0.030). Zhang et al. MMP-9 Is Associated With Vertebrobasilar Ectasia Conclusions: MMP-9 was associated with VBE and independent of VAD. High levels of MMP-9 may predict risk for ischemic stroke in patients with vertigo or dizziness who also have vascular risk factors.
This is a repository copy of Untangling the integration-performance link: levels of integration a... more This is a repository copy of Untangling the integration-performance link: levels of integration and functional integration strategies in post-acquisition integration.
IOP Conference Series: Materials Science and Engineering, 2019
Reversible addition-fragmentation chain transfer (RAFT) polymerization mechanism was used for the... more Reversible addition-fragmentation chain transfer (RAFT) polymerization mechanism was used for the preparation of molecularly imprinted polymers (MIPs) film using 4-cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid (CDTPA) as chain transfer reagent and visible light initiator. In addition, the effect of CDTPA concentration on the polymerization rate was monitored, establishing that too high CDTPA concentration would inhibit the polymerization rate. The MIPs film was characterized by contact angle measurement, frontier transfer infrared spectroscopy (FTIR) and scanning electron microscope (SEM) which showed the successful grafting of MIPs films onto surface plasmon resonance (SPR) sensor chip. The response of progesterone sensing ranged from 10−16 to 10−6mol/L with low detection limit of 1× 10−16mol/L in PBS buffer (pH 7.4) and the MIPs film exhibited good selectivity, reproducibility and stability. Moreover, the sensors had been successfully applied to detect progesterone...
Background and Purpose: To test the hypothesis that the imbalance between matrix metalloproteinas... more Background and Purpose: To test the hypothesis that the imbalance between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may play a potential role in bridging vertebrobasilar dolichoectasia (VBD) with lacunar infarction (LI) and white matter hyperintensities (WMH). Methods: We studied 212 patients with vertigo who underwent multimodal magnetic resonance imaging (MRI) tests for VBD, LI, and WMH identification. We investigated biomarkers of VBD with magnetic resonance angiography (MRA) via various physical characteristics of the vertebrobasilar arteries (VBAs). Similarly, LI and WMH biomarkers were extracted using T2-weighted and fluid attenuated inversion recovery (FLAIR) images. We first determined which of these neuroimaging markers were significant identifiers of VBD, LI and the different grades of WMH. We then sought to draw potential mechanistic conclusions from these MRI-derived parameters, by associating the aforementioned biomarkers with MMP and TIMP serum levels in patient blood samples using non-parametric statistical tests. Results: MMP-9 serum level was significantly higher in vertigo patients with VBAs dilation and basilar artery (BA) elongation compared to those with healthy arterial size, and the ratio of MMP-9/TIMP-1 level were higher in those patients. TIMP-1 level was also markedly higher in vertigo patients with BA tortuosity than those without BA tortuosity. The bending length (BL) of the BA was positively correlated with TIMP-1. The length, BL, and tortuosity index of the BA, as well as serum levels of TIMP-1 were greater in patients with higher WMH grades compared to those with low WMH grades. The vertebral artery and BA diameters, and the levels of MMP-2,-3,-9, TIMP-2 and cathepsin L were similar in patients with different WMH grades. Conclusion: In vertigo patients, we found various probably associations between MMP-9 and TIMP-1 with arterial alterations linked to both VBD and WMH that may help with the diagnosis and treatment of such diseases in the future.
IOP Conference Series: Earth and Environmental Science, 2019
In this work, a hydrophilic and high sensitivity sensor was fabricated based on BMS (MAA : HEMA =... more In this work, a hydrophilic and high sensitivity sensor was fabricated based on BMS (MAA : HEMA = 3 : 1, molar ratio) molecularly imprinted polymers (MIPs) film for 17β-estradiol (E2) detection in aqueous media combined with surface plasmon resonance (SPR) technique. In-situ UV polymerization method was used to synthesize the MIPs film on the gold surface which was modified with dodecyl mercaptan. Afterwards, the MIPs film was characterized by infrared spectroscopy (IR), scanning electron microscope (SEM) and contact angle measurements. The results showed that the MIPs film was successfully prepared on the surface of the sensor chip with good hydrophilicity and permeability. The analysis of SPR spectroscopy indicated that the MIPs film displayed greater selectivity to E2 than other competitors and non-imprinted polymers (NIPs) film and showed better adsorption performance than one kind of monomer for the same E2 concentration. The response of E2 sensor ranged from 2.5×10−16 to 2.5×1...
International Studies of Management & Organization, 2019
This study examines the relationship between foreign ownership and External Knowledge Acquisition... more This study examines the relationship between foreign ownership and External Knowledge Acquisition (EKA) in China, and posits that international subsidiaries and local firms exhibit different rationales with regard to EKA. Using nationwide enterprise survey data on 320 Chinese firms, this study tests a model developed from resource dependency theory and institutional theory. We find that foreign ownership positively affects EKA, and that this relationship is moderated by both institution legislation hazards and contract enforcement hazards but with contrasting effects: the positive moderation of the former but the negative one of the latter. This study also provides important implications for the managers of international subsidiaries and local firms regarding their knowledge acquisition strategies.
The subduction history of the Neo-Tethys is critical for understanding the early-stage tectonic e... more The subduction history of the Neo-Tethys is critical for understanding the early-stage tectonic evolution of the Qinghai-Tibetan Plateau. Arc volcanics, which usually record the subduction process, thus can help trace the evolution of the Neo-Tethys. In this paper, we report for the first time zircon LA-ICP-MS U-Pb ages, whole-rock major and trace element geochemistry, as well as Sr-Nd-Hf isotopic data for the volcanic rocks from the Danshiting Formation at the southern edge of the Lhasa Terrane. Two samples collected from the Danshiting Formation volcanic rocks yield zircon U-Pb ages of 97.1 ± 0.8 Ma and 90.1 ± 0.7 Ma, respectively. The volcanic rocks of the Danshiting Formation are composed dominantly of basalts and andesites characterized by depletion of high-field-strength elements, low (87 Sr/ 86 Sr) i ratios (0.7042-0.7045), high ε Nd (t) (+2.1 to +2.7) and high ε Hf (t) values (mean +11.6). These rocks show geochemical affinity of arc volcanic rocks. The volcanic rocks of the Danshiting Formation may have formed during the northward subduction of the Neo-Tethys. This paper, combined with the previous data, briefly divide the northward subduction of the Neo-Tethys into four periods: the Jurassic (195-150 Ma), when the magmatic activity was controlled by the northward high-angle subduction of the Neo-Tethys that produced volcanics of the Yeba and Bima formations; the Late Jurassic to Early Cretaceous (150-110 Ma), when the Neo-Tethys subducted at low-angles; the Late Cretaceous (110-80 Ma), when subduction was of the Andean-type and produced volcanic rocks of the Danshiting Formation; the Paleogene (70-40 Ma), when there was transition from ocean-to-continent subduction to continent-continent collision that produced volcanic rocks of the Linzizong Group.
Highlights BODIPY®507/545 IA is firstly used as a derivatization reagent of small thiols. Thi... more Highlights BODIPY®507/545 IA is firstly used as a derivatization reagent of small thiols. This study combines a HPLC-FLD method with in-situ cell imaging for thiols.
Like DIP-STR markers (deletion/insertion polymorphism-short tandem repeat combinations), SNP-STR ... more Like DIP-STR markers (deletion/insertion polymorphism-short tandem repeat combinations), SNP-STR markers (single nucleotide polymorphism-STR combinations) are also valuable in forensic DNA mixture analysis. In this study, eight SNP-STRs were selected, and a stable and sensitive multiplex polymerase chain reaction (PCR) assay was developed for amplifying these SNP-STRs and the Amelogenin gender marker according to the principle of amplification refractory mutation system (ARMS). This novel multiplex set allows detection of the minor DNA contributor in a DNA mixture of any gender and cellular origin with high resolution (beyond a DNA ratio of 1:20). In addition, SNP-STR haplotype frequencies were estimated based on a survey of 350 unrelated individuals from Chinese Han population, and the combined power of discrimination (PD) and power of exclusion (PE) of the eight SNP-STRs were calculated as 0.99999999965 and 0.9996, which were obviously higher than that of the eight STR loci: 0.999...
Melanoma is one of the most fatal and therapy-resistant types of cancer; therefore, identifying n... more Melanoma is one of the most fatal and therapy-resistant types of cancer; therefore, identifying novel therapeutic candidates to improve patient survival is an ongoing effort. Previous studies have revealed that pimozide is not sufficient to treat melanoma; therefore, enhancing the treatment is necessary. Indoleamine 2, 3‑dioxygenase (IDO) is an immunosuppressive, intracellular rate-limiting enzyme, which contributes to immune tolerance in various tumours, including melanoma, and inhibition of IDO may be considered a novel therapeutic strategy when combined with pimozide. The present study aimed to assess the antitumour activities of pimozide in vitro, and to investigate the effects of pimozide combined with L‑methyl-tryptophan (L‑MT) in vivo. For in vitro analyses, the B16 melanoma cell line was used. Cell cytotoxicity assay, cell viability assay, wound‑healing assay and western blotting were conducted to analyse the effects of pimozide on B16 cells. Furthermore, B16 cell-bearing mi...
We characterised wool traits, and skin gene expression profiles of fine wool Super Merino (SM) an... more We characterised wool traits, and skin gene expression profiles of fine wool Super Merino (SM) and coarse wool Small Tail Han (STH) sheep. SM sheep had a significantly higher total density of wool follicles, heavier fleeces, finer fibre diameter, and increased crimp frequency, staple length and wool grease (lanolin) production. We found 435 genes were expressed at significantly different levels in the skin of the two breeds (127 genes more highly in SM and 308 genes more highly in STH sheep). Classification of the genes more highly expressed in SM sheep revealed numerous lipid metabolic genes as well as genes encoding keratins, keratin-associated proteins, and wool follicle stem cell markers. In contrast, mammalian epidermal development complex genes and other genes associated with skin cornification and muscle function were more highly expressed in STH sheep. Genes identified in this study may be further evaluated for inclusion in breeding programs, or as targets for therapeutic or...
Considering the self-fields of relativistic electron beam (REB), the electron beam injected in pl... more Considering the self-fields of relativistic electron beam (REB), the electron beam injected in plasma will form an ion-channel, which can stably guide REB transmitted in plasma. Based on the effect of ion-channel, the EM dispersion characteristics in a dielectric waveguide filled with plasmas is studied by using linear electromagnetic (EM) hydrodynamics perturbation theory. Both the TM mode dispersion equation and the dispersion relation are derived. After that, a discussion on the conditions of Cherenkov radiation in this system is given. It was found that the betatron oscillation of the REB is one of the important factors for the slow-wave EM instability in this system. The dispersion relation is of the form of electromagnetic-electrostatic (EM-ES) hybrid mode, which is different from the case where the effect of the ion channel is neglected.
In the modern society, with the rapid development of industrial technology and information indust... more In the modern society, with the rapid development of industrial technology and information industry, electrical loads become more and more complex. As a result, the harmonics and reactive power problems have become increasingly serious. In the non-sinusoidal conditions, conventional power definitions don’t work well any more. Power theory is one of the foundations of financial accounts for energy, evaluation of the efficiency of power transmission and control of current compensation. Among them, the instantaneous reactive power theory is regarded as one of the most promising power theories. What’s more, it has been improved. Based on the three-phase three-wire system and four kinds of different supply voltage conditions, this paper compares the instantaneous reactive power theory (pq theory) with the extension pq theory. At last, the simulation results are presented. As a conclusion, the extension pq theory is the improvement of the pq theory and has a wider applicability.
By synthesizing two complementary theoretical perspectivesresource dependence theory (RDT) and th... more By synthesizing two complementary theoretical perspectivesresource dependence theory (RDT) and the resource-based view (RBV)this study explores why acquirers destroy the acquisition value in international acquisitions in high-technology industries. Using a multiple case study approach, we develop a two by three matrix to present the sources of value destruction from two dimensions: environment dynamics and strategic resources, which are drawn from the RDT and RBV, respectively. Our study contributes to the acquisition literature in three respects. First, it answers the call to integrate several theoretical perspectives to examine sources of value destruction, particularly in international acquisitions. Second, it attempts to unlock the black box of why value destruction exists in post-acquisition integration. Third, it advances understanding of the basis of value destruction in terms of non-financial measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
R factor = 0.047; wR factor = 0.134; data-to-parameter ratio = 13.0. The title compound, C16H16N2... more R factor = 0.047; wR factor = 0.134; data-to-parameter ratio = 13.0. The title compound, C16H16N2O2, was synthesized using a novel tandem annulation reaction between 1-(1H-benzo[d]i-]imidazol-2-yl)ethanone and ethyl (E)-4-bromobut-2-enoate under mild conditions. The dihedral angles formed by the mean plane of the five-membered imidazole ring with the dihydropyridin and benzene rings are 1.54 (9) and 1.85 (9), respectively. Related literature For the synthesis and characterization of pyrido[1,2-a]benz-
Abstract Baicalein is an important flavonoid compound extracted from the roots of Scutellaria bai... more Abstract Baicalein is an important flavonoid compound extracted from the roots of Scutellaria baicalensis. The interaction between baicalein and DPPC liposomes has been studied by differential scanning calorimetry, synchrotron X-ray diffraction and Fourier transform infrared spectroscopy. The results showed the phase states of liposomes change under the disturbance of baicalein. When the molar percentage of baicalein (x) is not more than 5%, the baicalein molecules promote the hydration degree of the head groups. At x=5%, the liposomes undergo a change from Lβ′ to Lβ phase. When x is between 5% and 10%, the liposomes are in Pβ′ phase. When x is more than 10%, the baicalein molecules alter the hydration state of head groups. Meanwhile, the phase states shift from Pβ′ to Pβ. This study is of great significance to further study the interaction between drugs and biomimetic membranes and to further investigate the phase transition mechanisms of DPPC liposome.
A novel tetracycline (TC) imprinted polymer was prepared in visible light via synergy of dual fun... more A novel tetracycline (TC) imprinted polymer was prepared in visible light via synergy of dual functional group monomers methacrylic acid (MAA) and itaconic acid (IA) for selective detection of TC in urine and milk samples.
Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease worldwide. ... more Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease worldwide. ω3-Fatty acids (ω3FAs) were found to attenuate kidney inflammation, glomerulosclerosis, and albuminuria in experimental and clinical studies of DN. As G protein-coupled receptor 120 (GPR120) was firstly identified as the receptor of ω3FAs, we here investigated the function of GPR120 in DN. We first examined the renal biopsies of DN patients, and found that GPR120 expression was negatively correlated with the progression of DN. Immunofluorescence staining analysis revealed that GPR120 protein was mainly located in the podocytes of the glomerulus. A potent and selective GPR120 agonist TUG-891 (35 mg • kg −1 • d −1 , ig) was administered to db/db mice for 4 weeks. We showed that TUG-891 administration significantly improved urinary albumin excretion, protected against podocyte injury, and reduced collagen deposition in the glomerulus. In db/db mice, TUG-891 administration significantly inhibited the mRNA and protein expression of fibronectin, collagen IV, α-SMA, TGF-β1, and IL-6, and downregulated the phosphorylation of Smad3 and STAT3 to alleviate glomerulosclerosis. Similar results were observed in high-glucose-treated MPC5 podocytes in the presence of TUG-891 (10 μM). Furthermore, we showed that TUG-891 effectively upregulated GPR120 expression, and suppressed TAK1-binding protein-1 expression as well as the phosphorylation of TAK1, IKKβ, NF-κB p65, JNK, and p38 MAPK in db/db mice and high-glucose-treated MPC5 podocytes. Knockdown of GPR120 in MPC5 podocytes caused the opposite effects of TUG-891. In summary, our results highlight that activation of GPR120 in podocytes ameliorates renal inflammation and fibrosis to protect against DN.
Differential scanning calorimetry and synchrotron X-ray diffraction techniques have been employed... more Differential scanning calorimetry and synchrotron X-ray diffraction techniques have been employed to investigate the interaction of paeonol with DPPC liposomes and to investigate the location of paeonol molecules in liposomes. The results showed that the location of the paeonol molecules in liposomes is concentration dependent. When the concentration of the paeonol is not more than 5 mol%, both main transition temperature and transition enthalpy of liposomes decrease with increasing the concentration of paeonol, indicating that paeonol molecules incorporate into the hydrophobic region of DPPC molecules. When the concentration of the paeonol is between 5 and 15 mol%, additional paeonol molecules will incorporate into the hydrophilic region of the DPPC molecules and interact with its polar groups, resulting in an increase tendency of the main transition enthalpy. When the concentration of the paeonol is more than 15 mol%, both main transition temperature and transition enthalpy of liposomes decrease with increasing the concentration of paeonol, indicating that the additional paeonol molecules locate at the region of hydrocarbon chains of DPPC again. Calorimetric data show that the main transition temperature of all paeonol/DPPC liposomes is lower than that of pure DPPC liposomes but the enthalpy of liposomes containing more than 10 mol% paeonol is higher than that of pure DPPC liposome, which is related to the nonsynchronous change of the head and tail part of DPPC molecules during the main transition. This study will play an important role in the further investigation of interaction of drugs with biomimetic membranes and in the further study of phase transition mechanisms of DPPC liposome.
Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequ... more Background and Purpose: Although vertebrobasilar ectasia (VBE) is diagnosed with increasing frequency, it is not clear whether this is because of altered hemodynamics caused by the effects of matrix metalloproteinases (MMPs) and/or vertebral artery dominance (VAD). Therefore, we investigate the relationship between plasma levels of MMPs and VBE in patients with vertigo or dizziness who also have vascular risk factors, in order to determine whether high levels of MMPs in VBE are independent of VAD. Methods: We prospectively studied 285 patients with vertigo or dizziness and at least one vascular risk factor. Plasma levels of MMPs, tissue inhibitor of metalloproteinases (TIMPs) and cathepsin L were measured. Subjects were classified as VBE-negative or VBE-positive, who were further classified based on the presence of VAD with magnetic resonance angiography. Acute ischemic stroke was screened by diffusion-weighted imaging, generally after bedside evaluation and the drawing of blood samples. Receiver operating characteristic (ROC) curves were applied to evaluate the utility of these potential biomarkers in predicting risk for ischemic stroke. Results: The prevalence of VBE in patients with vertigo or dizziness was 16.5%. Of the 82 patients with ischemic stroke, 14 strokes involved the cortex or subcortex. MMP-9 levels were significantly higher in the VBE-positive group than in the VBE-negative group (P = 0.022). There was a significant difference in the risk of posterior circulation ischemic stroke between the VBE-positive group and the VBE-negative group (P = 0.002). Levels of MMP-2 and cathepsin L tended to be higher in the VBE-negative group (P = 0.054, P = 0.060, respectively). Compared with the non-VAD subgroup, levels of MMP-2,−3,−9, TIMP-1,−2, and cathepsin L were similar in the VAD subgroup. ROC analysis showed that MMP-9 predicted risk for ischemic stroke (AUC = 0.582, 95%CI, 0.510-0.654, P = 0.030). Zhang et al. MMP-9 Is Associated With Vertebrobasilar Ectasia Conclusions: MMP-9 was associated with VBE and independent of VAD. High levels of MMP-9 may predict risk for ischemic stroke in patients with vertigo or dizziness who also have vascular risk factors.
This is a repository copy of Untangling the integration-performance link: levels of integration a... more This is a repository copy of Untangling the integration-performance link: levels of integration and functional integration strategies in post-acquisition integration.
IOP Conference Series: Materials Science and Engineering, 2019
Reversible addition-fragmentation chain transfer (RAFT) polymerization mechanism was used for the... more Reversible addition-fragmentation chain transfer (RAFT) polymerization mechanism was used for the preparation of molecularly imprinted polymers (MIPs) film using 4-cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid (CDTPA) as chain transfer reagent and visible light initiator. In addition, the effect of CDTPA concentration on the polymerization rate was monitored, establishing that too high CDTPA concentration would inhibit the polymerization rate. The MIPs film was characterized by contact angle measurement, frontier transfer infrared spectroscopy (FTIR) and scanning electron microscope (SEM) which showed the successful grafting of MIPs films onto surface plasmon resonance (SPR) sensor chip. The response of progesterone sensing ranged from 10−16 to 10−6mol/L with low detection limit of 1× 10−16mol/L in PBS buffer (pH 7.4) and the MIPs film exhibited good selectivity, reproducibility and stability. Moreover, the sensors had been successfully applied to detect progesterone...
Background and Purpose: To test the hypothesis that the imbalance between matrix metalloproteinas... more Background and Purpose: To test the hypothesis that the imbalance between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may play a potential role in bridging vertebrobasilar dolichoectasia (VBD) with lacunar infarction (LI) and white matter hyperintensities (WMH). Methods: We studied 212 patients with vertigo who underwent multimodal magnetic resonance imaging (MRI) tests for VBD, LI, and WMH identification. We investigated biomarkers of VBD with magnetic resonance angiography (MRA) via various physical characteristics of the vertebrobasilar arteries (VBAs). Similarly, LI and WMH biomarkers were extracted using T2-weighted and fluid attenuated inversion recovery (FLAIR) images. We first determined which of these neuroimaging markers were significant identifiers of VBD, LI and the different grades of WMH. We then sought to draw potential mechanistic conclusions from these MRI-derived parameters, by associating the aforementioned biomarkers with MMP and TIMP serum levels in patient blood samples using non-parametric statistical tests. Results: MMP-9 serum level was significantly higher in vertigo patients with VBAs dilation and basilar artery (BA) elongation compared to those with healthy arterial size, and the ratio of MMP-9/TIMP-1 level were higher in those patients. TIMP-1 level was also markedly higher in vertigo patients with BA tortuosity than those without BA tortuosity. The bending length (BL) of the BA was positively correlated with TIMP-1. The length, BL, and tortuosity index of the BA, as well as serum levels of TIMP-1 were greater in patients with higher WMH grades compared to those with low WMH grades. The vertebral artery and BA diameters, and the levels of MMP-2,-3,-9, TIMP-2 and cathepsin L were similar in patients with different WMH grades. Conclusion: In vertigo patients, we found various probably associations between MMP-9 and TIMP-1 with arterial alterations linked to both VBD and WMH that may help with the diagnosis and treatment of such diseases in the future.
IOP Conference Series: Earth and Environmental Science, 2019
In this work, a hydrophilic and high sensitivity sensor was fabricated based on BMS (MAA : HEMA =... more In this work, a hydrophilic and high sensitivity sensor was fabricated based on BMS (MAA : HEMA = 3 : 1, molar ratio) molecularly imprinted polymers (MIPs) film for 17β-estradiol (E2) detection in aqueous media combined with surface plasmon resonance (SPR) technique. In-situ UV polymerization method was used to synthesize the MIPs film on the gold surface which was modified with dodecyl mercaptan. Afterwards, the MIPs film was characterized by infrared spectroscopy (IR), scanning electron microscope (SEM) and contact angle measurements. The results showed that the MIPs film was successfully prepared on the surface of the sensor chip with good hydrophilicity and permeability. The analysis of SPR spectroscopy indicated that the MIPs film displayed greater selectivity to E2 than other competitors and non-imprinted polymers (NIPs) film and showed better adsorption performance than one kind of monomer for the same E2 concentration. The response of E2 sensor ranged from 2.5×10−16 to 2.5×1...
International Studies of Management & Organization, 2019
This study examines the relationship between foreign ownership and External Knowledge Acquisition... more This study examines the relationship between foreign ownership and External Knowledge Acquisition (EKA) in China, and posits that international subsidiaries and local firms exhibit different rationales with regard to EKA. Using nationwide enterprise survey data on 320 Chinese firms, this study tests a model developed from resource dependency theory and institutional theory. We find that foreign ownership positively affects EKA, and that this relationship is moderated by both institution legislation hazards and contract enforcement hazards but with contrasting effects: the positive moderation of the former but the negative one of the latter. This study also provides important implications for the managers of international subsidiaries and local firms regarding their knowledge acquisition strategies.
The subduction history of the Neo-Tethys is critical for understanding the early-stage tectonic e... more The subduction history of the Neo-Tethys is critical for understanding the early-stage tectonic evolution of the Qinghai-Tibetan Plateau. Arc volcanics, which usually record the subduction process, thus can help trace the evolution of the Neo-Tethys. In this paper, we report for the first time zircon LA-ICP-MS U-Pb ages, whole-rock major and trace element geochemistry, as well as Sr-Nd-Hf isotopic data for the volcanic rocks from the Danshiting Formation at the southern edge of the Lhasa Terrane. Two samples collected from the Danshiting Formation volcanic rocks yield zircon U-Pb ages of 97.1 ± 0.8 Ma and 90.1 ± 0.7 Ma, respectively. The volcanic rocks of the Danshiting Formation are composed dominantly of basalts and andesites characterized by depletion of high-field-strength elements, low (87 Sr/ 86 Sr) i ratios (0.7042-0.7045), high ε Nd (t) (+2.1 to +2.7) and high ε Hf (t) values (mean +11.6). These rocks show geochemical affinity of arc volcanic rocks. The volcanic rocks of the Danshiting Formation may have formed during the northward subduction of the Neo-Tethys. This paper, combined with the previous data, briefly divide the northward subduction of the Neo-Tethys into four periods: the Jurassic (195-150 Ma), when the magmatic activity was controlled by the northward high-angle subduction of the Neo-Tethys that produced volcanics of the Yeba and Bima formations; the Late Jurassic to Early Cretaceous (150-110 Ma), when the Neo-Tethys subducted at low-angles; the Late Cretaceous (110-80 Ma), when subduction was of the Andean-type and produced volcanic rocks of the Danshiting Formation; the Paleogene (70-40 Ma), when there was transition from ocean-to-continent subduction to continent-continent collision that produced volcanic rocks of the Linzizong Group.
Highlights BODIPY®507/545 IA is firstly used as a derivatization reagent of small thiols. Thi... more Highlights BODIPY®507/545 IA is firstly used as a derivatization reagent of small thiols. This study combines a HPLC-FLD method with in-situ cell imaging for thiols.
Like DIP-STR markers (deletion/insertion polymorphism-short tandem repeat combinations), SNP-STR ... more Like DIP-STR markers (deletion/insertion polymorphism-short tandem repeat combinations), SNP-STR markers (single nucleotide polymorphism-STR combinations) are also valuable in forensic DNA mixture analysis. In this study, eight SNP-STRs were selected, and a stable and sensitive multiplex polymerase chain reaction (PCR) assay was developed for amplifying these SNP-STRs and the Amelogenin gender marker according to the principle of amplification refractory mutation system (ARMS). This novel multiplex set allows detection of the minor DNA contributor in a DNA mixture of any gender and cellular origin with high resolution (beyond a DNA ratio of 1:20). In addition, SNP-STR haplotype frequencies were estimated based on a survey of 350 unrelated individuals from Chinese Han population, and the combined power of discrimination (PD) and power of exclusion (PE) of the eight SNP-STRs were calculated as 0.99999999965 and 0.9996, which were obviously higher than that of the eight STR loci: 0.999...
Melanoma is one of the most fatal and therapy-resistant types of cancer; therefore, identifying n... more Melanoma is one of the most fatal and therapy-resistant types of cancer; therefore, identifying novel therapeutic candidates to improve patient survival is an ongoing effort. Previous studies have revealed that pimozide is not sufficient to treat melanoma; therefore, enhancing the treatment is necessary. Indoleamine 2, 3‑dioxygenase (IDO) is an immunosuppressive, intracellular rate-limiting enzyme, which contributes to immune tolerance in various tumours, including melanoma, and inhibition of IDO may be considered a novel therapeutic strategy when combined with pimozide. The present study aimed to assess the antitumour activities of pimozide in vitro, and to investigate the effects of pimozide combined with L‑methyl-tryptophan (L‑MT) in vivo. For in vitro analyses, the B16 melanoma cell line was used. Cell cytotoxicity assay, cell viability assay, wound‑healing assay and western blotting were conducted to analyse the effects of pimozide on B16 cells. Furthermore, B16 cell-bearing mi...
We characterised wool traits, and skin gene expression profiles of fine wool Super Merino (SM) an... more We characterised wool traits, and skin gene expression profiles of fine wool Super Merino (SM) and coarse wool Small Tail Han (STH) sheep. SM sheep had a significantly higher total density of wool follicles, heavier fleeces, finer fibre diameter, and increased crimp frequency, staple length and wool grease (lanolin) production. We found 435 genes were expressed at significantly different levels in the skin of the two breeds (127 genes more highly in SM and 308 genes more highly in STH sheep). Classification of the genes more highly expressed in SM sheep revealed numerous lipid metabolic genes as well as genes encoding keratins, keratin-associated proteins, and wool follicle stem cell markers. In contrast, mammalian epidermal development complex genes and other genes associated with skin cornification and muscle function were more highly expressed in STH sheep. Genes identified in this study may be further evaluated for inclusion in breeding programs, or as targets for therapeutic or...
Considering the self-fields of relativistic electron beam (REB), the electron beam injected in pl... more Considering the self-fields of relativistic electron beam (REB), the electron beam injected in plasma will form an ion-channel, which can stably guide REB transmitted in plasma. Based on the effect of ion-channel, the EM dispersion characteristics in a dielectric waveguide filled with plasmas is studied by using linear electromagnetic (EM) hydrodynamics perturbation theory. Both the TM mode dispersion equation and the dispersion relation are derived. After that, a discussion on the conditions of Cherenkov radiation in this system is given. It was found that the betatron oscillation of the REB is one of the important factors for the slow-wave EM instability in this system. The dispersion relation is of the form of electromagnetic-electrostatic (EM-ES) hybrid mode, which is different from the case where the effect of the ion channel is neglected.
In the modern society, with the rapid development of industrial technology and information indust... more In the modern society, with the rapid development of industrial technology and information industry, electrical loads become more and more complex. As a result, the harmonics and reactive power problems have become increasingly serious. In the non-sinusoidal conditions, conventional power definitions don’t work well any more. Power theory is one of the foundations of financial accounts for energy, evaluation of the efficiency of power transmission and control of current compensation. Among them, the instantaneous reactive power theory is regarded as one of the most promising power theories. What’s more, it has been improved. Based on the three-phase three-wire system and four kinds of different supply voltage conditions, this paper compares the instantaneous reactive power theory (pq theory) with the extension pq theory. At last, the simulation results are presented. As a conclusion, the extension pq theory is the improvement of the pq theory and has a wider applicability.
By synthesizing two complementary theoretical perspectivesresource dependence theory (RDT) and th... more By synthesizing two complementary theoretical perspectivesresource dependence theory (RDT) and the resource-based view (RBV)this study explores why acquirers destroy the acquisition value in international acquisitions in high-technology industries. Using a multiple case study approach, we develop a two by three matrix to present the sources of value destruction from two dimensions: environment dynamics and strategic resources, which are drawn from the RDT and RBV, respectively. Our study contributes to the acquisition literature in three respects. First, it answers the call to integrate several theoretical perspectives to examine sources of value destruction, particularly in international acquisitions. Second, it attempts to unlock the black box of why value destruction exists in post-acquisition integration. Third, it advances understanding of the basis of value destruction in terms of non-financial measures.
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