Papers by stefania iannazzo
Additional file 2: Figure S2 Proportion of healthcare workers participating in the survey on anti... more Additional file 2: Figure S2 Proportion of healthcare workers participating in the survey on antibiotic use and antibiotic resistance, stratified by cluster and awareness of the Italian national Action Plan on antibiotic resistance, the European Awareness Antibiotic Day (EAAD) and Week (WAAW), Italy, 2019 (n = 1,693). *** p-values <0.001. Differential awareness of EAAD, WAAW and the national action plan on antibiotic resistance by the HCWs who participated in the ECDC survey on antibiotic use and antibiotic resistance.
Annali di igiene : medicina preventiva e di comunita, 2020
INTRODUCTION Despite continuing efforts, compliance rates and knowledge of best practices in hand... more INTRODUCTION Despite continuing efforts, compliance rates and knowledge of best practices in hand hygiene remain disappointing. Recognizing that conventional educational tools seem out of touch with young people and that the med and messages contents need refreshing, the Italian Study Group of Hospital Hygiene of the Italian Society of Hygiene, Preventive Medicine and Public Health devised a novel approach to promote the creation of innovative educational tools for improving knowledge of, and compliance with, hand hygiene rules among healthcare and medical students. METHODS A contest in creating educational material on hand hygiene practices involved university students of nursing and medicine, and of other healthcare degrees. Students from the universities of the GISIO network were invited to create educational material (e.g., videos, posters, presentations, leaflets, and screensavers) to be presented by May 5th 2019 during the World Hand Hygiene Day / Save Lives: Clean Your Hands ...
Annals of Microbiology, 2004
Forty-one water samples (dental unit waterlines, tap water, water tanks, boil- er) were collected... more Forty-one water samples (dental unit waterlines, tap water, water tanks, boil- er) were collected at six-month intervals for four times from a dental hospital in Rome and analysed for presence of Legionella, Pseudomonas, total cultivable flora (TVC, 37 and 22 °C). Legionella pneumophila serogroup 6 and Legionella micdadei were detected in summertime. Pseudomonas aeruginosa occurred more frequently in wintertime. These species were never detected at the same sampling occasion and site and their level was not correlated with TVC. A series of allogenic bacterial successions in the biofilm of the walls of the waterlines occurred, probably due to environmental changes.
Rivista italiana d'igiene, 2003
European Journal of Public Health, 2020
Background Measles is a highly contagious vaccine preventable disease that can lead to serious co... more Background Measles is a highly contagious vaccine preventable disease that can lead to serious complications, including death. All five regions of the World Health Organization have set targets to eliminate measles. In Italy, measles vaccination was introduced in 1976, with sustained low uptake in the 1980s and 1990s. Uptake improved in subsequent years but never reached 95% coverage required for elimination. Two doses of measles-mumps-rubella (MMR) vaccine are recommended (at 12-15 months and 5-6 years respectively). Since July 2017, MMR vaccine has become mandatory for all children up to 16 years of age. Large outbreaks continue to occur, with over 8.000 cases reported in 2017-2018. Methods We analysed measles cases reported to the national integrated measles and rubella surveillance system during January 1 - December 31, 2019. Results From 1 January to 31 December 2019, 1,627 cases (87% laboratory-confirmed), were reported from all 21 administrative regions. National incidence wa...
Igiene e sanita pubblica
Despite the WHO target for measles and rubella elimination in 2015, outbreaks still occur in all ... more Despite the WHO target for measles and rubella elimination in 2015, outbreaks still occur in all WHO Regions. After a description of the epidemiological situation of measles and rubella worldwide and especially in Europe, this paper aims to provide a detailed analysis of the current epidemiological context of Italy. The surge in the number of measles cases since the beginning of 2017, together with vaccination coverage still far from the 95% target, requires priority actions to be taken to achieve the elimination goals. Alongside the recently approved decree reintroducing compulsory vaccinations for school admissions, further measures are needed and should include the increase in the commitment of the 21 Regions; the implementation of supplemental immunization activities; improving the communication skills of health care workers; ensuring an effective communication with citizens; the enhancement of the surveillance network.
International journal of antimicrobial agents, Jan 24, 2018
The spread of antibiotic resistance is one of the leading public health problems in Italy. A Euro... more The spread of antibiotic resistance is one of the leading public health problems in Italy. A European Centre for Disease Prevention and Control country visit recently confirmed the major challenges and made important suggestions. In response, the Ministry of Health published the National Plan for Antimicrobial Resistance Containment, and a group of experts belonging to the Italian Group of Antimicrobial Stewardship (GISA) convened to develop a summary of practical recommendations. The GISA document is intended for use by practising physicians; it aims to increase the rational use of antimicrobials in the treatment of infections, and to change the culture of infection control of antibiotic-resistant bacteria, through the translation of theoretical knowledge into priority actions. This document has been endorsed by several national scientific societies, and reflects the particular challenges that are faced in Italy. Nevertheless, it is considered that the general principles and approa...
Annali di igiene : medicina preventiva e di comunita
Despite substantial progress towards measles and rubella control, outbreaks continue to threaten ... more Despite substantial progress towards measles and rubella control, outbreaks continue to threaten elimination goals worldwide. This paper aims to document progress towards the global eradication of measles and rubella. In particular, it investigates the major challenges faced by Italy in reaching the elimination goals. A review of the most important literature was carried out. Furthermore, a systematic review of the scientific literature on measles and rubella in the Italian setting was performed for the period 2000-2016. In the National Plan 2010-2015, Italy renewed its commitment to eliminate measles and rubella by 2015. However, Italy recently experienced a high measles burden (2,205 cases in 2013, 1,694 in 2014). Between June 2015 and May 2016, 515 cases were reported, accounting for 28% all cases in Europe. Immunization coverage decreased in recent years, with no Region reaching the 95% target. The systematic review included a total of 175 papers, with an upward trend in the num...
Annali di igiene : medicina preventiva e di comunità
The aim of this study has been to investigate the differences in the health-related behaviour by ... more The aim of this study has been to investigate the differences in the health-related behaviour by means of a questionnaire in a sample of elderly (>54 years, 1st generation) and younger adults (<54 years, 2nd generation, all of them sons/daughters of HCV positive subjects), given the high difference in HCV positive prevalence among the two groups (19.4% vs. 2.1%). Most (53.4% vs. 0.0%) of the 1st generation subjects used glass syringes while all the 2nd generation subjects used disposable syringes. Among the elderly, the frequency of hospitalisation (70% vs. 50%), transfusions (11.8% vs. 2.9%) and dental therapy by false dentists (52% vs. 0%) were higher. These results show that the use of non recyclable syringes is the main responsible for the drastic reduction of HCV circulation in the present community, and the consequent decrease in the risk for infection in younger subjects. Moreover, dental therapy was not related to an increased risk for infection, providing that the tre...
Eurosurveillance, 2014
We reviewed the epidemiology of pertussis in Italy over the last 125 years to identify disease tr... more We reviewed the epidemiology of pertussis in Italy over the last 125 years to identify disease trends and factors that could have influenced these trends. We described mortality rates (1888-2012), case fatality rates (1925-2012), cumulative incidence rates (1925-2013) and age-specific incidence rates (1974-2013). We compared data from routine surveillance with data from a paediatric sentinel surveillance system to estimate under-notification. Pertussis mortality decreased from 42.5 per 100,000 population in 1890 to no reported pertussis-related death after 2002. Incidence decreased from 86.3 per 100,000 in 1927 to 1 per 100,000 after 2008. Vaccine coverage increased from 32.8% in 1993 to about 96% after 2006. As for under-notification, mean sentinel/routine surveillance incidence ratio increased with age (from 1.8 in <1 yearolds to 12.9 in 10−14 year-olds). Pertussis mortality decreased before the introduction of immunisation. Incidence has decreased only after the introduction of pertussis vaccine and in particular after the achievement of a high immunisation coverage with acellular vaccines. Routine surveillance does not show an increase in cumulative incidence nor in ≥15 year-olds as reported by other countries. Underrecognition because of atypical presentation and the infrequent use of laboratory tests may be responsible for undernotification, and therefore affect incidence reports and management of immunisation programmes.
Eurosurveillance, 2013
, Italy experienced high measles burden with 5,568 measles cases (37.4% laboratory-confirmed) rep... more , Italy experienced high measles burden with 5,568 measles cases (37.4% laboratory-confirmed) reported to the enhanced measles surveillance system (cumulative incidence in the 15-month reference period: 9.2/100,000 population). Adolescents and young adults were especially affected, and the median age of cases was 18 years. Most cases (95.8%) were either unvaccinated or incompletely vaccinated. Complications were reported for 20.3% of cases, including 135 cases of pneumonia, seven of encephalitis and one case of Guillain-Barré syndrome. One death occurred in an immunocompromised adult. Over 1,300 cases were hospitalised. Identified priorities for reaching the measles elimination goal include evidence-based interventions such as reminder/recall for both doses of measles vaccine, supplementary immunisation activities aimed at susceptible age cohorts, and vaccinating healthcare workers.
European Journal of Public Health, 2020
Background Measles is a vaccine-preventable infectious disease and it remains one of the leading ... more Background Measles is a vaccine-preventable infectious disease and it remains one of the leading causes of infant mortality globally. The World Health Organization (WHO) has adopted the goal of eliminating measles and rubella. Detection and control of communicable diseases would not be possible without accurate laboratory results regarding when and where a particular disease circulates. Methods WHO/Europe therefore works with all Member States to steadily improve the quality of the laboratory data in order to determine the Region's progress towards measles and rubella elimination. For this purpose coordinates the European Measles and Rubella Laboratory Network (MR LabNet). National labs in this network undergoes regular external quality assessment through an annual accreditation programme. Results In Italy, a Sub-national Reference Laboratories Network for measles and rubella (MoRoNET) has been developed since March 2017 and currently includes 15 laboratories. MoRoNet was develo...
Vaccine, 2019
In recent years various EU/EEA countries have experienced an influx of migrants from low and midd... more In recent years various EU/EEA countries have experienced an influx of migrants from low and middleincome countries. In 2018, the ''Vaccine European New Integrated Collaboration Effort (VENICE)" survey group conducted a survey among 30 EU/EEA countries to investigate immunisation policies and practices targeting irregular migrants, refugees and asylum seekers (later called ''migrants" in this report). Twentynine countries participated in the survey. Twenty-eight countries reported having national policies targeting children/adolescent and adult migrants, however vaccinations offered to adult migrants are limited to specific conditions in seven countries. All the vaccinations included in the National Immunisation Programme (NIP) are offered to children/adolescents in 27/28 countries and to adults in 13/28 countries. In the 15 countries offering only certain vaccinations to adults, priority is given to diphtheria-tetanus, measles-mumps-rubella and polio vaccinations. Information about the vaccines given to child/adolescent migrants is recorded in 22 countries and to adult migrants in 19 countries with a large variation in recording methods found across countries. Individual and aggregated data are reportedly not shared with other centres/institutions in 13 and 15 countries, respectively. Twenty countries reported not collecting data on vaccination uptake among migrants; only three countries have these data at the national level. Procedures to guarantee migrants' access to vaccinations at the community level are available in 13 countries. In conclusion, although diversified, strategies for migrant vaccination are in place in all countries except for one, and the strategies are generally in line with international recommendations. Efforts are needed to strengthen partnerships and implement initiatives across countries of
Medico e bambino, 2007
Citation: Filia A, Curtale F, Kreidl P, Morosetti G, Nicoletti L, Perrelli F, Mantovani J, Campus... more Citation: Filia A, Curtale F, Kreidl P, Morosetti G, Nicoletti L, Perrelli F, Mantovani J, Campus D, Rossi G, Sanna MC, Zanetti AR, Magurano F, Fortuna C, Iannazzo S, Pompa MG, Ciofi Degli Atti M. Focolai di morbillo nella popolazione nomade in Italia: giugno-settembre ...
Eurosurveillance, Mar 24, 2016
Additional file 1: Figure S1 Proportion of healthcare workers participating in the survey on anti... more Additional file 1: Figure S1 Proportion of healthcare workers participating in the survey on antibiotic use and antibiotic resistance, stratified by cluster and social media use, Italy, 2019 (n = 1,693). ** p-values <0.01 or *** p-values <0.001. Differential use of social media by the HCWs who participated in the ECDC survey on antibiotic use and antibiotic resistance.
Computational and Structural Biotechnology Journal, 2022
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects.
Annali di igiene : medicina preventiva e di comunita, 2018
BACKGROUND Immunization Information Systems, or Immunisation registries (IRs), are essential to m... more BACKGROUND Immunization Information Systems, or Immunisation registries (IRs), are essential to monitor and evaluate the accessibility, quality and outcomes of immunisation programmes both at local and national level. STUDY DESIGN We conducted a cross-sectional survey in order to investigate and map the level of IRs implementation obtained by the 21 Italian Regional Health Authorities. On this basis we defined a roadmap towards implementing an Italian National IR. METHODS We designed an online questionnaire. Data were collected from July to September 2016 from all the 21 Regional Health Authorities in charge of infectious diseases control and immunization management. RESULTS 18/21 Italian Regions have fully implemented an IR, out of them, 11 use the same software for all Local Health Units. Two Regions have partially implemented their IRs and one Region is not yet computerised. CONCLUSION The decentralization of the Italian Health System is reflected also on the IRs characteristics ...
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Papers by stefania iannazzo