Malaria caused by genus Plasmodium, is a parasite which is the main health issue for humans and a... more Malaria caused by genus Plasmodium, is a parasite which is the main health issue for humans and about half of the population were suffered. An every year, approximately 1.2-2.7 million people died due to malaria globally. Therefore to prevent the spreading of malaria from the glob novel active drugs with specific activities are necessary. The present study aimed to identify novel drug molecule together with the bioinformatic tools for the development of active malarial drugs. As the search for latest anti malarial compound was developed, this work determined six active blends from various drug databases which possess drug-like characteristics and presents a significant anti malarial actions in in-silico level. Compound ID 300238, 889, 76569, 87324, 45678, and Z185397112are a few of the ligands were got from the Toss lab, Maybridge, Cambridge, Life chem, Bitter, and Examine drug databases and docked against hexokinase 1 protein (PDB: 1CZA) with high throughput practical screening (HTVS) using Glide v6.6. Amid the 6 compounds, compound no: 300238 from Toss lab has the greatest docking score of À9.889 kcal/mol targeting 1CZA protein. The active sites of Hexokinase I of protein were determine by using superimposition of the destination and template structure showed similar structural folds and active sites which were decidedly conserved. The quality of hexokinase I protein was considered to be sterically stable where the protein was prepared by utilizing the software protein preparation execute in the Schrodinger suite. Prepared proteins were evaluated using SAVES and the studies of molecular dynamics of the hexokinase, and the GROMACS were performed for protein-ligand complex. The low HOMO-LUMO energy gaps of the compound verified the greater stability of the molecule. Here, the tested drug candidates have good absorption, distribution, metabolism, and excretion (ADME) properties which were established by using QikProp, version 3.4 of Schrodinger.
The vision of a sensor network as a database has been reasonably well explored in the recent lite... more The vision of a sensor network as a database has been reasonably well explored in the recent literature. Several sensor database systems have been prototyped [1, 11], and some have even been deployed [2]. However, these systems have largely integrated the query processing and the routing mechanisms. In this paper, we explore the design and implementation of a sensor database system (specifically, TinyDB [11]) on top of a generic sensor network data dissemination mechanism (Directed Diffusion [8]). Such a decoupled ...
A 17-year-long δ13C and δ18O record from a scleractinian coral (Porites spp.) of Bangaram island ... more A 17-year-long δ13C and δ18O record from a scleractinian coral (Porites spp.) of Bangaram island (Lakshadweep Archipelago) is based on a nearly-monthly sample interval. This live coral head of Porites spp. was recovered from the lagoon of Bangaram (Lakshadweep) island at ∼20 m water-depth. The skeletal δ13C and δ18O values varied approximately in phase and exhibit a positive relationship with each other. High-density (monsoon) bands are characterized by enriched δ18O values and low-density (non-monsoon) bands by depleted δ18O values. Coral δ13C and δ18O primarily reflects local oceanographic and climatic variability. The high-density bands were formed during the southwest monsoon (June–September) because of increased turbidity and cloud cover, whereas low-density bands were deposited during the non-monsoon months (October–May). Temporal changes in coral-derived sea surface temperature (SST) show a good agreement with instrumental SST record. The δ18O values in monsoon and non-monsoo...
Malaria caused by genus Plasmodium, is a parasite which is the main health issue for humans and a... more Malaria caused by genus Plasmodium, is a parasite which is the main health issue for humans and about half of the population were suffered. An every year, approximately 1.2-2.7 million people died due to malaria globally. Therefore to prevent the spreading of malaria from the glob novel active drugs with specific activities are necessary. The present study aimed to identify novel drug molecule together with the bioinformatic tools for the development of active malarial drugs. As the search for latest anti malarial compound was developed, this work determined six active blends from various drug databases which possess drug-like characteristics and presents a significant anti malarial actions in in-silico level. Compound ID 300238, 889, 76569, 87324, 45678, and Z185397112are a few of the ligands were got from the Toss lab, Maybridge, Cambridge, Life chem, Bitter, and Examine drug databases and docked against hexokinase 1 protein (PDB: 1CZA) with high throughput practical screening (HTVS) using Glide v6.6. Amid the 6 compounds, compound no: 300238 from Toss lab has the greatest docking score of À9.889 kcal/mol targeting 1CZA protein. The active sites of Hexokinase I of protein were determine by using superimposition of the destination and template structure showed similar structural folds and active sites which were decidedly conserved. The quality of hexokinase I protein was considered to be sterically stable where the protein was prepared by utilizing the software protein preparation execute in the Schrodinger suite. Prepared proteins were evaluated using SAVES and the studies of molecular dynamics of the hexokinase, and the GROMACS were performed for protein-ligand complex. The low HOMO-LUMO energy gaps of the compound verified the greater stability of the molecule. Here, the tested drug candidates have good absorption, distribution, metabolism, and excretion (ADME) properties which were established by using QikProp, version 3.4 of Schrodinger.
The vision of a sensor network as a database has been reasonably well explored in the recent lite... more The vision of a sensor network as a database has been reasonably well explored in the recent literature. Several sensor database systems have been prototyped [1, 11], and some have even been deployed [2]. However, these systems have largely integrated the query processing and the routing mechanisms. In this paper, we explore the design and implementation of a sensor database system (specifically, TinyDB [11]) on top of a generic sensor network data dissemination mechanism (Directed Diffusion [8]). Such a decoupled ...
A 17-year-long δ13C and δ18O record from a scleractinian coral (Porites spp.) of Bangaram island ... more A 17-year-long δ13C and δ18O record from a scleractinian coral (Porites spp.) of Bangaram island (Lakshadweep Archipelago) is based on a nearly-monthly sample interval. This live coral head of Porites spp. was recovered from the lagoon of Bangaram (Lakshadweep) island at ∼20 m water-depth. The skeletal δ13C and δ18O values varied approximately in phase and exhibit a positive relationship with each other. High-density (monsoon) bands are characterized by enriched δ18O values and low-density (non-monsoon) bands by depleted δ18O values. Coral δ13C and δ18O primarily reflects local oceanographic and climatic variability. The high-density bands were formed during the southwest monsoon (June–September) because of increased turbidity and cloud cover, whereas low-density bands were deposited during the non-monsoon months (October–May). Temporal changes in coral-derived sea surface temperature (SST) show a good agreement with instrumental SST record. The δ18O values in monsoon and non-monsoo...
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