The Loess Hilly–Gully region (LHGR) is the most serious soil erosion area in the world. For the s... more The Loess Hilly–Gully region (LHGR) is the most serious soil erosion area in the world. For the small watershed with high management in this area, the scientific problem that has been paid attention to in recent years is the impact of the land consolidation project on the erosion environment in the gully region. In this study, the 3D simulation method of vegetation, eroded sediment and pollutant transport was innovated based on the principles of erosion sediment dynamics and similarity theory, and the impacts of GLCP were analyzed on the erosion environment at different scales. The verification results show that the design method and the scale conversion relationship (geometric scale: λl = 100) were reasonable and could simulate the transport process on the complex underlying surface of a small watershed. Compared with untreated watersheds, a significant change was the current flood peak lagging behind the sediment peak. There were two important critical values of GLCP impact on the...
Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients wi... more Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients with cancer. Gonadotrophin-releasing hormone analogs (GnRHa) protect ovarian function, but its molecular mechanisms have not yet been determined. In this study, we attempted to determine the previously unknown molecular mechanism by which such protection occurs. Serum anti-Müllerian hormone (AMH) levels were tested in tumor-bearing nude mice, a series of exploratory experiments were conducted. We discovered that GnRHa protects granulosa cells from chemotherapeutic toxicity in vivo and in vitro. We also showed that CTX-induced endoplasmic reticulum stress inhibits the secretion of AMH, and treatment with GnRHa relieves ER stress and the subsequent unfolded-protein response by modulating mTOR signaling to induce autophagy. The results of mechanistic studies indicated that GnRHa-modulated mTOR signaling to induce autophagy, which alleviated CTX-induced ER stress and promoted the secretion of ...
<p>: In view of the weak research on the rheological characteristic... more <p>: In view of the weak research on the rheological characteristics involved in the variation of the fluid movement caused by the storm runoff carrying a large amount of pollutants and sediments, this study uses the NDJ-5S rotary viscometer and the self-made slim tube viscometer of Northwest Agriculture and Forestry University. On the basis of the research, the influence of pollutants on the rheological characteristics of high-concentration sandy water flow is studied. The results show that the NDJ-5S rotary viscometer can be used well under the sand content of less than 300kg/m<sup>3</sup>. The double vertical tube slim tube viscometer made by Northwest A&F University can better simulate the sand content of 0～800kg/m<sup>3</sup>; The structure of flocculation between particles in sandy water flow will affect the viscosity of muddy water, and the concentration of sediment and other pollutants will have a certain impact on flocculation. Under the same conditions, the concentration of pollutants increases (0～440kg/m3), the viscosity coefficient of fluid increases (90%～114%), and the variation of sand content from Newtonian body to Bingham body is about 300～400kg/m<sup>3</sup>, The influence of pollutants on the variation points of rheological properties is not significant.</p><p>Keywords: pollutants; sediment; variation; viscometer; Newtonian fluid; Bingham fluid</p><p>Funding: This study was funded by the National Natural Science Foundation of China (No. 41877078, 41371276), Key research and development project of Shaanxi Province (2020ZDLSF06-03-01), National Key Research and Development Program of China (No. 2017YFC0504703) and Knowledge Innovation Program of the Chinese Academy of Sciences (No. A315021615). </p>
Background The predicting value of AMH for ovarian dysfunction after chemotherapy is controversia... more Background The predicting value of AMH for ovarian dysfunction after chemotherapy is controversial. This study is designed to evaluate the value of serum AMH clinically and theoretically. Methods We detected the serum estradiol, FSH and AMH in 144 pre-menopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. The differences of hormones before and after chemotherapy were compared; the correlations among the hormones and amenorrhea, menstrual recovery were analyzed. In addition, serum AMH was detected randomly in 177 normal healthy women and 36 normal female C57BL/6J mice of different ages, meanwhile the status of ovary follicles was observed. Furthermore, 72 Balb/c nude mice with breast cancer were randomly assigned to three groups with different dosage of CTX (control, 100mg/kg, 200mg/kg), the alterations of serum AMH and ovary follicles were recorded and analyzed. Results Chemotherapy induced amenorrhea was associated with pre-chemo AMH level, E2 level and ...
The predictive value of anti-Müllerian hormone (AMH) for ovarian dysfunction postchemotherapy is ... more The predictive value of anti-Müllerian hormone (AMH) for ovarian dysfunction postchemotherapy is controversial. This study aimed to evaluate the value of serum AMH levels clinically and theoretically. Patients, Animals, and Methods: We detected the serum estradiol, follicular stimulating hormone (FSH), luteinizing hormone (LH), and AMH levels in 144 premenopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. The hormone levels before and postchemotherapy were compared; the correlations among the hormones and amenorrhea and menstrual recovery were analyzed. In addition, the serum AMH levels were detected randomly in 177 normal healthy women and 36 normal female C57BL/6J mice of different ages; meanwhile, the status of ovarian follicles was also examined. Furthermore, 72 Balb/c nude mice with breast cancer were randomly assigned to three groups that received different doses of cyclophosphamide (CTX) (control, 100 mg/kg, and 200 mg/kg), and the alterations in serum AMH levels and ovarian follicles were recorded and analyzed. Results: Chemotherapy-induced amenorrhea was associated with prechemotherapy AMH levels, E2 levels, and FSH levels (P < 0.0001). The recovery of menstruation was associated with prechemotherapy AMH levels (P < 0.0001), but not with E2 and FSH levels (P > 0.05). In patients with breast cancer treated with chemotherapy, the serum AMH levels did not differ significantly between the pre-and post-chemotherapy periods in patients aged <35 years (P > 0.05), whereas a dramatic reduction was detected in patients aged >35 years (P < 0.0001). In healthy women, the serum AMH levels declined sharply after 35 years of age (P < 0.0001) and remained relatively stable at a younger age. Similar results were obtained in experiments using normal mice. The cancer-bearing mice exposed to 200 mg/kg CTX exhibited a significant decline in AMH levels and a remarkable decrease in the number of primordial and growing follicles (P < 0.0001). Conclusion: Our results indicate that AMH is an efficient marker for predicting postchemotherapy ovarian function exclusively in premenopausal female patients with breast cancer aged >35 years.
surgical treatment improves the prognosis in primary metastatic breast cancer patients with a sin... more surgical treatment improves the prognosis in primary metastatic breast cancer patients with a single distant metastasis except for brain metastasis, The Breast (2019), doi:
SETD7 is a methyltransferase that specifically catalyzes the monomethylation of lysine 4 on histo... more SETD7 is a methyltransferase that specifically catalyzes the monomethylation of lysine 4 on histone H3. A variety of studies has revealed the role of SETD7 in posttranslational modifications of non-histone proteins. However, the prognostic value of SETD7 on breast cancer and the ability of SETD7 of regulating intrinsic redox homeostasis has never been investigated. In this study, using The Cancer Genome Atlas (TCGA) database, we revealed that SETD7 was a potential prognostic marker of breast cancer. Median survival time of patients with low SETD7 expression (18.1 years) was twice than that of SETD7 low-expressed patients (9.5 years). We demonstrated that SETD7 promoted tumor cell proliferation and prevented cell apoptosis and that SETD7 delicately maintained the redox homeostasis through regulating the levels of GSH/GSSG and ROS. Further studies indicated that SETD7 was a positive activator of KEAP1-NRF2 pathway. Using dual luciferase assay, we revealed the role of SETD7 as a transc...
The Loess Hilly–Gully region (LHGR) is the most serious soil erosion area in the world. For the s... more The Loess Hilly–Gully region (LHGR) is the most serious soil erosion area in the world. For the small watershed with high management in this area, the scientific problem that has been paid attention to in recent years is the impact of the land consolidation project on the erosion environment in the gully region. In this study, the 3D simulation method of vegetation, eroded sediment and pollutant transport was innovated based on the principles of erosion sediment dynamics and similarity theory, and the impacts of GLCP were analyzed on the erosion environment at different scales. The verification results show that the design method and the scale conversion relationship (geometric scale: λl = 100) were reasonable and could simulate the transport process on the complex underlying surface of a small watershed. Compared with untreated watersheds, a significant change was the current flood peak lagging behind the sediment peak. There were two important critical values of GLCP impact on the...
Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients wi... more Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients with cancer. Gonadotrophin-releasing hormone analogs (GnRHa) protect ovarian function, but its molecular mechanisms have not yet been determined. In this study, we attempted to determine the previously unknown molecular mechanism by which such protection occurs. Serum anti-Müllerian hormone (AMH) levels were tested in tumor-bearing nude mice, a series of exploratory experiments were conducted. We discovered that GnRHa protects granulosa cells from chemotherapeutic toxicity in vivo and in vitro. We also showed that CTX-induced endoplasmic reticulum stress inhibits the secretion of AMH, and treatment with GnRHa relieves ER stress and the subsequent unfolded-protein response by modulating mTOR signaling to induce autophagy. The results of mechanistic studies indicated that GnRHa-modulated mTOR signaling to induce autophagy, which alleviated CTX-induced ER stress and promoted the secretion of ...
&amp;amp;lt;p&amp;amp;gt;: In view of the weak research on the rheological characteristic... more &amp;amp;lt;p&amp;amp;gt;: In view of the weak research on the rheological characteristics involved in the variation of the fluid movement caused by the storm runoff carrying a large amount of pollutants and sediments, this study uses the NDJ-5S rotary viscometer and the self-made slim tube viscometer of Northwest Agriculture and Forestry University. On the basis of the research, the influence of pollutants on the rheological characteristics of high-concentration sandy water flow is studied. The results show that the NDJ-5S rotary viscometer can be used well under the sand content of less than 300kg/m&amp;amp;lt;sup&amp;amp;gt;3&amp;amp;lt;/sup&amp;amp;gt;. The double vertical tube slim tube viscometer made by Northwest A&amp;amp;amp;F University can better simulate the sand content of 0&amp;amp;amp;#65374;800kg/m&amp;amp;lt;sup&amp;amp;gt;3&amp;amp;lt;/sup&amp;amp;gt;; The structure of flocculation between particles in sandy water flow will affect the viscosity of muddy water, and the concentration of sediment and other pollutants will have a certain impact on flocculation. Under the same conditions, the concentration of pollutants increases (0&amp;amp;amp;#65374;440kg/m3), the viscosity coefficient of fluid increases (90%&amp;amp;amp;#65374;114%), and the variation of sand content from Newtonian body to Bingham body is about 300&amp;amp;amp;#65374;400kg/m&amp;amp;lt;sup&amp;amp;gt;3&amp;amp;lt;/sup&amp;amp;gt;, The influence of pollutants on the variation points of rheological properties is not significant.&amp;amp;lt;/p&amp;amp;gt;&amp;amp;lt;p&amp;amp;gt;Keywords: pollutants; sediment; variation; viscometer; Newtonian fluid; Bingham fluid&amp;amp;lt;/p&amp;amp;gt;&amp;amp;lt;p&amp;amp;gt;Funding: This study was funded by the National Natural Science Foundation of China (No. 41877078, 41371276), Key research and development project of Shaanxi Province (2020ZDLSF06-03-01), National Key Research and Development Program of China (No. 2017YFC0504703) and Knowledge Innovation Program of the Chinese Academy of Sciences (No. A315021615).&amp;amp;amp;#160;&amp;amp;lt;/p&amp;amp;gt;
Background The predicting value of AMH for ovarian dysfunction after chemotherapy is controversia... more Background The predicting value of AMH for ovarian dysfunction after chemotherapy is controversial. This study is designed to evaluate the value of serum AMH clinically and theoretically. Methods We detected the serum estradiol, FSH and AMH in 144 pre-menopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. The differences of hormones before and after chemotherapy were compared; the correlations among the hormones and amenorrhea, menstrual recovery were analyzed. In addition, serum AMH was detected randomly in 177 normal healthy women and 36 normal female C57BL/6J mice of different ages, meanwhile the status of ovary follicles was observed. Furthermore, 72 Balb/c nude mice with breast cancer were randomly assigned to three groups with different dosage of CTX (control, 100mg/kg, 200mg/kg), the alterations of serum AMH and ovary follicles were recorded and analyzed. Results Chemotherapy induced amenorrhea was associated with pre-chemo AMH level, E2 level and ...
The predictive value of anti-Müllerian hormone (AMH) for ovarian dysfunction postchemotherapy is ... more The predictive value of anti-Müllerian hormone (AMH) for ovarian dysfunction postchemotherapy is controversial. This study aimed to evaluate the value of serum AMH levels clinically and theoretically. Patients, Animals, and Methods: We detected the serum estradiol, follicular stimulating hormone (FSH), luteinizing hormone (LH), and AMH levels in 144 premenopausal women with breast cancer receiving cyclophosphamide-based chemotherapy. The hormone levels before and postchemotherapy were compared; the correlations among the hormones and amenorrhea and menstrual recovery were analyzed. In addition, the serum AMH levels were detected randomly in 177 normal healthy women and 36 normal female C57BL/6J mice of different ages; meanwhile, the status of ovarian follicles was also examined. Furthermore, 72 Balb/c nude mice with breast cancer were randomly assigned to three groups that received different doses of cyclophosphamide (CTX) (control, 100 mg/kg, and 200 mg/kg), and the alterations in serum AMH levels and ovarian follicles were recorded and analyzed. Results: Chemotherapy-induced amenorrhea was associated with prechemotherapy AMH levels, E2 levels, and FSH levels (P < 0.0001). The recovery of menstruation was associated with prechemotherapy AMH levels (P < 0.0001), but not with E2 and FSH levels (P > 0.05). In patients with breast cancer treated with chemotherapy, the serum AMH levels did not differ significantly between the pre-and post-chemotherapy periods in patients aged <35 years (P > 0.05), whereas a dramatic reduction was detected in patients aged >35 years (P < 0.0001). In healthy women, the serum AMH levels declined sharply after 35 years of age (P < 0.0001) and remained relatively stable at a younger age. Similar results were obtained in experiments using normal mice. The cancer-bearing mice exposed to 200 mg/kg CTX exhibited a significant decline in AMH levels and a remarkable decrease in the number of primordial and growing follicles (P < 0.0001). Conclusion: Our results indicate that AMH is an efficient marker for predicting postchemotherapy ovarian function exclusively in premenopausal female patients with breast cancer aged >35 years.
surgical treatment improves the prognosis in primary metastatic breast cancer patients with a sin... more surgical treatment improves the prognosis in primary metastatic breast cancer patients with a single distant metastasis except for brain metastasis, The Breast (2019), doi:
SETD7 is a methyltransferase that specifically catalyzes the monomethylation of lysine 4 on histo... more SETD7 is a methyltransferase that specifically catalyzes the monomethylation of lysine 4 on histone H3. A variety of studies has revealed the role of SETD7 in posttranslational modifications of non-histone proteins. However, the prognostic value of SETD7 on breast cancer and the ability of SETD7 of regulating intrinsic redox homeostasis has never been investigated. In this study, using The Cancer Genome Atlas (TCGA) database, we revealed that SETD7 was a potential prognostic marker of breast cancer. Median survival time of patients with low SETD7 expression (18.1 years) was twice than that of SETD7 low-expressed patients (9.5 years). We demonstrated that SETD7 promoted tumor cell proliferation and prevented cell apoptosis and that SETD7 delicately maintained the redox homeostasis through regulating the levels of GSH/GSSG and ROS. Further studies indicated that SETD7 was a positive activator of KEAP1-NRF2 pathway. Using dual luciferase assay, we revealed the role of SETD7 as a transc...
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