Dhaka University Journal of Pharmaceutical Sciences, 2007
Efficiency of kollicoat EMM 30 D and SR 30D as matrix forming material was investigated. It was f... more Efficiency of kollicoat EMM 30 D and SR 30D as matrix forming material was investigated. It was found that, theophylline loaded granules prepared with these two polymers could not sustain drug release for a significant period of time. However, compression of these granules into tablets retarded drug release for up to 8 hours. Release was faster from EMM 30D polymeric system than that from SR 30D matrix. Effects of fillers and rate modifiers on drug liberation have been assessed. Incorporation of Avicel RC 591 and starch caused substantial release of theophylline from both the polymeric systems. Avicel PH 101 intensified the retardation effect of both EMM 30D and SR 30D on theophylline release. HPMC 50 cps, when added to the matrix, caused the release of theophylline to follow near zero order pattern. Increasing the content of HPMC in both EMM 30D and SR 30D compressed tablets decreased the rate and extent of theophylline release. In the presence of excipients, no significant differe...
Dhaka University Journal of Pharmaceutical Sciences, 2008
In the present study an attempt has been made to investigate the effect of ethylcellulose as a ra... more In the present study an attempt has been made to investigate the effect of ethylcellulose as a rate retarding material to sustain the release of diltiazem hydrochloride from pellets prepared by air suspension technique. Aqueous ethylcellulose dispersion (Surelease) with different weight ratios was chosen to sustain the release of the drug. Drug was loaded on dummy seeds by following matrix system as well as barrier coating system. The comparative study of this two manufacturing processes was also the goal of this study. In vitro dissolution studies were carried out using USP dissolution apparatus Type-2. The release of drug was faster from matrix system than that of barrier coating system. About 100% drug was released within 3 hours with 5% polymer load from both systems. While the polymer content was 10%, about 4h & 7h required for 50% & 80% drug release respectively from barrier coating system. The effect of ethylcellulose on the release of diltiazem hydrochloride was found to be ...
High iron (Fe)–bearing groundwater in Bangladesh contaminates the groundwater aquifer with subseq... more High iron (Fe)–bearing groundwater in Bangladesh contaminates the groundwater aquifer with subsequent health risk. All the populations of Rangpur City Corporation (RpCC) depend on groundwater for their drinking, domestics, and irrigation purposes. This study investigates the concentration of Fe in groundwater of RpCC with special attention on the associated health risk of the dwellers residing in it. Stratified random sampling was adopted to collect 101 water samples from 33 wards of which each ward has 3 samples from tube well to identify Fe concentration using atomic absorption spectroscopy (AAS). The data are analyzed following several statistical technique and compared with Bangladesh and WHO standard values. Maximum mean concentration was found in ward no. 11which is 1.620 mg/L and minimum mean concentration was found in ward no. 6 which is 0.006 mg/L. Single Factor Index (SFI) and Nemerow Index (NI) were applied to analyze the quality of groundwater for the whole data set. Hazard Quotient (HQ) and Hazard Index (HI) were used to assess health risk and it ensures that the females of the study area are more susceptible to iron health risk than the males. However, geostatistical analyses using ArcGIS-10.5 were used to show the spatial distribution and autocorrelation among several variables. Spatial distribution maps show important visualization for understanding Fe concentration zoning, distribution of quality indices, and health risk. The findings of this work will help the city corporation authority, environmental planner, and policymaker to understand the potential health risk due to Fe concentration.
ABSTRACT: The main objective of the present study was to compare the release profiles of ethylcel... more ABSTRACT: The main objective of the present study was to compare the release profiles of ethylcellulose and eudragit L100 based matrix tablets of naproxen. Dissolution studies were carried out by using United States Pharmacopoeia-XXIII type-II dissolution apparatus. The granules ...
Dhaka University Journal of Pharmaceutical Sciences, 2007
Efficiency of kollicoat EMM 30 D and SR 30D as matrix forming material was investigated. It was f... more Efficiency of kollicoat EMM 30 D and SR 30D as matrix forming material was investigated. It was found that, theophylline loaded granules prepared with these two polymers could not sustain drug release for a significant period of time. However, compression of these granules into tablets retarded drug release for up to 8 hours. Release was faster from EMM 30D polymeric system than that from SR 30D matrix. Effects of fillers and rate modifiers on drug liberation have been assessed. Incorporation of Avicel RC 591 and starch caused substantial release of theophylline from both the polymeric systems. Avicel PH 101 intensified the retardation effect of both EMM 30D and SR 30D on theophylline release. HPMC 50 cps, when added to the matrix, caused the release of theophylline to follow near zero order pattern. Increasing the content of HPMC in both EMM 30D and SR 30D compressed tablets decreased the rate and extent of theophylline release. In the presence of excipients, no significant differe...
Dhaka University Journal of Pharmaceutical Sciences, 2008
In the present study an attempt has been made to investigate the effect of ethylcellulose as a ra... more In the present study an attempt has been made to investigate the effect of ethylcellulose as a rate retarding material to sustain the release of diltiazem hydrochloride from pellets prepared by air suspension technique. Aqueous ethylcellulose dispersion (Surelease) with different weight ratios was chosen to sustain the release of the drug. Drug was loaded on dummy seeds by following matrix system as well as barrier coating system. The comparative study of this two manufacturing processes was also the goal of this study. In vitro dissolution studies were carried out using USP dissolution apparatus Type-2. The release of drug was faster from matrix system than that of barrier coating system. About 100% drug was released within 3 hours with 5% polymer load from both systems. While the polymer content was 10%, about 4h & 7h required for 50% & 80% drug release respectively from barrier coating system. The effect of ethylcellulose on the release of diltiazem hydrochloride was found to be ...
High iron (Fe)–bearing groundwater in Bangladesh contaminates the groundwater aquifer with subseq... more High iron (Fe)–bearing groundwater in Bangladesh contaminates the groundwater aquifer with subsequent health risk. All the populations of Rangpur City Corporation (RpCC) depend on groundwater for their drinking, domestics, and irrigation purposes. This study investigates the concentration of Fe in groundwater of RpCC with special attention on the associated health risk of the dwellers residing in it. Stratified random sampling was adopted to collect 101 water samples from 33 wards of which each ward has 3 samples from tube well to identify Fe concentration using atomic absorption spectroscopy (AAS). The data are analyzed following several statistical technique and compared with Bangladesh and WHO standard values. Maximum mean concentration was found in ward no. 11which is 1.620 mg/L and minimum mean concentration was found in ward no. 6 which is 0.006 mg/L. Single Factor Index (SFI) and Nemerow Index (NI) were applied to analyze the quality of groundwater for the whole data set. Hazard Quotient (HQ) and Hazard Index (HI) were used to assess health risk and it ensures that the females of the study area are more susceptible to iron health risk than the males. However, geostatistical analyses using ArcGIS-10.5 were used to show the spatial distribution and autocorrelation among several variables. Spatial distribution maps show important visualization for understanding Fe concentration zoning, distribution of quality indices, and health risk. The findings of this work will help the city corporation authority, environmental planner, and policymaker to understand the potential health risk due to Fe concentration.
ABSTRACT: The main objective of the present study was to compare the release profiles of ethylcel... more ABSTRACT: The main objective of the present study was to compare the release profiles of ethylcellulose and eudragit L100 based matrix tablets of naproxen. Dissolution studies were carried out by using United States Pharmacopoeia-XXIII type-II dissolution apparatus. The granules ...
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