International journal of infertility and fetal medicine, Apr 1, 2021
Background: Oocyte cryopreservation has been an enigma for many years. It has not been easy to fr... more Background: Oocyte cryopreservation has been an enigma for many years. It has not been easy to freeze the largest cell of the body owing to its large water content and low surface-to-volume ratio. The recovery of cryopreserved oocytes, for many years, remained dismal at best due to ice crystal formation and insufficient cryoprotectant permeation. In recent years, particularly after the advent of vitrification, a much more successful cryopreservation recovery has been achieved, and oocyte cryopreservation has now become a mainstream treatment procedure in artificial reproduction technology (ART). Aim and objective: Our study aims to retrospectively analyze oocyte cryopreservation data collected over a period of 5 years, between two centers, with a standardized vitrification-warming technique. The parameters taken into consideration were oocyte survival, fertilization, blastocysts formation, implantation rate, and live birth rate. Result: We have observed no significant difference in fresh vs frozen oocytes in the donor as well as patient cohorts in terms of implantation rates and live birth outcomes. Our data have been very encouraging, so that we can offer oocyte cryopreservation to the desiring women seeking this technology, and have opened up a plethora of opportunities with the successful application of oocyte vitrification. Conclusion: We are attempting a further, more elaborate study with much bigger sample size and many more individual criteria to follow-up the success of this technique more closely.
International journal of infertility and fetal medicine, 2011
This study was conducted to determine the efficacy of using the technique of intracytoplasm morph... more This study was conducted to determine the efficacy of using the technique of intracytoplasm morphologically selected sperm injection (IMSI) as compared to the conventionally used intracytoplasmic sperm injection ((ICSI) procedure. IMSI, as the name suggests, is the technique of selecting the most normal looking sperm by magnifying it to about 7200 times. A total of 192 patients who underwent the treatment of in vitro fertilization (IVF) with us by either one of the two procedures of IMSI or ICSI over a period of 18 months were included in the study. Out of these 92 were included in the IMSI group while 100 others in the ICSI group according to our inclusion and exclusion criteria. The pregnancy rate among patients who underwent IMSI was found to be significantly higher (52.1%) as compared to those with ICSI (36%). Furthermore, even the implantation rates were higher in the IMSI group (30.12%) than the ICSI (19.93%) group.
About 1/3 rd of all women diagnosed with subfertility have a tubo-peritoneal factor contributing ... more About 1/3 rd of all women diagnosed with subfertility have a tubo-peritoneal factor contributing to their condition. Most of these alterations in tubo-ovarian function come from post-inflammatory damage inflicted after a pelvic or sexually transmitted infection. Salpingitis occurs in an estimated 15% of reproductive-age women, and 2.5% of all women become infertile as a result of salpingitis by age 35. Predominant organisms today include those from the Chamydia species and the infection causes minimal to no symptomsleading to chronic infection and consequently more damage. Again, a large proportion of patients suffering from pelvic infection contributing to their subfertility are undiagnosed to be having an infection. Chronic inflammation of the cervix and endometrium, alterations in reproductive tract secretions, induction of immune mediators that interfere with gamete or embryo physiology, and structural disorders such as intrauterine synechiae all contribute to female infertility. Infection is also a major factor in male subfertility, second only to abnormal semen parameters. Epididymal or ductal obstruction, testicular damage from orchitis, development of anti-sperm antibodies, etc are all possible mechanisms by which infection can affect male fertility.
IJCP Sutra: "Eat iron-rich foods such as meat, chicken, fish, eggs, dried beans and fortified gra... more IJCP Sutra: "Eat iron-rich foods such as meat, chicken, fish, eggs, dried beans and fortified grains. The form of iron in meat products, called heme, is more easily absorbed than the iron in vegetables."
About 1/3rd of all women diagnosed with subfertility have a tubo-peritoneal factor contri‐ buting... more About 1/3rd of all women diagnosed with subfertility have a tubo-peritoneal factor contri‐ buting to their condition. Most of these alterations in tubo-ovarian function come from post-inflammatory damage inflicted after a pelvic or sexually transmitted infection. Sal‐ pingitis occurs in an estimated 15% of reproductive-age women, and 2.5% of all women become infertile as a result of salpingitis by age 35. Predominant organisms today include those from the Chamydia species and the infection causes minimal to no symptoms – leading to chronic infection and consequently more damage. Again, a large proportion of patients suffering from pelvic infection contributing to their subfertility are undiagnosed to be having an infection. Chronic inflammation of the cervix and endometrium, altera‐ tions in reproductive tract secretions, induction of immune mediators that interfere with gamete or embryo physiology, and structural disorders such as intrauterine synechiae all contribute to female inf...
OBJECTIVE To assess reproductive performance in women with septate uterus and otherwise unexplain... more OBJECTIVE To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. STUDY DESIGN A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women within one year of surgery was studied and analyzed. RESULTS Thirty-three women (45.83%) conceived within one year of surgery. Only 4 women (12%) had spontaneous abortions, and only 5 (15%) had preterm delivery. CONCLUSION Hysteroscopic metroplasty in women with septate uterus significantly improves reproductive outcomes.
International Journal of Infertility & Fetal Medicine
Artificial intelligence (AI) has found its way into medicine in the form of robotics, operational... more Artificial intelligence (AI) has found its way into medicine in the form of robotics, operational and computational tools. We have software to store and recall a patient's history instantly and algorithms to decide the course of treatment depending on past data. We have robots performing surgeries and witnessing systems to help prevent human errors. There have been significant advancements in the incorporation of AI in the artificial reproduction technology (ART) labs. In vitro fertilization (IVF) at present is a very subjective science, depending on the expertise and experience of the operators, mainly embryologists. Automation and AI are expected to bring about a more calculated, computed, and standardized approach to IVF. Presently, AI is used in the IVF lab for witnessing, data collection, record maintenance, and selecting the best possible embryo for transfer. Continuous research is being undertaken towards bringing more and more automation in the form of robotics. Artificial intelligence in ART is a very exciting upcoming field of research. Our review enlists the present AI in an ART lab and its future prospects.
Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. I... more Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. It may cause many diseases, including obesity, cancer, and infertility. In this chapter, we focus our attention on the association of infection and fertility alteration. Numerous studies have suggested that genetic polymorphisms influencing infection are associated with infertility. So we also review the genetic influence on infection and risk of infertility.
Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. I... more Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. It may cause many diseases, including obesity, cancer, and infertility. In this chapter, we focus our attention on the association of infection and fertility alteration. Numerous studies have suggested that genetic polymorphisms influencing infection are associated with infertility. So we also review the genetic influence on infection and risk of infertility.
Objective: To assess reproductive performance in women with septate uterus and otherwise unexplai... more Objective: To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. Study design: A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women within one year of surgery was studied and analyzed. Results: Thirty-three women (45.83%) conceived within one year of surgery. Only 4 women (12%) had spontaneous abortions, and only 5 (15%) had preterm delivery. Conclusion: Hysteroscopic metroplasty in women with septate uterus significantly improves reproductive outcomes.
To assess reproductive performance in women with septate uterus and otherwise unexplained inferti... more To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women within one year of surgery was studied and analyzed. Thirty-three women (45.83%) conceived within one year of surgery. Only 4 women (12%) had spontaneous abortions, and only 5 (15%) had preterm delivery. Hysteroscopic metroplasty in women with septate uterus significantly improves reproductive outcomes.
International journal of infertility and fetal medicine, Apr 1, 2021
Background: Oocyte cryopreservation has been an enigma for many years. It has not been easy to fr... more Background: Oocyte cryopreservation has been an enigma for many years. It has not been easy to freeze the largest cell of the body owing to its large water content and low surface-to-volume ratio. The recovery of cryopreserved oocytes, for many years, remained dismal at best due to ice crystal formation and insufficient cryoprotectant permeation. In recent years, particularly after the advent of vitrification, a much more successful cryopreservation recovery has been achieved, and oocyte cryopreservation has now become a mainstream treatment procedure in artificial reproduction technology (ART). Aim and objective: Our study aims to retrospectively analyze oocyte cryopreservation data collected over a period of 5 years, between two centers, with a standardized vitrification-warming technique. The parameters taken into consideration were oocyte survival, fertilization, blastocysts formation, implantation rate, and live birth rate. Result: We have observed no significant difference in fresh vs frozen oocytes in the donor as well as patient cohorts in terms of implantation rates and live birth outcomes. Our data have been very encouraging, so that we can offer oocyte cryopreservation to the desiring women seeking this technology, and have opened up a plethora of opportunities with the successful application of oocyte vitrification. Conclusion: We are attempting a further, more elaborate study with much bigger sample size and many more individual criteria to follow-up the success of this technique more closely.
International journal of infertility and fetal medicine, 2011
This study was conducted to determine the efficacy of using the technique of intracytoplasm morph... more This study was conducted to determine the efficacy of using the technique of intracytoplasm morphologically selected sperm injection (IMSI) as compared to the conventionally used intracytoplasmic sperm injection ((ICSI) procedure. IMSI, as the name suggests, is the technique of selecting the most normal looking sperm by magnifying it to about 7200 times. A total of 192 patients who underwent the treatment of in vitro fertilization (IVF) with us by either one of the two procedures of IMSI or ICSI over a period of 18 months were included in the study. Out of these 92 were included in the IMSI group while 100 others in the ICSI group according to our inclusion and exclusion criteria. The pregnancy rate among patients who underwent IMSI was found to be significantly higher (52.1%) as compared to those with ICSI (36%). Furthermore, even the implantation rates were higher in the IMSI group (30.12%) than the ICSI (19.93%) group.
About 1/3 rd of all women diagnosed with subfertility have a tubo-peritoneal factor contributing ... more About 1/3 rd of all women diagnosed with subfertility have a tubo-peritoneal factor contributing to their condition. Most of these alterations in tubo-ovarian function come from post-inflammatory damage inflicted after a pelvic or sexually transmitted infection. Salpingitis occurs in an estimated 15% of reproductive-age women, and 2.5% of all women become infertile as a result of salpingitis by age 35. Predominant organisms today include those from the Chamydia species and the infection causes minimal to no symptomsleading to chronic infection and consequently more damage. Again, a large proportion of patients suffering from pelvic infection contributing to their subfertility are undiagnosed to be having an infection. Chronic inflammation of the cervix and endometrium, alterations in reproductive tract secretions, induction of immune mediators that interfere with gamete or embryo physiology, and structural disorders such as intrauterine synechiae all contribute to female infertility. Infection is also a major factor in male subfertility, second only to abnormal semen parameters. Epididymal or ductal obstruction, testicular damage from orchitis, development of anti-sperm antibodies, etc are all possible mechanisms by which infection can affect male fertility.
IJCP Sutra: "Eat iron-rich foods such as meat, chicken, fish, eggs, dried beans and fortified gra... more IJCP Sutra: "Eat iron-rich foods such as meat, chicken, fish, eggs, dried beans and fortified grains. The form of iron in meat products, called heme, is more easily absorbed than the iron in vegetables."
About 1/3rd of all women diagnosed with subfertility have a tubo-peritoneal factor contri‐ buting... more About 1/3rd of all women diagnosed with subfertility have a tubo-peritoneal factor contri‐ buting to their condition. Most of these alterations in tubo-ovarian function come from post-inflammatory damage inflicted after a pelvic or sexually transmitted infection. Sal‐ pingitis occurs in an estimated 15% of reproductive-age women, and 2.5% of all women become infertile as a result of salpingitis by age 35. Predominant organisms today include those from the Chamydia species and the infection causes minimal to no symptoms – leading to chronic infection and consequently more damage. Again, a large proportion of patients suffering from pelvic infection contributing to their subfertility are undiagnosed to be having an infection. Chronic inflammation of the cervix and endometrium, altera‐ tions in reproductive tract secretions, induction of immune mediators that interfere with gamete or embryo physiology, and structural disorders such as intrauterine synechiae all contribute to female inf...
OBJECTIVE To assess reproductive performance in women with septate uterus and otherwise unexplain... more OBJECTIVE To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. STUDY DESIGN A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women within one year of surgery was studied and analyzed. RESULTS Thirty-three women (45.83%) conceived within one year of surgery. Only 4 women (12%) had spontaneous abortions, and only 5 (15%) had preterm delivery. CONCLUSION Hysteroscopic metroplasty in women with septate uterus significantly improves reproductive outcomes.
International Journal of Infertility & Fetal Medicine
Artificial intelligence (AI) has found its way into medicine in the form of robotics, operational... more Artificial intelligence (AI) has found its way into medicine in the form of robotics, operational and computational tools. We have software to store and recall a patient's history instantly and algorithms to decide the course of treatment depending on past data. We have robots performing surgeries and witnessing systems to help prevent human errors. There have been significant advancements in the incorporation of AI in the artificial reproduction technology (ART) labs. In vitro fertilization (IVF) at present is a very subjective science, depending on the expertise and experience of the operators, mainly embryologists. Automation and AI are expected to bring about a more calculated, computed, and standardized approach to IVF. Presently, AI is used in the IVF lab for witnessing, data collection, record maintenance, and selecting the best possible embryo for transfer. Continuous research is being undertaken towards bringing more and more automation in the form of robotics. Artificial intelligence in ART is a very exciting upcoming field of research. Our review enlists the present AI in an ART lab and its future prospects.
Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. I... more Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. It may cause many diseases, including obesity, cancer, and infertility. In this chapter, we focus our attention on the association of infection and fertility alteration. Numerous studies have suggested that genetic polymorphisms influencing infection are associated with infertility. So we also review the genetic influence on infection and risk of infertility.
Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. I... more Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. It may cause many diseases, including obesity, cancer, and infertility. In this chapter, we focus our attention on the association of infection and fertility alteration. Numerous studies have suggested that genetic polymorphisms influencing infection are associated with infertility. So we also review the genetic influence on infection and risk of infertility.
Objective: To assess reproductive performance in women with septate uterus and otherwise unexplai... more Objective: To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. Study design: A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women within one year of surgery was studied and analyzed. Results: Thirty-three women (45.83%) conceived within one year of surgery. Only 4 women (12%) had spontaneous abortions, and only 5 (15%) had preterm delivery. Conclusion: Hysteroscopic metroplasty in women with septate uterus significantly improves reproductive outcomes.
To assess reproductive performance in women with septate uterus and otherwise unexplained inferti... more To assess reproductive performance in women with septate uterus and otherwise unexplained infertility after hysteroscopic metroplasty. A total of 72 women with septate uterus and otherwise unexplained primary infertility were included in the study. All of the women underwent hysteroscopic septal resection. Reproductive performance of these women within one year of surgery was studied and analyzed. Thirty-three women (45.83%) conceived within one year of surgery. Only 4 women (12%) had spontaneous abortions, and only 5 (15%) had preterm delivery. Hysteroscopic metroplasty in women with septate uterus significantly improves reproductive outcomes.
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