The objectives of this study were to determine whether a new degradable synthetic barrier membran... more The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb) composed of poly(dl-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes. In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (muCT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model. New bone formation could be detected by post-mortem microradiography in 130 samples and by muCT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes. In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.
The alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida (oleovorans) to met... more The alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida (oleovorans) to metabolize alkanes. In this paper we report the nucleotide sequence of a 4592 bp region of the alkBFGHJKL operon encoding the AlkJ, AlkK and AlkL polypeptides. The alkJ gene encodes a protein of 59 kilodaltons. The predicted amino acid sequence shows significant homology with four flavin proteins: choline dehydrogenase, a glucose dehydrogenase and two oxidases. AlkJ is membrane-bound and converts aiiphatic medium-chain-tength alcohois into aldehydes. The properties of AlkJ suggest that it is linked to the electron transfer chain. AlkJ is necessary for growth on aikanes only in P. putida alcohol dehydrogenase (AIcA) mutants. AlkK is homologous to a range of proteins which act by an ATP-dependent covalent binding of AMP to their substrate. This list includes the acetate, coumarate and long-chain fatty acid CoA iigases. The alkK gene compiements a fadD mutation in Escherichia coll., which shows that it indeed encodes an acyl-CoA synthetase. AlkK is a 60 kilodalton protein located in the cytoplasm. AlkL is homologous to OmpW, a Vibrio cholerae outer membrane protein of unknown function, and a hypothetical polypeptide encoded by ytt4 in E. coli. AlkL, OmpW and Ytt4 all have a signal peptide and end with a sequence characteristic of outer membrane proteins. The alkL gene product was found in
International Journal of Oral and Maxillofacial Surgery, Oct 1, 2017
Since the introduction of rigid internal fixation devices, more and more surgeons favour an open ... more Since the introduction of rigid internal fixation devices, more and more surgeons favour an open approach to treating condylar fractures of the mandible in adult patients. Different indications for open treatment have been published. Open treatment is associated with surgical complications because of the technique employed. The aim of this systematic review was to provide an overview of the studies published exclusively on open treatment, and to summarize the existing open treatment modalities and their clinical outcomes. A total of seventy studies were selected for detailed analysis. Most studies reported good results with regard to the outcome measures of open treatment. Surgical complications including hematoma, wound infection, weakness of the facial nerve, sialocele, salivary fistula, sensory disturbance of the great auricular nerve, unsatisfactory scarring, and fixation failure were reported in the studies. This review suggests that because of the high level of methodological variance in the relevant studies published to date, among other factors, there are currently no evidence-based conclusions or guidelines that can be formulated with regard to the most appropriate open treatment. Establishment of such standards could potentially improve treatment outcomes.
Bunium persicum fruit oils from wild type (WT), first (CY1) and second year (CY2) cultivars (four... more Bunium persicum fruit oils from wild type (WT), first (CY1) and second year (CY2) cultivars (fourth and fifth year plants) were analyzed by GC and GC/MS. The essential oil content of the WT (9.1% v/w) was higher than the oil content of the CY1 (6.2% v/w) and CY2 (5.1% v/w). No significant differences were found with respect to the oil constituents. The main constituents were g-terpinene (
Chiral gas chromatography for the determination of 1,2-O-isopropylidene-sn-glycerol stereoisomers... more Chiral gas chromatography for the determination of 1,2-O-isopropylidene-sn-glycerol stereoisomers A stereospecific gas chromatography (GC) method using a (6-O-t Butyldimethylsilyl-2,3-di-O-methyl)-b-cyclodextrin as the chiral stationary phase has been developed and validated for the determination of the enantiomers of 1,2-O-isopropylidene-snglycerol (IPG), an important chiral synthon, in kinetic resolution experiments. After liquid-liquid extraction with ethyl acetate, the enantiomers of R-(-)-IPG and S-(+)-IPG and their corresponding butyrate-and caprylate esters were baseline separated using this chiral GC method. The method was accurate, reproducible, specific, and precise and recoveries of at least 77% were accomplished. The detection limits for IPG and its esters were 0.6 ng and 0.1 ng, respectively. The application of this method was demonstrated by a kinetic resolution experiment using the lipase A of Bacillus subtilis.
A new valerenan e sesquiterpenoid, m ethyl valerenate (1), was found in the essential oil from u ... more A new valerenan e sesquiterpenoid, m ethyl valerenate (1), was found in the essential oil from u nderground parts of Valeriana officinalis L. s.l. S pectral d ata of m ethyl valerenate, which was synthesized from valerenic acid (2), are given in this paper.
The objectives of this study were to determine whether a new degradable synthetic barrier membran... more The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb) composed of poly(dl-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes. In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (muCT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model. New bone formation could be detected by post-mortem microradiography in 130 samples and by muCT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes. In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.
The essential oils of Sassafras albidum, obtained by hydrodistallation of the root bark and root ... more The essential oils of Sassafras albidum, obtained by hydrodistallation of the root bark and root wood, were analyzed by GC and GC/MS. The main component of the root bark and root wood oils was safrole (61.29–88.80%). Both oils contained the same constituents although there were some quantitative differences.
... Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida, Swieteniamacrop... more ... Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida, Swieteniamacrophylla and Phyllantus ... Jamu: The Indonesian traditional herbal medicine 25 Antidiabetic Diabetes mellitus is ... clinically to treat diabetes have shown their antidiabetes activity in vitro ...
... Ondanks de grotere maatvoering zijn zij dan nog altijd minder sterk. ... Van de hui-dige gene... more ... Ondanks de grotere maatvoering zijn zij dan nog altijd minder sterk. ... Van de hui-dige generatie degradeerbare osteosynthesematerialen is echter tot nu toe niet bewezen dat zij het even goed doen als metalen systemen (Buijs et al., 2006). ...
International Journal of Oral and Maxillofacial Surgery, Nov 1, 2007
To present relevant mechanical data to simplify the selection of an osteofixation system for situ... more To present relevant mechanical data to simplify the selection of an osteofixation system for situations requiring immobilization in oral and maxillofacial surgery. Materials and Methods: Seven biodegradable and 2 titanium osteofixation systems were investigated. The plates and screws were fixed to 2 polymethylmethacrylate (PMMA) blocks to simulate bone segments. The plates and screws were subjected to tensile, side bending, and torsion tests. During tensile tests, the strength of the osteofixation system was monitored. The stiffness was calculated for the tensile, side bending, and torsion tests. Results: The 2 titanium systems (1.5 mm and 2.0 mm) presented significantly higher tensile strength and stiffness compared with the 7 biodegradable systems (2.0 mm, 2.1 mm, and 2.5 mm). The 2.0 mm titanium system showed significantly higher side bending and torsion stiffness than the other 8 systems. Conclusion: Based on the results of the current study, it can be concluded that the titanium osteofixation systems were (significantly) stronger and stiffer than the biodegradable systems. The BioSorb FX
The essential oils of lamina and petiole of Heracleum dissectum are described. Fifty-seven compou... more The essential oils of lamina and petiole of Heracleum dissectum are described. Fifty-seven compounds have been identified by mass spectrometry and retention indices. Differences between the oils of the two organs were mainly quantitative.
... ESSENTIAL OILS Approximately 50 g of terminal 15 cm vege-tative growth were harvested at 0900... more ... ESSENTIAL OILS Approximately 50 g of terminal 15 cm vege-tative growth were harvested at 0900. Within two hours the foliage and stems were steam-dis-tilled in a Neo-Clevenger of Moritz after Kaiser and Lang (1951) with the modification of He-fendehl (Rudloff 1969). ...
Journal of Oral and Maxillofacial Surgery, Dec 1, 2011
Take-down policy If you believe that this document breaches copyright please contact us providing... more Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
The objectives of this study were to determine whether a new degradable synthetic barrier membran... more The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb) composed of poly(dl-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes. In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (muCT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model. New bone formation could be detected by post-mortem microradiography in 130 samples and by muCT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes. In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.
The alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida (oleovorans) to met... more The alkBFGHJKL and alkST operons encode enzymes that allow Pseudomonas putida (oleovorans) to metabolize alkanes. In this paper we report the nucleotide sequence of a 4592 bp region of the alkBFGHJKL operon encoding the AlkJ, AlkK and AlkL polypeptides. The alkJ gene encodes a protein of 59 kilodaltons. The predicted amino acid sequence shows significant homology with four flavin proteins: choline dehydrogenase, a glucose dehydrogenase and two oxidases. AlkJ is membrane-bound and converts aiiphatic medium-chain-tength alcohois into aldehydes. The properties of AlkJ suggest that it is linked to the electron transfer chain. AlkJ is necessary for growth on aikanes only in P. putida alcohol dehydrogenase (AIcA) mutants. AlkK is homologous to a range of proteins which act by an ATP-dependent covalent binding of AMP to their substrate. This list includes the acetate, coumarate and long-chain fatty acid CoA iigases. The alkK gene compiements a fadD mutation in Escherichia coll., which shows that it indeed encodes an acyl-CoA synthetase. AlkK is a 60 kilodalton protein located in the cytoplasm. AlkL is homologous to OmpW, a Vibrio cholerae outer membrane protein of unknown function, and a hypothetical polypeptide encoded by ytt4 in E. coli. AlkL, OmpW and Ytt4 all have a signal peptide and end with a sequence characteristic of outer membrane proteins. The alkL gene product was found in
International Journal of Oral and Maxillofacial Surgery, Oct 1, 2017
Since the introduction of rigid internal fixation devices, more and more surgeons favour an open ... more Since the introduction of rigid internal fixation devices, more and more surgeons favour an open approach to treating condylar fractures of the mandible in adult patients. Different indications for open treatment have been published. Open treatment is associated with surgical complications because of the technique employed. The aim of this systematic review was to provide an overview of the studies published exclusively on open treatment, and to summarize the existing open treatment modalities and their clinical outcomes. A total of seventy studies were selected for detailed analysis. Most studies reported good results with regard to the outcome measures of open treatment. Surgical complications including hematoma, wound infection, weakness of the facial nerve, sialocele, salivary fistula, sensory disturbance of the great auricular nerve, unsatisfactory scarring, and fixation failure were reported in the studies. This review suggests that because of the high level of methodological variance in the relevant studies published to date, among other factors, there are currently no evidence-based conclusions or guidelines that can be formulated with regard to the most appropriate open treatment. Establishment of such standards could potentially improve treatment outcomes.
Bunium persicum fruit oils from wild type (WT), first (CY1) and second year (CY2) cultivars (four... more Bunium persicum fruit oils from wild type (WT), first (CY1) and second year (CY2) cultivars (fourth and fifth year plants) were analyzed by GC and GC/MS. The essential oil content of the WT (9.1% v/w) was higher than the oil content of the CY1 (6.2% v/w) and CY2 (5.1% v/w). No significant differences were found with respect to the oil constituents. The main constituents were g-terpinene (
Chiral gas chromatography for the determination of 1,2-O-isopropylidene-sn-glycerol stereoisomers... more Chiral gas chromatography for the determination of 1,2-O-isopropylidene-sn-glycerol stereoisomers A stereospecific gas chromatography (GC) method using a (6-O-t Butyldimethylsilyl-2,3-di-O-methyl)-b-cyclodextrin as the chiral stationary phase has been developed and validated for the determination of the enantiomers of 1,2-O-isopropylidene-snglycerol (IPG), an important chiral synthon, in kinetic resolution experiments. After liquid-liquid extraction with ethyl acetate, the enantiomers of R-(-)-IPG and S-(+)-IPG and their corresponding butyrate-and caprylate esters were baseline separated using this chiral GC method. The method was accurate, reproducible, specific, and precise and recoveries of at least 77% were accomplished. The detection limits for IPG and its esters were 0.6 ng and 0.1 ng, respectively. The application of this method was demonstrated by a kinetic resolution experiment using the lipase A of Bacillus subtilis.
A new valerenan e sesquiterpenoid, m ethyl valerenate (1), was found in the essential oil from u ... more A new valerenan e sesquiterpenoid, m ethyl valerenate (1), was found in the essential oil from u nderground parts of Valeriana officinalis L. s.l. S pectral d ata of m ethyl valerenate, which was synthesized from valerenic acid (2), are given in this paper.
The objectives of this study were to determine whether a new degradable synthetic barrier membran... more The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb) composed of poly(dl-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes. In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (muCT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model. New bone formation could be detected by post-mortem microradiography in 130 samples and by muCT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes. In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.
The essential oils of Sassafras albidum, obtained by hydrodistallation of the root bark and root ... more The essential oils of Sassafras albidum, obtained by hydrodistallation of the root bark and root wood, were analyzed by GC and GC/MS. The main component of the root bark and root wood oils was safrole (61.29–88.80%). Both oils contained the same constituents although there were some quantitative differences.
... Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida, Swieteniamacrop... more ... Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida, Swieteniamacrophylla and Phyllantus ... Jamu: The Indonesian traditional herbal medicine 25 Antidiabetic Diabetes mellitus is ... clinically to treat diabetes have shown their antidiabetes activity in vitro ...
... Ondanks de grotere maatvoering zijn zij dan nog altijd minder sterk. ... Van de hui-dige gene... more ... Ondanks de grotere maatvoering zijn zij dan nog altijd minder sterk. ... Van de hui-dige generatie degradeerbare osteosynthesematerialen is echter tot nu toe niet bewezen dat zij het even goed doen als metalen systemen (Buijs et al., 2006). ...
International Journal of Oral and Maxillofacial Surgery, Nov 1, 2007
To present relevant mechanical data to simplify the selection of an osteofixation system for situ... more To present relevant mechanical data to simplify the selection of an osteofixation system for situations requiring immobilization in oral and maxillofacial surgery. Materials and Methods: Seven biodegradable and 2 titanium osteofixation systems were investigated. The plates and screws were fixed to 2 polymethylmethacrylate (PMMA) blocks to simulate bone segments. The plates and screws were subjected to tensile, side bending, and torsion tests. During tensile tests, the strength of the osteofixation system was monitored. The stiffness was calculated for the tensile, side bending, and torsion tests. Results: The 2 titanium systems (1.5 mm and 2.0 mm) presented significantly higher tensile strength and stiffness compared with the 7 biodegradable systems (2.0 mm, 2.1 mm, and 2.5 mm). The 2.0 mm titanium system showed significantly higher side bending and torsion stiffness than the other 8 systems. Conclusion: Based on the results of the current study, it can be concluded that the titanium osteofixation systems were (significantly) stronger and stiffer than the biodegradable systems. The BioSorb FX
The essential oils of lamina and petiole of Heracleum dissectum are described. Fifty-seven compou... more The essential oils of lamina and petiole of Heracleum dissectum are described. Fifty-seven compounds have been identified by mass spectrometry and retention indices. Differences between the oils of the two organs were mainly quantitative.
... ESSENTIAL OILS Approximately 50 g of terminal 15 cm vege-tative growth were harvested at 0900... more ... ESSENTIAL OILS Approximately 50 g of terminal 15 cm vege-tative growth were harvested at 0900. Within two hours the foliage and stems were steam-dis-tilled in a Neo-Clevenger of Moritz after Kaiser and Lang (1951) with the modification of He-fendehl (Rudloff 1969). ...
Journal of Oral and Maxillofacial Surgery, Dec 1, 2011
Take-down policy If you believe that this document breaches copyright please contact us providing... more Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
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