rabia shah

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Don Ross

University College Cork

Vittorio Gallese

Università degli Studi di Parma (Italy)

Anne Bruton

University of Southampton

Paulo Azevedo

Universidade Federal de São Paulo (UNIFESP)

Dr. Mohammed Abdul Hannan Hazari

Deccan College of Medical Sciences, Hyderabad, India.

Claude J SPICHER

McGill University

Carlo Semenza

Università degli Studi di Padova

Bulent Elbasan

Gazi University

Irina Malkina-Pykh

Saint-Petersburg State University

Physical Treatments: Specific Physical Therapy Journal (PTJ)

University of Social Welfare and Rehabilitation Sciences

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Papers by rabia shah

Osteogenic sarcoma producing human chorionic gonadotrophin: Case report with immunohistochemical studies

Cancer, 1984

An osteogenic sarcoma occurring in a 22-year-old woman was found to be associated with production... more An osteogenic sarcoma occurring in a 22-year-old woman was found to be associated with production of a large amount of beta human chorionic gonadotrophin (B-hCG). Pregnancy was excluded on the basis of a normal ultrasonogram and a proliferative type endometrium obtained by curettage. A homogenate of the tumor was strongly positive for B-hCG while immunohistochemical staining of the tumor cells was strongly positive for B-hCG and negative for pregnancy associated glycoprotein. These results indicate ectopic production of hCG by the osteosarcoma.

Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis

BMC Cancer, 2009

Background The present study is aimed at identifying potential candidate genes as prognostic mark... more Background The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling. Methods The gene expression profile of patients (n=37) with oral tongue SCC were analyzed using Affymetrix HG_U95Av2 high-density oligonucleotide arrays. Patients (n=20) from which there were available tumor and matched normal mucosa were grouped into stage (early vs. late) and nodal disease (node positive vs. node negative) subgroups and genes differentially expressed in tumor vs. normal and between the subgroups were identified. Three genes, GLUT3, HSAL2, and PACE4, were selected for their potential biological significance in a larger cohort of 49 patients via quantitative real-time RT-PCR. Results Hierarchical clustering analyses failed to show significant segregation of patients. In patients (n=20) with available tumor and matched normal mucosa, 77 genes were found to be differentially expressed (PMMP-1 encoding interstitial collagenase showed the highest level of increase (average: 34.18 folds). Using the criterion of two-fold or greater as overexpression, 30.6%, 24.5% and 26.5% of patients showed high levels of GLUT3, HSAL2 and PACE4, respectively. Univariate analyses demonstrated that GLUT3 over-expression correlated with depth of invasion (PHSAL2 was positively associated with depth of invasion (P=0.015) and advanced T stage (P=0.047). In survival studies, only GLUT3 showed a prognostic value with disease-free (P=0.049), relapse-free (P=0.002) and overall survival (P=0.003). PACE4 mRNA expression failed to show correlation with any of the relevant parameters. Conclusion The characterization of genes identified to be significant predictors of prognosis by oligonucleotide microarray and further validation by real-time RT-PCR offers a powerful strategy for identification of novel targets for prognostication and treatment of oral tongue carcinoma.

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Superparamagnetic bimetallic iron palladium nanoalloy: synthesis and characterization

Nanotechnology, 2008

Iron-palladium nanoalloy in the particle size range of 15-30 nm is synthesized by the relatively ... more Iron-palladium nanoalloy in the particle size range of 15-30 nm is synthesized by the relatively low temperature thermal decomposition of coprecipitated [Fe(Bipy) 3 ]Cl 2 and [Pd(Bipy) 3 ]Cl 2 in an inert ambient of dry argon gas. The silvery black Fe-Pd alloy nanoparticles are air-stable and have been characterized by EDX-RF, XRD, AFM, TEM, magnetometry, 57 Fe Mössbauer and impedance spectroscopy. This Fe-Pd nanoalloy is in single phase and contains iron sites having up to 11 nearest-neighboring atoms. It is superparamagnetic in nature with high magnetic susceptibility, low coercivity and hyperfine field.

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Cerebroprotective effect of Korean ginseng tea against global and focal models of ischemia in rats

Journal of Ethnopharmacology, 2005

Korean ginseng tea (KGT), prepared from the roots of Panax ginseng, is widely used by Korean peop... more Korean ginseng tea (KGT), prepared from the roots of Panax ginseng, is widely used by Korean people for antistress, antifatigue, and endurance promoting effects. In the present study we evaluated neuroprotective/cerebroprotective actions of KGT in stroke, using rat global and focal models of ischemia. Varied biochemical/enzymatic alterations, produced subsequent to the application of middle cerebral artery (MCAO) and bilateral carotid artery occlusion (BCAO) followed by reperfusion viz. increase in lipid peroxidation (LPO) and decrease in glutathione (GSH), glutathione reductase (GR), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx) and superoxide dismutase (SOD), were markedly reversed and restored to near normal levels in the groups pre-treated with KGT (350 mg/kg given orally for 10 days). It is concluded that the protective action, exhibited by KGT against hypoperfusion/reperfusion induced brain injury, suggests its therapeutic potential in cerebrovascular diseases (CVD) including stroke. These findings are important because: (a) the present treatment strategies for CVD are far from adequate and (b) KGT with wide usage is known to be a safe natural product.

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WEED FLORA OF PIR MEHR ALI SHAH ARID AGRICULTURE UNIVERSITY RAWALPINDI: WINTER ASPECT

Weeds inventory survey was conducted in the PMAS-Arid Agriculture University, Rawalpindi campus d... more Weeds inventory survey was conducted in the PMAS-Arid Agriculture University, Rawalpindi campus during October, 2007 to February, 2008 and mounted on sheet and deposited in the Department of Botany, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi. The status of each taxa was determined by taking frequency percentage. During the survey, a total of 42 weed species belonging to 37 genera and 18 families were identified. Among them, 27 species were dicot and 15 monocot. Poaceae was found to be the most dominant family in the campus that contributed 30.95% followed by Amaranthaceae (14.29%), Euphorbiaceae and Fabaceae (9.52% each). Most of the species recorded were annual (54%), followed by perennial (29%) and biennial (17%). The most common species were Alternanthera pungens Linn. , Cannabis sativa Linn. , Convolvulus arvensis Linn. , Euphorbia hirta Linn. , Malvestrum coromendilianum (Linn.) Garcke, Oxalis corniculata Linn., Parthenium hysterophorus Linn. and Tribulus terrestris Linn.

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Attenuation of Stress-Elicited Brain Catecholamines, Serotonin and Plasma Corticosterone Levels by Calcined Gold Preparations Used in Indian System of Medicine

Basic & Clinical Pharmacology & Toxicology, 2005

Problems associated with mental health have increased tremendously in modern times. The search fo... more Problems associated with mental health have increased tremendously in modern times. The search for effective and safe alternatives should, therefore, be persued vigourously. Forced immobilization is one of the best explored models of stress in rats and the role of corticosterone, serotonin (5-HT) and catecholamines, i.e. norepinephrine, epinephrine, dopamine is well documented. We investigated the therapeutic potential of two gold preparations (Ayurvedic Swarna Bhasma and Unani Kushta Tila Kalan) in restraint induced stress at different time points of 1 hr, 2 hr and 4 hr. We pretreated rats with two gold prepaprations, Ayurvedic Swarna Bhasma and Unani Kushta Tila Kalan (25 mg/kg, orally for 10 days) prior to restraint stress. Brain catecholamine, serotonin and plasma corticosterone levels were determined following 1, 2 and 4 hr restraint stress, using HPLC and also plasma corticosterone using luminescence spectrophotometry. Gold preparations restored restraint stress-induced elevation in levels of brain catecholamines (norepinephrine, epinephrine and dopmine), 5-HT and plasma corticosterone to near normal levels. Gold, widely used in modern medicine for the treatment of rheumatoid arthritis, is highly valued for various medicinal uses in Indian systems of medicine. Traditional gold preparations are attributed with tonic/rejuvenating and antioxidant properties. Our earlier studies revealed interesting analgesic, immunostimulant, adaptogenic and glycogen sparing properties in these preparations, but their effects in stress and depression have not been investigated yet. Significant restoration of altered values to near normal levels suggest potentials for gold preparations in stress and depression.

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Postnatal depression and its comparison with the gender of newborn in fourth pregnancy

International Journal of Culture and Mental Health, 2011

The present research aimed to study postnatal depression in pregnant mothers and to find out its ... more The present research aimed to study postnatal depression in pregnant mothers and to find out its association with the gender of the newborn in the fourth pregnancy. Cohort research design with purposive sampling technique was used. The sample comprised of 500 pregnant mothers with three alive female issues, taken from the department of gynecology and obstetrics, Sir Ganga Ram Hospital, Lahore. The assessment tools included a demographic questionnaire, the Siddique Shah Depression Scale, the Edinburgh Postnatal Depression Scale and the DSM-IV-TR's criteria of depression. The subjects were divided into two groups after the fourth delivery. Group I included mothers with female issue and group II mothers who gave birth to male issue. Assessment was completed in two phases firstly during the last trimester and then within 16 to 27 days after delivery. Results indicated that there was insignificant mean difference in depression scores of both groups at phase one. However, group I showed significantly higher mean score than group II at phase two. The results support that the birth of female child increases the likelihood of postnatal depression. The results are discussed in the light of previous literature.

Selective and differential enumerations of Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium spp. in yoghurt — A review

International Journal of Food Microbiology, 2011

Yoghurt is increasingly being used as a carrier of probiotic bacteria for their potential health ... more Yoghurt is increasingly being used as a carrier of probiotic bacteria for their potential health benefits. To meet with a recommended level of ≥ 10 6 viable cells/g of a product, assessment of viability of probiotic bacteria in market preparations is crucial. This requires a working method for selective enumeration of these probiotic bacteria and lactic acid bacteria in yoghurt such as Streptococcus thermophilus, Lactobacillus delbrueckii subsp. bulgaricus, Lb. acidophilus, Lb. casei and Bifidobacterium. This chapter presents an overview of media that could be used for differential and selective enumerations of yoghurt bacteria. De Man Rogosa Sharpe agar containing fructose (MRSF), MRS agar pH 5.2 (MRS 5.2), reinforced clostridial prussian blue agar at pH 5.0 (RCPB 5.0) or reinforced clostridial agar at pH 5.3 (RCA 5.3) are suitable for enumeration of Lb. delbrueckii subsp. bulgaricus when the incubation is carried out at 45°C for 72 h. S. thermophilus (ST) agar and M17 are recommended for selective enumeration of S. thermophilus. Selective enumeration of Lb. acidophilus in mixed culture could be made in Rogosa agar added with 5-bromo-4-chloro-3-indolyl-β-D-glucopyranoside (X-Glu) or MRS containing maltose (MRSM) and incubation in a 20% CO 2 atmosphere. Lb. casei could be selectively enumerated on specially formulated Lb. casei (LC) agar from products containing yoghurt starter bacteria (S. thermophilus and Lb. delbrueckii subsp. bulgaricus), Lb. acidophilus, Bifidobacterium spp. and Lb. casei. Bifidobacterium could be enumerated on MRS agar supplemented with nalidixic acid, paromomycin, neomycin sulphate and lithium chloride (MRS-NPNL) under anaerobic incubation at 37°C for 72 h.

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KGF1 plasmid delivered with electroporation accelerates wound closure in diabetic mice

Journal of The American College of Surgeons, 2004

plasmid transfections with EP) had similar results; . Single EP transfection of a KGF plasmid vec... more

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Production of dextran from sucrose by a newly isolated strain of Leuconostoc mesenteroides (PCSIR-3) with reference to L. mesenteroides NRRL B512F

Biotechnology and Applied Biochemistry, 2001

A newly isolated strain of Leuconostoc mesenteroides (PCSIR-3) produced a different dextran compa... more A newly isolated strain of Leuconostoc mesenteroides (PCSIR-3) produced a different dextran compared with that of L. mesenteroides NRRL B-512F. Different media compositions used for dextran production showed that media containing CaCl(2) produced dextran in higher quantities compared with other media. The viscosity of the dextran produced in different media varied in nature. Dextran from media 1 and 2 was of higher molecular mass compared with that from media 3, 4 and 5. Dextran production is also effected by the sucrose concentration in the media. The higher the initial concentration of sucrose, the higher is the yield of dextran produced per unit volume; however, the percentage conversion of sucrose into dextran decreases. A continuous drop in pH was associated with growth and dextran production. The yield of dextran increases during the growth phase and maximum yield was obtained at the end of the exponential phase. Dextran produced by L. mesenteroides PCSIR-3 is quite different from the dextran produced by NRRL B-512F. Maximum dextran production from L. mesenteroides PCSIR-3 occurs in 18 h compared with 12 h for NRRL B-512F.

Osteogenic sarcoma producing human chorionic gonadotrophin: Case report with immunohistochemical studies

Cancer, 1984